TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 345.476 | Formula: C21H31NO3
H donors: 1 H acceptors: 1 LogP: 3.85 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CC[C@@H](COc1ccc2c(c1)CCC1(O2)CCN(CC1)C1CCC1)O
InChi: 1S/C21H31NO3/c1-2-18(23)15-24-19-6-7-20-16(14-19)8-9-21(25-20)10-12-22(13-11-21)17-4-3-5-17/h6-7,14,17-18,23H,2-5,8-13,15H2,1H3/t18-/m0/s1
InChiKey: PZONYCWNCPPYJG-SFHVURJKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Histamine H3 receptor	Starlite/ChEMBL	References
Homo sapiens	histamine receptor H3	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	biogenic amine 5HT receptor	Histamine H3 receptor	445 aa	405 aa	25.2 %
Loa Loa (eye worm)	hypothetical protein	Histamine H3 receptor	445 aa	384 aa	22.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0186	0.2277	0.2277
Schistosoma mansoni	signal transduction protein lnk-related	0.0294	0.5488	0.5488
Echinococcus granulosus	raf serine:threonine protein kinase	0.0151	0.1222	0.1222
Schistosoma mansoni	subfamily M12A unassigned peptidase (M12 family)	0.027	0.4781	0.4781
Brugia malayi	SH2 domain containing protein	0.0445	1	1
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0151	0.1222	0.1222
Loa Loa (eye worm)	hypothetical protein	0.0294	0.5488	0.5488
Loa Loa (eye worm)	TK/ACK protein kinase	0.0151	0.1222	0.1222
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Echinococcus granulosus	signal transduction protein lnk realted	0.0294	0.5488	0.5488
Echinococcus granulosus	SH2 motif	0.0294	0.5488	0.5488
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0151	0.1222	0.5
Giardia lamblia	Protein 21.1	0.0151	0.1222	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0445	1	1
Plasmodium vivax	protein kinase, putative	0.0151	0.1222	0.5
Echinococcus multilocularis	carboxylesterase 5A	0.0146	0.1063	0.1063
Schistosoma mansoni	protein kinase	0.0151	0.1222	0.1222
Echinococcus granulosus	expressed conserved protein	0.0294	0.5488	0.5488
Schistosoma mansoni	GTPase activating protein	0.0294	0.5488	0.5488
Echinococcus granulosus	carboxylesterase 5A	0.0146	0.1063	0.1063
Brugia malayi	Protein kinase domain containing protein	0.0151	0.1222	0.1222
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0151	0.1222	0.1222
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0294	0.5488	0.5488
Entamoeba histolytica	protein kinase, putative	0.0294	0.5488	0.4859
Loa Loa (eye worm)	TK protein kinase	0.0151	0.1222	0.1222
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0151	0.1222	0.1222
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0445	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Echinococcus granulosus	integrin linked protein kinase	0.0151	0.1222	0.1222
Echinococcus granulosus	tyrosine protein kinase Srms	0.0445	1	1
Echinococcus granulosus	tyrosine protein kinase HCK	0.0151	0.1222	0.1222
Schistosoma mansoni	protein kinase	0.0151	0.1222	0.1222
Loa Loa (eye worm)	hypothetical protein	0.0294	0.5488	0.5488
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1222	0.1222
Schistosoma mansoni	tyrosine kinase	0.0151	0.1222	0.1222
Loa Loa (eye worm)	TK protein kinase	0.0151	0.1222	0.1222
Schistosoma mansoni	serine/threonine protein kinase	0.0151	0.1222	0.1222
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0151	0.1222	0.1222
Brugia malayi	Protein kinase domain containing protein	0.0151	0.1222	0.1222
Schistosoma mansoni	tyrosine kinase	0.0151	0.1222	0.1222
Brugia malayi	Protein kinase domain containing protein	0.0445	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0151	0.1222	0.1222
Schistosoma mansoni	protein kinase	0.0151	0.1222	0.1222
Schistosoma mansoni	tyrosine kinase	0.0151	0.1222	0.1222
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0294	0.5488	0.5488
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0294	0.5488	0.5488
Loa Loa (eye worm)	TK protein kinase	0.0445	1	1
Loa Loa (eye worm)	hypothetical protein	0.0294	0.5488	0.5488
Schistosoma mansoni	ephrin receptor	0.0151	0.1222	0.1222
Echinococcus granulosus	epidermal growth factor receptor	0.0151	0.1222	0.1222
Brugia malayi	Protein kinase domain containing protein	0.0151	0.1222	0.1222
Brugia malayi	SH2 domain containing protein	0.0294	0.5488	0.5488
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0151	0.1222	0.1222
Brugia malayi	Variant SH3 domain containing protein	0.0294	0.5488	0.5488
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0151	0.1222	0.1222
Onchocerca volvulus		0.0294	0.5488	0.5488
Echinococcus granulosus	tyrosine kinase	0.0445	1	1
Loa Loa (eye worm)	TK/EPH protein kinase	0.0151	0.1222	0.1222
Brugia malayi	Low-density lipoprotein receptor repeat class B containing protein	0.027	0.4781	0.4781
