TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 360.403 | Formula: C23H20O4
H donors: 0 H acceptors: 1 LogP: 5.11 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1cc(ccc1OCC)c1cc(=O)c2c(o1)c1ccccc1cc2
InChi: 1S/C23H20O4/c1-3-25-20-12-10-16(13-22(20)26-4-2)21-14-19(24)18-11-9-15-7-5-6-8-17(15)23(18)27-21/h5-14H,3-4H2,1-2H3
InChiKey: HHWMKRNWUGWKTF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0416	0.999	0.999
Onchocerca volvulus		0.0416	0.999	1
Brugia malayi	Protein kinase domain containing protein	0.0259	0.567	0.5675
Entamoeba histolytica	tyrosin kinase, putative	0.0259	0.567	0.5675
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0259	0.567	0.567
Giardia lamblia	Protein 21.1	0.0259	0.567	0.5
Onchocerca volvulus		0.0259	0.567	0.3931
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Loa Loa (eye worm)	hypothetical protein	0.0157	0.2872	0.2875
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0416	0.999	0.999
Trichomonas vaginalis	STE family protein kinase	0.0259	0.567	0.5
Brugia malayi	ephrin receptor 1 precursor	0.0259	0.567	0.5675
Brugia malayi	Protein kinase domain containing protein	0.0259	0.567	0.5675
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0259	0.567	0.5675
Echinococcus multilocularis	protein kinase	0.0259	0.567	0.5675
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0259	0.567	0.5675
Entamoeba histolytica	hypothetical protein	0.0259	0.567	0.5675
Entamoeba histolytica	protein kinase, putative	0.0259	0.567	0.5675
Loa Loa (eye worm)	TK/FER protein kinase	0.0259	0.567	0.5675
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0157	0.2872	0.2875
Onchocerca volvulus		0.0259	0.567	0.3931
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0416	0.999	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0259	0.567	0.5675
Schistosoma mansoni	tyrosine kinase	0.0259	0.567	0.5675
Entamoeba histolytica	protein kinase, putative	0.0259	0.567	0.5675
Loa Loa (eye worm)	STAT protein	0.0157	0.2872	0.2875
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0259	0.567	0.567
Loa Loa (eye worm)	hypothetical protein	0.0259	0.567	0.5675
Brugia malayi	integrin-linked kinase	0.0259	0.567	0.5675
Loa Loa (eye worm)	TK/FER protein kinase	0.0259	0.567	0.5675
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0259	0.567	0.5675
Entamoeba histolytica	tyrosine kinase, putative	0.0259	0.567	0.5675
Entamoeba histolytica	protein kinase, putative	0.0259	0.567	0.5675
Schistosoma mansoni	tyrosine kinase	0.0259	0.567	0.5675
Echinococcus multilocularis	tyrosine protein kinase csk	0.0259	0.567	0.5675
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Onchocerca volvulus		0.0259	0.567	0.3931
Entamoeba histolytica	protein kinase domain containing protein	0.0259	0.567	0.5675
Plasmodium falciparum	protein kinase, putative	0.0259	0.568	1
Schistosoma mansoni	protein kinase	0.0259	0.567	0.5675
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Echinococcus granulosus	natriuretic peptide receptor 1	0.0259	0.567	0.567
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0259	0.567	0.567
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0157	0.2872	0.2875
Loa Loa (eye worm)	TK/FER protein kinase	0.0416	0.999	1
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0259	0.567	0.5675
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0259	0.567	0.567
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0259	0.567	0.5675
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Brugia malayi	Protein kinase domain containing protein	0.0259	0.567	0.5675
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0259	0.567	0.5675
Echinococcus granulosus	signal transduction protein lnk realted	0.0157	0.2872	0.2872
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Echinococcus granulosus	N chimaerin	0.0157	0.2872	0.2872
Schistosoma mansoni	serine/threonine RGC	0.0259	0.567	0.5675
Echinococcus granulosus	SH2 domain containing protein 7	0.0157	0.2872	0.2872
Brugia malayi	Protein kinase domain containing protein	0.0259	0.567	0.5675
Loa Loa (eye worm)	hypothetical protein	0.0259	0.567	0.5675
Schistosoma mansoni	tyrosine kinase	0.0259	0.567	0.5675
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0259	0.567	0.5675
Loa Loa (eye worm)	TK/FER protein kinase	0.0259	0.567	0.5675
Schistosoma mansoni	GTPase activating protein	0.0157	0.2872	0.2875
Loa Loa (eye worm)	cytochrome P450 family protein	0.0065	0.0342	0.0343
Brugia malayi	Protein kinase domain containing protein	0.0259	0.567	0.5675
Schistosoma mansoni	tyrosine kinase	0.0259	0.567	0.5675
Brugia malayi	Protein kinase domain containing protein	0.0259	0.567	0.5675
Schistosoma mansoni	tyrosine kinase	0.0259	0.567	0.5675
Brugia malayi	hypothetical protein	0.0259	0.567	0.5675
Brugia malayi	Protein kinase domain containing protein	0.0259	0.567	0.5675
Schistosoma mansoni	growth factor receptor-bound protein	0.0157	0.2872	0.2875
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0259	0.567	0.5675
Schistosoma mansoni	tyrosine kinase	0.0259	0.567	0.5675
