Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Serotonin 6 (5-HT6) receptor | Starlite/ChEMBL | References |
Homo sapiens | potassium voltage-gated channel, subfamily H (eag-related), member 2 | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | orexin receptor type 2 | Serotonin 6 (5-HT6) receptor | 436 aa | 355 aa | 23.4 % |
Schistosoma mansoni | biogenic amine (5HT) receptor | Serotonin 6 (5-HT6) receptor | 436 aa | 351 aa | 31.9 % |
Echinococcus multilocularis | orexin receptor type 2 | Serotonin 6 (5-HT6) receptor | 436 aa | 358 aa | 23.7 % |
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Serotonin 6 (5-HT6) receptor | 436 aa | 352 aa | 31.2 % |
Loa Loa (eye worm) | hypothetical protein | Serotonin 6 (5-HT6) receptor | 436 aa | 370 aa | 21.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | voltage-gated potassium channel | 0.0009 | 0.0009 | 0.0033 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0045 | 0.0188 | 0.0179 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0013 | 0.0029 | 0.002 |
Entamoeba histolytica | kinesin, putative | 0.0083 | 0.038 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.0208 | 0.0758 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0029 | 0.0552 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0009 | 0.0009 | 0.0033 |
Brugia malayi | Kinesin motor domain containing protein | 0.0083 | 0.038 | 1 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0009 | 0.0009 | 0.0033 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.0173 | 1 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0009 | 0.0009 | 0.0033 |
Echinococcus granulosus | voltage gated potassium channel | 0.0013 | 0.0029 | 0.002 |
Plasmodium vivax | kinesin-5 | 0.0083 | 0.038 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0045 | 0.0188 | 0.4818 |
Plasmodium falciparum | kinesin-5 | 0.0083 | 0.038 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0013 | 0.0029 | 0.0552 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0083 | 0.038 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.0173 | 1 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0009 | 0.0009 | 0.0033 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.2006 | 1 | 1 |
Echinococcus granulosus | kinesin family 1 | 0.0639 | 0.3161 | 0.3155 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0013 | 0.0029 | 0.002 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0009 | 0.0009 | 0.0033 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0029 | 0.0107 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0029 | 0.0107 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0158 | 0.4024 |
Giardia lamblia | Kinesin-5 | 0.0083 | 0.038 | 0.5 |
Echinococcus multilocularis | kinesin family 1 | 0.0639 | 0.3161 | 0.3155 |
Schistosoma mansoni | hypothetical protein | 0.0556 | 0.2746 | 1 |
Schistosoma mansoni | kinesin eg-5 | 0.0083 | 0.038 | 0.1384 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.0208 | 0.0758 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0083 | 0.038 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0045 | 0.0188 | 0.4818 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0045 | 0.0188 | 0.0179 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0013 | 0.0029 | 0.002 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 3.6 nM | Antagonist activity at human recombinant 5-HT6 receptor expressed human astrocytoma cells assessed as inhibition of 5-HT-induced cAMP accumulation after 1 hr preincubation by HTRF assay | ChEMBL. | 22153937 |
IC50 (binding) | = 1 uM | Inhibition of human ERG by patch express assay | ChEMBL. | 22153937 |
Ki (binding) | = 1.6 nM | Displacement of [3H]LSD from full length human 5HT6 receptor | ChEMBL. | 22153937 |
Ki (binding) | = 6.9 nM | Displacement of [3H]LSD from full length rat 5HT6 receptor | ChEMBL. | 22153937 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.