Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.096 | 0.451 | 1 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0387 | 0.1024 | 0.1024 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.096 | 0.451 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0387 | 0.1024 | 0.2272 |
Schistosoma mansoni | choline o-acyltransferase | 0.0218 | 0 | 0.5 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.096 | 0.451 | 1 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.096 | 0.451 | 1 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0387 | 0.1024 | 0.2272 |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.0387 | 0.1024 | 0.2272 |
Onchocerca volvulus | 0.0218 | 0 | 0.5 | |
Onchocerca volvulus | 0.0218 | 0 | 0.5 | |
Schistosoma mansoni | choline o-acyltransferase | 0.0218 | 0 | 0.5 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0387 | 0.1024 | 0.1024 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.096 | 0.451 | 1 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0387 | 0.1024 | 1 |
Onchocerca volvulus | 0.0218 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.1863 | 1 | 1 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.0387 | 0.1024 | 0.2272 |
Onchocerca volvulus | 0.0218 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.