Detailed information for compound 1612140

Basic information

Technical information
  • TDR Targets ID: 1612140
  • Name: 1,3-di(phenyl)-3-piperidin-1-ylpropan-1-one
  • MW: 293.403 | Formula: C20H23NO
  • H donors: 0 H acceptors: 1 LogP: 3.95 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccccc1)CC(c1ccccc1)N1CCCCC1
  • InChi: 1S/C20H23NO/c22-20(18-12-6-2-7-13-18)16-19(17-10-4-1-5-11-17)21-14-8-3-9-15-21/h1-2,4-7,10-13,19H,3,8-9,14-16H2
  • InChiKey: CVVZGKZBSZURJO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1,3-di(phenyl)-3-(1-piperidyl)propan-1-one
  • 1,3-di(phenyl)-3-piperidino-propan-1-one
  • 1,3-di(phenyl)-3-piperidin-1-yl-propan-1-one
  • 5350-97-0
  • 3-PIPERIDINO-3-PHENYLPROPIOPHENONE
  • NSC87
  • 1,3-diphenyl-3-(1-piperidinyl)-1-propanone
  • NSC35446
  • PROPIOPHENONE, 3-PHENYL-3-PIPERIDINO-
  • STOCK3S-74713
  • NCI60_003184

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Schistosoma mansoni tyrosine kinase 0.0179 0.9953 1
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0073 0.0947 0.0951
Schistosoma mansoni protein kinase 0.0073 0.0947 0.0951
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0107 0.3858 0.3233
Brugia malayi SH2 domain containing protein 0.0179 0.9953 1
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0073 0.0947 0.0947
Loa Loa (eye worm) SRC-1 0.0179 0.9953 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0107 0.3811 0.3829
Trypanosoma brucei Flagellum attachment zone protein 20 0.0073 0.0947 0.9527
Schistosoma mansoni protein tyrosine kinase 0.0073 0.0947 0.0951
Echinococcus granulosus tyrosine protein kinase csk 0.0073 0.0947 0.0947
Loa Loa (eye worm) hypothetical protein 0.0073 0.0947 0.0951
Echinococcus multilocularis activated cdc42 kinase 1 0.0073 0.0947 0.0951
Loa Loa (eye worm) TK/FER protein kinase 0.0179 0.9953 1
Brugia malayi SH2 domain containing protein 0.0107 0.3811 0.3829
Loa Loa (eye worm) TK/ROR protein kinase 0.0073 0.0947 0.0951
Echinococcus granulosus tyrosine protein kinase Src42A 0.0107 0.3811 0.3811
Plasmodium vivax protein kinase, putative 0.0073 0.0947 0.5
Echinococcus multilocularis SH2 motif 0.0107 0.3811 0.3829
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Brugia malayi integrin-linked kinase 0.0073 0.0947 0.0951
Toxoplasma gondii STE kinase 0.0073 0.0947 0.9527
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Schistosoma mansoni hypothetical protein 0.0073 0.0947 0.0951
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0073 0.0947 0.0951
Schistosoma mansoni protein kinase 0.0073 0.0994 0.0998
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Loa Loa (eye worm) hypothetical protein 0.0073 0.0947 0.0951
Leishmania major protein kinase, putative 0.0073 0.0947 0.9527
Brugia malayi cytokine inducible SH2-containing protein 5 0.0107 0.3811 0.3829
Loa Loa (eye worm) hypothetical protein 0.0107 0.3811 0.3829
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0179 0.9953 0.9953
Echinococcus multilocularis 0.0107 0.3811 0.3829
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0179 0.9953 1
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0073 0.0947 0.0951
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0179 0.9953 0.9953
Echinococcus granulosus tyrosine protein kinase csk 0.0073 0.0947 0.0947
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0073 0.0994 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0107 0.3811 0.3829
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0073 0.0947 0.0951
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0947 0.0951
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Onchocerca volvulus 0.0179 0.9953 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Onchocerca volvulus 0.0107 0.3811 0.3181
Brugia malayi Guanylyl cyclase protein 23 0.0073 0.0947 0.0951
Brugia malayi SRC-1 0.0179 0.9953 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0073 0.0947 0.0947
Echinococcus granulosus tyrosine protein kinase Src42A 0.0179 0.9953 0.9953
Echinococcus granulosus tyrosine protein kinase HCK 0.0073 0.0947 0.0947
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0107 0.3811 0.3829
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Echinococcus granulosus tyrosine protein kinase Srms 0.0179 0.9953 0.9953
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0073 0.0947 0.0951
Brugia malayi Immunoglobulin I-set domain containing protein 0.0073 0.0947 0.0951
Loa Loa (eye worm) hypothetical protein 0.0107 0.3811 0.3829
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Echinococcus multilocularis NCK adaptor protein 0.0107 0.3811 0.3829
