Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CAMK family protein kinase | 0.1557 | 1 | 0.5 |
Trypanosoma cruzi | NIMA-related kinase, putative | 0.1557 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.1557 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) | 0.1161 | 0 | 0.5 |
Plasmodium falciparum | NIMA related kinase 2 | 0.1557 | 1 | 0.5 |
Plasmodium vivax | serine/threonine-protein kinase Nek1, putative | 0.1557 | 1 | 0.5 |
Toxoplasma gondii | NEK kinase | 0.1557 | 1 | 0.5 |
Giardia lamblia | Kinase, NEK | 0.1557 | 1 | 0.5 |
Toxoplasma gondii | NEK kinase | 0.1557 | 1 | 0.5 |
Mycobacterium tuberculosis | Isocitrate lyase Icl (isocitrase) (isocitratase) | 0.1161 | 0 | 0.5 |
Plasmodium falciparum | NIMA related kinase 4 | 0.1557 | 1 | 0.5 |
Leishmania major | protein kinase, putative | 0.1557 | 1 | 0.5 |
Mycobacterium ulcerans | isocitrate lyase Icl | 0.1161 | 0 | 0.5 |
Leishmania major | protein kinase, putative,serine/threonine-protein kinase Nek1, putative | 0.1557 | 1 | 0.5 |
Toxoplasma gondii | NEK kinase | 0.1557 | 1 | 0.5 |
Trypanosoma cruzi | Serine/threonine-protein kinase NEK11, putative | 0.1557 | 1 | 1 |
Plasmodium vivax | serine/threonine-protein kinase NEK4, putative | 0.1557 | 1 | 0.5 |
Trypanosoma brucei | Serine/threonine-protein kinase NEK16, putative | 0.1557 | 1 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.1557 | 1 | 0.5 |
Trypanosoma cruzi | Serine/threonine-protein kinase NEK16, putative | 0.1557 | 1 | 1 |
Mycobacterium ulcerans | isocitrate lyase AceAb | 0.1161 | 0 | 0.5 |
Trichomonas vaginalis | STE family protein kinase | 0.1557 | 1 | 0.5 |
Trypanosoma brucei | NIMA-related protein kinase | 0.1557 | 1 | 0.5 |
Leishmania major | serine/threonine-protein kinase, putative | 0.1557 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) | 0.1161 | 0 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.1557 | 1 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase Nek1 | 0.1517 | 0.8998 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1557 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE ISOCITRATE LYASE AceA (ISOCITRASE) (ISOCITRATASE) (ICL) | 0.1161 | 0 | 0.5 |
Trypanosoma brucei | Serine/threonine-protein kinase NEK11, putative | 0.1557 | 1 | 0.5 |
Trypanosoma cruzi | Serine/threonine-protein kinase NEK11, putative | 0.1557 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase Nek1 | 0.1517 | 0.8998 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.58 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.413 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.364 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.111 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.