Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0566 | 0.2962 | 0.5411 |
Brugia malayi | hypothetical protein | 0.0638 | 0.3578 | 1 |
Schistosoma mansoni | adam (A disintegrin and metalloprotease | 0.0638 | 0.3578 | 0.6268 |
Echinococcus multilocularis | adam 17 protease | 0.056 | 0.2916 | 0.5328 |
Brugia malayi | Disintegrin family protein | 0.0298 | 0.0678 | 0.0887 |
Loa Loa (eye worm) | hypothetical protein | 0.0462 | 0.2074 | 0.1615 |
Echinococcus multilocularis | adam | 0.0638 | 0.3578 | 0.6538 |
Loa Loa (eye worm) | reprolysin | 0.0861 | 0.5473 | 0.5211 |
Schistosoma mansoni | dihydroceramide desaturase | 0.0298 | 0.0678 | 0.0556 |
Schistosoma mansoni | subfamily M12B unassigned peptidase (M12 family) | 0.0861 | 0.5473 | 1 |
Echinococcus granulosus | adam 17 protease | 0.0798 | 0.4938 | 0.9023 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0566 | 0.2962 | 0.5411 |
Echinococcus multilocularis | subfamily M12B unassigned peptidase | 0.0861 | 0.5473 | 1 |
Echinococcus granulosus | subfamily M12B unassigned peptidase | 0.0861 | 0.5473 | 1 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0265 | 0.0396 | 0.0723 |
Brugia malayi | angiogenesis inhibito | 0.0282 | 0.0547 | 0.0475 |
Brugia malayi | ADAM-TS Spacer 1 family protein | 0.0282 | 0.0547 | 0.0475 |
Echinococcus granulosus | disintegrin and metalloproteinase | 0.0298 | 0.0678 | 0.1239 |
Schistosoma mansoni | subfamily M12B unassigned peptidase (M12 family) | 0.0861 | 0.5473 | 1 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0265 | 0.0396 | 0.0723 |
Echinococcus granulosus | adam | 0.0638 | 0.3578 | 0.6538 |
Brugia malayi | ADAMTS-like protease | 0.0282 | 0.0547 | 0.0475 |
Brugia malayi | Reprolysin | 0.0623 | 0.3451 | 0.96 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.056 | 0.2916 | 0.4964 |
Echinococcus multilocularis | disintegrin and metalloproteinase | 0.0298 | 0.0678 | 0.1239 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the K-562 Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.