Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sodium channel, voltage-gated, type V, alpha subunit | Starlite/ChEMBL | References |
Homo sapiens | potassium inwardly-rectifying channel, subfamily J, member 11 | Starlite/ChEMBL | References |
Homo sapiens | potassium voltage-gated channel, subfamily H (eag-related), member 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.00482346 | 0.385196 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0102041 | 1 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.00325276 | 0.205725 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.00383893 | 0.272702 | 0.707956 |
Schistosoma mansoni | voltage-gated potassium channel | 0.00420245 | 0.314238 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0102041 | 1 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.00383893 | 0.272702 | 0.272702 |
Loa Loa (eye worm) | hypothetical protein | 0.0102041 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0102041 | 1 | 1 |
Echinococcus granulosus | sodium channel protein | 0.00482346 | 0.385196 | 1 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0102041 | 1 | 1 |
Echinococcus multilocularis | sodium channel protein | 0.00482346 | 0.385196 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.00383893 | 0.272702 | 1 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.00482346 | 0.385196 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.00420245 | 0.314238 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.00383893 | 0.272702 | 0.707956 |
Loa Loa (eye worm) | hypothetical protein | 0.00333631 | 0.215271 | 0.215271 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.00325276 | 0.205725 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CL (ADMET) | = 30 ml/min.kg | Intrinsic clearance in CD9 mouse liver microsomes at 2 mM | ChEMBL. | 22708838 |
EC50 (functional) | = 390 nM | Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by MSF assay | ChEMBL. | 22708838 |
EC90 (functional) | = 1300 nM | Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by MSF assay | ChEMBL. | 22708838 |
IC50 (binding) | = 4.31 uM | Inhibition of human ERG by patch clamp assay | ChEMBL. | 22708838 |
IC50 (binding) | > 5 uM | Inhibition of Nav1.5 assessed as tonic inhibition by patch clamp assay | ChEMBL. | 22708838 |
IC50 (binding) | > 5 uM | Inhibition of Nav1.5 assessed as phasic inhibition by patch clamp assay | ChEMBL. | 22708838 |
IC50 (binding) | > 5 uM | Inhibition of Kir6.2 by patch clamp assay | ChEMBL. | 22708838 |
Inhibition (ADMET) | = 71 % | Inhibition of CYP2D6 in human liver microsomes at 10 uM after 20 mins by LC-MS/MS analysis relative to control | ChEMBL. | 22708838 |
Inhibition (ADMET) | = 92 % | Inhibition of CYP2D6 in human liver microsomes at 1 uM after 20 mins by LC-MS/MS analysis relative to control | ChEMBL. | 22708838 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 22708838 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.