Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | arachidonate 5-lipoxygenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | serine:threonine protein kinase MARK2 | 0.0297 | 0.2494 | 0.3404 |
Schistosoma mansoni | lipoxygenase | 0.0142 | 0.0542 | 0.0542 |
Schistosoma mansoni | serine/threonine kinase | 0.089 | 1 | 1 |
Echinococcus granulosus | calcium activated potassium channel | 0.0297 | 0.2494 | 0.3404 |
Echinococcus multilocularis | maternal embryonic leucine zipper kinase | 0.0596 | 0.6275 | 1 |
Echinococcus multilocularis | hypothetical protein | 0.0294 | 0.2465 | 0.3355 |
Echinococcus multilocularis | serine:threonine protein kinase MARK2 | 0.0297 | 0.2494 | 0.3404 |
Echinococcus granulosus | serine:threonine protein kinase MARK2 | 0.0297 | 0.2494 | 0.3404 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0297 | 0.2494 | 0.2494 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0297 | 0.2494 | 0.2494 |
Echinococcus multilocularis | calcium activated potassium channel | 0.0297 | 0.2494 | 0.3404 |
Echinococcus granulosus | serine:threonine protein kinase MARK2 | 0.0297 | 0.2494 | 0.3404 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0297 | 0.2494 | 0.2494 |
Schistosoma mansoni | hypothetical protein | 0.0294 | 0.2465 | 0.2465 |
Schistosoma mansoni | hypothetical protein | 0.0294 | 0.2465 | 0.2465 |
Echinococcus granulosus | maternal embryonic leucine zipper kinase | 0.0596 | 0.6275 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0297 | 0.2494 | 0.2494 |
Trichomonas vaginalis | CAMK family protein kinase | 0.089 | 1 | 1 |
Loa Loa (eye worm) | CAMK/CAMKL/MELK protein kinase | 0.089 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0297 | 0.2494 | 0.2494 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.61 uM | Inhibition of 5-lipoxygenase in S100 cell free fraction of human polymorphonuclear leukocytes assessed as reduction in 5-LO product formation preincubated for 15 mins measured after 10 mins by HPLC analysis | ChEMBL. | 22326163 |
IC50 (binding) | = 1.5 uM | Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as reduction in A23187 and AA-stimulated 5-LO product formation preincubated for 15 mins prior stimulation measured after 10 mins by HPLC analysis | ChEMBL. | 22326163 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.