Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1837 | 0.0913 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1837 | 0.0913 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.1837 | 0.0913 | 0.0913 |
Loa Loa (eye worm) | hypothetical protein | 0.1837 | 0.0913 | 0.2198 |
Plasmodium vivax | vivapain-2 | 0.1837 | 0.0913 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.1837 | 0.0913 | 0.0913 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.149 | 0.0536 | 0.1716 |
Onchocerca volvulus | 0.1837 | 0.0913 | 1 | |
Leishmania major | cysteine peptidase A (CPA) | 0.1837 | 0.0913 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1837 | 0.0913 | 0.2924 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.1837 | 0.0913 | 0.2198 |
Echinococcus multilocularis | cysteine protease | 0.1837 | 0.0913 | 0.0913 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.1837 | 0.0913 | 0.0913 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1837 | 0.0913 | 1 |
Leishmania major | cathepsin L-like protease | 0.1837 | 0.0913 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.149 | 0.0536 | 0.5 |
Echinococcus granulosus | cathepsin b | 0.3868 | 0.3123 | 0.3123 |
Leishmania major | cathepsin L-like protease | 0.1837 | 0.0913 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1837 | 0.0913 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1837 | 0.0913 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.1837 | 0.0913 | 1 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.3868 | 0.3123 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1837 | 0.0913 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1265 | 0.029 | 0.093 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.1265 | 0.029 | 0.093 |
Onchocerca volvulus | Cathepsin L homolog | 0.1837 | 0.0913 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.149 | 0.0536 | 0.0866 |
Onchocerca volvulus | 0.1837 | 0.0913 | 1 | |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.149 | 0.0536 | 0.1716 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Onchocerca volvulus | 0.1837 | 0.0913 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.1265 | 0.029 | 0.093 |
Brugia malayi | Cathepsin L-like precursor | 0.1837 | 0.0913 | 0.2924 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1837 | 0.0913 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1837 | 0.0913 | 0.2924 |
Leishmania major | cathepsin L-like protease | 0.1837 | 0.0913 | 1 |
Leishmania major | cathepsin L-like protease | 0.1837 | 0.0913 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.149 | 0.0536 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1837 | 0.0913 | 0.2924 |
Leishmania major | cathepsin L-like protease | 0.1837 | 0.0913 | 1 |
Plasmodium vivax | vivapain-2 | 0.1837 | 0.0913 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1837 | 0.0913 | 0.2924 |
Onchocerca volvulus | Cathepsin L homolog | 0.1837 | 0.0913 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.1837 | 0.0913 | 0.0913 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.1837 | 0.0913 | 0.0913 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.1837 | 0.0913 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1837 | 0.0913 | 0.2924 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.3868 | 0.3123 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.1265 | 0.029 | 0.093 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1837 | 0.0913 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.1265 | 0.029 | 0.029 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1265 | 0.029 | 0.093 |
Leishmania major | cathepsin L-like protease | 0.1837 | 0.0913 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.1837 | 0.0913 | 0.2198 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.1837 | 0.0913 | 0.0913 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.3868 | 0.3123 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.1837 | 0.0913 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1837 | 0.0913 | 0.2924 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1837 | 0.0913 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.149 | 0.0536 | 0.5868 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.1837 | 0.0913 | 0.2198 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1837 | 0.0913 | 0.2924 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1837 | 0.0913 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1837 | 0.0913 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1837 | 0.0913 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.1837 | 0.0913 | 0.2924 |
Echinococcus multilocularis | cysteine protease | 0.1837 | 0.0913 | 0.0913 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1265 | 0.029 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1837 | 0.0913 | 0.2924 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.149 | 0.0536 | 0.5868 |
Brugia malayi | Cathepsin L-like precursor | 0.1837 | 0.0913 | 0.2924 |
Onchocerca volvulus | Cathepsin F homolog | 0.1837 | 0.0913 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.149 | 0.0536 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.1837 | 0.0913 | 1 |
Onchocerca volvulus | 0.1837 | 0.0913 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Onchocerca volvulus | 0.1837 | 0.0913 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Onchocerca volvulus | 0.1837 | 0.0913 | 1 | |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1837 | 0.0913 | 0.2924 |
Onchocerca volvulus | 0.1837 | 0.0913 | 1 | |
Loa Loa (eye worm) | fibroinase | 0.1837 | 0.0913 | 0.2198 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1265 | 0.029 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1837 | 0.0913 | 0.2924 |
Echinococcus multilocularis | cathepsin b | 0.3868 | 0.3123 | 0.3123 |
Brugia malayi | Papain family cysteine protease containing protein | 0.1837 | 0.0913 | 0.2924 |
Loa Loa (eye worm) | hypothetical protein | 0.3868 | 0.3123 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.1837 | 0.0913 | 0.0913 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.3868 | 0.3123 | 1 |
Echinococcus granulosus | cathepsin b | 0.3868 | 0.3123 | 0.3123 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.3868 | 0.3123 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.1837 | 0.0913 | 0.2198 |
Leishmania major | cathepsin L-like protease | 0.1837 | 0.0913 | 1 |
Echinococcus multilocularis | EGFP:Bcl2 fusion protein | 1.019 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1837 | 0.0913 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.3868 | 0.3123 | 1 |
Echinococcus multilocularis | cathepsin b | 0.3868 | 0.3123 | 0.3123 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1265 | 0.029 | 0.3182 |
Entamoeba histolytica | cysteine protease, putative | 0.1837 | 0.0913 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.1837 | 0.0913 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1265 | 0.029 | 0.093 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1837 | 0.0913 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.