Schistosoma mansoni tyrosine kinase 0.0179 0.9953 1
Echinococcus multilocularis kinase suppressor of Ras 1 0.0073 0.0947 0.0951
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0073 0.0947 0.0951
Schistosoma mansoni nck2/grb4 0.0107 0.3811 0.3829
Leishmania major protein kinase, putative 0.0073 0.0994 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Trichomonas vaginalis protein tyrosine kinase, putative 0.0073 0.0947 1
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Echinococcus granulosus epidermal growth factor receptor 0.0073 0.0947 0.0947
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Echinococcus multilocularis natriuretic peptide receptor 1 0.0073 0.0947 0.0951
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0073 0.0947 1
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0073 0.0947 0.0947
Schistosoma mansoni protein kinase 0.0073 0.0947 0.0951
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0947 1
Brugia malayi SH2 domain containing protein 0.0107 0.3811 0.3829
Schistosoma mansoni protein kinase 0.0073 0.0947 0.0951
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0073 0.0947 0.0951
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0107 0.3811 0.3829
Echinococcus granulosus tyrosine protein kinase Fyn 0.0179 0.9953 0.9953
Brugia malayi ephrin receptor 1 precursor 0.0073 0.0947 0.0951
Echinococcus granulosus insulin receptor 0.0073 0.0947 0.0947
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0073 0.0947 0.0951
Loa Loa (eye worm) hypothetical protein 0.0073 0.0947 0.0951
Echinococcus granulosus tyrosine protein kinase csk 0.0073 0.0947 0.0947
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Loa Loa (eye worm) TK/FER protein kinase 0.0179 0.9953 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Schistosoma mansoni protein kinase 0.0073 0.0994 0.0998
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0073 0.0947 0.0951
Echinococcus granulosus tyrosine protein kinase Fyn 0.0179 0.9953 0.9953
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0947 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.0179 0.9953 1
Brugia malayi SH2 domain containing protein 0.0107 0.3811 0.3829
Brugia malayi Immunoglobulin I-set domain containing protein 0.0073 0.0947 0.0951
Loa Loa (eye worm) hypothetical protein 0.0107 0.3811 0.3829
Echinococcus granulosus activated cdc42 kinase 1 0.0073 0.0947 0.0947
Loa Loa (eye worm) hypothetical protein 0.0107 0.3811 0.3829
Onchocerca volvulus 0.0107 0.3811 0.3181
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0179 0.9953 0.9953
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0947 0.0951
Echinococcus granulosus growth factor receptor bound protein 2 0.0107 0.3811 0.3811
Echinococcus multilocularis raf serine:threonine protein kinase 0.0073 0.0947 0.0951
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Echinococcus granulosus suppressor of cytokine signaling 6 0.0107 0.3811 0.3811
Loa Loa (eye worm) TK/CSK protein kinase 0.0073 0.0947 0.0951
Toxoplasma gondii protein kinase domain-containing protein 0.0073 0.0947 0.9527
Echinococcus multilocularis protein kinase 0.0073 0.0947 0.0951
Loa Loa (eye worm) TK/ABL protein kinase 0.0179 0.9953 1
Echinococcus multilocularis protein KINase family member (kin 25) 0.0073 0.0947 0.0951
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0107 0.3811 0.3829
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0073 0.0994 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Echinococcus granulosus ephrin type A receptor 4 A 0.0073 0.0947 0.0947
Schistosoma mansoni serine/threonine RGC 0.0073 0.0947 0.0951
Brugia malayi Protein kinase domain containing protein 0.0179 0.9953 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Echinococcus multilocularis N chimaerin 0.0107 0.3811 0.3829
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0179 0.9953 1
Schistosoma mansoni protein kinase 0.0073 0.0947 0.0951
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0107 0.3811 0.3811
Brugia malayi SH2 domain containing protein 0.0107 0.3811 0.3829
Schistosoma mansoni ephrin receptor 0.0073 0.0947 0.0951
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Schistosoma mansoni shc transforming protein 0.0107 0.3811 0.3829
Echinococcus granulosus tyrosine kinase 0.0179 0.9953 0.9953
Loa Loa (eye worm) hypothetical protein 0.0107 0.3811 0.3829
Trichomonas vaginalis TK family protein kinase 0.0073 0.0947 1
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Echinococcus granulosus activated cdc42 kinase 1 0.0073 0.0947 0.0947
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0107 0.3811 0.3829
