TDR Targets

Basic information

Technical information

TDR Targets ID: 1616677
Name: ethyl 7-chloro-6-fluoro-4-oxo-1-prop-2-ynylqu inoline-3-carboxylate
MW: 307.704 | Formula: C15H11ClFNO3
H donors: 0 H acceptors: 2 LogP: 2.97 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)c1cn(CC#C)c2c(c1=O)cc(c(c2)Cl)F
InChi: 1S/C15H11ClFNO3/c1-3-5-18-8-10(15(20)21-4-2)14(19)9-6-12(17)11(16)7-13(9)18/h1,6-8H,4-5H2,2H3
InChiKey: JCXDNWKUPWPDPJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

ethyl 7-chloro-6-fluoro-4-oxo-1-prop-2-ynyl-quinoline-3-carboxylate
7-chloro-6-fluoro-4-oxo-1-prop-2-ynyl-3-quinolinecarboxylic acid ethyl ester
7-chloro-6-fluoro-4-keto-1-propargyl-quinoline-3-carboxylic acid ethyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0486	0.0654
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0189	0.2395	0.3222
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0361	0.4789	0.4789
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0055	0.0513	0.0547
Entamoeba histolytica	protein kinase, putative	0.0189	0.2395	0.3222
Echinococcus multilocularis	protein kinase	0.0189	0.2395	0.2395
Brugia malayi	Protein kinase domain containing protein	0.0189	0.2395	0.3222
Entamoeba histolytica	receptor protein kinase, putative	0.0189	0.2395	0.3222
Trypanosoma cruzi	trypanothione reductase, putative	0.005	0.0454	0.1894
Echinococcus multilocularis	c src tyrosine kinase	0.055	0.7433	0.7433
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0083	0.0913	0.3811
Schistosoma mansoni	adapter molecule crk	0.0361	0.4789	0.4789
Echinococcus granulosus	integrin linked protein kinase	0.0189	0.2395	0.2395
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.055	0.7433	0.7433
Brugia malayi	Protein kinase domain containing protein	0.0189	0.2395	0.3222
Loa Loa (eye worm)	TK protein kinase	0.0189	0.2395	0.3222
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0189	0.2395	1
Loa Loa (eye worm)	glutathione reductase	0.005	0.0454	0.061
Leishmania major	cathepsin L-like protease	0.0068	0.0699	0.2917
Brugia malayi	hypothetical protein	0.055	0.7433	1
Onchocerca volvulus		0.0361	0.4789	0.6443
Entamoeba histolytica	protein kinase, putative	0.0189	0.2395	0.3222
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Loa Loa (eye worm)	serine/threonine protein kinase	0.0189	0.2395	0.3222
Trypanosoma cruzi	major cysteine proteinase, putative	0.0053	0.0496	0.2071
Echinococcus granulosus	tyrosine protein kinase pr2	0.0189	0.2395	0.2395
Entamoeba histolytica	tyrosin kinase, putative	0.0189	0.2395	0.3222
Echinococcus multilocularis	signal transduction protein lnk realted	0.0361	0.4789	0.4789
Entamoeba histolytica	protein kinase, putative	0.0189	0.2395	0.3222
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0189	0.2395	0.2395
Schistosoma mansoni	tyrosine kinase	0.0189	0.2395	0.2395
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0189	0.2395	0.2395
Brugia malayi	Thioredoxin reductase	0.005	0.0454	0.061
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0128	0.1532	1
Brugia malayi	SH2 domain containing protein	0.0361	0.4789	0.6443
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0029	0.0151	0.0632
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0189	0.2395	0.2395
Loa Loa (eye worm)	hypothetical protein	0.0361	0.4789	0.6443
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0189	0.2395	0.3222
Entamoeba histolytica	tyrosine kinase, putative	0.0189	0.2395	0.3222
Entamoeba histolytica	cysteine surface protein, putative	0.0189	0.2395	0.3222
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0189	0.2395	0.2395
Loa Loa (eye worm)	TK/FER protein kinase	0.055	0.7433	1
Schistosoma mansoni	serine/threonine protein kinase	0.0189	0.2395	0.2395
Onchocerca volvulus		0.0053	0.0486	0.0654
Loa Loa (eye worm)	TK/FER protein kinase	0.0189	0.2395	0.3222
Onchocerca volvulus		0.0189	0.2395	0.3222
Echinococcus granulosus	thioredoxin glutathione reductase	0.005	0.0454	0.0454
Entamoeba histolytica	protein kinase domain containing protein	0.0189	0.2395	0.3222
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0361	0.4789	0.4789
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0361	0.4789	0.6443
