Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | protein kinase domain containing protein | 0.0183 | 0.5997 | 0.828 |
Plasmodium vivax | hypothetical protein, conserved | 0.0119 | 0.3134 | 1 |
Toxoplasma gondii | cell-cycle-associated protein kinase DYRK2, putative | 0.0211 | 0.7243 | 1 |
Echinococcus granulosus | dual specificity | 0.0211 | 0.7243 | 0.7333 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0183 | 0.5997 | 0.828 |
Brugia malayi | endochitinase | 0.0084 | 0.1561 | 0.1581 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0211 | 0.7243 | 0.7333 |
Mycobacterium tuberculosis | Possible chitinase | 0.0064 | 0.0659 | 0.5 |
Trypanosoma cruzi | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0211 | 0.7243 | 1 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK2 protein kinase | 0.0211 | 0.7243 | 0.7243 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0211 | 0.7243 | 1 |
Leishmania major | chitinase | 0.0075 | 0.1155 | 0.1595 |
Echinococcus granulosus | dual specificity | 0.0183 | 0.5997 | 0.6072 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.3134 | 0.3134 |
Entamoeba histolytica | chitinase, putative | 0.0075 | 0.1155 | 0.1595 |
Onchocerca volvulus | Putative endochitinase | 0.0084 | 0.1561 | 0.2052 |
Brugia malayi | hypothetical protein | 0.027 | 0.9876 | 1 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0183 | 0.5997 | 0.5997 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.027 | 0.9876 | 1 |
Brugia malayi | Endochitinase | 0.0084 | 0.1561 | 0.1581 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0211 | 0.7243 | 1 |
Echinococcus multilocularis | dual specificity | 0.0211 | 0.7243 | 0.7333 |
Entamoeba histolytica | protein kinase, putative | 0.0183 | 0.5997 | 0.828 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0211 | 0.7243 | 1 |
Brugia malayi | endochitinase | 0.0075 | 0.1155 | 0.117 |
Brugia malayi | Hepatocellular carcinoma-associated antigen 59 family protein | 0.0119 | 0.3134 | 0.3173 |
Echinococcus multilocularis | dual specificity | 0.0183 | 0.5997 | 0.6072 |
Loa Loa (eye worm) | cuticular endochitinase | 0.0075 | 0.1155 | 0.1155 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0211 | 0.7243 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.5874 | 0.5874 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0211 | 0.7243 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.5874 | 0.5874 |
Loa Loa (eye worm) | microfilarial chitinase | 0.0073 | 0.1065 | 0.1065 |
Giardia lamblia | Kinase, CMGC DYRK | 0.0211 | 0.7243 | 1 |
Leishmania major | protein kinase, putative,dual-specificity protein kinase, putative | 0.0211 | 0.7243 | 1 |
Loa Loa (eye worm) | haspin protein kinase | 0.027 | 0.9876 | 0.9876 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0211 | 0.7243 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0183 | 0.5997 | 0.6072 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0211 | 0.7243 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.3134 | 0.3134 |
Trypanosoma brucei | CMGC/DYRK protein kinase, putative | 0.0183 | 0.5997 | 0.828 |
Onchocerca volvulus | 0.0119 | 0.3134 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0119 | 0.3134 | 0.3173 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0064 | 0.0659 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.027 | 0.9876 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0211 | 0.7243 | 1 |
Onchocerca volvulus | 0.0119 | 0.3134 | 1 | |
Echinococcus granulosus | dual specificity | 0.0211 | 0.7243 | 0.7333 |
Plasmodium falciparum | conserved protein, unknown function | 0.0119 | 0.3134 | 1 |
Echinococcus multilocularis | dual specificity | 0.0211 | 0.7243 | 0.7333 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.027 | 0.9876 | 1 |
Echinococcus multilocularis | Hepatocellular carcinoma associated antigen 59 | 0.0119 | 0.3134 | 0.3173 |
Brugia malayi | Dual-specificity tyrosine-phosphorylation regulated kinase 2 | 0.0211 | 0.7243 | 0.7333 |
Echinococcus granulosus | dual specificity | 0.0211 | 0.7243 | 0.7333 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.027 | 0.9876 | 1 |
Onchocerca volvulus | Putative endochitinase | 0.0084 | 0.1561 | 0.2052 |
Schistosoma mansoni | hypothetical protein | 0.027 | 0.9876 | 1 |
Echinococcus granulosus | Hepatocellular carcinoma associated antigen 59 | 0.0119 | 0.3134 | 0.3173 |
Brugia malayi | GSG2 | 0.027 | 0.9876 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0659 | 0.0659 |
Trypanosoma brucei | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0211 | 0.7243 | 1 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0064 | 0.0659 | 0.5 |
Onchocerca volvulus | Putative endochitinase | 0.0084 | 0.1561 | 0.2052 |
Entamoeba histolytica | protein kinase, putative | 0.0183 | 0.5997 | 0.828 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0183 | 0.5997 | 0.828 |
Echinococcus multilocularis | dual specificity | 0.0211 | 0.7243 | 0.7333 |
Loa Loa (eye worm) | haspin protein kinase | 0.027 | 0.9876 | 0.9876 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0183 | 0.5997 | 0.828 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.027 | 0.9876 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0183 | 0.5997 | 0.828 |
Brugia malayi | Protein kinase domain containing protein | 0.0183 | 0.5997 | 0.6072 |
Loa Loa (eye worm) | chitinase I | 0.0075 | 0.1155 | 0.1155 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.