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0073 0.0947 0.0951
Echinococcus granulosus retinal guanylyl cyclase 2 0.0073 0.0947 0.0947
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Echinococcus granulosus c src tyrosine kinase 0.0179 0.9953 0.9953
Schistosoma mansoni hypothetical protein 0.0107 0.3811 0.3829
Echinococcus multilocularis SHC transforming protein 3 0.0107 0.3811 0.3829
Brugia malayi SH2 domain containing protein 0.0107 0.3811 0.3829
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0947 0.0951
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0073 0.0947 0.0951
Echinococcus multilocularis tyrosine kinase 0.0073 0.0947 0.0951
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Echinococcus multilocularis SH2 motif 0.0107 0.3811 0.3829
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Echinococcus multilocularis signal transduction protein lnk realted 0.0107 0.3811 0.3829
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Loa Loa (eye worm) TK/FER protein kinase 0.0179 0.9953 1
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0073 0.0947 0.0951
Echinococcus granulosus tyrosine protein kinase 0.0073 0.0947 0.0947
Brugia malayi hypothetical protein 0.0179 0.9953 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0073 0.0947 0.0951
Brugia malayi hypothetical protein 0.0107 0.3811 0.3829
Echinococcus granulosus N chimaerin 0.0107 0.3811 0.3811
Giardia lamblia Protein 21.1 0.0073 0.0947 1
Loa Loa (eye worm) STAT protein 0.0107 0.3811 0.3829
Loa Loa (eye worm) hypothetical protein 0.0107 0.3811 0.3829
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0073 0.0947 0.0951
Trichomonas vaginalis protein kinase atn1, putative 0.0073 0.0947 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0107 0.3811 0.3829
Echinococcus multilocularis SH2 domain containing protein 7 0.0107 0.3811 0.3829
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0073 0.0947 0.0951
Echinococcus multilocularis tyrosine protein kinase csk 0.0073 0.0947 0.0951
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0179 0.9953 1
Loa Loa (eye worm) SH2 domain-containing protein 0.0107 0.3811 0.3829
Echinococcus granulosus NCK adaptor protein 0.0107 0.3811 0.3811
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Trypanosoma cruzi protein kinase, putative 0.0073 0.0947 0.9527
Trypanosoma brucei Pseudokinase, putative 0.0073 0.0947 0.9527
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0073 0.0947 0.9527
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Echinococcus granulosus tyrosine kinase 0.0073 0.0947 0.0947
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0073 0.0947 0.0947
Schistosoma mansoni tensin 0.0107 0.3811 0.3829
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0073 0.0947 0.9527
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Brugia malayi Raf kinase 0.0073 0.0947 0.0951
Echinococcus granulosus tyrosine protein kinase pr2 0.0073 0.0947 0.0947
Loa Loa (eye worm) TK protein kinase 0.0073 0.0947 0.0951
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Loa Loa (eye worm) SH2 domain-containing protein 0.0107 0.3811 0.3829
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0107 0.3811 0.3829
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Onchocerca volvulus 0.0107 0.3811 0.3181
Loa Loa (eye worm) TK protein kinase 0.0073 0.0947 0.0951
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0947 1
Brugia malayi Tyrosine-protein kinase PR2 0.0073 0.0947 0.0951
Echinococcus granulosus tyrosine protein kinase Src64B 0.0179 0.9953 0.9953
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Schistosoma mansoni SH2A 0.0107 0.3811 0.3829
Echinococcus multilocularis tyrosine protein kinase csk 0.0073 0.0947 0.0951
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0107 0.3811 0.3829
Onchocerca volvulus 0.0179 0.9953 1
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Echinococcus multilocularis tyrosine protein kinase 0.0073 0.0947 0.0951
Brugia malayi Protein kinase domain containing protein 0.0179 0.9953 1
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0073 0.0947 0.9527
Loa Loa (eye worm) TK/FER protein kinase 0.0179 0.9953 1
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Schistosoma mansoni signal transduction protein lnk-related 0.0107 0.3811 0.3829
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0107 0.3811 0.3829
Schistosoma mansoni tyrosine kinase 0.0179 0.9953 1
Onchocerca volvulus 0.0107 0.3811 0.3181
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Echinococcus multilocularis tensin 0.0107 0.3811 0.3829
Loa Loa (eye worm) hypothetical protein 0.0073 0.0947 0.0951