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0259	0.567	0.567
Entamoeba histolytica	protein kinase, putative	0.0259	0.567	0.5675
Brugia malayi	Furin-like cysteine rich region family protein	0.0259	0.567	0.5675
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0259	0.567	0.5675
Entamoeba histolytica	hypothetical protein	0.0259	0.567	0.5675
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0157	0.2872	0.2875
Entamoeba histolytica	protein kinase domain containing protein	0.0259	0.567	0.5675
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0157	0.2872	0.2875
Loa Loa (eye worm)	hypothetical protein	0.0157	0.2872	0.2875
Loa Loa (eye worm)	TK/FER protein kinase	0.0416	0.999	1
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0157	0.2872	0.2875
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0259	0.568	1
Echinococcus granulosus	c src tyrosine kinase	0.0416	0.999	0.999
Loa Loa (eye worm)	hypothetical protein	0.0157	0.2872	0.2875
Echinococcus granulosus	insulin receptor	0.0259	0.567	0.567
Schistosoma mansoni	serine/threonine protein kinase	0.0259	0.567	0.5675
Entamoeba histolytica	protein kinase domain containing protein	0.0259	0.567	0.5675
Echinococcus granulosus	epidermal growth factor receptor	0.0259	0.567	0.567
Loa Loa (eye worm)	TK/ACK protein kinase	0.0259	0.567	0.5675
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0259	0.567	0.3931
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0259	0.568	0.568
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0259	0.567	0.5675
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0157	0.2872	0.2872
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0259	0.567	0.5675
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0259	0.567	0.5675
Schistosoma mansoni	signal transduction protein lnk-related	0.0157	0.2872	0.2875
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0259	0.567	0.567
Loa Loa (eye worm)	hypothetical protein	0.0259	0.567	0.5675
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0259	0.567	0.5675
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Loa Loa (eye worm)	hypothetical protein	0.0157	0.2872	0.2875
Brugia malayi	SH2 domain containing protein	0.0416	0.999	1
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Loa Loa (eye worm)	TK protein kinase	0.0259	0.567	0.5675
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0157	0.2872	0.2875
Entamoeba histolytica	protein kinase, putative	0.0158	0.2882	0.2885
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0157	0.2872	0.2875
Entamoeba histolytica	serine/threonine kinase, putative	0.0259	0.567	0.5675
Schistosoma mansoni	suppressor of cytokine signaling	0.0157	0.2872	0.2875
Entamoeba histolytica	protein kinase, putative	0.0259	0.567	0.5675
Loa Loa (eye worm)	hypothetical protein	0.0259	0.567	0.5675
Loa Loa (eye worm)	TK protein kinase	0.0259	0.567	0.5675
Schistosoma mansoni	protein kinase	0.0259	0.567	0.5675
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0259	0.568	1
Entamoeba histolytica	protein kinase domain containing protein	0.0259	0.567	0.5675
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0416	0.999	1
Schistosoma mansoni	tyrosine kinase	0.0259	0.567	0.5675
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0157	0.2872	0.2875
Echinococcus multilocularis	NCK adaptor protein	0.0157	0.2872	0.2875
Loa Loa (eye worm)	TK/RYK protein kinase	0.0259	0.567	0.5675
Entamoeba histolytica	receptor protein kinase, putative	0.0259	0.567	0.5675
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0259	0.567	0.5675
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0259	0.567	0.5675
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0259	0.567	0.5675
Trichomonas vaginalis	conserved hypothetical protein	0.0259	0.567	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0416	0.999	1
Entamoeba histolytica	tyrosine kinase, putative	0.0259	0.567	0.5675
Onchocerca volvulus		0.0416	0.999	1
Entamoeba histolytica	tyrosin kinase, putative	0.0259	0.567	0.5675
Loa Loa (eye worm)	hypothetical protein	0.0157	0.2872	0.2875
Giardia lamblia	Kinase, NEK	0.0259	0.567	0.5
Brugia malayi	SH2 domain containing protein	0.0157	0.2872	0.2875
Entamoeba histolytica	protein kinase domain containing protein	0.0259	0.567	0.5675
Echinococcus granulosus	tyrosine protein kinase Blk	0.0416	0.999	0.999
Entamoeba histolytica	protein kinase domain containing protein	0.0259	0.567	0.5675
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0259	0.567	0.5675
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0416	0.999	1
Entamoeba histolytica	hypothetical protein	0.0259	0.567	0.5675
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Brugia malayi	Protein kinase domain containing protein	0.0259	0.567	0.5675
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0259	0.567	0.567
Brugia malayi	Cytochrome P450 family protein	0.0065	0.0342	0.0343
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0259	0.567	0.5675
