Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | cathepsin L-like protease | 0.1165 | 0.9212 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1165 | 0.9212 | 1 |
Onchocerca volvulus | 0.1165 | 0.9212 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1165 | 0.9212 | 0.9212 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.079 | 0.2931 | 0.2931 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1165 | 0.9212 | 1 |
Echinococcus multilocularis | cysteine protease | 0.1165 | 0.9212 | 0.9212 |
Entamoeba histolytica | cysteine proteinase, putative | 0.079 | 0.2931 | 0.3182 |
Leishmania major | cathepsin L-like protease | 0.1165 | 0.9212 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1165 | 0.9212 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1165 | 0.9212 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1165 | 0.9212 | 0.9212 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1165 | 0.9212 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1165 | 0.9212 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.1165 | 0.9212 | 0.9212 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.1165 | 0.9212 | 0.9212 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1165 | 0.9212 | 0.9212 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1165 | 0.9212 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1165 | 0.9212 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.079 | 0.2931 | 0.2931 |
Loa Loa (eye worm) | fibroinase | 0.1165 | 0.9212 | 0.8885 |
Onchocerca volvulus | 0.1165 | 0.9212 | 1 | |
Echinococcus multilocularis | cathepsin b | 0.1212 | 1 | 1 |
Echinococcus multilocularis | sodium channel protein | 0.0908 | 0.4914 | 0.4914 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1165 | 0.9212 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1165 | 0.9212 | 0.8885 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1165 | 0.9212 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.1165 | 0.9212 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1165 | 0.9212 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.1165 | 0.9212 | 0.9212 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1165 | 0.9212 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1165 | 0.9212 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.1212 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.1212 | 1 | 1 |
Onchocerca volvulus | 0.1165 | 0.9212 | 1 | |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.1165 | 0.9212 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1165 | 0.9212 | 1 |
Echinococcus granulosus | cathepsin b | 0.1212 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.1212 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1212 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.1165 | 0.9212 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1212 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1212 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1165 | 0.9212 | 1 |
Echinococcus granulosus | cathepsin b | 0.1212 | 1 | 1 |
Echinococcus granulosus | sodium channel protein | 0.0908 | 0.4914 | 0.4914 |
Brugia malayi | Cathepsin L-like precursor | 0.1165 | 0.9212 | 0.9212 |
Echinococcus multilocularis | cysteine protease | 0.1165 | 0.9212 | 0.9212 |
Echinococcus granulosus | cathepsin l1 | 0.1165 | 0.9212 | 0.9212 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1165 | 0.9212 | 1 |
Onchocerca volvulus | 0.1165 | 0.9212 | 1 | |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.079 | 0.2931 | 0.2931 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.1165 | 0.9212 | 0.9212 |
Onchocerca volvulus | Cathepsin L homolog | 0.1165 | 0.9212 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.1165 | 0.9212 | 0.8885 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1165 | 0.9212 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.079 | 0.2931 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1165 | 0.9212 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1165 | 0.9212 | 0.9212 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1165 | 0.9212 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1165 | 0.9212 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.079 | 0.2931 | 0.2931 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1165 | 0.9212 | 0.9212 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1165 | 0.9212 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1165 | 0.9212 | 1 |
Leishmania major | cathepsin L-like protease | 0.1165 | 0.9212 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1165 | 0.9212 | 1 |
Leishmania major | cathepsin L-like protease | 0.1165 | 0.9212 | 1 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0908 | 0.4914 | 0.4914 |
Loa Loa (eye worm) | hypothetical protein | 0.1212 | 1 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.1165 | 0.9212 | 0.9212 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.1165 | 0.9212 | 0.8885 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.1165 | 0.9212 | 0.9212 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1165 | 0.9212 | 1 |
Onchocerca volvulus | 0.1165 | 0.9212 | 1 | |
Toxoplasma gondii | cathepsin CPL | 0.1165 | 0.9212 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.1165 | 0.9212 | 1 |
Leishmania major | cathepsin L-like protease | 0.1165 | 0.9212 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1165 | 0.9212 | 0.9212 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1165 | 0.9212 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1165 | 0.9212 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.1165 | 0.9212 | 0.8885 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1165 | 0.9212 | 1 |
Onchocerca volvulus | 0.1165 | 0.9212 | 1 | |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.1165 | 0.9212 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.079 | 0.2931 | 0.2931 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1165 | 0.9212 | 0.9212 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1165 | 0.9212 | 0.9212 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1165 | 0.9212 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1165 | 0.9212 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1165 | 0.9212 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1165 | 0.9212 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.1165 | 0.9212 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1165 | 0.9212 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1165 | 0.9212 | 0.9212 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1165 | 0.9212 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.1165 | 0.9212 | 1 |
Plasmodium vivax | vivapain-2 | 0.1165 | 0.9212 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.1165 | 0.9212 | 1 |
Leishmania major | cathepsin L-like protease | 0.1165 | 0.9212 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.1165 | 0.9212 | 0.9212 |
Brugia malayi | Papain family cysteine protease containing protein | 0.1165 | 0.9212 | 0.9212 |
Leishmania major | cathepsin L-like protease | 0.1165 | 0.9212 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1165 | 0.9212 | 0.9212 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.079 | 0.2931 | 0.3182 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.1165 | 0.9212 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1165 | 0.9212 | 0.9212 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1165 | 0.9212 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.079 | 0.2931 | 0.2931 |
Plasmodium vivax | vivapain-2 | 0.1165 | 0.9212 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1165 | 0.9212 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.1165 | 0.9212 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.079 | 0.2931 | 0.2931 |
Loa Loa (eye worm) | cysteine protease | 0.1165 | 0.9212 | 0.8885 |
Onchocerca volvulus | 0.1165 | 0.9212 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1165 | 0.9212 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.413 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the K-562 Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.226 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.048 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.047 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.