Trichomonas vaginalis	conserved hypothetical protein	0.0151	0.1222	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Echinococcus multilocularis	SH2 motif	0.0294	0.5488	0.5488
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0445	1	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0294	0.5488	0.5488
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0146	0.1063	0.1063
Brugia malayi	Protein kinase domain containing protein	0.0445	1	1
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0151	0.1222	0.1222
Loa Loa (eye worm)	TK protein kinase	0.0151	0.1222	0.1222
Schistosoma mansoni	tyrosine kinase	0.0445	1	1
Brugia malayi	SH2 domain containing protein	0.0294	0.5488	0.5488
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1222	0.1222
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0151	0.1222	0.1222
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0151	0.1222	0.1222
Loa Loa (eye worm)	TK protein kinase	0.0151	0.1222	0.1222
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0294	0.5488	0.5488
Echinococcus granulosus	tyrosine protein kinase	0.0151	0.1222	0.1222
Echinococcus multilocularis	tensin	0.0294	0.5488	0.5488
Loa Loa (eye worm)	TK/FER protein kinase	0.0151	0.1222	0.1222
Schistosoma mansoni	tyrosine kinase	0.0151	0.1222	0.1222
Echinococcus granulosus	activin receptor type	0.0151	0.1222	0.1222
Loa Loa (eye worm)	TK protein kinase	0.0151	0.1222	0.1222
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Loa Loa (eye worm)	hypothetical protein	0.0294	0.5488	0.5488
Loa Loa (eye worm)	TK/FER protein kinase	0.0151	0.1222	0.1222
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0151	0.1222	0.1222
Echinococcus multilocularis	protein kinase	0.0151	0.1222	0.1222
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0294	0.5488	0.5488
Leishmania major	protein kinase, putative	0.0151	0.1222	0.5
Loa Loa (eye worm)	STAT protein	0.0294	0.5488	0.5488
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0151	0.1222	0.1222
Echinococcus granulosus	kinase suppressor of Ras 1	0.0151	0.1222	0.1222
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Onchocerca volvulus		0.0445	1	1
Loa Loa (eye worm)	hypothetical protein	0.027	0.4781	0.4781
Echinococcus multilocularis	insulin receptor	0.0151	0.1222	0.1222
Toxoplasma gondii	calcium binding egf domain-containing protein	0.027	0.4781	1
Toxoplasma gondii	calcium binding egf domain-containing protein	0.027	0.4781	1
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1222	0.1222
Loa Loa (eye worm)	TK/FAK protein kinase	0.0151	0.1222	0.1222
Loa Loa (eye worm)	TK/CSK protein kinase	0.0151	0.1222	0.1222
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0186	0.2277	0.2277
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0151	0.1222	0.1222
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Schistosoma mansoni	tyrosine kinase	0.0151	0.1222	0.1222
Trichomonas vaginalis	conserved hypothetical protein	0.0151	0.1222	0.5
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1222	0.1222
Onchocerca volvulus		0.0445	1	1
Schistosoma mansoni	protein kinase	0.0151	0.1222	0.1222
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Schistosoma mansoni	protein kinase	0.0151	0.1222	0.1222
Onchocerca volvulus		0.0151	0.1222	0.1222
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0151	0.1222	0.5
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0151	0.1222	0.5
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0294	0.5488	0.5488
Schistosoma mansoni	egf-like domain protein	0.027	0.4781	0.4781
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0151	0.1222	0.1222
Echinococcus multilocularis	epidermal growth factor receptor	0.0151	0.1222	0.1222
Echinococcus granulosus	c src tyrosine kinase	0.0445	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Onchocerca volvulus		0.0294	0.5488	0.5488
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0294	0.5488	0.5488
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0445	1	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0294	0.5488	0.5488
Echinococcus granulosus	tyrosine protein kinase pr2	0.0151	0.1222	0.1222
Brugia malayi	Protein kinase domain containing protein	0.0151	0.1222	0.1222
Echinococcus multilocularis	activated cdc42 kinase 1	0.0151	0.1222	0.1222
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0151	0.1222	0.1222
Trichomonas vaginalis	protein kinase atn1, putative	0.0151	0.1222	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0151	0.1222	0.5
Echinococcus granulosus	tensin	0.0294	0.5488	0.5488
Loa Loa (eye worm)	acetylcholinesterase 1	0.0146	0.1063	0.1063