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Loa Loa (eye worm) SH2 domain-containing protein 0.0107 0.3811 0.3829
Echinococcus granulosus SH2 domain containing protein 7 0.0107 0.3811 0.3811
Schistosoma mansoni protein kinase 0.0073 0.0947 0.0951
Echinococcus granulosus tyrosine protein kinase Fyn 0.0179 0.9953 0.9953
Brugia malayi RhoGAP domain containing protein 0.0107 0.3811 0.3829
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0179 0.9953 0.9953
Onchocerca volvulus 0.0179 0.9953 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.0994 0.0052
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.0947 0.0951
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0073 0.0947 0.0951
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0947 0.0951
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0073 0.0947 0.0951
Echinococcus granulosus SHC transforming protein 3 0.0107 0.3811 0.3811
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0179 0.9953 1
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0073 0.0947 0.0947
Brugia malayi Protein kinase domain containing protein 0.0179 0.9953 1
Loa Loa (eye worm) protein kinase domain-containing protein 0.0073 0.0947 0.0951
Schistosoma mansoni growth factor receptor-bound protein 0.0107 0.3811 0.3829
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0073 0.0947 0.0951
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Entamoeba histolytica protein kinase, putative 0.0107 0.3858 0.3233
Loa Loa (eye worm) hypothetical protein 0.0073 0.0947 0.0951
Trichomonas vaginalis STE family protein kinase 0.0073 0.0947 1
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Echinococcus multilocularis epidermal growth factor receptor 0.0073 0.0947 0.0951
Giardia lamblia Kinase, NEK 0.0073 0.0947 1
Echinococcus granulosus integrin linked protein kinase 0.0073 0.0947 0.0947
Echinococcus granulosus tyrosine protein kinase ABL1 0.0179 0.9953 0.9953
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0947 1
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.0947 0.0951
Loa Loa (eye worm) TK/Met protein kinase 0.0073 0.0947 0.0951
Schistosoma mansoni tensin 0.0107 0.3811 0.3829
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0947 1
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0947 0.0951
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0179 0.9953 1
Trichomonas vaginalis CAMK family protein kinase 0.0073 0.0947 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Echinococcus multilocularis tensin 0.0107 0.3811 0.3829
Schistosoma mansoni hypothetical protein 0.0107 0.3811 0.3829
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Echinococcus multilocularis heat shock protein 70 0.0073 0.0947 0.0951
Loa Loa (eye worm) hypothetical protein 0.0107 0.3811 0.3829
Plasmodium vivax tyrosine kinase-like protein, putative 0.0073 0.0947 0.5
Loa Loa (eye worm) hypothetical protein 0.0107 0.3811 0.3829
Schistosoma mansoni tyrosine kinase 0.0179 0.9953 1
Loa Loa (eye worm) TK protein kinase 0.0073 0.0947 0.0951
Echinococcus granulosus raf serine:threonine protein kinase 0.0073 0.0947 0.0947
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0179 0.9953 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0073 0.0947 0.0951
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0073 0.0947 0.0951
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Loa Loa (eye worm) TK/FER protein kinase 0.0179 0.9953 1
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0073 0.0947 0.0951
Brugia malayi SH2 domain containing protein 0.0107 0.3811 0.3829
Echinococcus multilocularis activin receptor type 0.0073 0.0994 0.0998
Loa Loa (eye worm) TK/FAK protein kinase 0.0073 0.0947 0.0951
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0107 0.3811 0.3811
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.0947 0.0951
Loa Loa (eye worm) TK/ALK protein kinase 0.0073 0.0947 0.0951
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Echinococcus granulosus tyrosine protein kinase Blk 0.0179 0.9953 0.9953
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0107 0.3811 0.3181
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0073 0.0947 0.0951
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Leishmania major hypothetical protein, conserved 0.0073 0.0947 0.9527
Schistosoma mansoni protein kinase 0.0073 0.0994 0.0998
Loa Loa (eye worm) TK/DDR protein kinase 0.0073 0.0947 0.0951
Loa Loa (eye worm) hypothetical protein 0.0107 0.3811 0.3829
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Brugia malayi Variant SH3 domain containing protein 0.0107 0.3811 0.3829