Brugia malayi	protein-tyrosine kinase	0.055	0.7433	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0189	0.2395	0.3222
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0189	0.2395	0.2395
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.055	0.7433	0.7433
Entamoeba histolytica	protein kinase domain containing protein	0.0189	0.2395	0.3222
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0055	0.0513	0.0547
Echinococcus granulosus	raf serine:threonine protein kinase	0.0189	0.2395	0.2395
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Plasmodium falciparum	glutathione reductase	0.005	0.0454	0.1894
Entamoeba histolytica	protein kinase domain containing protein	0.0189	0.2395	0.3222
Entamoeba histolytica	protein kinase domain containing protein	0.0189	0.2395	0.3222
Entamoeba histolytica	protein kinase, putative	0.0189	0.2395	0.3222
Echinococcus granulosus	tyrosine kinase	0.055	0.7433	0.7433
Entamoeba histolytica	SH2 domain containing protein	0.0361	0.4789	0.6443
Entamoeba histolytica	ankyrin repeat protein	0.0189	0.2395	0.3222
Brugia malayi	Furin-like cysteine rich region family protein	0.0189	0.2395	0.3222
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0029	0.0151	0.0632
Schistosoma mansoni	tyrosine kinase	0.0189	0.2395	0.2395
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0189	0.2395	0.3222
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Entamoeba histolytica	hypothetical protein	0.0189	0.2395	0.3222
Loa Loa (eye worm)	hypothetical protein	0.0189	0.2395	0.3222
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0189	0.2395	0.2395
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0189	0.2395	1
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0189	0.2395	0.3222
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0115	0.1353	0.8342
Schistosoma mansoni	tensin-related	0.0361	0.4789	0.4789
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Entamoeba histolytica	protein kinase, putative	0.0189	0.2395	0.3222
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0189	0.2395	0.3222
Entamoeba histolytica	tyrosin kinase, putative	0.0189	0.2395	0.3222
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0189	0.2395	0.2395
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0189	0.2395	0.2395
Trichomonas vaginalis	conserved hypothetical protein	0.0189	0.2395	1
Echinococcus granulosus	tyrosine protein kinase Lyn	0.055	0.7433	0.7433
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.055	0.7433	0.7433
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0361	0.4789	0.4789
Echinococcus granulosus	tensin	0.0361	0.4789	0.4789
Schistosoma mansoni	tyrosine kinase	0.0189	0.2395	0.2395
Brugia malayi	Protein kinase domain containing protein	0.0189	0.2395	0.3222
Entamoeba histolytica	protein kinase domain containing protein	0.0189	0.2395	0.3222
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0189	0.2395	0.3222
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0361	0.4789	0.4789
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.055	0.7433	0.7433
Schistosoma mansoni	tyrosine protein kinase	0.0189	0.2395	0.2395
Entamoeba histolytica	hypothetical protein	0.0189	0.2395	0.3222
Schistosoma mansoni	signal transduction protein lnk-related	0.0361	0.4789	0.4789
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0361	0.4789	0.6443
Entamoeba histolytica	protein kinase, putative	0.0189	0.2395	0.3222
Echinococcus granulosus	kinase suppressor of Ras 1	0.0189	0.2395	0.2395
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0361	0.4789	0.4789
Loa Loa (eye worm)	hypothetical protein	0.0189	0.2395	0.3222
Loa Loa (eye worm)	hypothetical protein	0.0189	0.2395	0.3222
Trypanosoma cruzi	protein kinase, putative	0.0189	0.2395	1
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0361	0.4789	0.4789
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0189	0.2395	0.2395
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0189	0.2395	0.2395
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0189	0.2395	0.3222
Onchocerca volvulus		0.055	0.7433	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.055	0.7433	0.7433
Plasmodium falciparum	thioredoxin reductase	0.005	0.0454	0.1894
