Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.0802 | 0.2898 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0336 | 0.1173 | 0.1091 |
Echinococcus multilocularis | 0.192 | 0.7033 | 1 | |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.0054 | 0.444 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0164 | 0.0068 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.062 | 0.2224 | 0.2148 |
Trypanosoma brucei | phosphatidylinositol 3-kinase tor, putative | 0.0021 | 0.001 | 0.0033 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.0812 | 0.2935 | 0.2876 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.062 | 0.2224 | 0.7622 |
Giardia lamblia | GTOR | 0.0045 | 0.0097 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.0336 | 0.1173 | 0.1087 |
Loa Loa (eye worm) | hypothetical protein | 0.0802 | 0.2898 | 0.2839 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0336 | 0.1173 | 0.1087 |
Schistosoma mansoni | protein kinase | 0.192 | 0.7033 | 0.7004 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0687 | 0.2471 | 0.3422 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0038 | 0.0072 | 0.6827 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0164 | 0.0068 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.003 | 0.1267 |
Trypanosoma cruzi | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.0802 | 0.2898 | 1 |
Echinococcus granulosus | Serine/threonine-protein kinase Genghis Khan | 0.0812 | 0.2935 | 0.2876 |
Loa Loa (eye worm) | STE/STE20/KHS protein kinase | 0.0812 | 0.2935 | 0.2876 |
Echinococcus multilocularis | carbonic anhydrase | 0.0336 | 0.1173 | 0.1552 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0063 | 0.556 |
Echinococcus multilocularis | carbonic anhydrase | 0.0336 | 0.1173 | 0.1552 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.062 | 0.2224 | 0.2156 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0336 | 0.1173 | 0.1087 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0045 | 0.0097 | 0.0119 |
Plasmodium falciparum | carbonic anhydrase | 0.0336 | 0.1173 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.003 | 0.1267 |
Loa Loa (eye worm) | hypothetical protein | 0.0802 | 0.2898 | 0.2839 |
Brugia malayi | Protein kinase domain containing protein | 0.0812 | 0.2935 | 0.2866 |
Schistosoma mansoni | vam6/vps39 related | 0.0802 | 0.2898 | 0.2829 |
Loa Loa (eye worm) | hypothetical protein | 0.2712 | 0.9964 | 1 |
Echinococcus granulosus | Vam6:Vps39 protein | 0.0802 | 0.2898 | 0.2839 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0029 | 0.1138 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0336 | 0.1173 | 0.1087 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.0021 | 0.0018 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.062 | 0.2224 | 0.7674 |
Echinococcus multilocularis | carbonic anhydrase II | 0.062 | 0.2224 | 0.3067 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.0164 | 0.0098 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.062 | 0.2224 | 0.2148 |
Schistosoma mansoni | protein kinase | 0.0812 | 0.2935 | 0.2866 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.062 | 0.2224 | 0.2156 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.0054 | 0.444 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.0054 | 0.444 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0045 | 0.0097 | 1 |
Schistosoma mansoni | mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 | 0.0802 | 0.2898 | 0.2829 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.0164 | 0.0069 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.0045 | 0.0097 | 0.0156 |
Echinococcus granulosus | GTPase activating Rap:RanGAP domain 3 | 0.0802 | 0.2898 | 0.2839 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0164 | 0.0068 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0336 | 0.1173 | 0.1087 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0063 | 0.556 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0336 | 0.1173 | 0.1087 |
Echinococcus granulosus | carbonic anhydrase | 0.0336 | 0.1173 | 0.1091 |
Echinococcus multilocularis | serine:threonine protein kinase MRCK beta | 0.0812 | 0.2935 | 0.4091 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0812 | 0.2935 | 0.4091 |
Echinococcus granulosus | carbonic anhydrase | 0.0336 | 0.1173 | 0.1091 |
Echinococcus granulosus | protein kinase | 0.192 | 0.7033 | 0.703 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0045 | 0.0097 | 1 |
Schistosoma mansoni | protein kinase | 0.2722 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.003 | 0.0042 | 0.2856 |
Loa Loa (eye worm) | hypothetical protein | 0.0802 | 0.2898 | 0.2839 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0687 | 0.2471 | 0.2406 |