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0073 0.0947 0.0951
Brugia malayi Variant SH3 domain containing protein 0.0107 0.3811 0.3829
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0947 0.0951
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0073 0.0947 0.0951
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0073 0.0947 0.0947
Loa Loa (eye worm) TK protein kinase 0.0073 0.0947 0.0951
Schistosoma mansoni adapter molecule crk 0.0107 0.3811 0.3829
Echinococcus granulosus expressed conserved protein 0.0107 0.3811 0.3811
Echinococcus multilocularis insulin receptor 0.0073 0.0947 0.0951
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0073 0.0947 0.0951
Loa Loa (eye worm) hypothetical protein 0.0107 0.3811 0.3829
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0179 0.9953 0.9953
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Schistosoma mansoni suppressor of cytokine signaling 0.0107 0.3811 0.3829
Echinococcus granulosus protein kinase 0.0073 0.0947 0.0947
Echinococcus multilocularis growth factor receptor bound protein 2 0.0107 0.3811 0.3829
Echinococcus multilocularis integrin linked protein kinase 0.0073 0.0947 0.0951
Brugia malayi hypothetical protein 0.0073 0.0947 0.0951
Loa Loa (eye worm) TK protein kinase 0.0073 0.0947 0.0951
Schistosoma mansoni tensin 0.0107 0.3811 0.3829
Loa Loa (eye worm) TK protein kinase 0.0179 0.9953 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Onchocerca volvulus 0.0107 0.3811 0.3181
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Trypanosoma brucei protein kinase, putative 0.0073 0.0994 1
Loa Loa (eye worm) TK/FER protein kinase 0.0179 0.9953 1
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0073 0.0947 0.0951
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0073 0.0947 0.0951
Loa Loa (eye worm) hypothetical protein 0.0073 0.0947 0.0951
Echinococcus granulosus kinase suppressor of Ras 1 0.0073 0.0947 0.0947
Loa Loa (eye worm) RGC/RGC protein kinase 0.0073 0.0947 0.0951
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0179 0.9953 1
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0073 0.0994 0.0994
Echinococcus multilocularis tyrosine protein kinase pr2 0.0073 0.0947 0.0951
Giardia lamblia Kinase, NEK 0.0073 0.0947 1
Loa Loa (eye worm) serine/threonine protein kinase 0.0073 0.0947 0.0951
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0107 0.3811 0.3829
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0179 0.9953 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0179 0.9953 1
Echinococcus multilocularis tyrosine protein kinase Srms 0.0179 0.9953 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0947 0.0951
Onchocerca volvulus 0.0179 0.9953 1
Echinococcus multilocularis tyrosine protein kinase shark 0.0179 0.9953 1
Brugia malayi Variant SH3 domain containing protein 0.0107 0.3811 0.3829
Trichomonas vaginalis AGC family protein kinase 0.0073 0.0947 1
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0073 0.0947 0.0947
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0073 0.0947 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Schistosoma mansoni tyrosine protein kinase 0.0073 0.0947 0.0951
Loa Loa (eye worm) hypothetical protein 0.0179 0.9953 1
Echinococcus multilocularis tyrosine protein kinase HCK 0.0073 0.0947 0.0951
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0179 0.9953 1
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0073 0.0947 0.0951
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.0947 0.0951
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0107 0.3811 0.3829
Schistosoma mansoni ephrin receptor 0.0073 0.0947 0.0951
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0073 0.0947 0.0947
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0107 0.3811 0.3829
Echinococcus multilocularis tyrosine kinase 0.0179 0.9953 1
Brugia malayi Variant SH3 domain containing protein 0.0107 0.3811 0.3829
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0107 0.3811 0.3829
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0947 0.0951
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0073 0.0994 0.0998
Giardia lamblia Kinase 0.0073 0.0947 1
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0073 0.0947 0.0947
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0107 0.3811 0.3829
Brugia malayi bone morphogenetic protein type 1 receptor 0.0073 0.0947 0.0951
Schistosoma mansoni tyrosine kinase 0.0179 0.9953 1
Echinococcus granulosus tensin 0.0107 0.3811 0.3811
Echinococcus granulosus SH2 motif 0.0107 0.3811 0.3811
Schistosoma mansoni suppressor of cytokine signaling 0.0107 0.3811 0.3829