Brugia malayi	Tyrosine-protein kinase PR2	0.0151	0.1222	0.1222
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0151	0.1222	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Echinococcus multilocularis	SH2 motif	0.0294	0.5488	0.5488
Schistosoma mansoni	tensin-related	0.0294	0.5488	0.5488
Leishmania major	hypothetical protein, conserved	0.0151	0.1222	0.5
Schistosoma mansoni	tensin-related	0.0294	0.5488	0.5488
Schistosoma mansoni	tyrosine kinase	0.0151	0.1222	0.1222
Echinococcus multilocularis	N chimaerin	0.0294	0.5488	0.5488
Brugia malayi	Furin-like cysteine rich region family protein	0.0151	0.1222	0.1222
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0445	1	1
Echinococcus granulosus	SH2 domain containing protein 7	0.0294	0.5488	0.5488
Brugia malayi	Variant SH3 domain containing protein	0.0294	0.5488	0.5488
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0151	0.1222	0.1222
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0294	0.5488	0.5488
Loa Loa (eye worm)	hypothetical protein	0.0294	0.5488	0.5488
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Schistosoma mansoni	SH2A	0.0294	0.5488	0.5488
Onchocerca volvulus		0.0445	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0445	1	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0294	0.5488	0.5488
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0445	1	1
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0294	0.5488	0.5488
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0151	0.1222	0.1222
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0151	0.1222	0.1222
Trichomonas vaginalis	conserved hypothetical protein	0.0151	0.1222	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Echinococcus granulosus	growth factor receptor bound protein 2	0.0294	0.5488	0.5488
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0151	0.1222	0.1222
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0445	1	1
Echinococcus multilocularis	acetylcholinesterase	0.0146	0.1063	0.1063
Onchocerca volvulus		0.0294	0.5488	0.5488
Schistosoma mansoni	tyrosine kinase	0.0151	0.1222	0.1222
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0151	0.1222	0.1222
Trypanosoma brucei	protein kinase, putative	0.0151	0.1222	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0151	0.1222	0.1222
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0445	1	1
Loa Loa (eye worm)	hypothetical protein	0.0294	0.5488	0.5488
Schistosoma mansoni	tyrosine kinase	0.0151	0.1222	0.1222
Brugia malayi	Carboxylesterase family protein	0.0146	0.1063	0.1063
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0294	0.5488	0.5488
Schistosoma mansoni	protein kinase	0.0151	0.1222	0.1222
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1222	0.1222
Loa Loa (eye worm)	TK protein kinase	0.0151	0.1222	0.1222
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Brugia malayi	Fibulin-1 precursor	0.027	0.4781	0.4781
Onchocerca volvulus		0.0151	0.1222	0.1222
Brugia malayi	Protein kinase domain containing protein	0.0151	0.1222	0.1222
Brugia malayi	SH2 domain containing protein	0.0294	0.5488	0.5488
Brugia malayi	integrin-linked kinase	0.0151	0.1222	0.1222
Brugia malayi	SH2 domain containing protein	0.0294	0.5488	0.5488
Loa Loa (eye worm)	multiple epidermal growth factor-like domains 6	0.027	0.4781	0.4781
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0294	0.5488	0.5488
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Schistosoma mansoni	protein kinase	0.0151	0.1222	0.1222
Echinococcus multilocularis	tyrosine protein kinase csk	0.0151	0.1222	0.1222
Schistosoma mansoni	tyrosine kinase	0.0445	1	1
Schistosoma mansoni	tyrosine kinase	0.0151	0.1222	0.1222
Loa Loa (eye worm)	hypothetical protein	0.0294	0.5488	0.5488
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0445	1	1
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0186	0.2277	0.2277
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0294	0.5488	0.5488
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0151	0.1222	0.1222
Loa Loa (eye worm)	hypothetical protein	0.0294	0.5488	0.5488
Brugia malayi	hypothetical protein	0.0151	0.1222	0.1222
Onchocerca volvulus		0.0151	0.1222	0.1222
Brugia malayi	SH2 domain containing protein	0.0294	0.5488	0.5488
Loa Loa (eye worm)	TK protein kinase	0.0151	0.1222	0.1222
Loa Loa (eye worm)	TK/Met protein kinase	0.0151	0.1222	0.1222
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0151	0.1222	0.1222
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0151	0.1222	0.1222
Brugia malayi	Raf kinase	0.0151	0.1222	0.1222
Brugia malayi	Protein kinase domain containing protein	0.0151	0.1222	0.1222