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0416	0.999	1
Schistosoma mansoni	protein kinase	0.0259	0.567	0.5675
Trichomonas vaginalis	CAMK family protein kinase	0.0259	0.567	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0259	0.567	0.5675
Schistosoma mansoni	nck2/grb4	0.0157	0.2872	0.2875
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0259	0.567	0.567
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0416	0.999	1
Loa Loa (eye worm)	TK protein kinase	0.0259	0.567	0.5675
Entamoeba histolytica	hypothetical protein	0.0259	0.567	0.5675
Schistosoma mansoni	hypothetical protein	0.0157	0.2872	0.2875
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0259	0.567	0.5675
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0259	0.567	0.5675
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0259	0.567	0.5675
Echinococcus multilocularis	N chimaerin	0.0157	0.2872	0.2875
Onchocerca volvulus		0.0259	0.567	0.3931
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Brugia malayi	SH2 domain containing protein	0.0157	0.2872	0.2875
Schistosoma mansoni	tyrosine kinase	0.0259	0.567	0.5675
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0157	0.2872	0.2875
Loa Loa (eye worm)	TK/FER protein kinase	0.0416	0.999	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0259	0.567	0.567
Loa Loa (eye worm)	hypothetical protein	0.0157	0.2872	0.2875
Echinococcus multilocularis	SH2 motif	0.0157	0.2872	0.2875
Loa Loa (eye worm)	TK/EPH protein kinase	0.0259	0.567	0.5675
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0157	0.2872	0.2875
Echinococcus multilocularis	transfer RNA-Thr	0.0259	0.567	0.5675
Brugia malayi	Tyrosine-protein kinase abl-1	0.0416	0.999	1
Onchocerca volvulus		0.0416	0.999	1
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0259	0.568	1
Schistosoma mansoni	SH2A	0.0157	0.2872	0.2875
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0259	0.567	0.5675
Giardia lamblia	Kinase, NEK	0.0259	0.567	0.5
Schistosoma mansoni	tensin	0.0157	0.2872	0.2875
Echinococcus granulosus	protein tyrosine kinase	0.0259	0.567	0.567
Loa Loa (eye worm)	TK protein kinase	0.0259	0.567	0.5675
Brugia malayi	hypothetical protein	0.0157	0.2872	0.2875
Echinococcus granulosus	integrin linked protein kinase	0.0259	0.567	0.567
Trichomonas vaginalis	conserved hypothetical protein	0.0259	0.567	0.5
Echinococcus granulosus	kinase suppressor of Ras 1	0.0259	0.567	0.567
Loa Loa (eye worm)	hypothetical protein	0.0157	0.2872	0.2875
Brugia malayi	Protein kinase domain containing protein	0.0416	0.999	1
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Loa Loa (eye worm)	hypothetical protein	0.0157	0.2872	0.2875
Entamoeba histolytica	protein kinase domain containing protein	0.0259	0.567	0.5675
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0259	0.567	0.567
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0157	0.2872	0.2875
Echinococcus granulosus	protein kinase	0.0259	0.567	0.567
Brugia malayi	RhoGAP domain containing protein	0.0157	0.2872	0.2875
Trichomonas vaginalis	conserved hypothetical protein	0.0259	0.567	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0259	0.567	0.5675
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0259	0.567	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0157	0.2872	0.2875
Schistosoma mansoni	tyrosine kinase	0.0259	0.567	0.5675
Echinococcus granulosus	activin receptor type	0.0259	0.568	0.568
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0259	0.567	0.3931
Loa Loa (eye worm)	TK/Met protein kinase	0.0259	0.567	0.5675
Onchocerca volvulus		0.0259	0.567	0.3931
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0416	0.999	0.999
Echinococcus granulosus	tyrosine protein kinase shark	0.0416	0.999	0.999
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0259	0.567	0.5675
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Onchocerca volvulus		0.0416	0.999	1
Echinococcus granulosus	tyrosine protein kinase Srms	0.0416	0.999	0.999
Loa Loa (eye worm)	TK/FER protein kinase	0.0259	0.567	0.5675
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0416	0.999	1
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Loa Loa (eye worm)	hypothetical protein	0.0157	0.2872	0.2875
Entamoeba histolytica	serine/threonine kinase, putative	0.0259	0.567	0.5675
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0157	0.2872	0.2872
Entamoeba histolytica	tyrosine kinase, putative	0.0259	0.567	0.5675
Entamoeba histolytica	protein kinase, putative	0.0259	0.567	0.5675
Schistosoma mansoni	protein kinase	0.0259	0.567	0.5675
Schistosoma mansoni	tyrosine kinase	0.0259	0.567	0.5675
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0416	0.999	0.999
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0416	0.999	1
Loa Loa (eye worm)	serine/threonine protein kinase	0.0259	0.567	0.5675
Entamoeba histolytica	tyrosine kinase, putative	0.0259	0.567	0.5675
Trypanosoma brucei	protein kinase, putative	0.0259	0.568	1
Echinococcus granulosus	activated cdc42 kinase 1	0.0259	0.567	0.567
