Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0243 | 0.0018 | 0.0045 |
Onchocerca volvulus | 0.0742 | 0.0378 | 0.2681 | |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.0018 | 0.0018 |
Loa Loa (eye worm) | hypothetical protein | 0.2103 | 0.1361 | 0.1361 |
Echinococcus granulosus | expressed conserved protein | 0.0795 | 0.0417 | 0.04 |
Mycobacterium tuberculosis | Probable ionic transporter integral membrane protein ChaA | 0.0355 | 0.0099 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0243 | 0.0018 | 0.0045 |
Schistosoma mansoni | na/ca exchanger | 0.0355 | 0.0099 | 0.0081 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0742 | 0.0378 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0355 | 0.0099 | 0.0477 |
Loa Loa (eye worm) | hypothetical protein | 0.5626 | 0.3906 | 0.3906 |
Echinococcus granulosus | sodium:potassium:calcium exchanger 6 | 0.0355 | 0.0099 | 0.0081 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.0018 | 0.0018 |
Brugia malayi | Sodium/calcium exchanger protein | 0.5626 | 0.3906 | 1 |
Echinococcus multilocularis | sodium:potassium:calcium exchanger 6 | 0.0355 | 0.0099 | 0.0081 |
Echinococcus multilocularis | sodium:potassium:calcium exchanger | 0.0355 | 0.0099 | 0.0081 |
Loa Loa (eye worm) | hypothetical protein | 0.2103 | 0.1361 | 0.1361 |
Loa Loa (eye worm) | trypsin family protein | 0.0243 | 0.0018 | 0.0018 |
Brugia malayi | Trypsin family protein | 0.0243 | 0.0018 | 0.0045 |
Brugia malayi | Kringle domain containing protein | 0.0742 | 0.0378 | 0.0968 |
Onchocerca volvulus | 0.186 | 0.1186 | 0.8694 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0742 | 0.0378 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0355 | 0.0099 | 0.0099 |
Loa Loa (eye worm) | hypothetical protein | 0.0355 | 0.0099 | 0.0099 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.2103 | 0.1361 | 0.1346 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0243 | 0.0018 | 0.0045 |
Schistosoma mansoni | potassium-dependent sodium-calcium exchanger 3 4 | 0.0355 | 0.0099 | 0.0081 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0355 | 0.0099 | 0.0477 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.2481 | 0.1634 | 1 |
Brugia malayi | Trypsin family protein | 0.0243 | 0.0018 | 0.0045 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.2481 | 0.1634 | 1 |
Echinococcus multilocularis | expressed conserved protein | 0.0795 | 0.0417 | 0.04 |
Brugia malayi | Protein kinase domain containing protein | 0.0742 | 0.0378 | 0.0968 |
Brugia malayi | Na/Ca eXchangers family member (ncx-4) | 0.0355 | 0.0099 | 0.0253 |
Onchocerca volvulus | 0.2103 | 0.1361 | 1 | |
Brugia malayi | Trypsin family protein | 0.2103 | 0.1361 | 0.3485 |
Entamoeba histolytica | sodium/calcium exchanger protein, putative | 0.0355 | 0.0099 | 0.5 |
Toxoplasma gondii | kringle domain-containing protein | 0.0742 | 0.0378 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0243 | 0.0018 | 0.5 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0742 | 0.0378 | 0.0361 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0742 | 0.0378 | 0.0378 |
Schistosoma mansoni | hypothetical protein | 0.0355 | 0.0099 | 0.0081 |
Schistosoma mansoni | potassium-dependent sodium-calcium exchanger 3 4 | 0.0355 | 0.0099 | 0.0081 |
Echinococcus granulosus | sodium:potassium:calcium exchanger | 0.0355 | 0.0099 | 0.0081 |
Mycobacterium leprae | Probable ionic transporter integral membrane protein ChaA | 0.0355 | 0.0099 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.2103 | 0.1361 | 0.1346 |
Loa Loa (eye worm) | hypothetical protein | 0.0742 | 0.0378 | 0.0378 |
Schistosoma mansoni | hypothetical protein | 0.0742 | 0.0378 | 0.0361 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0742 | 0.0378 | 1 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0742 | 0.0378 | 0.0361 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.0018 | 0.0018 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.0018 | 0.0018 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0243 | 0.0018 | 0.0045 |
Leishmania major | hypothetical protein, conserved | 0.0742 | 0.0378 | 0.5 |
Loa Loa (eye worm) | Na/Ca eXchangers family member | 0.0355 | 0.0099 | 0.0099 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.0018 | 0.0018 |
Treponema pallidum | hypothetical protein | 0.0355 | 0.0099 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0355 | 0.0099 | 0.0477 |
Brugia malayi | K+-dependent Na+/Ca+ exchanger related-protein | 0.0355 | 0.0099 | 0.0253 |
Onchocerca volvulus | Sodium\/potassium\/calcium exchanger | 0.0355 | 0.0099 | 0.0602 |
Onchocerca volvulus | 0.0249 | 0.0022 | 0.003 | |
Loa Loa (eye worm) | hypothetical protein | 0.0355 | 0.0099 | 0.0099 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.543 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.491 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.423 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.298 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.247 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.022 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.008 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.