Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | cathepsin L-like protease | 0.1102 | 1 | 0.5 |
Echinococcus granulosus | cathepsin b | 0.0773 | 0.3754 | 0.3754 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1102 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1102 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1102 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1102 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1102 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0743 | 0.3182 | 0.3182 |
Echinococcus multilocularis | cathepsin b | 0.0773 | 0.3754 | 0.3754 |
Brugia malayi | Papain family cysteine protease containing protein | 0.1102 | 1 | 1 |
Onchocerca volvulus | 0.1102 | 1 | 1 | |
Echinococcus granulosus | cathepsin l1 | 0.0743 | 0.3182 | 0.3182 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1102 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.1102 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1102 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.1102 | 1 | 0.5 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.1102 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0773 | 0.3754 | 0.3754 |
Leishmania major | cathepsin L-like protease | 0.1102 | 1 | 0.5 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.1102 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1102 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1102 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1102 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1102 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1102 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1102 | 1 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.1102 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1102 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1102 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1102 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1102 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1102 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.1102 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1102 | 1 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.1102 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0773 | 0.3754 | 0.3754 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1102 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.1102 | 1 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0743 | 0.3182 | 0.3182 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1102 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1102 | 1 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.1102 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0773 | 0.3754 | 0.3754 |
Onchocerca volvulus | 0.1102 | 1 | 1 | |
Onchocerca volvulus | Cathepsin L homolog | 0.1102 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0743 | 0.3182 | 0.3182 |
Onchocerca volvulus | Cathepsin L homolog | 0.1102 | 1 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.1102 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.0773 | 0.3754 | 0.3754 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1102 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.1102 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1102 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1102 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0773 | 0.3754 | 0.3754 |
Onchocerca volvulus | Cathepsin F homolog | 0.1102 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1102 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.1102 | 1 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1102 | 1 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.1102 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1102 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1102 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1102 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.1102 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1102 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.1102 | 1 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0743 | 0.3182 | 0.3182 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0773 | 0.3754 | 0.3754 |
Leishmania major | cathepsin L-like protease | 0.1102 | 1 | 0.5 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.1102 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.1102 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.1102 | 1 | 1 |
Loa Loa (eye worm) | fibroinase | 0.1102 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0773 | 0.3754 | 0.0839 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1102 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.1102 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0743 | 0.3182 | 0.3182 |
Onchocerca volvulus | 0.1102 | 1 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.1102 | 1 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.1102 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1102 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1102 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1102 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.1102 | 1 | 0.5 |
Echinococcus multilocularis | cysteine protease | 0.1102 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1102 | 1 | 1 |
Onchocerca volvulus | 0.1102 | 1 | 1 | |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1102 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1102 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0743 | 0.3182 | 0.3182 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1102 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0743 | 0.3182 | 0.3182 |
Echinococcus multilocularis | cathepsin b | 0.0773 | 0.3754 | 0.3754 |
Onchocerca volvulus | 0.1102 | 1 | 1 | |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.1102 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1102 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.1102 | 1 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1102 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1102 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1102 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1102 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0773 | 0.3754 | 0.3754 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1102 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1102 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.1102 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0743 | 0.3182 | 0.3182 |
Onchocerca volvulus | 0.1102 | 1 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.1102 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1102 | 1 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.1102 | 1 | 0.5 |
Brugia malayi | cathepsin L-like precursor | 0.0743 | 0.3182 | 0.3182 |
Onchocerca volvulus | 0.1102 | 1 | 1 | |
Toxoplasma gondii | cathepsin CPL | 0.1102 | 1 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.1102 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.614 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.097 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.982 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.944 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.933 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.875 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.847 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.806 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.804 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.786 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.779 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.