Schistosoma mansoni	tyrosine kinase	0.0259	0.567	0.5675
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0259	0.567	0.5675
Entamoeba histolytica	protein kinase domain containing protein	0.0259	0.567	0.5675
Plasmodium vivax	protein kinase, putative	0.0259	0.567	0.5
Echinococcus granulosus	activated cdc42 kinase 1	0.0259	0.567	0.567
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0259	0.567	0.5675
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0157	0.2872	0.2875
Loa Loa (eye worm)	hypothetical protein	0.0416	0.999	1
Brugia malayi	Protein kinase domain containing protein	0.0259	0.567	0.5675
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0259	0.567	0.5675
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Brugia malayi	SH2 domain containing protein	0.0157	0.2872	0.2875
Brugia malayi	Protein kinase domain containing protein	0.0259	0.567	0.5675
Echinococcus granulosus	NCK adaptor protein	0.0157	0.2872	0.2872
Loa Loa (eye worm)	SH2 domain-containing protein	0.0157	0.2872	0.2875
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0157	0.2872	0.2875
Echinococcus multilocularis	protein kinase	0.0259	0.567	0.5675
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0259	0.567	0.5675
Loa Loa (eye worm)	hypothetical protein	0.0259	0.567	0.5675
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0259	0.567	0.5
Entamoeba histolytica	protein kinase, putative	0.0259	0.567	0.5675
Entamoeba histolytica	protein kinase domain containing protein	0.0259	0.567	0.5675
Loa Loa (eye worm)	TK/DDR protein kinase	0.0259	0.567	0.5675
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0259	0.567	0.5675
Loa Loa (eye worm)	TK/FER protein kinase	0.0259	0.567	0.5675
Loa Loa (eye worm)	SH2 domain-containing protein	0.0157	0.2872	0.2875
Echinococcus granulosus	tyrosine protein kinase csk	0.0259	0.567	0.567
Loa Loa (eye worm)	hypothetical protein	0.0157	0.2872	0.2875
Schistosoma mansoni	tyrosine kinase	0.0259	0.567	0.5675
Entamoeba histolytica	protein kinase, putative	0.0259	0.567	0.5675
Echinococcus multilocularis	activated cdc42 kinase 1	0.0259	0.567	0.5675
Schistosoma mansoni	serine/threonine protein kinase	0.0259	0.567	0.5675
Echinococcus multilocularis	cyclin dependent kinase 9	0.0062	0.0252	0.0252
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0259	0.567	0.5675
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0259	0.567	0.5
Schistosoma mansoni	tyrosine kinase	0.0259	0.567	0.5675
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0259	0.567	0.5675
Echinococcus multilocularis	SH2 domain containing protein 7	0.0157	0.2872	0.2875
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0416	0.999	0.999
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Echinococcus granulosus	raf serine:threonine protein kinase	0.0259	0.567	0.567
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0259	0.567	0.5675
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0259	0.567	0.567
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0158	0.2882	0.2885
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Brugia malayi	SH2 domain containing protein	0.0157	0.2872	0.2875
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0259	0.567	0.5675
Echinococcus multilocularis	epidermal growth factor receptor	0.0259	0.567	0.5675
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0259	0.567	0.567
Entamoeba histolytica	serine/threonine kinase, putative	0.0259	0.567	0.5675
Echinococcus granulosus	tensin	0.0157	0.2872	0.2872
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0259	0.567	0.5
Echinococcus multilocularis	tyrosine protein kinase shark	0.0416	0.999	1
Entamoeba histolytica	tyrosine kinase, putative	0.0259	0.567	0.5675
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0259	0.567	0.567
Echinococcus multilocularis	epidermal growth factor receptor	0.0259	0.567	0.5675
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Echinococcus multilocularis	integrin linked protein kinase	0.0259	0.567	0.5675
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0157	0.2872	0.2875
Echinococcus multilocularis	protein tyrosine kinase	0.0259	0.567	0.5675
Echinococcus multilocularis	FL cytokine receptor	0.0259	0.567	0.5675
Schistosoma mansoni	serine/threonine protein kinase	0.0259	0.567	0.5675
Entamoeba histolytica	protein kinase, putative	0.0259	0.567	0.5675
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0259	0.567	0.5675
Schistosoma mansoni	tyrosine kinase	0.0259	0.567	0.5675
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0416	0.999	1
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0259	0.567	0.5675
Echinococcus multilocularis	signal transduction protein lnk realted	0.0157	0.2872	0.2875
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0259	0.567	0.567
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0259	0.567	0.5675
Entamoeba histolytica	hypothetical protein	0.0259	0.567	0.5675
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Brugia malayi	Protein kinase domain containing protein	0.0259	0.567	0.5675