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Schistosoma mansoni	tyrosine kinase	0.0189	0.2395	0.2395
Schistosoma mansoni	tyrosine kinase	0.0189	0.2395	0.2395
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Schistosoma mansoni	tyrosine kinase	0.055	0.7433	0.7433
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0361	0.4789	0.4789
Echinococcus multilocularis	tyrosine protein kinase Blk	0.055	0.7433	0.7433
Entamoeba histolytica	serine/threonine kinase, putative	0.0189	0.2395	0.3222
Loa Loa (eye worm)	hypothetical protein	0.0189	0.2395	0.3222
Entamoeba histolytica	protein kinase, putative	0.0361	0.4789	0.6443
Entamoeba histolytica	serine/threonine kinase, putative	0.0189	0.2395	0.3222
Brugia malayi	Protein kinase domain containing protein	0.0189	0.2395	0.3222
Loa Loa (eye worm)	hypothetical protein	0.0361	0.4789	0.6443
Loa Loa (eye worm)	thioredoxin reductase	0.005	0.0454	0.061
Entamoeba histolytica	protein kinase, putative	0.0198	0.2514	0.3383
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.055	0.7433	0.7433
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Entamoeba histolytica	hypothetical protein	0.0189	0.2395	0.3222
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0189	0.2395	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0189	0.2395	0.3222
Echinococcus granulosus	tyrosine protein kinase shark	0.055	0.7433	0.7433
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0189	0.2395	0.2395
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0189	0.2395	0.2395
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0189	0.2395	0.2395
Schistosoma mansoni	tensin-related	0.0361	0.4789	0.4789
Loa Loa (eye worm)	hypothetical protein	0.0361	0.4789	0.6443
Echinococcus multilocularis	epidermal growth factor receptor	0.0189	0.2395	0.2395
Loa Loa (eye worm)	TK/RYK protein kinase	0.0189	0.2395	0.3222
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0189	0.2395	1
Schistosoma mansoni	hypothetical protein	0.0189	0.2395	0.2395
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Loa Loa (eye worm)	TK/EPH protein kinase	0.0189	0.2395	0.3222
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0189	0.2395	0.3222
Loa Loa (eye worm)	hypothetical protein	0.0361	0.4789	0.6443
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0189	0.2395	0.3222
Trichomonas vaginalis	protein kinase atn1, putative	0.0189	0.2395	1
Onchocerca volvulus		0.055	0.7433	1
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0189	0.2395	0.2395
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0361	0.4789	0.4789
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0083	0.0913	0.5
Brugia malayi	Protein kinase domain containing protein	0.055	0.7433	1
Trichomonas vaginalis	AGC family protein kinase	0.0189	0.2395	1
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0189	0.2395	0.2395
Loa Loa (eye worm)	TK protein kinase	0.0189	0.2395	0.3222
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0361	0.4789	0.4789
Schistosoma mansoni	tensin	0.0361	0.4789	0.4789
Schistosoma mansoni	protein kinase	0.0189	0.2395	0.2395
Loa Loa (eye worm)	hypothetical protein	0.0189	0.2395	0.3222
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0083	0.0913	0.0913
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Brugia malayi	Protein kinase domain containing protein	0.0189	0.2395	0.3222
Echinococcus granulosus	epidermal growth factor receptor	0.0189	0.2395	0.2395
Giardia lamblia	Kinase	0.0189	0.2395	0.5
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0361	0.4789	0.6443
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.055	0.7433	0.7433
Loa Loa (eye worm)	TK protein kinase	0.0189	0.2395	0.3222
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0189	0.2395	0.2395
Loa Loa (eye worm)	TK/FER protein kinase	0.055	0.7433	1
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0055	0.0513	0.0513
Entamoeba histolytica	protein kinase, putative	0.0189	0.2395	0.3222
Schistosoma mansoni	tyrosine kinase	0.0189	0.2395	0.2395
Entamoeba histolytica	hypothetical protein	0.0198	0.2514	0.3383
Schistosoma mansoni	tyrosine kinase	0.0189	0.2395	0.2395
Entamoeba histolytica	protein kinase, putative	0.0189	0.2395	0.3222
Brugia malayi	Tyrosine-protein kinase PR2	0.0189	0.2395	0.3222
