Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 1 (interstitial collagenase) | Starlite/ChEMBL | References |
Homo sapiens | ADAM metallopeptidase domain 17 | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 13 (collagenase 3) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Echinococcus granulosus | adam 17 protease | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Echinococcus multilocularis | adam 17 protease | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Schistosoma japonicum | ko:K06059 a disintegrin and metalloproteinase domain 17, putative | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Matrixin family protein | matrix metallopeptidase 1 (interstitial collagenase) | 403 aa | 401 aa | 27.7 % |
Brugia malayi | Disintegrin family protein | ADAM metallopeptidase domain 17 | 824 aa | 724 aa | 27.4 % |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | matrix metallopeptidase 13 (collagenase 3) | 471 aa | 448 aa | 34.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.0352 | 0.6795 | 1 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.0352 | 0.6795 | 1 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0268 | 0.4479 | 0.6592 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0352 | 0.6795 | 1 |
Brugia malayi | Peptidase family M28 containing protein | 0.0352 | 0.6795 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0268 | 0.4479 | 0.6592 |
Echinococcus multilocularis | adam 17 protease | 0.0223 | 0.324 | 0.4768 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.014 | 0.0953 | 0.1403 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0352 | 0.6795 | 1 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.014 | 0.0953 | 0.1403 |
Loa Loa (eye worm) | matrixin family protein | 0.0178 | 0.2007 | 0.0483 |
Echinococcus granulosus | adam 17 protease | 0.0245 | 0.3852 | 0.5669 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0223 | 0.324 | 0.4768 |
Brugia malayi | Matrixin family protein | 0.0178 | 0.2007 | 0.2954 |
Loa Loa (eye worm) | hypothetical protein | 0.0352 | 0.6795 | 0.6183 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 20 nM | Concentration required in vitro to inhibit TNF-alpha converting enzyme (TACE) | ChEMBL. | 12270165 |
IC50 (binding) | = 20 nM | Concentration required in vitro to inhibit TNF-alpha converting enzyme (TACE) | ChEMBL. | 12270165 |
IC50 (binding) | = 34.6 nM | Concentration of the compound required in vitro to inhibit Matrix metalloproteinase-13 | ChEMBL. | 12270165 |
IC50 (binding) | = 34.6 nM | Concentration of the compound required in vitro to inhibit Matrix metalloproteinase-13 | ChEMBL. | 12270165 |
IC50 (binding) | = 95.5 nM | Concentration required in vitro to inhibit Matrix metalloproteinase-9 | ChEMBL. | 12270165 |
IC50 (binding) | = 95.5 nM | Concentration required in vitro to inhibit Matrix metalloproteinase-9 | ChEMBL. | 12270165 |
IC50 (binding) | = 260 nM | Concentration required in vitro to inhibit Matrix metalloproteinase-1 | ChEMBL. | 12270165 |
IC50 (binding) | = 260 nM | Concentration required in vitro to inhibit Matrix metalloproteinase-1 | ChEMBL. | 12270165 |
Inhibition (functional) | = 44 % | Compound was tested for its ability to inhibit TNF-alpha in a cellular assay using THP-1 cells at 3 microM | ChEMBL. | 12270165 |
Inhibition (functional) | = 44 % | Compound was tested for its ability to inhibit TNF-alpha in a cellular assay using THP-1 cells at 3 microM | ChEMBL. | 12270165 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.