TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 432.902 | Formula: C24H21ClN4O2
H donors: 1 H acceptors: 1 LogP: 3.73 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)c1oc2c(c1)COc1c(n3c2ncc3)ccc(c1)N1CCNCC1
InChi: 1S/C24H21ClN4O2/c25-18-3-1-16(2-4-18)21-13-17-15-30-22-14-19(28-10-7-26-8-11-28)5-6-20(22)29-12-9-27-24(29)23(17)31-21/h1-6,9,12-14,26H,7-8,10-11,15H2
InChiKey: RFJBIIHNLZVSQS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	mitogen-activated protein kinase-activated protein kinase 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_131483	All targets in OG5_131483
Loa Loa (eye worm)	camk/mapkapk/mapkapk protein kinase	Get druggable targets OG5_131483	All targets in OG5_131483
Echinococcus multilocularis	MAP kinase activated protein kinase 2	Get druggable targets OG5_131483	All targets in OG5_131483
Echinococcus granulosus	MAP kinase activated protein kinase 2	Get druggable targets OG5_131483	All targets in OG5_131483
Brugia malayi	map kinase activated protein kinase protein 2	Get druggable targets OG5_131483	All targets in OG5_131483
Schistosoma japonicum	ko:K04443 mitogen-activated protein kinase-activated protein kinase 2, putative	Get druggable targets OG5_131483	All targets in OG5_131483

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	mitogen-activated protein kinase-activated protein kinase 2	370 aa	303 aa	26.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	SET domain protein, putative	0.003	0.0285	1
Echinococcus multilocularis	GA binding protein alpha chain	0.0073	0.0814	0.0814
Brugia malayi	TAR-binding protein	0.0064	0.0701	0.2648
Echinococcus granulosus	replication factor c subunit 1	0.001	0.0036	0.0042
Loa Loa (eye worm)	hypothetical protein	0.001	0.0036	0.0135
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0208	0.0787
Echinococcus multilocularis	Niemann Pick C1 protein	0.0141	0.1664	0.1664
Mycobacterium leprae	PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+])	0.001	0.0036	0.1722
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0073	0.0814	0.3075
Brugia malayi	map kinase activated protein kinase protein 2	0.0217	0.2607	0.9844
Schistosoma mansoni	ets-related	0.0221	0.2648	0.3117
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0122	0.5844
Echinococcus granulosus	protein C ets 2	0.0011	0.0044	0.0052
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0.0134	1
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0036	0.0125
Schistosoma mansoni	hypothetical protein	0.0041	0.042	0.0494
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0208	1
Plasmodium vivax	replication factor C subunit 1, putative	0.001	0.0036	0.126
Schistosoma mansoni	chromosome transmission fidelity factor	0.001	0.0036	0.0042
Brugia malayi	DKFZp564C0469 protein	0.001	0.0036	0.0135
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0208	0.183
Echinococcus multilocularis	sterol regulatory element binding protein	0.0042	0.0439	0.0439
Brugia malayi	Fli-1 protein	0.0221	0.2648	1
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0042	0.0439	0.1658
Echinococcus granulosus	MAP kinase activated protein kinase 2	0.0217	0.2607	0.3068
Echinococcus granulosus	Niemann Pick C1 protein	0.0141	0.1664	0.1958
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0208	1
Giardia lamblia	Replication factor C, subunit 1	0.001	0.0036	0.5
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0208	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0285	0.1075
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0208	1
Toxoplasma gondii	ATPase, AAA family protein	0.001	0.0036	0.126
Trypanosoma cruzi	FHA domain containing protein, putative	0.001	0.0036	1
Echinococcus granulosus	expressed conserved protein	0.0093	0.1064	0.1252
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0208	0.0787
Loa Loa (eye worm)	hypothetical protein	0.005	0.0529	0.1996
Echinococcus multilocularis	ewsr:fli fusion protein type	0.0011	0.0044	0.0044
Echinococcus multilocularis	MAP kinase activated protein kinase 2	0.0217	0.2607	0.2607
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0036	0.0125
Echinococcus multilocularis	ets variant gene 4	0.0011	0.0044	0.0044
Echinococcus granulosus	ETS domain containing protein Elk 1	0.0011	0.0044	0.0052
Echinococcus granulosus	ETS transcription factor Elf 2	0.0011	0.0044	0.0052
Brugia malayi	Pax transcription activation domain interacting protein	0.001	0.0036	0.0135
Brugia malayi	Ets-domain containing protein	0.0073	0.0814	0.3075
Echinococcus granulosus	nibrin	0.001	0.0036	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0684	0.2581
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0036	0.0125
Echinococcus granulosus	GA binding protein alpha chain	0.0073	0.0814	0.0958
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0701	0.0825
Trypanosoma cruzi	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.001	0.0036	1
Trichomonas vaginalis	replication factor C large subunit, putative	0.001	0.0036	0.0125
Wolbachia endosymbiont of Brugia malayi	NAD-dependent DNA ligase, Lig	0.001	0.0036	0.5
Brugia malayi	DNA-binding protein D-ETS-3	0.0011	0.0044	0.0166
Echinococcus granulosus	sterol regulatory element binding protein	0.0042	0.0439	0.0517
