Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | selinide water dikinase | 0.0024 | 0.0153 | 0.0398 |
Toxoplasma gondii | selenide, water dikinase | 0.0024 | 0.0153 | 0.0651 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0469 | 0.2707 |
Onchocerca volvulus | 0.0057 | 0.0555 | 0.3242 | |
Giardia lamblia | Hypothetical protein | 0.005 | 0.0469 | 0.5 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0367 | 0.4394 | 0.4307 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0029 | 0.0218 | 1 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0367 | 0.4394 | 0.4307 |
Entamoeba histolytica | hypothetical protein | 0.005 | 0.0469 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0029 | 0.0218 | 1 |
Plasmodium vivax | selenophosphate synthetase, putative | 0.0024 | 0.0153 | 1 |
Brugia malayi | folate-like transporter 3 | 0.005 | 0.0469 | 0.2707 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.1322 | 1 |
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.0322 | 0.3833 | 1 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0029 | 0.0218 | 0.0066 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0119 | 0.1322 | 0.1187 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0469 | 0.2707 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0367 | 0.4394 | 0.4307 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0029 | 0.0218 | 0.5 |
Echinococcus granulosus | Major facilitator superfamily general substrate transporter | 0.0323 | 0.3852 | 0.3757 |
Echinococcus granulosus | neuropeptide s receptor | 0.0367 | 0.4394 | 0.4307 |
Plasmodium falciparum | selenide water dikinase, putative | 0.0024 | 0.0153 | 1 |
Chlamydia trachomatis | methionyl tRNAformyltransferase | 0.0012 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0469 | 0.2707 |
Brugia malayi | Inositol-1 | 0.0029 | 0.0218 | 0.0558 |
Schistosoma mansoni | inositol monophosphatase | 0.0029 | 0.0218 | 0.0567 |
Mycobacterium ulcerans | thiamine monophosphate kinase | 0.0014 | 0.0034 | 0.0089 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0029 | 0.0218 | 0.5 |
Brugia malayi | Muscleblind-like protein | 0.0119 | 0.1322 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0323 | 0.3847 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0469 | 0.2707 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0029 | 0.0218 | 0.0928 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0469 | 0.2707 |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylamine--glycine ligase | 0.0322 | 0.3833 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0119 | 0.1322 | 0.1187 |
Mycobacterium tuberculosis | Probable phosphoribosylformylglycinamidine CYCLO-ligase PurM (AIRS) (phosphoribosyl-aminoimidazole synthetase) (air synthase) | 0.0071 | 0.0734 | 1 |
Treponema pallidum | methionyl-tRNA formyltransferase (fmt) | 0.0012 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable phosphoribosylamine--glycine ligase PurD (GARS) (glycinamide ribonucleotide synthetase) (phosphoribosylglycinamide synt | 0.0047 | 0.0436 | 0.5947 |
Loa Loa (eye worm) | inositol-1 | 0.0029 | 0.0218 | 0.0558 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0026 | 0.018 | 0.2456 |
Echinococcus multilocularis | folate receptor beta | 0.082 | 1 | 1 |
Brugia malayi | Reduced folate carrier family protein | 0.005 | 0.0469 | 0.2707 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0029 | 0.0218 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylformylglycinamidine synthase domain-containing protein | 0.0024 | 0.0153 | 0.0399 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0469 | 0.2707 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0469 | 0.2707 |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylaminoimidazole synthetase | 0.0071 | 0.0734 | 0.1914 |
Mycobacterium leprae | PROBABLE PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIGASE PURM (AIRS) (PHOSPHORIBOSYL-AMINOIMIDAZOLE SYNTHETASE) (AIR SYNTHASE) | 0.0071 | 0.0734 | 0.1841 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0029 | 0.0218 | 0.0569 |
Trypanosoma cruzi | selenophosphate synthetase, putative | 0.0024 | 0.0153 | 0.7011 |
Onchocerca volvulus | 0.0071 | 0.0734 | 1 | |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0029 | 0.0218 | 1 |
Mycobacterium leprae | PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT | 0.0322 | 0.3833 | 1 |
Trypanosoma brucei | Selenophosphate synthetase 2 | 0.0024 | 0.0153 | 0.7011 |
Mycobacterium ulcerans | phosphoribosylaminoimidazole synthetase | 0.0071 | 0.0734 | 0.1914 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0029 | 0.0218 | 0.0066 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.1322 | 1 |
Trypanosoma cruzi | selenophosphate synthetase, putative | 0.0024 | 0.0153 | 0.7011 |
Leishmania major | selenophosphate synthetase, putative | 0.0024 | 0.0153 | 0.7011 |
Mycobacterium tuberculosis | Phosphoribosylformylglycinamidine synthase II PurL (FGAM synthase II) | 0.0024 | 0.0153 | 0.2085 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0029 | 0.0218 | 1 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0026 | 0.018 | 0.0384 |
Echinococcus multilocularis | Major facilitator superfamily, general substrate transporter | 0.0323 | 0.3852 | 0.3757 |
Toxoplasma gondii | hypothetical protein | 0.0202 | 0.235 | 1 |
Mycobacterium leprae | PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE II PURL (FGAM SYNTHASE II) | 0.0024 | 0.0153 | 0.0313 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0469 | 0.2707 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0469 | 0.2707 |
Mycobacterium ulcerans | phosphoribosylformylglycinamidine synthase II | 0.0024 | 0.0153 | 0.0399 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0469 | 0.2707 |
Echinococcus granulosus | muscleblind protein | 0.0119 | 0.1322 | 0.1187 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0029 | 0.0218 | 0.0569 |
Schistosoma mansoni | inositol monophosphatase | 0.0029 | 0.0218 | 0.0567 |
Loa Loa (eye worm) | reduced folate carrier family protein | 0.005 | 0.0469 | 0.2707 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.