Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CMGC family protein kinase | 0.0381 | 0.7373 | 1 |
Loa Loa (eye worm) | microfilarial chitinase | 0.0078 | 0.0227 | 0.0227 |
Brugia malayi | Protein kinase domain containing protein | 0.0088 | 0.0473 | 0.0202 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0707 | 0.0707 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0288 | 0.5184 | 1 |
Brugia malayi | Dual-specificity tyrosine-phosphorylation regulated kinase 2 | 0.0381 | 0.7373 | 0.7366 |
Leishmania major | serine/threonine kinase-like protein, putative | 0.0088 | 0.0473 | 0.0275 |
Echinococcus granulosus | serine:threonine protein kinase NLK | 0.0088 | 0.0473 | 0.0094 |
Echinococcus multilocularis | dual specificity | 0.0381 | 0.7373 | 0.7337 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0381 | 0.7373 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 15 | 0.0088 | 0.0473 | 0.0094 |
Schistosoma mansoni | hypothetical protein | 0.0127 | 0.1385 | 0.1052 |
Entamoeba histolytica | protein kinase, putative | 0.0102 | 0.0797 | 0.0732 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0088 | 0.0473 | 0.0275 |
Brugia malayi | Cell division protein kinase 2 | 0.0088 | 0.0473 | 0.0202 |
Echinococcus multilocularis | dual specificity | 0.0381 | 0.7373 | 0.7337 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.1385 | 0.1385 |
Brugia malayi | GSG2 | 0.0489 | 0.991 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0102 | 0.0797 | 0.0539 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0381 | 0.7373 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0127 | 0.1385 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0088 | 0.0473 | 0.0094 |
Giardia lamblia | Kinase, CMGC DYRK | 0.0381 | 0.7373 | 1 |
Trypanosoma cruzi | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0381 | 0.7373 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0102 | 0.0797 | 0.0732 |
Entamoeba histolytica | hypothetical protein | 0.0085 | 0.0383 | 0.0148 |
Echinococcus multilocularis | cyclin dependent kinase 9 | 0.0088 | 0.0473 | 0.0094 |
Onchocerca volvulus | 0.0127 | 0.1385 | 1 | |
Brugia malayi | endochitinase | 0.009 | 0.0505 | 0.0236 |
Echinococcus granulosus | dual specificity | 0.0381 | 0.7373 | 0.7337 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0102 | 0.0797 | 0.0732 |
Echinococcus multilocularis | dual specificity | 0.0102 | 0.0797 | 0.0435 |
Leishmania major | mitogen-activated protein kinase, putative,map kinase-like protein | 0.0088 | 0.0473 | 0.0275 |
Toxoplasma gondii | cell-cycle-associated protein kinase DYRK2, putative | 0.0381 | 0.7373 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0381 | 0.7373 | 1 |
Echinococcus granulosus | dual specificity | 0.0381 | 0.7373 | 0.7337 |
Echinococcus multilocularis | serine:threonine protein kinase NLK | 0.0088 | 0.0473 | 0.0094 |
Plasmodium falciparum | conserved protein, unknown function | 0.0127 | 0.1385 | 1 |
Trypanosoma brucei | CMGC/DYRK protein kinase, putative | 0.0102 | 0.0797 | 0.047 |
Onchocerca volvulus | Putative endochitinase | 0.009 | 0.0505 | 0.2052 |
Brugia malayi | Endochitinase | 0.009 | 0.0505 | 0.0236 |
Loa Loa (eye worm) | CMGC/CDK/CRK7 protein kinase | 0.0088 | 0.0473 | 0.0473 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0489 | 0.991 | 1 |
Schistosoma mansoni | protein kinase | 0.0088 | 0.0473 | 0.0094 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0288 | 0.5184 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0102 | 0.0797 | 0.0435 |
Echinococcus granulosus | Cell division cycle 2 protein kinase | 0.0088 | 0.0473 | 0.0094 |
Echinococcus granulosus | dual specificity | 0.0102 | 0.0797 | 0.0435 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0489 | 0.991 | 1 |
Leishmania major | protein kinase, putative,dual-specificity protein kinase, putative | 0.0381 | 0.7373 | 1 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0102 | 0.0797 | 0.047 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0381 | 0.7373 | 1 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0102 | 0.0797 | 0.0797 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0489 | 0.991 | 1 |
Echinococcus granulosus | dual specificity | 0.0381 | 0.7373 | 0.7337 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0381 | 0.7373 | 1 |
Brugia malayi | cyclin-dependent kinase 7 homolog | 0.0088 | 0.0473 | 0.0202 |
Echinococcus multilocularis | Hepatocellular carcinoma associated antigen 59 | 0.0127 | 0.1385 | 0.1052 |
Entamoeba histolytica | protein kinase, putative | 0.0381 | 0.7373 | 1 |
Echinococcus granulosus | cyclin dependent kinase 9 | 0.0088 | 0.0473 | 0.0094 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0088 | 0.0473 | 0.0473 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0102 | 0.0797 | 0.047 |
Loa Loa (eye worm) | chitinase I | 0.008 | 0.0278 | 0.0278 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK2 protein kinase | 0.0381 | 0.7373 | 0.7373 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0707 | 0.0707 |
Echinococcus multilocularis | Cell division cycle 2 protein kinase | 0.0088 | 0.0473 | 0.0094 |
Schistosoma mansoni | serine/threonine kinase | 0.0088 | 0.0473 | 0.0094 |
Brugia malayi | Hepatocellular carcinoma-associated antigen 59 family protein | 0.0127 | 0.1385 | 0.115 |
Trypanosoma brucei | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0381 | 0.7373 | 1 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0268 | 0.4706 | 1 |
Loa Loa (eye worm) | haspin protein kinase | 0.0489 | 0.991 | 0.991 |
Loa Loa (eye worm) | cuticular endochitinase | 0.008 | 0.0278 | 0.0278 |
Echinococcus granulosus | Hepatocellular carcinoma associated antigen 59 | 0.0127 | 0.1385 | 0.1052 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0489 | 0.991 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.1385 | 0.1385 |
Onchocerca volvulus | Putative endochitinase | 0.009 | 0.0505 | 0.2052 |
Onchocerca volvulus | 0.0127 | 0.1385 | 1 | |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0489 | 0.991 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0381 | 0.7373 | 0.7337 |
Entamoeba histolytica | protein kinase, putative | 0.0102 | 0.0797 | 0.0732 |
Echinococcus multilocularis | dual specificity | 0.0381 | 0.7373 | 0.7337 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0381 | 0.7373 | 1 |
Brugia malayi | hypothetical protein | 0.0489 | 0.991 | 1 |
Onchocerca volvulus | Putative endochitinase | 0.009 | 0.0505 | 0.2052 |
Schistosoma mansoni | hypothetical protein | 0.0489 | 0.991 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0102 | 0.0797 | 0.0732 |
Loa Loa (eye worm) | haspin protein kinase | 0.0489 | 0.991 | 0.991 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0088 | 0.0473 | 0.0275 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.793 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.776 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.774 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.712 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.704 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.702 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.696 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.681 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.673 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.619 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.573 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.