Brugia malayi	Protein kinase domain containing protein	0.0259	0.567	0.5675
Echinococcus multilocularis	heat shock protein 70	0.0259	0.567	0.5675
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Schistosoma mansoni	protein kinase	0.0259	0.568	0.5685
Loa Loa (eye worm)	hypothetical protein	0.0157	0.2872	0.2875
Brugia malayi	Protein kinase domain containing protein	0.0259	0.567	0.5675
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0259	0.567	0.5675
Entamoeba histolytica	protein kinase, putative	0.0259	0.567	0.5675
Brugia malayi	Protein kinase domain containing protein	0.0416	0.999	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0259	0.567	0.567
Brugia malayi	Protein kinase domain containing protein	0.0259	0.567	0.5675
Onchocerca volvulus		0.0416	0.999	1
Echinococcus granulosus	ephrin type A receptor 4 A	0.0259	0.567	0.567
Schistosoma mansoni	hypothetical protein	0.0259	0.567	0.5675
Loa Loa (eye worm)	TK/FER protein kinase	0.0416	0.999	1
Trichomonas vaginalis	protein kinase atn1, putative	0.0259	0.567	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0259	0.568	0.5685
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0416	0.999	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0259	0.567	0.5675
Brugia malayi	Protein kinase domain containing protein	0.0416	0.999	1
Schistosoma mansoni	protein kinase	0.0259	0.568	0.5685
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0259	0.567	0.5675
Schistosoma mansoni	ephrin receptor	0.0259	0.567	0.5675
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0259	0.567	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0416	0.999	1
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0259	0.567	0.5675
Entamoeba histolytica	hypothetical protein	0.0259	0.567	0.5675
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0259	0.567	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0259	0.567	0.5675
Loa Loa (eye worm)	hypothetical protein	0.0259	0.567	0.5675
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0259	0.567	0.5
Loa Loa (eye worm)	hypothetical protein	0.0259	0.567	0.5675
Loa Loa (eye worm)	TK/INSR protein kinase	0.0259	0.567	0.5675
Trichomonas vaginalis	conserved hypothetical protein	0.0259	0.567	0.5
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0157	0.2872	0.2872
Loa Loa (eye worm)	hypothetical protein	0.0259	0.567	0.5675
Entamoeba histolytica	tyrosine kinase, putative	0.0259	0.567	0.5675
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0259	0.567	0.5675
Echinococcus multilocularis	tyrosine kinase	0.0259	0.567	0.5675
Giardia lamblia	Kinase	0.0259	0.567	0.5
Schistosoma mansoni	tyrosine kinase	0.0259	0.567	0.5675
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0157	0.2872	0.2872
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Schistosoma mansoni	tyrosine kinase	0.0259	0.567	0.5675
Brugia malayi	Tensin	0.0157	0.2872	0.2875
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0157	0.2872	0.2872
Loa Loa (eye worm)	hypothetical protein	0.0157	0.2872	0.2875
Trichomonas vaginalis	conserved hypothetical protein	0.0259	0.567	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Entamoeba histolytica	hypothetical protein, conserved	0.0259	0.567	0.5675
Entamoeba histolytica	hypothetical protein	0.0259	0.567	0.5675
Brugia malayi	Protein kinase domain containing protein	0.0259	0.567	0.5675
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0157	0.2872	0.2872
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0259	0.567	0.5675
Echinococcus multilocularis	insulin receptor	0.0259	0.567	0.5675
Entamoeba histolytica	protein kinase domain containing protein	0.0259	0.567	0.5675
Entamoeba histolytica	cysteine surface protein, putative	0.0259	0.567	0.5675
Loa Loa (eye worm)	TK/FAK protein kinase	0.0259	0.567	0.5675
Entamoeba histolytica	tyrosin kinase, putative	0.0259	0.567	0.5675
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Loa Loa (eye worm)	SRC-1	0.0416	0.999	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0157	0.2872	0.2875
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0157	0.2872	0.2875
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0416	0.999	1
Entamoeba histolytica	protein kinase domain containing protein	0.0259	0.567	0.5675
Entamoeba histolytica	tyrosine kinase, putative	0.0259	0.567	0.5675
Echinococcus granulosus	hypothetical protein	0.0157	0.2872	0.2872
Echinococcus granulosus	tyrosine protein kinase	0.0259	0.567	0.567
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0157	0.2872	0.2875
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Brugia malayi	protein-tyrosine kinase	0.0416	0.999	1
Entamoeba histolytica	protein kinase, putative	0.0259	0.567	0.5675
Brugia malayi	Protein kinase domain containing protein	0.0416	0.999	1
Entamoeba histolytica	ankyrin repeat protein	0.0259	0.567	0.5675
Schistosoma mansoni	protein kinase	0.0259	0.567	0.5675
Entamoeba histolytica	tyrosin kinase, putative	0.0259	0.567	0.5675