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0699	0.1263
Plasmodium vivax	glutathione reductase, putative	0.005	0.0454	0.1894
Loa Loa (eye worm)	SH2 domain-containing protein	0.0361	0.4789	0.6443
Entamoeba histolytica	serine/threonine kinase, putative	0.0189	0.2395	0.3222
Schistosoma mansoni	serine/threonine protein kinase	0.0189	0.2395	0.2395
Schistosoma mansoni	peptidase Clp (S14 family)	0.0083	0.0913	0.0913
Echinococcus multilocularis	activin receptor type	0.0189	0.2395	0.2395
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0189	0.2395	0.3222
Loa Loa (eye worm)	TK/INSR protein kinase	0.0189	0.2395	0.3222
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Loa Loa (eye worm)	hypothetical protein	0.0361	0.4789	0.6443
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0361	0.4789	0.6443
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0189	0.2395	0.2395
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0361	0.4789	0.4789
Echinococcus granulosus	activated cdc42 kinase 1	0.0189	0.2395	0.2395
Brugia malayi	Protein kinase domain containing protein	0.0189	0.2395	0.3222
Entamoeba histolytica	protein kinase domain containing protein	0.0189	0.2395	0.3222
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0189	0.2395	1
Echinococcus multilocularis	SH2 motif	0.0361	0.4789	0.4789
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Echinococcus multilocularis	heat shock protein 70	0.0189	0.2395	0.2395
Echinococcus multilocularis	protein kinase	0.0189	0.2395	0.2395
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0361	0.4789	0.6443
Entamoeba histolytica	hypothetical protein	0.0198	0.2514	0.3383
Brugia malayi	SH2 domain containing protein	0.0361	0.4789	0.6443
Echinococcus granulosus	tyrosine protein kinase Src42A	0.055	0.7433	0.7433
Entamoeba histolytica	protein kinase, putative	0.0189	0.2395	0.3222
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0189	0.2395	0.2395
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Entamoeba histolytica	tyrosine kinase, putative	0.0189	0.2395	0.3222
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0189	0.2395	0.2395
Brugia malayi	Protein kinase domain containing protein	0.0189	0.2395	0.3222
Echinococcus granulosus	tyrosine protein kinase Fyn	0.055	0.7433	0.7433
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0189	0.2395	0.2395
Schistosoma mansoni	protein kinase	0.0189	0.2395	0.2395
Echinococcus multilocularis	tyrosine protein kinase Srms	0.055	0.7433	0.7433
Entamoeba histolytica	hypothetical protein	0.0189	0.2395	0.3222
Echinococcus granulosus	tyrosine protein kinase csk	0.0189	0.2395	0.2395
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0083	0.0913	0.5514
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0361	0.4789	0.4789
Brugia malayi	SH2 domain containing protein	0.0361	0.4789	0.6443
Schistosoma mansoni	suppressor of cytokine signaling	0.0361	0.4789	0.4789
Trichomonas vaginalis	conserved hypothetical protein	0.0189	0.2395	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0189	0.2395	0.3222
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0361	0.4789	0.4789
Entamoeba histolytica	serine/threonine kinase, putative	0.0189	0.2395	0.3222
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0083	0.0913	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Loa Loa (eye worm)	TK/FER protein kinase	0.055	0.7433	1
Onchocerca volvulus		0.0189	0.2395	0.3222
Loa Loa (eye worm)	TK/FER protein kinase	0.055	0.7433	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0189	0.2395	0.3222
Echinococcus multilocularis	tyrosine protein kinase csk	0.0189	0.2395	0.2395
Brugia malayi	Raf kinase	0.0189	0.2395	0.3222
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0189	0.2395	0.3222
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0189	0.2395	0.2395
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0189	0.2395	0.3222
Entamoeba histolytica	protein kinase, putative	0.0189	0.2395	0.3222
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0189	0.2395	0.3222
Entamoeba histolytica	protein kinase domain containing protein	0.0189	0.2395	0.3222
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.055	0.7433	0.7433
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0189	0.2395	0.2395
