Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.1287 | 0.5928 | 0.6668 |
Trichomonas vaginalis | STE family protein kinase | 0.0304 | 0.0378 | 1 |
Brugia malayi | Neuronal symmetry protein 1 | 0.1287 | 0.5928 | 0.5768 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0304 | 0.0378 | 0.0434 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0297 | 0.0341 | 0.9037 |
Trichomonas vaginalis | STE family protein kinase | 0.0304 | 0.0378 | 1 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0392 | 0.088 | 0.5 |
Echinococcus multilocularis | p21 activated protein kinase 1 Dpak1 | 0.0304 | 0.0378 | 0.0434 |
Schistosoma mansoni | protein kinase | 0.0304 | 0.0378 | 0.0637 |
Loa Loa (eye worm) | STE/STE20/PAKB protein kinase | 0.2008 | 1 | 1 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0392 | 0.088 | 0.5 |
Trichomonas vaginalis | STE family protein kinase | 0.0304 | 0.0378 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PAK 4 | 0.1778 | 0.8701 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0304 | 0.0378 | 1 |
Giardia lamblia | Kinase, STE STE20 | 0.0304 | 0.0378 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 4 | 0.1778 | 0.8701 | 1 |
Entamoeba histolytica | p21-activated kinase | 0.0304 | 0.0378 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.1287 | 0.5928 | 0.6813 |
Schistosoma mansoni | protein kinase | 0.1287 | 0.5928 | 1 |
Schistosoma mansoni | protein kinase | 0.1287 | 0.5928 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0304 | 0.0378 | 0.0434 |
Loa Loa (eye worm) | hypothetical protein | 0.128 | 0.5891 | 0.5746 |
Loa Loa (eye worm) | hypothetical protein | 0.0386 | 0.0844 | 0.052 |
Loa Loa (eye worm) | STE/STE11/ASK protein kinase | 0.0392 | 0.088 | 0.0558 |
Schistosoma mansoni | protein kinase | 0.0304 | 0.0378 | 0.0637 |
Trichomonas vaginalis | STE family protein kinase | 0.0304 | 0.0378 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 75 % | Analgesic activity in Swiss albino mouse assessed as protection against acetic acid-induced wriths at 50 mg/kg, po administered 30 mins prior acetic acid challenge measured for 10 mins | ChEMBL. | 22357113 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.