Echinococcus granulosus	tyrosine protein kinase HCK	0.0259	0.567	0.567
Brugia malayi	Protein kinase domain containing protein	0.0259	0.567	0.5675
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Entamoeba histolytica	SH2 domain containing protein	0.0157	0.2872	0.2875
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0259	0.567	0.5675
Schistosoma mansoni	tyrosine kinase	0.0259	0.567	0.5675
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Schistosoma mansoni	vav2	0.0157	0.2872	0.2875
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0416	0.999	0.999
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0259	0.567	0.5675
Loa Loa (eye worm)	TK/ABL protein kinase	0.0416	0.999	1
Onchocerca volvulus		0.0259	0.567	0.3931
Entamoeba histolytica	protein kinase, putative	0.0259	0.567	0.5675
Entamoeba histolytica	protein kinase, putative	0.0259	0.567	0.5675
Echinococcus granulosus	receptor type guanylyl cyclase	0.0259	0.567	0.567
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0416	0.999	0.999
Brugia malayi	Protein kinase domain containing protein	0.0259	0.567	0.5675
Schistosoma mansoni	tyrosine kinase	0.0259	0.567	0.5675
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0259	0.567	0.5675
Onchocerca volvulus		0.0416	0.999	1
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0157	0.2872	0.2872
Echinococcus granulosus	tyrosine protein kinase pr2	0.0259	0.567	0.567
Loa Loa (eye worm)	hypothetical protein	0.0157	0.2872	0.2875
Schistosoma mansoni	tyrosine kinase	0.0259	0.567	0.5675
Echinococcus granulosus	epidermal growth factor receptor	0.0259	0.567	0.567
Brugia malayi	SH2 domain containing protein	0.0416	0.999	1
Brugia malayi	Receptor family ligand binding region containing protein	0.0259	0.567	0.5675
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Loa Loa (eye worm)	TK protein kinase	0.0259	0.567	0.5675
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0416	0.999	1
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0259	0.567	0.5675
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0259	0.567	0.567
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0416	0.999	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0259	0.567	0.5675
Schistosoma mansoni	tyrosine kinase	0.0416	0.999	1
Echinococcus granulosus	SHC transforming protein 3	0.0157	0.2872	0.2872
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0157	0.2872	0.2875
Schistosoma mansoni	tyrosine kinase	0.0259	0.567	0.5675
Schistosoma mansoni	ephrin receptor	0.0259	0.567	0.5675
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0259	0.567	0.5675
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0157	0.2872	0.2875
Entamoeba histolytica	tyrosine kinase, putative	0.0259	0.567	0.5675
Echinococcus granulosus	SH2 motif	0.0157	0.2872	0.2872
Brugia malayi	Variant SH3 domain containing protein	0.0157	0.2872	0.2875
Entamoeba histolytica	hypothetical protein	0.0259	0.567	0.5675
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0259	0.567	0.5675
Loa Loa (eye worm)	TK/FER protein kinase	0.0259	0.567	0.5675
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0416	0.999	1
Echinococcus granulosus	tyrosine kinase	0.0416	0.999	0.999
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0416	0.999	1
Loa Loa (eye worm)	TK/ALK protein kinase	0.0259	0.567	0.5675
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0157	0.2872	0.2875
Loa Loa (eye worm)	TK protein kinase	0.0259	0.567	0.5675
Entamoeba histolytica	hypothetical protein	0.0259	0.567	0.5675
Brugia malayi	Protein kinase domain containing protein	0.0259	0.567	0.5675
Schistosoma mansoni	suppressor of cytokine signaling	0.0157	0.2872	0.2875
Entamoeba histolytica	hypothetical protein	0.0259	0.567	0.5675
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0157	0.2872	0.2875
Brugia malayi	Sex muscle abnormal protein 5	0.0157	0.2872	0.2875
Schistosoma mansoni	tensin-related	0.0157	0.2872	0.2875
Loa Loa (eye worm)	TK/FER protein kinase	0.0416	0.999	1
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0259	0.567	0.5675
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0259	0.567	0.5675
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0416	0.999	0.999
Echinococcus multilocularis	SHC transforming protein 3	0.0157	0.2872	0.2875
Loa Loa (eye worm)	hypothetical protein	0.0157	0.2872	0.2875
Entamoeba histolytica	tyrosine kinase, putative	0.0259	0.567	0.5675
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0259	0.567	0.5675
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0259	0.567	0.5675
Entamoeba histolytica	protein kinase, putative	0.0259	0.567	0.5675
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0259	0.567	0.5675
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0259	0.567	0.5675
Onchocerca volvulus	Tyrosine kinase homolog	0.0259	0.567	0.3931
Echinococcus multilocularis	SH2 motif	0.0157	0.2872	0.2875
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0259	0.567	0.5
Brugia malayi	Protein kinase domain containing protein	0.0259	0.567	0.5675