Schistosoma mansoni	serine/threonine protein kinase	0.0217	0.2607	0.3068
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0208	0.0787
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0044	0.0166
Schistosoma mansoni	microtubule-associated protein tau	0.0693	0.8497	1
Echinococcus multilocularis	ETS transcription factor Elf 2	0.0011	0.0044	0.0044
Brugia malayi	topoisomerase	0.001	0.0036	0.0135
Schistosoma mansoni	patched 1	0.0042	0.0439	0.0517
Schistosoma mansoni	hypothetical protein	0.0041	0.042	0.0494
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0208	0.0787
Echinococcus granulosus	ETS transcription factor Elf 5	0.0011	0.0044	0.0052
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.001	0.0036	0.0125
Schistosoma mansoni	cellular tumor antigen P53	0.005	0.0529	0.0622
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0134	0.0505
Loa Loa (eye worm)	RNA binding protein	0.0064	0.0701	0.2648
Loa Loa (eye worm)	hypothetical protein	0.001	0.0036	0.0135
Echinococcus multilocularis	Niemann Pick C1 protein	0.0099	0.1138	0.1138
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0208	1
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.0036	0.0125
Brugia malayi	hypothetical protein	0.001	0.0036	0.0135
Loa Loa (eye worm)	fli-1 protein	0.0221	0.2648	1
Brugia malayi	RNA recognition motif domain containing protein	0.0064	0.0701	0.2648
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.001	0.0036	0.0315
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0285	0.0335
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0482	0.0568
Onchocerca volvulus		0.003	0.0285	0.0996
Schistosoma mansoni	DNA ligase IV	0.001	0.0036	0.0042
Loa Loa (eye worm)	hypothetical protein	0.001	0.0036	0.0135
Schistosoma mansoni	topbp1	0.001	0.0036	0.0042
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0439	0.1535
Schistosoma mansoni	elf1	0.0011	0.0044	0.0052
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0208	1
Schistosoma mansoni	gabp alpha	0.0073	0.0814	0.0958
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0208	1
Loa Loa (eye worm)	D-ets-2 protein	0.0011	0.0044	0.0166
Plasmodium vivax	acyl-CoA synthetase, putative	0.0018	0.0134	0.4698
Loa Loa (eye worm)	hypothetical protein	0.001	0.0036	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0208	0.0787
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0134	0.6421
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0285	0.0285
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0208	0.183
Brugia malayi	RNA binding protein	0.0064	0.0701	0.2648
Brugia malayi	transcription factor E74 isoform	0.0011	0.0044	0.0166
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0099	0.1138	1
Loa Loa (eye worm)	DNA-binding protein D-ETS-3	0.0011	0.0044	0.0166
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.0285	0.0335
Brugia malayi	ATP dependent DNA ligase C terminal region family protein	0.001	0.0036	0.0135
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0482	0.0568
Schistosoma mansoni	ets-related	0.0011	0.0044	0.0052
Echinococcus multilocularis	tumor protein p63	0.0339	0.4116	0.4116
Echinococcus multilocularis	ETS domain containing protein Elk 1	0.0011	0.0044	0.0044
Trypanosoma cruzi	hypothetical protein, conserved	0.001	0.0036	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0208	1
Echinococcus multilocularis	expressed conserved protein	0.0093	0.1064	0.1064
Loa Loa (eye worm)	TAR-binding protein	0.0064	0.0701	0.2648
Schistosoma mansoni	hypothetical protein	0.0041	0.042	0.0494
Trypanosoma brucei	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.001	0.0036	1
Brugia malayi	Pre-SET motif family protein	0.003	0.0285	0.1075
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.0036	0.0125
Mycobacterium ulcerans	NAD-dependent DNA ligase LigA	0.001	0.0036	0.1722
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0018	0.0134	0.6421
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0208	1
Echinococcus multilocularis	replication factor c subunit 1	0.001	0.0036	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1138	0.4297
Echinococcus multilocularis	ETS transcription factor Elf 5	0.0011	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0557	0.2104
Loa Loa (eye worm)	hypothetical protein	0.001	0.0036	0.0135
Echinococcus multilocularis	ETS transcription factor Elf 1	0.0011	0.0044	0.0044
Brugia malayi	Ets-domain containing protein	0.0011	0.0044	0.0166
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0209	0.2502	0.9449
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0482	0.0568
Echinococcus multilocularis	protein C ets 2	0.0011	0.0044	0.0044
Schistosoma mansoni	polyomavirus enhancer activator 3 pea3	0.0011	0.0044	0.0052
Onchocerca volvulus		0.0238	0.286	1
Echinococcus granulosus	ETS transcription factor Elf 2	0.0011	0.0044	0.0052
Echinococcus granulosus	microtubule associated protein 2	0.0693	0.8497	1
Trichomonas vaginalis	set domain proteins, putative	0.0238	0.286	1
Schistosoma mansoni	hypothetical protein	0.0041	0.042	0.0494
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0122	0.5844
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0482	0.0568
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0134	0.0505
