Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.4156 | 0.4061 | 0.4061 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.4156 | 0.4061 | 0.4061 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0671 | 0 | 0.5 |
Trypanosoma cruzi | Bromodomain factor 1 | 0.0671 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved,predicted bromodomain protein | 0.0671 | 0 | 0.5 |
Trypanosoma brucei | Bromodomain, putative | 0.0671 | 0 | 0.5 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.4156 | 0.4061 | 0.4061 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.4156 | 0.4061 | 0.4061 |
Schistosoma mansoni | CREB-binding protein 2 | 0.4037 | 0.3922 | 0.3922 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.4156 | 0.4061 | 0.4061 |
Plasmodium vivax | bromodomain protein, putative | 0.0671 | 0 | 0.5 |
Echinococcus granulosus | CREB binding protein | 0.2724 | 0.2392 | 0.2392 |
Schistosoma mansoni | bromodomain-containing protein 3 brd3 | 0.9253 | 1 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.5768 | 0.5939 | 0.5939 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.4156 | 0.4061 | 0.4061 |
Trichomonas vaginalis | bromodomain containing protein, putative | 0.5768 | 0.5939 | 0.5939 |
Brugia malayi | TAZ zinc finger family protein | 0.4037 | 0.3922 | 0.3922 |
Entamoeba histolytica | bromodomain-containing protein | 0.4156 | 0.4061 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.9253 | 1 | 1 |
Entamoeba histolytica | bromodomain-containing protein | 0.4156 | 0.4061 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.4156 | 0.4061 | 0.4061 |
Leishmania major | DNA-binding protein, putative,predicted bromodomain protein | 0.0671 | 0 | 0.5 |
Trypanosoma brucei | Bromodomain, putative | 0.0671 | 0 | 0.5 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.5768 | 0.5939 | 0.5939 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.4156 | 0.4061 | 0.4061 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.4156 | 0.4061 | 0.4061 |
Trypanosoma brucei | Bromodomain factor 1 | 0.0671 | 0 | 0.5 |
Giardia lamblia | Kinase, putative | 0.4156 | 0.4061 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.5768 | 0.5939 | 0.5939 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.5768 | 0.5939 | 0.5939 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.4156 | 0.4061 | 0.4061 |
Trichomonas vaginalis | histone acetyltransferase gcn5, putative | 0.4156 | 0.4061 | 0.4061 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.4156 | 0.4061 | 0.4061 |
Plasmodium vivax | hypothetical protein, conserved | 0.0671 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0671 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0671 | 0 | 0.5 |
Trypanosoma brucei | bromodomain factor 2 protein, putative | 0.0671 | 0 | 0.5 |
Trypanosoma cruzi | Bromodomain, putative | 0.0671 | 0 | 0.5 |
Trypanosoma brucei | AAA ATPase, putative | 0.0671 | 0 | 0.5 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.4156 | 0.4061 | 0.4061 |
Trypanosoma cruzi | Bromodomain, putative | 0.0671 | 0 | 0.5 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.4156 | 0.4061 | 0.4061 |
Brugia malayi | hypothetical protein | 0.3485 | 0.3279 | 0.3279 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.4156 | 0.4061 | 0.4061 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0671 | 0 | 0.5 |
Plasmodium vivax | conserved Plasmodium protein, unknown function | 0.0671 | 0 | 0.5 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.4156 | 0.4061 | 0.4061 |
Trichomonas vaginalis | conserved hypothetical protein | 0.5097 | 0.5157 | 0.5157 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.4156 | 0.4061 | 0.4061 |
Plasmodium falciparum | bromodomain protein 1 | 0.0671 | 0 | 0.5 |
Echinococcus granulosus | CREB binding protein | 0.4037 | 0.3922 | 0.3922 |
Toxoplasma gondii | bromodomain-containing protein | 0.4156 | 0.4061 | 1 |
Plasmodium vivax | bromodomain protein, putative | 0.0671 | 0 | 0.5 |
Echinococcus multilocularis | Bromodomain containing protein | 0.4156 | 0.4061 | 0.4061 |
Loa Loa (eye worm) | bromodomain containing protein | 0.4156 | 0.4061 | 0.4061 |
Trypanosoma cruzi | bromodomain-containing protein 3 | 0.0671 | 0 | 0.5 |
Schistosoma mansoni | CREB-binding protein 1 (SmCBP1) | 0.4037 | 0.3922 | 0.3922 |
Trypanosoma cruzi | Bromodomain, putative | 0.0671 | 0 | 0.5 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.4156 | 0.4061 | 0.4061 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.9253 | 1 | 1 |
Trypanosoma cruzi | bromodomain factor 2 protein | 0.0671 | 0 | 0.5 |
Trypanosoma cruzi | Bromodomain, putative | 0.0671 | 0 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.9253 | 1 | 1 |
Trypanosoma brucei | Bromodomain, putative | 0.0671 | 0 | 0.5 |
Onchocerca volvulus | 0.4156 | 0.4061 | 1 | |
Echinococcus multilocularis | bromodomain containing 2 | 0.9253 | 1 | 1 |
Trichomonas vaginalis | bromodomain-containing protein 4, brd4, putative | 0.4156 | 0.4061 | 0.4061 |
Loa Loa (eye worm) | hypothetical protein | 0.1608 | 0.1092 | 0.1092 |
Trypanosoma cruzi | Bromodomain, putative | 0.0671 | 0 | 0.5 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.4156 | 0.4061 | 0.4061 |
Plasmodium vivax | bromodomain protein, putative | 0.0671 | 0 | 0.5 |
Loa Loa (eye worm) | CBP-B | 0.299 | 0.2703 | 0.2703 |
Loa Loa (eye worm) | hypothetical protein | 0.9253 | 1 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.4156 | 0.4061 | 0.4061 |
Echinococcus granulosus | bromodomain containing 2 | 0.9253 | 1 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.4156 | 0.4061 | 0.4061 |
Plasmodium falciparum | bromodomain protein, putative | 0.0671 | 0 | 0.5 |
Plasmodium vivax | SET domain containing protein | 0.0671 | 0 | 0.5 |
Plasmodium falciparum | bromodomain protein 2, putative | 0.0671 | 0 | 0.5 |
Trichomonas vaginalis | bromodomain containing protein, putative | 0.4156 | 0.4061 | 0.4061 |
Entamoeba histolytica | bromodomain-containing protein | 0.4156 | 0.4061 | 1 |
Echinococcus multilocularis | CREB binding protein | 0.2961 | 0.2668 | 0.2668 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.451 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.328 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.99 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.932 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.861 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.806 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.797 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.794 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.688 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.