Entamoeba histolytica	tyrosine kinase, putative	0.0259	0.567	0.5675
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0259	0.567	0.5675
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Brugia malayi	C-terminal src kinase protein 1	0.0259	0.567	0.5675
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Loa Loa (eye worm)	hypothetical protein	0.0259	0.567	0.5675
Schistosoma mansoni	tyrosine kinase	0.0416	0.999	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0416	0.999	1
Schistosoma mansoni	tyrosine protein kinase	0.0259	0.567	0.5675
Entamoeba histolytica	protein kinase domain containing protein	0.0259	0.567	0.5675
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0259	0.567	0.5675
Schistosoma mansoni	tensin	0.0157	0.2872	0.2875
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0416	0.999	1
Brugia malayi	Protein kinase domain containing protein	0.0259	0.567	0.5675
Schistosoma mansoni	tyrosine kinase	0.0416	0.999	1
Echinococcus multilocularis	activin receptor type	0.0259	0.568	0.5685
Onchocerca volvulus		0.0259	0.567	0.3931
Entamoeba histolytica	tyrosine kinase, putative	0.0259	0.567	0.5675
Schistosoma mansoni	tyrosine kinase	0.0259	0.567	0.5675
Echinococcus multilocularis	tensin	0.0157	0.2872	0.2875
Loa Loa (eye worm)	TK protein kinase	0.0259	0.567	0.5675
Brugia malayi	hypothetical protein	0.0259	0.567	0.5675
Echinococcus granulosus	tyrosine protein kinase csk	0.0259	0.567	0.567
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0259	0.567	0.5
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0416	0.999	1
Schistosoma mansoni	tyrosine kinase	0.0416	0.999	1
Loa Loa (eye worm)	TK protein kinase	0.0259	0.567	0.5675
Entamoeba histolytica	ankyrin repeat protein	0.0259	0.567	0.5675
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0416	0.999	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0259	0.567	0.5675
Entamoeba histolytica	protein kinase domain containing protein	0.0259	0.567	0.5675
Schistosoma mansoni	tensin-related	0.0157	0.2872	0.2875
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Schistosoma mansoni	tyrosine kinase	0.0259	0.567	0.5675
Schistosoma mansoni	protein kinase	0.0259	0.567	0.5675
Schistosoma mansoni	protein kinase	0.0259	0.568	0.5685
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0157	0.2872	0.2875
Loa Loa (eye worm)	TK/ROR protein kinase	0.0259	0.567	0.5675
Brugia malayi	SH2 domain containing protein	0.0157	0.2872	0.2875
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0157	0.2872	0.2875
Echinococcus multilocularis	tensin	0.0157	0.2872	0.2875
Schistosoma mansoni	adapter molecule crk	0.0157	0.2872	0.2875
Entamoeba histolytica	tyrosine kinase, putative	0.0259	0.567	0.5675
Loa Loa (eye worm)	hypothetical protein	0.0259	0.567	0.5675
Brugia malayi	SH2 domain containing protein	0.0157	0.2872	0.2875
Onchocerca volvulus		0.0259	0.567	0.3931
Echinococcus multilocularis		0.0157	0.2872	0.2875
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0259	0.567	0.5675
Schistosoma mansoni	shc transforming protein	0.0157	0.2872	0.2875
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0259	0.568	1
Echinococcus granulosus	expressed conserved protein	0.0157	0.2872	0.2872
Brugia malayi	Protein kinase domain containing protein	0.0259	0.567	0.5675
Brugia malayi	Protein kinase domain containing protein	0.0259	0.567	0.5675
Loa Loa (eye worm)	TK protein kinase	0.0259	0.567	0.5675
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0259	0.567	0.5675
Schistosoma mansoni	tyrosine kinase	0.0259	0.567	0.5675
Entamoeba histolytica	receptor protein kinase, putative	0.0259	0.567	0.5675
Entamoeba histolytica	protein kinase, putative	0.0259	0.567	0.5675
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Entamoeba histolytica	protein kinase, putative	0.0259	0.567	0.5675
Schistosoma mansoni	protein tyrosine kinase	0.0259	0.567	0.5675
Loa Loa (eye worm)	TK/FER protein kinase	0.0416	0.999	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0157	0.2872	0.2872
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0416	0.999	0.999
Brugia malayi	Guanylyl cyclase protein 23	0.0259	0.567	0.5675
Entamoeba histolytica	protein kinase domain containing protein	0.0259	0.567	0.5675
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0259	0.567	0.5675
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0157	0.2872	0.2875
Entamoeba histolytica	serine/threonine kinase, putative	0.0259	0.567	0.5675
Brugia malayi	Raf kinase	0.0259	0.567	0.5675
Schistosoma mansoni	tensin	0.0157	0.2872	0.2875
Leishmania major	protein kinase, putative	0.0259	0.568	1
Brugia malayi	Protein kinase domain containing protein	0.0259	0.567	0.5675
Brugia malayi	Protein kinase domain containing protein	0.0416	0.999	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0157	0.2872	0.2875
Brugia malayi	Variant SH3 domain containing protein	0.0157	0.2872	0.2875
Loa Loa (eye worm)	hypothetical protein	0.0157	0.2872	0.2875
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0157	0.2872	0.2875