Echinococcus granulosus	natriuretic peptide receptor 1	0.0151	0.1222	0.1222
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Brugia malayi	ephrin receptor 1 precursor	0.0151	0.1222	0.1222
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0445	1	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0151	0.1222	0.1222
Echinococcus multilocularis	epidermal growth factor receptor	0.0151	0.1222	0.1222
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0151	0.1222	0.1222
Loa Loa (eye worm)	hypothetical protein	0.027	0.4781	0.4781
Schistosoma mansoni	adapter molecule crk	0.0294	0.5488	0.5488
Loa Loa (eye worm)	TK/FER protein kinase	0.0445	1	1
Brugia malayi	Guanylyl cyclase protein 23	0.0151	0.1222	0.1222
Loa Loa (eye worm)	hypothetical protein	0.027	0.4781	0.4781
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0151	0.1222	0.1222
Loa Loa (eye worm)	hypothetical protein	0.0294	0.5488	0.5488
Brugia malayi	Protein kinase domain containing protein	0.0151	0.1222	0.1222
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0151	0.1222	0.1222
Brugia malayi	Protein kinase domain containing protein	0.0151	0.1222	0.1222
Loa Loa (eye worm)	hypothetical protein	0.0294	0.5488	0.5488
Brugia malayi	Variant SH3 domain containing protein	0.0294	0.5488	0.5488
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0151	0.1222	0.5
Loa Loa (eye worm)	hypothetical protein	0.0294	0.5488	0.5488
Onchocerca volvulus		0.0445	1	1
Echinococcus granulosus	activated cdc42 kinase 1	0.0151	0.1222	0.1222
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0294	0.5488	0.5488
Schistosoma mansoni	protein kinase	0.0151	0.1222	0.1222
Trichomonas vaginalis	CAMK family protein kinase	0.0151	0.1222	0.5
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0151	0.1222	0.1222
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Schistosoma mansoni	tyrosine kinase	0.0445	1	1
Echinococcus granulosus	Tolloid protein 1	0.027	0.4781	0.4781
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0151	0.1222	0.1222
Loa Loa (eye worm)	TK/FER protein kinase	0.0445	1	1
Schistosoma mansoni	tensin	0.0294	0.5488	0.5488
Loa Loa (eye worm)	SH2 domain-containing protein	0.0294	0.5488	0.5488
Loa Loa (eye worm)	SH2 domain-containing protein	0.0294	0.5488	0.5488
Loa Loa (eye worm)	TK/FER protein kinase	0.0445	1	1
Brugia malayi	SH2 domain containing protein	0.0445	1	1
Schistosoma mansoni	tyrosine kinase	0.0151	0.1222	0.1222
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0445	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0445	1	1
Onchocerca volvulus		0.0151	0.1222	0.1222
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0151	0.1222	0.1222
Schistosoma mansoni	tyrosine kinase	0.0151	0.1222	0.1222
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Echinococcus granulosus	epidermal growth factor receptor	0.0151	0.1222	0.1222
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Echinococcus granulosus	tyrosine protein kinase csk	0.0151	0.1222	0.1222
Loa Loa (eye worm)	bone morphogenetic protein 1b	0.027	0.4781	0.4781
Echinococcus multilocularis	tyrosine kinase	0.0151	0.1222	0.1222
Schistosoma mansoni	protein kinase	0.0151	0.1222	0.1222
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0445	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0445	1	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0294	0.5488	0.5488
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0186	0.2277	0.2277
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0151	0.1222	0.1222
Echinococcus multilocularis	SHC transforming protein 3	0.0294	0.5488	0.5488
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0294	0.5488	0.4859
Entamoeba histolytica	SH2 domain containing protein	0.0294	0.5488	0.4859
Echinococcus granulosus	receptor type guanylyl cyclase	0.0151	0.1222	0.1222
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0151	0.1222	0.1222
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0151	0.1222	0.1222
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0294	0.5488	0.5488
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0445	1	1
Brugia malayi	Protein kinase domain containing protein	0.0445	1	1
Plasmodium falciparum	protein kinase, putative	0.0151	0.1222	0.5
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0294	0.5488	0.5488
Trichomonas vaginalis	TK family protein kinase	0.0151	0.1222	0.5
Loa Loa (eye worm)	TK/ROR protein kinase	0.0151	0.1222	0.1222
Trichomonas vaginalis	conserved hypothetical protein	0.0151	0.1222	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Echinococcus granulosus	hypothetical protein	0.0294	0.5488	0.5488
Brugia malayi	hypothetical protein	0.0294	0.5488	0.5488
