Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 6 (neurotransmitter transporter, glycine), member 9 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | serotonin transporter | solute carrier family 6 (neurotransmitter transporter, glycine), member 9 | 633 aa | 616 aa | 38.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.9288 | 0.961 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0096 | 0.9288 | 0.9288 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.9288 | 0.961 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0096 | 0.9288 | 0.9288 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.7706 | 0.8297 |
Onchocerca volvulus | 0.008 | 0.7371 | 1 | |
Plasmodium vivax | amine transporter, putative | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0101 | 1 | 1 |
Plasmodium falciparum | transporter, putative | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0096 | 0.9288 | 1 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0096 | 0.9288 | 0.9288 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0101 | 1 | 1 |
Plasmodium falciparum | amino acid transporter, putative | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0096 | 0.9288 | 0.9288 |
Echinococcus granulosus | jun protein | 0.0101 | 1 | 1 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | jun protein | 0.0101 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0019 | 0 | 0.5 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0019 | 0 | 0.5 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.9664 | 1 |
Schistosoma mansoni | jun-related protein | 0.0082 | 0.7706 | 0.8297 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0096 | 0.9288 | 1 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0019 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0019 | 0 | 0.5 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0096 | 0.9288 | 0.9288 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0096 | 0.9288 | 0.961 |
Toxoplasma gondii | hypothetical protein | 0.0019 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.008 | 0.7371 | 0.7371 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.5 nM | Inhibition of human GlyT1 expressed in CHO cells assessed as inhibition of [3H]glycine uptake preincubated for 1 mins measured after 2 hrs by liquid scintillation counting | ChEMBL. | 21975065 |
IC50 (binding) | = 7.51 nM | Inhibition of GlyT1 in human JAR cells assessed as inhibition of [3H]glycine uptake preincubated for 1 mins measured after 2 hrs by liquid scintillation counting | ChEMBL. | 21975065 |
Ratio IC50 (binding) | = 11 | Ratio of SSR504734 IC50 to compound IC50 for human GlyT1 | ChEMBL. | 21975065 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.