Entamoeba histolytica	tyrosine kinase, putative	0.0189	0.2395	0.3222
Plasmodium falciparum	tyrosine kinase-like protein	0.0189	0.2395	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0189	0.2395	0.2395
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Loa Loa (eye worm)	hypothetical protein	0.0189	0.2395	0.3222
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0189	0.2395	0.3222
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0189	0.2395	0.2395
Entamoeba histolytica	protein kinase domain containing protein	0.0189	0.2395	0.3222
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0361	0.4789	0.4789
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Plasmodium falciparum	protein kinase, putative	0.0189	0.2395	1
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0361	0.4789	0.4789
Entamoeba histolytica	protein kinase domain containing protein	0.0189	0.2395	0.3222
Echinococcus granulosus	c src tyrosine kinase	0.055	0.7433	0.7433
Onchocerca volvulus		0.0361	0.4789	0.6443
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Echinococcus granulosus	natriuretic peptide receptor 1	0.0189	0.2395	0.2395
Echinococcus multilocularis	protein tyrosine kinase	0.0189	0.2395	0.2395
Echinococcus granulosus	tyrosine protein kinase csk	0.0189	0.2395	0.2395
Schistosoma mansoni	vav2	0.0361	0.4789	0.4789
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0189	0.2395	0.2395
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Loa Loa (eye worm)	hypothetical protein	0.0361	0.4789	0.6443
Schistosoma mansoni	tensin	0.0361	0.4789	0.4789
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Entamoeba histolytica	protein kinase domain containing protein	0.0189	0.2395	0.3222
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0189	0.2395	0.2395
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0189	0.2395	0.2395
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0055	0.0513	0.2616
Schistosoma mansoni	growth factor receptor-bound protein	0.0361	0.4789	0.4789
Leishmania major	protein kinase, putative	0.0189	0.2395	1
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.055	0.7433	0.7433
Mycobacterium tuberculosis	Probable reductase	0.0115	0.1353	0.8342
Onchocerca volvulus		0.0189	0.2395	0.3222
Giardia lamblia	Kinase, NEK	0.0189	0.2395	0.5
Schistosoma mansoni	hypothetical protein	0.0361	0.4789	0.4789
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0062	0.0617	0.2574
Brugia malayi	Protein kinase domain containing protein	0.0189	0.2395	0.3222
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0189	0.2395	0.3222
Brugia malayi	C-terminal src kinase protein 1	0.0189	0.2395	0.3222
Schistosoma mansoni	GTPase activating protein	0.0361	0.4789	0.4789
Brugia malayi	Protein kinase domain containing protein	0.0189	0.2395	0.3222
Entamoeba histolytica	receptor protein kinase, putative	0.0189	0.2395	0.3222
Trypanosoma cruzi	cysteine peptidase, putative	0.0068	0.0699	0.2917
Trypanosoma cruzi	cysteine peptidase, putative	0.0068	0.0699	0.2917
Brugia malayi	Protein kinase domain containing protein	0.055	0.7433	1
Echinococcus multilocularis	tensin	0.0361	0.4789	0.4789
Brugia malayi	Variant SH3 domain containing protein	0.0361	0.4789	0.6443
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0189	0.2395	0.2395
Toxoplasma gondii	STE kinase	0.0189	0.2395	1
Loa Loa (eye worm)	TK/FER protein kinase	0.055	0.7433	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0189	0.2395	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Schistosoma mansoni	tyrosine kinase	0.0189	0.2395	0.2395
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0189	0.2395	1
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0189	0.2395	0.3222
Onchocerca volvulus		0.055	0.7433	1
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0361	0.4789	0.6443
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0699	0.1263
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.055	0.7433	0.7433
Loa Loa (eye worm)	TK/FER protein kinase	0.055	0.7433	1
Echinococcus multilocularis	SH2 motif	0.0361	0.4789	0.4789
Entamoeba histolytica	hypothetical protein	0.0189	0.2395	0.3222
Echinococcus multilocularis	tyrosine protein kinase Abl	0.055	0.7433	0.7433