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1222	0.1222
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0151	0.1222	0.1222
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0445	1	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0151	0.1222	0.1222
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1222	0.1222
Loa Loa (eye worm)	TK/FER protein kinase	0.0445	1	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0151	0.1222	0.1222
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0294	0.5488	0.5488
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Brugia malayi	Protein kinase domain containing protein	0.0151	0.1222	0.1222
Schistosoma mansoni	suppressor of cytokine signaling	0.0294	0.5488	0.5488
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0445	1	1
Echinococcus multilocularis	SH2 motif	0.0294	0.5488	0.5488
Loa Loa (eye worm)	TK/FER protein kinase	0.0151	0.1222	0.1222
Onchocerca volvulus		0.0445	1	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0445	1	1
Echinococcus multilocularis	Tolloid protein 1	0.027	0.4781	0.4781
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0294	0.5488	0.5488
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0151	0.1222	0.1222
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0151	0.1222	0.1222
Loa Loa (eye worm)	serine/threonine protein kinase	0.0151	0.1222	0.1222
Schistosoma mansoni	nck2/grb4	0.0294	0.5488	0.5488
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0151	0.1222	0.5
Echinococcus multilocularis	protein kinase	0.0151	0.1222	0.1222
Loa Loa (eye worm)	hypothetical protein	0.0294	0.5488	0.5488
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0445	1	1
Loa Loa (eye worm)	TK/INSR protein kinase	0.0151	0.1222	0.1222
Schistosoma mansoni	tensin	0.0294	0.5488	0.5488
Entamoeba histolytica	hypothetical protein	0.0158	0.1433	0.024
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Schistosoma mansoni	suppressor of cytokine signaling	0.0294	0.5488	0.5488
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0151	0.1222	0.1222
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Schistosoma mansoni	tyrosine kinase	0.0151	0.1222	0.1222
Echinococcus multilocularis	c src tyrosine kinase	0.0445	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Schistosoma mansoni	protein kinase	0.0151	0.1222	0.1222
Schistosoma mansoni	tyrosine kinase	0.0445	1	1
Loa Loa (eye worm)	TK/ALK protein kinase	0.0151	0.1222	0.1222
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Schistosoma mansoni	tyrosine kinase	0.0151	0.1222	0.1222
Schistosoma mansoni	tyrosine kinase	0.0151	0.1222	0.1222
Echinococcus multilocularis	heat shock protein 70	0.0151	0.1222	0.1222
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0151	0.1222	0.1222
Schistosoma mansoni	tyrosine kinase	0.0151	0.1222	0.1222
Giardia lamblia	Kinase, NEK	0.0151	0.1222	0.5
Onchocerca volvulus	Arrow homolog	0.027	0.4781	0.4781
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0151	0.1222	0.1222
Entamoeba histolytica	hypothetical protein	0.0158	0.1433	0.024
Schistosoma mansoni	hypothetical protein	0.0151	0.1222	0.1222
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0151	0.1222	0.1222
Echinococcus granulosus	SH2 motif	0.0294	0.5488	0.5488
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1222	0.1222
Schistosoma mansoni	growth factor receptor-bound protein	0.0294	0.5488	0.5488
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0151	0.1222	0.5
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0151	0.1222	0.1222
Loa Loa (eye worm)	TK protein kinase	0.0151	0.1222	0.1222
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Echinococcus multilocularis	tyrosine kinase	0.0445	1	1
Schistosoma mansoni	vav2	0.0294	0.5488	0.5488
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0151	0.1222	0.1222
Schistosoma mansoni	tyrosine kinase	0.0151	0.1222	0.1222
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0294	0.5488	0.5488
Schistosoma mansoni	tyrosine kinase	0.0151	0.1222	0.1222
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Onchocerca volvulus		0.0151	0.1222	0.1222
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0186	0.2277	0.2277
Loa Loa (eye worm)	hypothetical protein	0.0445	1	1
Brugia malayi	SH2 domain containing protein	0.0294	0.5488	0.5488
Trichomonas vaginalis	conserved hypothetical protein	0.0151	0.1222	0.5
Brugia malayi	Protein kinase domain containing protein	0.0151	0.1222	0.1222
Echinococcus multilocularis		0.0294	0.5488	0.5488
Schistosoma mansoni	tensin	0.0294	0.5488	0.5488
Echinococcus granulosus	tyrosine kinase	0.0445	1	1
Echinococcus granulosus	acetylcholinesterase	0.0146	0.1063	0.1063