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0482	0.1822
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0208	1
Echinococcus multilocularis	nibrin	0.001	0.0036	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0044	0.0166
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0208	1
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0701	0.0825
Echinococcus granulosus	Protein patched homolog 1	0.0042	0.0439	0.0517
Echinococcus granulosus	tar DNA binding protein	0.0064	0.0701	0.0825
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.001	0.0036	0.126
Echinococcus multilocularis	protein patched	0.0042	0.0439	0.0439
Schistosoma mansoni	ets	0.0011	0.0044	0.0052
Echinococcus multilocularis	protein dispatched 1	0.0048	0.0513	0.0513
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0208	1
Echinococcus granulosus	ETS transcription factor Elf 1	0.0011	0.0044	0.0052
Entamoeba histolytica	hypothetical protein	0.001	0.0036	0.0315
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0482	0.0568
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0134	0.0505
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0285	1
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.001	0.0036	0.0125
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0482	0.0482
Onchocerca volvulus		0.001	0.0036	0.0125
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.0285	0.0335
Echinococcus granulosus	Niemann Pick C1 protein	0.0099	0.1138	0.1339
Echinococcus granulosus	tumor protein p63	0.0339	0.4116	0.4844
Brugia malayi	CHE-14 protein	0.0042	0.0439	0.1658
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0011	0.0044	0.0166
Brugia malayi	Pre-SET motif family protein	0.0209	0.2502	0.9449
Loa Loa (eye worm)	ets-domain-containing protein	0.0011	0.0044	0.0166
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.0285	0.0285
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0482	0.1822
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0701	0.0825
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0482	0.0482
Onchocerca volvulus		0.005	0.0529	0.1848
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0439	0.1658
Echinococcus multilocularis	microtubule associated protein 2	0.0693	0.8497	0.8497
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0122	0.5844
Trypanosoma cruzi	hypothetical protein, conserved	0.001	0.0036	1
Plasmodium falciparum	acyl-CoA synthetase	0.0018	0.0134	1
Onchocerca volvulus		0.0024	0.0208	0.0728
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.01	0.1157	0.1362
Schistosoma mansoni	hypothetical protein	0.0011	0.0044	0.0052
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0208	0.0787
Schistosoma mansoni	hypothetical protein	0.0011	0.0044	0.0052
Entamoeba histolytica	acyl-coA synthetase, putative	0.0024	0.0208	0.183
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0701	0.0825
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0134	0.0505
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0208	1
Echinococcus multilocularis	tar DNA binding protein	0.0064	0.0701	0.0701
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0701	0.0825
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0036	0.0125
Brugia malayi	hypothetical protein	0.001	0.0036	0.0135
Echinococcus multilocularis	ETS transcription factor Elf 2	0.0011	0.0044	0.0044
Brugia malayi	Ets-domain containing protein	0.0073	0.0814	0.3075
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0134	0.0505
Loa Loa (eye worm)	camk/mapkapk/mapkapk protein kinase	0.0217	0.2607	0.9844
Echinococcus granulosus	ewsr:fli fusion protein type	0.0011	0.0044	0.0052
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0208	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0036	0.0135
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0064	0.0701	0.2648
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0285	0.0335
Brugia malayi	Niemann-Pick C1 protein precursor	0.0099	0.1138	0.4297
Plasmodium falciparum	replication factor C subunit 1, putative	0.001	0.0036	0.2682
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0036	0.0125
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0271	0.0319
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0122	0.5844
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0208	1
Treponema pallidum	DNA ligase (lig)	0.001	0.0036	0.5
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0285	0.0335
Schistosoma mansoni	topbp1	0.001	0.0036	0.0042

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (binding)		Inhibition of MK2-mediated HSP27 phosphorylation at Ser78 in LPS-stimulated human THP-1 cells pre-incubated for 60 mins before LPS treatment measured after 60 mins	ChEMBL.	22182499
IC50 (binding)	= 18 nM	Inhibition of MK2 using TAMRA-labeled peptide as substrate pre-incubated for 30 mins prior substrate addition measured after 30 mins incubation in dark using fluorescence polarization assay	ChEMBL.	22182499
Inhibition (binding)		Noncompetitive inhibition of MK2 using TAMRA-labeled peptide as substrate by fluorescence-based thermal shift assay	ChEMBL.	22182499

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1938691

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1597726