Echinococcus multilocularis	tyrosine kinase	0.0416	0.999	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0259	0.567	0.5675
Echinococcus multilocularis	tyrosine protein kinase csk	0.0259	0.567	0.5675
Brugia malayi	Protein kinase domain containing protein	0.0259	0.567	0.5675
Entamoeba histolytica	hypothetical protein	0.0259	0.567	0.5675
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Schistosoma mansoni	protein kinase	0.0259	0.567	0.5675
Schistosoma mansoni	tyrosine kinase	0.0416	0.999	1
Schistosoma mansoni	hypothetical protein	0.0157	0.2872	0.2875
Brugia malayi	Variant SH3 domain containing protein	0.0157	0.2872	0.2875
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Loa Loa (eye worm)	TK/CSK protein kinase	0.0259	0.567	0.5675
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0259	0.567	0.5675
Entamoeba histolytica	protein kinase domain containing protein	0.0259	0.567	0.5675
Echinococcus multilocularis	c src tyrosine kinase	0.0416	0.999	1
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0157	0.2872	0.2872
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0259	0.567	0.5675
Onchocerca volvulus		0.0259	0.567	0.3931
Brugia malayi	Protein kinase domain containing protein	0.0259	0.567	0.5675
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0259	0.567	0.5675
Schistosoma mansoni	tyrosine kinase	0.0259	0.567	0.5675
Entamoeba histolytica	protein kinase domain containing protein	0.0259	0.567	0.5675
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0259	0.567	0.5675
Echinococcus granulosus	growth factor receptor bound protein 2	0.0157	0.2872	0.2872
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0259	0.567	0.5675
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0259	0.567	0.5675
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0259	0.568	0.5685
Entamoeba histolytica	protein kinase, putative	0.0259	0.567	0.5675
Echinococcus multilocularis	tyrosine protein kinase	0.0259	0.567	0.5675
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0416	0.999	0.999
Brugia malayi	SH2 domain containing protein	0.0157	0.2872	0.2875
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Schistosoma mansoni	tyrosine kinase	0.0259	0.567	0.5675
Echinococcus granulosus	tyrosine kinase	0.0416	0.999	0.999
Echinococcus granulosus	cyclin dependent kinase 9	0.0062	0.0252	0.0252
Entamoeba histolytica	tyrosine kinase, putative	0.0259	0.567	0.5675
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0259	0.567	0.5675
Trichomonas vaginalis	conserved hypothetical protein	0.0259	0.567	0.5
Echinococcus granulosus	tyrosine kinase	0.0259	0.567	0.567
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0259	0.567	0.5675
Echinococcus multilocularis	SH2 motif	0.0157	0.2872	0.2875
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Trichomonas vaginalis	TK family protein kinase	0.0259	0.567	0.5
Schistosoma mansoni	tyrosine kinase	0.0416	0.999	1
Brugia malayi	hypothetical protein	0.0416	0.999	1
Loa Loa (eye worm)	hypothetical protein	0.0259	0.567	0.5675
Entamoeba histolytica	protein kinase domain containing protein	0.0259	0.567	0.5675
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0259	0.567	0.5675
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0416	0.999	1
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0259	0.567	0.567
Loa Loa (eye worm)	TK/FER protein kinase	0.0416	0.999	1
Brugia malayi	SRC-1	0.0416	0.999	1
Entamoeba histolytica	protein kinase, putative	0.0259	0.567	0.5675
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Echinococcus granulosus	SH2 motif	0.0157	0.2872	0.2872
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Schistosoma mansoni	growth factor receptor-bound protein	0.0157	0.2872	0.2875
Entamoeba histolytica	tyrosine kinase, putative	0.0259	0.567	0.5675
Entamoeba histolytica	protein kinase domain containing protein	0.0259	0.567	0.5675
Loa Loa (eye worm)	hypothetical protein	0.0259	0.567	0.5675
Entamoeba histolytica	protein kinase, putative	0.0259	0.567	0.5675
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0259	0.567	0.5675
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0259	0.567	0.5675
Echinococcus multilocularis	tyrosine protein kinase csk	0.0259	0.567	0.5675
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0416	0.999	0.999
Trichomonas vaginalis	TKL family protein kinase	0.0259	0.567	0.5
Brugia malayi	Tyrosine-protein kinase PR2	0.0259	0.567	0.5675
Entamoeba histolytica	tyrosine kinase, putative	0.0259	0.567	0.5675
Loa Loa (eye worm)	TK protein kinase	0.0416	0.999	1
Schistosoma mansoni	protein kinase	0.0259	0.567	0.5675

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 2 %	Antiinflammatory activity in mouse N9 cells assessed as reduction of LPS-induced microglial activation at 1 to 10 uM measured as nitrite level after 24 hrs by Griess reagent-based assay	ChEMBL.	22192055

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1951820

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1615425