Plasmodium falciparum	protein kinase, putative	0.0151	0.1222	0.5
Brugia malayi	Protein kinase domain containing protein	0.0151	0.1222	0.1222
Schistosoma mansoni	tyrosine kinase	0.0151	0.1222	0.1222
Loa Loa (eye worm)	TK/FER protein kinase	0.0445	1	1
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1063	0.1063
Schistosoma mansoni	protein kinase	0.0151	0.1222	0.1222
Schistosoma mansoni	tyrosine kinase	0.0151	0.1222	0.1222
Schistosoma mansoni	hypothetical protein	0.0294	0.5488	0.5488
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0151	0.1222	0.1222
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Echinococcus multilocularis	tyrosine protein kinase	0.0151	0.1222	0.1222
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0445	1	1
Echinococcus multilocularis	fibrillin 1	0.027	0.4781	0.4781
Echinococcus granulosus	tyrosine protein kinase Blk	0.0445	1	1
Echinococcus multilocularis	signal transduction protein lnk realted	0.0294	0.5488	0.5488
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0151	0.1222	0.1222
Brugia malayi	Calcium binding EGF domain containing protein	0.027	0.4781	0.4781
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0294	0.5488	0.5488
Plasmodium falciparum	tyrosine kinase-like protein	0.0151	0.1222	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0445	1	1
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0151	0.1222	0.1222
Brugia malayi	Receptor family ligand binding region containing protein	0.0151	0.1222	0.1222
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0151	0.1222	0.1222
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0151	0.1222	0.1222
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0151	0.1222	0.1222
Brugia malayi	protein-tyrosine kinase	0.0445	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0445	1	1
Loa Loa (eye worm)	hypothetical protein	0.0294	0.5488	0.5488
Brugia malayi	Protein kinase domain containing protein	0.0151	0.1222	0.1222
Brugia malayi	hypothetical protein	0.0151	0.1222	0.1222
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0151	0.1222	0.1222
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0158	0.1433	0.024
Onchocerca volvulus	Putative nachr subunit	0.0186	0.2277	0.2277
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1222	0.1222
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0445	1	1
Loa Loa (eye worm)	hypothetical protein	0.0186	0.2277	0.2277
Trichomonas vaginalis	STE family protein kinase	0.0151	0.1222	0.5
Loa Loa (eye worm)	TK/ABL protein kinase	0.0445	1	1
Loa Loa (eye worm)	carboxylesterase	0.0146	0.1063	0.1063
Echinococcus granulosus	tyrosine protein kinase shark	0.0445	1	1
Brugia malayi	SRC-1	0.0445	1	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0151	0.1222	0.1222
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0294	0.5488	0.5488
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0186	0.2277	0.2277
Brugia malayi	Protein kinase domain containing protein	0.0151	0.1222	0.1222
Echinococcus granulosus	acetylcholinesterase	0.0146	0.1063	0.1063
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0186	0.2277	0.2277
Brugia malayi	Protein kinase domain containing protein	0.0151	0.1222	0.1222
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0445	1	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0151	0.1222	0.1222
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0151	0.1222	0.1222
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0294	0.5488	0.5488
Loa Loa (eye worm)	TK/RYK protein kinase	0.0151	0.1222	0.1222
Echinococcus granulosus	insulin receptor	0.0151	0.1222	0.1222
Brugia malayi	Protein kinase domain containing protein	0.0151	0.1222	0.1222
Brugia malayi	Protein kinase domain containing protein	0.0151	0.1222	0.1222
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0151	0.1222	0.1222
Loa Loa (eye worm)	low-density lipoprotein receptor repeat class B containing protein	0.027	0.4781	0.4781
Echinococcus granulosus	tyrosine protein kinase csk	0.0151	0.1222	0.1222
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0151	0.1222	0.1222
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1222	0.1222
Echinococcus multilocularis	transfer RNA-Thr	0.0151	0.1222	0.1222
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0151	0.1222	0.1222
Echinococcus multilocularis	laminin	0.027	0.4781	0.4781
Brugia malayi	Sex muscle abnormal protein 5	0.0294	0.5488	0.5488
Loa Loa (eye worm)	TK/FER protein kinase	0.0151	0.1222	0.1222
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0294	0.5488	0.5488
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0445	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Onchocerca volvulus		0.0294	0.5488	0.5488
