Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.1664 | 0.4298 | 1 |
Echinococcus granulosus | caspase 8 | 0.1664 | 0.4298 | 0.4298 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.1885 | 0.4874 | 0.4874 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1664 | 0.4298 | 1 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0071 | 0.0127 | 0.5 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0071 | 0.0127 | 0.0296 |
Trypanosoma brucei | metacaspase MCA2 | 0.1664 | 0.4298 | 1 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.1664 | 0.4298 | 1 |
Echinococcus multilocularis | caspase 3 | 0.2068 | 0.5355 | 0.5355 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0071 | 0.0127 | 0.0296 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0071 | 0.0127 | 0.0296 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.3733 | 0.971 | 0.971 |
Onchocerca volvulus | 0.1885 | 0.4874 | 0.4874 | |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.1664 | 0.4298 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1664 | 0.4298 | 1 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0071 | 0.0127 | 0.0296 |
Trypanosoma cruzi | metacaspase 5, putative | 0.1664 | 0.4298 | 1 |
Echinococcus granulosus | caspase 3 apoptosis cysteine peptidase | 0.3733 | 0.971 | 0.971 |
Trypanosoma brucei | metacaspase 5, putative | 0.1664 | 0.4298 | 1 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.1664 | 0.4298 | 1 |
Brugia malayi | mucosa associated lymphoid tissue lymphoma translocation protein 1 | 0.1664 | 0.4298 | 0.4298 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.1664 | 0.4298 | 1 |
Leishmania major | metacaspase, putative | 0.1664 | 0.4298 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.1664 | 0.4298 | 1 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.1664 | 0.4298 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0071 | 0.0127 | 0.0296 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.3733 | 0.971 | 0.971 |
Trypanosoma brucei | Metacaspase-4 | 0.1664 | 0.4298 | 1 |
Echinococcus multilocularis | caspase | 0.3733 | 0.971 | 0.971 |
Mycobacterium ulcerans | proteasome PrcB | 0.0071 | 0.0127 | 0.5 |
Echinococcus granulosus | proteasome prosome macropain | 0.0071 | 0.0127 | 0.0127 |
Schistosoma mansoni | caspase-3 (C14 family) | 0.3733 | 0.971 | 0.971 |
Echinococcus multilocularis | caspase 8 | 0.1664 | 0.4298 | 0.4298 |
Trypanosoma brucei | metacaspase | 0.1664 | 0.4298 | 1 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0071 | 0.0127 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.1885 | 0.4874 | 0.4874 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0071 | 0.0127 | 0.0296 |
Plasmodium falciparum | metacaspase 1 | 0.1664 | 0.4298 | 1 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0071 | 0.0127 | 0.0127 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0071 | 0.0127 | 0.0127 |
Loa Loa (eye worm) | hypothetical protein | 0.1885 | 0.4874 | 0.4874 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.1664 | 0.4298 | 1 |
Trypanosoma cruzi | metacaspase, putative | 0.1664 | 0.4298 | 1 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0071 | 0.0127 | 0.0127 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.1664 | 0.4298 | 1 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0071 | 0.0127 | 0.5 |
Trypanosoma cruzi | metacaspase 5, putative | 0.1664 | 0.4298 | 1 |
Trypanosoma cruzi | metacaspase, putative | 0.1664 | 0.4298 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1664 | 0.4298 | 1 |
Brugia malayi | hypothetical protein | 0.1885 | 0.4874 | 0.4874 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.1664 | 0.4298 | 1 |
Echinococcus granulosus | caspase | 0.3733 | 0.971 | 0.971 |
Trypanosoma brucei | metacaspase MCA3 | 0.1664 | 0.4298 | 1 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0071 | 0.0127 | 1 |
Plasmodium vivax | metacaspase 1, putative | 0.1664 | 0.4298 | 1 |
Trypanosoma cruzi | metacaspase, putative | 0.1664 | 0.4298 | 1 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.1885 | 0.4874 | 0.4874 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.1664 | 0.4298 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1664 | 0.4298 | 1 |
Schistosoma mansoni | subfamily C14A unassigned peptidase (C14 family) | 0.1664 | 0.4298 | 0.4298 |
Plasmodium falciparum | metacaspase-like protein | 0.1664 | 0.4298 | 1 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.1664 | 0.4298 | 1 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0071 | 0.0127 | 0.0296 |
Loa Loa (eye worm) | hypothetical protein | 0.1664 | 0.4298 | 0.4298 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.1664 | 0.4298 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1664 | 0.4298 | 1 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0071 | 0.0127 | 0.0296 |
Trypanosoma cruzi | metacaspase, putative | 0.1664 | 0.4298 | 1 |
Echinococcus granulosus | caspase 3 | 0.2068 | 0.5355 | 0.5355 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0071 | 0.0127 | 0.0127 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.1664 | 0.4298 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.669 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.619 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.451 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.444 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.393 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.341 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.162 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.