Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.0162 | 0.0051 | 0.0051 |
Schistosoma mansoni | protein kinase | 0.0541 | 1 | 1 |
Trypanosoma cruzi | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.016 | 0 | 0.5 |
Onchocerca volvulus | 0.016 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.054 | 0.9949 | 1 |
Schistosoma mansoni | protein kinase | 0.0382 | 0.5822 | 0.5822 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0162 | 0.0051 | 0.0088 |
Loa Loa (eye worm) | STE/STE20/MSN protein kinase | 0.0382 | 0.5822 | 0.5852 |
Trypanosoma brucei | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.016 | 0 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.0162 | 0.0051 | 0.0051 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0162 | 0.0051 | 0.0051 |
Schistosoma mansoni | protein kinase | 0.0162 | 0.0051 | 0.0051 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0162 | 0.0051 | 0.0088 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0162 | 0.0051 | 0.0051 |
Echinococcus granulosus | Serine/threonine-protein kinase Genghis Khan | 0.0162 | 0.0051 | 0.0051 |
Brugia malayi | Protein kinase domain containing protein | 0.0162 | 0.0051 | 0.0051 |
Echinococcus multilocularis | serine:threonine protein kinase MRCK beta | 0.0162 | 0.0051 | 0.0088 |
Echinococcus granulosus | protein kinase | 0.0382 | 0.5822 | 0.5852 |
Echinococcus multilocularis | 0.0382 | 0.5822 | 1 | |
Loa Loa (eye worm) | STE/STE20/KHS protein kinase | 0.0162 | 0.0051 | 0.0051 |
Echinococcus granulosus | serine:threonine protein kinase mig 15 | 0.054 | 0.9949 | 1 |
Trypanosoma cruzi | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.016 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.