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Loa Loa (eye worm)	hypothetical protein	0.027	0.4781	0.4781
Schistosoma mansoni	tyrosine kinase	0.0445	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0151	0.1222	0.5
Echinococcus multilocularis	protein tyrosine kinase	0.0151	0.1222	0.1222
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0186	0.2277	0.2277
Schistosoma mansoni	protein tyrosine kinase	0.0151	0.1222	0.1222
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0294	0.5488	0.5488
Trichomonas vaginalis	AGC family protein kinase	0.0151	0.1222	0.5
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1222	0.1222
Loa Loa (eye worm)	TK/FER protein kinase	0.0151	0.1222	0.1222
Brugia malayi	Tyrosine-protein kinase abl-1	0.0445	1	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0151	0.1222	0.1222
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0294	0.5488	0.5488
Echinococcus granulosus	N chimaerin	0.0294	0.5488	0.5488
Brugia malayi	Protein kinase domain containing protein	0.0151	0.1222	0.1222
Brugia malayi	Protein kinase domain containing protein	0.0151	0.1222	0.1222
Loa Loa (eye worm)	TK/FER protein kinase	0.0151	0.1222	0.1222
Onchocerca volvulus		0.0151	0.1222	0.1222
Plasmodium falciparum	tyrosine kinase-like protein	0.0151	0.1222	0.5
Brugia malayi	Protein kinase domain containing protein	0.0151	0.1222	0.1222
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0445	1	1
Onchocerca volvulus		0.0294	0.5488	0.5488
Loa Loa (eye worm)	TK/FER protein kinase	0.0445	1	1
Loa Loa (eye worm)	hypothetical protein	0.027	0.4781	0.4781
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0151	0.1222	0.5
Schistosoma mansoni	tyrosine kinase	0.0151	0.1222	0.1222
Echinococcus multilocularis	integrin linked protein kinase	0.0151	0.1222	0.1222
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0151	0.1222	0.1222
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0151	0.1222	0.5
Schistosoma mansoni	growth factor receptor-bound protein	0.0294	0.5488	0.5488
Loa Loa (eye worm)	TK/FER protein kinase	0.0445	1	1
Schistosoma mansoni	serine/threonine RGC	0.0151	0.1222	0.1222
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Echinococcus granulosus	tyrosine protein kinase csk	0.0151	0.1222	0.1222
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0294	0.5488	0.5488
Echinococcus multilocularis	SH2 domain containing protein 7	0.0294	0.5488	0.5488
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0294	0.5488	0.5488
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0294	0.5488	0.5488
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0445	1	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0294	0.5488	0.5488
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0151	0.1222	0.1222
Schistosoma mansoni	tyrosine kinase	0.0445	1	1
Schistosoma mansoni	ephrin receptor	0.0151	0.1222	0.1222
Schistosoma mansoni	tyrosine kinase	0.0151	0.1222	0.1222
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0151	0.1222	0.1222
Brugia malayi	Tensin	0.0294	0.5488	0.5488
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0445	1	1
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0151	0.1222	0.5
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0151	0.1222	0.1222
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0151	0.1222	0.1222
Onchocerca volvulus		0.0151	0.1222	0.1222
Echinococcus granulosus	laminin	0.027	0.4781	0.4781
Brugia malayi	Protein kinase domain containing protein	0.0151	0.1222	0.1222
Onchocerca volvulus		0.0294	0.5488	0.5488
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Schistosoma mansoni	tyrosine kinase	0.0151	0.1222	0.1222
Loa Loa (eye worm)	TK/DDR protein kinase	0.0151	0.1222	0.1222
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0151	0.1222	0.1222
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0445	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0151	0.1222	0.1222
Trypanosoma brucei	Pseudokinase, putative	0.0151	0.1222	0.5
Schistosoma mansoni	tyrosine kinase	0.0151	0.1222	0.1222
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0151	0.1222	0.1222
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0151	0.1222	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0294	0.5488	0.5488
Trypanosoma cruzi	protein kinase, putative	0.0151	0.1222	0.5
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0151	0.1222	0.1222
Echinococcus multilocularis	acetylcholinesterase	0.0146	0.1063	0.1063
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0151	0.1222	0.1222
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0151	0.1222	0.1222