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Brugia malayi Sex muscle abnormal protein 5 0.0107 0.3811 0.3829
Echinococcus granulosus receptor type guanylyl cyclase 0.0073 0.0947 0.0947
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0107 0.3811 0.3829
Schistosoma mansoni tensin-related 0.0107 0.3811 0.3829
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0947 1
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Loa Loa (eye worm) TK/INSR protein kinase 0.0073 0.0947 0.0951
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0073 0.0947 0.0951
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Loa Loa (eye worm) hypothetical protein 0.0107 0.3811 0.3829
Onchocerca volvulus 0.0179 0.9953 1
Echinococcus granulosus natriuretic peptide receptor 1 0.0073 0.0947 0.0947
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Brugia malayi tRNA modification GTPase TrmE family protein 0.0107 0.3811 0.3829
Loa Loa (eye worm) TK protein kinase 0.0073 0.0947 0.0951
Loa Loa (eye worm) TK/RYK protein kinase 0.0073 0.0947 0.0951
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0947 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0947 0.0951
Loa Loa (eye worm) TK protein kinase 0.0073 0.0947 0.0951
Brugia malayi SH2 domain containing protein 0.0107 0.3811 0.3829
Loa Loa (eye worm) hypothetical protein 0.0107 0.3811 0.3829
Echinococcus granulosus tyrosine protein kinase shark 0.0179 0.9953 0.9953
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Echinococcus multilocularis tyrosine protein kinase csk 0.0073 0.0947 0.0951
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0107 0.3811 0.3829
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0073 0.0947 1
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0107 0.3811 0.3829
Schistosoma mansoni protein kinase 0.0073 0.0947 0.0951
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0179 0.9953 1
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0073 0.0947 0.0947
Brugia malayi hypothetical protein 0.0073 0.0947 0.0951
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0107 0.3811 0.3811
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0073 0.0947 0.0947
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0073 0.0947 0.0951
Echinococcus granulosus fibroblast growth factor receptor 4 0.0073 0.0947 0.0947
Brugia malayi Protein kinase domain containing protein 0.0179 0.9953 1
Echinococcus granulosus tyrosine kinase 0.0179 0.9953 0.9953
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0107 0.3811 0.3811
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Echinococcus granulosus suppressor of cytokine signaling 7 0.0107 0.3811 0.3811
Loa Loa (eye worm) hypothetical protein 0.0073 0.0947 0.0951
Echinococcus multilocularis tyrosine protein kinase Abl 0.0179 0.9953 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0073 0.0947 0.0951
Brugia malayi C-terminal src kinase protein 1 0.0073 0.0947 0.0951
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0073 0.0947 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Loa Loa (eye worm) hypothetical protein 0.0107 0.3811 0.3829
Brugia malayi Tensin 0.0107 0.3811 0.3829
Brugia malayi Protein kinase domain containing protein 0.0179 0.9953 1
Loa Loa (eye worm) hypothetical protein 0.0107 0.3811 0.3829
Loa Loa (eye worm) TK/FER protein kinase 0.0179 0.9953 1
Echinococcus multilocularis receptor type guanylyl cyclase 0.0073 0.0947 0.0951
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Echinococcus granulosus retinal guanylyl cyclase 2 0.0073 0.0947 0.0947
Loa Loa (eye worm) TK protein kinase 0.0073 0.0947 0.0951
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0073 0.0947 0.0951
Echinococcus multilocularis protein tyrosine kinase 0.0073 0.0947 0.0951
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0073 0.0947 0.0951
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0179 0.9953 1
Schistosoma mansoni tensin-related 0.0107 0.3811 0.3829
Loa Loa (eye worm) TK/ACK protein kinase 0.0073 0.0947 0.0951
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0073 0.0947 0.0951
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Brugia malayi STAT protein, DNA binding domain containing protein 0.0107 0.3811 0.3829
Loa Loa (eye worm) TK/FER protein kinase 0.0179 0.9953 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0107 0.3811 0.3829
Schistosoma mansoni tyrosine kinase 0.0179 0.9953 1
Schistosoma mansoni protein kinase 0.0073 0.0947 0.0951
Plasmodium falciparum protein kinase, putative 0.0073 0.0994 1
Loa Loa (eye worm) TK/EPH protein kinase 0.0073 0.0947 0.0951
Echinococcus multilocularis c src tyrosine kinase 0.0179 0.9953 1