Echinococcus multilocularis | carbonic anhydrase | 0.0336 | 0.1173 | 0.1552 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0164 | 0.0068 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0336 | 0.1173 | 0.1087 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0063 | 0.556 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0812 | 0.2935 | 0.2866 |
Echinococcus multilocularis | tumor protein p63 | 0.0336 | 0.1175 | 0.1554 |
Toxoplasma gondii | hypothetical protein | 0.0336 | 0.1173 | 1 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0045 | 0.0097 | 0.0119 |
Echinococcus multilocularis | GTPase activating Rap:RanGAP domain 3 | 0.0802 | 0.2898 | 0.4039 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.0812 | 0.2935 | 0.2876 |
Echinococcus granulosus | serine:threonine protein kinase mig 15 | 0.2712 | 0.9964 | 1 |
Onchocerca volvulus | 0.0802 | 0.2898 | 1 | |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0119 | 0.0371 | 0.0278 |
Echinococcus granulosus | carbonic anhydrase II | 0.062 | 0.2224 | 0.2156 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.0164 | 0.0068 |
Trypanosoma brucei | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.0802 | 0.2898 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.0054 | 0.444 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0036 | 0.0063 | 0.0217 |
Brugia malayi | RNA binding protein | 0.0063 | 0.0164 | 0.0068 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0045 | 0.0097 | 0.0334 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0063 | 0.556 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.0021 | 0.0018 |
Leishmania major | carbonic anhydrase-like protein | 0.062 | 0.2224 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.0054 | 0.444 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0063 | 0.556 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.0164 | 0.0069 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0029 | 0.1138 |
Brugia malayi | hypothetical protein | 0.0802 | 0.2898 | 0.2829 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.0164 | 0.0068 |
Brugia malayi | MH2 domain containing protein | 0.0119 | 0.0371 | 0.0277 |
Loa Loa (eye worm) | STE/STE20/MSN protein kinase | 0.192 | 0.7033 | 0.703 |
Schistosoma mansoni | mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 | 0.0802 | 0.2898 | 0.2829 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0049 | 0.0113 | 0.0017 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0812 | 0.2935 | 0.2866 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.0021 | 0.0018 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0336 | 0.1173 | 0.1087 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.062 | 0.2224 | 0.2148 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0336 | 0.1173 | 0.1091 |
Brugia malayi | Temporarily assigned gene name protein 59 | 0.0802 | 0.2898 | 0.2829 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0045 | 0.0097 | 0.5 |
Schistosoma mansoni | rap gtpase-activating protein | 0.0802 | 0.2898 | 0.2829 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0045 | 0.0097 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0113 | 0.0017 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.062 | 0.2224 | 0.2148 |
Loa Loa (eye worm) | hypothetical protein | 0.0336 | 0.1173 | 0.1091 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.003 | 0.1267 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0045 | 0.0097 | 0.0334 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0029 | 0.0039 | 0.2387 |
Echinococcus granulosus | carbonic anhydrase | 0.0336 | 0.1173 | 0.1091 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0119 | 0.0371 | 0.0278 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.0164 | 0.0069 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.0045 | 0.0097 | 0.0156 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0336 | 0.1173 | 0.1087 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0812 | 0.2935 | 0.4091 |
Schistosoma mansoni | hypothetical protein | 0.0336 | 0.1173 | 0.1087 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0164 | 0.0068 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.0054 | 0.444 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0045 | 0.0097 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0336 | 0.1173 | 0.1091 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.0164 | 0.0069 |
Schistosoma mansoni | hypothetical protein | 0.0802 | 0.2898 | 0.2829 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.062 | 0.2224 | 0.7622 |
Echinococcus granulosus | tumor protein p63 | 0.0336 | 0.1175 | 0.1092 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.0021 | 0.0018 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.0054 | 0.444 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0687 | 0.2471 | 0.2397 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 17 % | Induction of weight loss in C3H/HeN mouse at 0.47 umol/kg, ip after 60 days (Rvb = 27.7 +/- 4.6 %) | ChEMBL. | 22200344 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.