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0151	0.1222	0.1222
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0445	1	1
Echinococcus granulosus	activated cdc42 kinase 1	0.0151	0.1222	0.1222
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0151	0.1222	0.1222
Echinococcus multilocularis	FL cytokine receptor	0.0151	0.1222	0.1222
Schistosoma mansoni	serine/threonine protein kinase	0.0151	0.1222	0.1222
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Giardia lamblia	Kinase	0.0151	0.1222	0.5
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1222	0.1222
Echinococcus granulosus	SHC transforming protein 3	0.0294	0.5488	0.5488
Schistosoma mansoni	tyrosine kinase	0.0151	0.1222	0.1222
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Echinococcus multilocularis	NCK adaptor protein	0.0294	0.5488	0.5488
Giardia lamblia	Kinase, NEK	0.0151	0.1222	0.5
Echinococcus granulosus	ephrin type A receptor 4 A	0.0151	0.1222	0.1222
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Schistosoma mansoni	tyrosine kinase	0.0151	0.1222	0.1222
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0151	0.1222	0.1222
Schistosoma mansoni	shc transforming protein	0.0294	0.5488	0.5488
Schistosoma mansoni	hypothetical protein	0.0294	0.5488	0.5488
Echinococcus multilocularis	tyrosine protein kinase csk	0.0151	0.1222	0.1222
Echinococcus multilocularis	tensin	0.0294	0.5488	0.5488
Brugia malayi	hypothetical protein	0.0445	1	1
Brugia malayi	Protein kinase domain containing protein	0.0151	0.1222	0.1222
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Brugia malayi	C-terminal src kinase protein 1	0.0151	0.1222	0.1222
Schistosoma mansoni	tyrosine protein kinase	0.0151	0.1222	0.1222
Brugia malayi	Protein kinase domain containing protein	0.0445	1	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0151	0.1222	0.5
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0294	0.5488	0.5488
Onchocerca volvulus		0.0151	0.1222	0.1222
Brugia malayi	Protein kinase domain containing protein	0.0151	0.1222	0.1222
Echinococcus granulosus	protein tyrosine kinase	0.0151	0.1222	0.1222
Loa Loa (eye worm)	TK protein kinase	0.0151	0.1222	0.1222
Brugia malayi	Protein kinase domain containing protein	0.0151	0.1222	0.1222
Echinococcus granulosus	tyrosine kinase	0.0151	0.1222	0.1222
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0445	1	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0151	0.1222	0.1222
Brugia malayi	RhoGAP domain containing protein	0.0294	0.5488	0.5488
Trypanosoma cruzi	protein kinase, putative	0.0151	0.1222	0.5
Onchocerca volvulus	Tyrosine kinase homolog	0.0151	0.1222	0.1222
Loa Loa (eye worm)	hypothetical protein	0.0294	0.5488	0.5488
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0445	1	1
Echinococcus multilocularis	tyrosine protein kinase shark	0.0445	1	1
Echinococcus granulosus	protein kinase	0.0151	0.1222	0.1222
Plasmodium falciparum	protein kinase, putative	0.0151	0.1222	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Echinococcus granulosus	NCK adaptor protein	0.0294	0.5488	0.5488
Leishmania major	protein kinase, putative	0.0151	0.1222	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0294	0.5488	0.5488
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0294	0.5488	0.5488
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1063	0.1063
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0294	0.5488	0.5488
Loa Loa (eye worm)	SRC-1	0.0445	1	1
Echinococcus multilocularis	activin receptor type	0.0151	0.1222	0.1222
Brugia malayi	Protein kinase domain containing protein	0.0151	0.1222	0.1222
Onchocerca volvulus		0.0151	0.1222	0.1222
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0151	0.1222	0.1222
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0294	0.5488	0.5488
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Onchocerca volvulus		0.0445	1	1
Brugia malayi	Carboxylesterase family protein	0.0146	0.1063	0.1063
Entamoeba histolytica	protein kinase, putative	0.0158	0.1433	0.024
Entamoeba histolytica	hypothetical protein	0.0158	0.1433	0.024
Brugia malayi	SH2 domain containing protein	0.0294	0.5488	0.5488
Trichomonas vaginalis	TKL family protein kinase	0.0151	0.1222	0.5
Brugia malayi	Protein kinase domain containing protein	0.0151	0.1222	0.1222
Loa Loa (eye worm)	hypothetical protein	0.0294	0.5488	0.5488

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 26 nM	Binding affinity to human histamine H3 receptor	ChEMBL.	22153342
Ki (binding)	= 112 nM	Binding affinity to rat histamine H3 receptor	ChEMBL.	22153342

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1935410

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1601792