Echinococcus multilocularis epidermal growth factor receptor 0.0073 0.0947 0.0951
Loa Loa (eye worm) hypothetical protein 0.0073 0.0947 0.0951
Trypanosoma cruzi protein kinase, putative 0.0073 0.0947 0.9527
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0073 0.0947 0.0951
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0179 0.9953 1
Echinococcus multilocularis protein kinase 0.0073 0.0947 0.0951
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0107 0.3811 0.3829
Schistosoma mansoni tyrosine kinase 0.0073 0.0947 0.0951
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0107 0.3811 0.3181
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Onchocerca volvulus 0.0179 0.9953 1
Entamoeba histolytica SH2 domain containing protein 0.0107 0.3811 0.3181
Loa Loa (eye worm) TK/FER protein kinase 0.0179 0.9953 1
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0947 0.0951
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Loa Loa (eye worm) TK protein kinase 0.0073 0.0947 0.0951
Schistosoma mansoni vav2 0.0107 0.3811 0.3829
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0073 0.0994 1
Loa Loa (eye worm) hypothetical protein 0.0107 0.3811 0.3829
Echinococcus granulosus activin receptor type 0.0073 0.0994 0.0994
Loa Loa (eye worm) RGC/RGC protein kinase 0.0073 0.0947 0.0951
Onchocerca volvulus 0.0107 0.3811 0.3181
Echinococcus granulosus protein tyrosine kinase 0.0073 0.0947 0.0947
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0179 0.9953 1
Brugia malayi protein-tyrosine kinase 0.0179 0.9953 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Echinococcus granulosus SH2 motif 0.0107 0.3811 0.3811
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0107 0.3811 0.3811
Schistosoma mansoni growth factor receptor-bound protein 0.0107 0.3811 0.3829
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Brugia malayi Receptor family ligand binding region containing protein 0.0073 0.0947 0.0951
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0179 0.9953 1
Loa Loa (eye worm) TK/EGFR protein kinase 0.0073 0.0947 0.0951
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Echinococcus multilocularis transfer RNA-Thr 0.0073 0.0947 0.0951
Brugia malayi Furin-like cysteine rich region family protein 0.0073 0.0947 0.0951
Echinococcus granulosus SH2 domain containing adapter protein F 0.0107 0.3811 0.3811
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0073 0.0947 0.0947
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0073 0.0947 0.0947
Echinococcus multilocularis FL cytokine receptor 0.0073 0.0947 0.0951
Echinococcus multilocularis SH2 motif 0.0107 0.3811 0.3829
Loa Loa (eye worm) hypothetical protein 0.0073 0.0947 0.0951
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0073 0.0994 1
Brugia malayi SH2 domain containing protein 0.0179 0.9953 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0179 0.9953 1
Brugia malayi Protein kinase domain containing protein 0.0073 0.0947 0.0951
Schistosoma mansoni GTPase activating protein 0.0107 0.3811 0.3829
Echinococcus granulosus hypothetical protein 0.0107 0.3811 0.3811
Plasmodium vivax tyrosine kinase-like protein, putative 0.0073 0.0947 0.5
Toxoplasma gondii protein kinase 0.0073 0.0947 0.9527
Loa Loa (eye worm) RGC/RGC protein kinase 0.0073 0.0947 0.0951
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Echinococcus granulosus epidermal growth factor receptor 0.0073 0.0947 0.0947
Schistosoma mansoni protein kinase 0.0073 0.0947 0.0951
Loa Loa (eye worm) TK/FER protein kinase 0.0179 0.9953 1
Echinococcus multilocularis ephrin type A receptor 4 A 0.0073 0.0947 0.0951
Trichomonas vaginalis TKL family protein kinase 0.0073 0.0947 1
Echinococcus granulosus signal transduction protein lnk realted 0.0107 0.3811 0.3811
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0107 0.3811 0.3829

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.912 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.902 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.823 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.822 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.807 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.807 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.797 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.796 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.77 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.721 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.717 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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