Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Transient receptor potential cation channel subfamily A member 1 | Starlite/ChEMBL | References |
Homo sapiens | transient receptor potential cation channel, subfamily A, member 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0004 | 0.0059 | 0.00000029421 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0141 | 0.36 | 1 |
Brugia malayi | olfactory channel protein osm-9 | 0.0004 | 0.0066 | 0.0022 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0141 | 0.36 | 1 |
Echinococcus granulosus | glycogen synthase kinase 3 beta | 0.0141 | 0.36 | 0.3565 |
Brugia malayi | intracellular kinase | 0.0141 | 0.36 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0141 | 0.36 | 0.5 |
Echinococcus granulosus | protein kinase shaggy | 0.0141 | 0.36 | 0.3565 |
Loa Loa (eye worm) | hypothetical protein | 0.0004 | 0.0059 | 0.00000029421 |
Toxoplasma gondii | cell-cycle-associated protein kinase GSK, putative | 0.0141 | 0.36 | 1 |
Giardia lamblia | Kinase, CMGC GSK | 0.0141 | 0.36 | 1 |
Echinococcus multilocularis | calcium activated potassium channel | 0.0005 | 0.0093 | 0.0035 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0004 | 0.0066 | 0.0008 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0004 | 0.0066 | 0.0008 |
Leishmania major | glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 | 0.0141 | 0.36 | 1 |
Trypanosoma cruzi | glycogen synthase kinase 3, putative | 0.0141 | 0.36 | 1 |
Echinococcus granulosus | calcium activated potassium channel | 0.0005 | 0.0093 | 0.0035 |
Schistosoma mansoni | glycogen synthase kinase 3-related (gsk3) (cmgc group III) | 0.0141 | 0.36 | 0.3601 |
Echinococcus multilocularis | ankyrin repeat protein | 0.0384 | 0.9891 | 0.9891 |
Schistosoma mansoni | transient receptor potential channel | 0.0004 | 0.0066 | 0.0008 |
Plasmodium falciparum | glycogen synthase kinase 3 | 0.0141 | 0.36 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0004 | 0.0066 | 0.0022 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0004 | 0.0059 | 0.00000010479 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0388 | 0.9992 | 1 |
Schistosoma mansoni | transient receptor potential channel | 0.0004 | 0.0059 | 0.00000010595 |
Plasmodium vivax | glycogen synthase kinase 3, putative | 0.0141 | 0.36 | 0.5 |
Schistosoma mansoni | transient receptor potential channel | 0.0004 | 0.0059 | 0.00000010595 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0141 | 0.36 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0141 | 0.36 | 1 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0004 | 0.0066 | 0.0008 |
Echinococcus multilocularis | glycogen synthase kinase 3 beta | 0.0141 | 0.36 | 0.3562 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0004 | 0.0059 | 0.00000010487 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0004 | 0.0066 | 0.0008 |
Echinococcus multilocularis | protein kinase shaggy | 0.0141 | 0.36 | 0.3562 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0141 | 0.36 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0141 | 0.36 | 0.5 |
Onchocerca volvulus | 0.0141 | 0.36 | 1 | |
Giardia lamblia | Kinase, CMGC GSK | 0.0141 | 0.36 | 1 |
Schistosoma mansoni | transient receptor potential cation channel subfamily A member | 0.0384 | 0.9891 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0141 | 0.36 | 0.5 |
Echinococcus granulosus | ankyrin repeat protein | 0.0384 | 0.9891 | 0.9898 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.003 uM | Antagonist activity at rat TRPA1 expressed in HEK293 cells assessed as inhibition of BITC-induced increase in intracellular calcium concentration by Fluo4-AM based fluorometric assay | ChEMBL. | 22222037 |
IC50 (functional) | = 0.085 uM | Antagonist activity at human TRPA1 expressed in HEK293 cells assessed as inhibition of 5H-dibenzo[b,e]azepine-10-carboxylic acid methyl ester-induced increase in intracellular calcium by Fluo4-AM based fluorometric assay | ChEMBL. | 22222037 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.