Entamoeba histolytica	tyrosine kinase, putative	0.0189	0.2395	0.3222
Loa Loa (eye worm)	TK/FER protein kinase	0.055	0.7433	1
Loa Loa (eye worm)	TK/FER protein kinase	0.055	0.7433	1
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0189	0.2395	0.2395
Entamoeba histolytica	hypothetical protein	0.0198	0.2514	0.3383
Toxoplasma gondii	hypothetical protein	0.0029	0.0151	0.0632
Brugia malayi	SH2 domain containing protein	0.0361	0.4789	0.6443
Brugia malayi	Protein kinase domain containing protein	0.0189	0.2395	0.3222
Onchocerca volvulus		0.055	0.7433	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0361	0.4789	0.4789
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0189	0.2395	1
Schistosoma mansoni	ephrin receptor	0.0189	0.2395	0.2395
Schistosoma mansoni	protein kinase	0.0189	0.2395	0.2395
Onchocerca volvulus		0.0189	0.2395	0.3222
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0189	0.2395	0.2395
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Entamoeba histolytica	protein kinase domain containing protein	0.0189	0.2395	0.3222
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0115	0.1353	0.8342
Giardia lamblia	Protein 21.1	0.0189	0.2395	0.5
Echinococcus granulosus	tyrosine kinase	0.0189	0.2395	0.2395
Entamoeba histolytica	ankyrin repeat protein	0.0189	0.2395	0.3222
Mycobacterium tuberculosis	Probable dehydrogenase	0.0115	0.1353	0.8342
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0083	0.0913	0.3811
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0189	0.2395	0.2395
Echinococcus multilocularis	SH2 motif	0.0361	0.4789	0.4789
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0189	0.2395	0.2395
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0189	0.2395	0.2395
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0361	0.4789	0.4789
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0189	0.2395	0.2395
Trichomonas vaginalis	conserved hypothetical protein	0.0189	0.2395	1
Schistosoma mansoni	tyrosine kinase	0.0189	0.2395	0.2395
Echinococcus granulosus	tyrosine protein kinase Fyn	0.055	0.7433	0.7433
Schistosoma mansoni	tyrosine kinase	0.0189	0.2395	0.2395
Giardia lamblia	Kinase, NEK	0.0189	0.2395	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Entamoeba histolytica	protein kinase, putative	0.0189	0.2395	0.3222
Schistosoma mansoni	tyrosine kinase	0.0189	0.2395	0.2395
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0361	0.4789	0.6443
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0189	0.2395	1
Schistosoma mansoni	tyrosine kinase	0.0189	0.2395	0.2395
Onchocerca volvulus		0.0361	0.4789	0.6443
Schistosoma mansoni	protein kinase	0.0189	0.2395	0.2395
Echinococcus granulosus	SH2 motif	0.0361	0.4789	0.4789
Loa Loa (eye worm)	SH2 domain-containing protein	0.0361	0.4789	0.6443
Loa Loa (eye worm)	SRC-1	0.055	0.7433	1
Entamoeba histolytica	protein kinase domain containing protein	0.0189	0.2395	0.3222
Toxoplasma gondii	protein kinase	0.0189	0.2395	1
Onchocerca volvulus		0.0361	0.4789	0.6443
Entamoeba histolytica	hypothetical protein	0.0189	0.2395	0.3222
Brugia malayi	SH2 domain containing protein	0.0361	0.4789	0.6443
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0361	0.4789	0.4789
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0083	0.0913	0.3811
Entamoeba histolytica	hypothetical protein, conserved	0.0189	0.2395	0.3222
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0189	0.2395	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Entamoeba histolytica	tyrosine kinase, putative	0.0189	0.2395	0.3222
Entamoeba histolytica	tyrosine kinase, putative	0.0189	0.2395	0.3222
Loa Loa (eye worm)	hypothetical protein	0.0189	0.2395	0.3222
Schistosoma mansoni	tyrosine kinase	0.0189	0.2395	0.2395
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0115	0.1353	0.8342
Schistosoma mansoni	nck2/grb4	0.0361	0.4789	0.4789
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0699	0.1263
Echinococcus granulosus	tyrosine protein kinase Src64B	0.055	0.7433	0.7433
Loa Loa (eye worm)	hypothetical protein	0.0361	0.4789	0.6443
Echinococcus multilocularis	SH2 domain containing protein 7	0.0361	0.4789	0.4789
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0189	0.2395	0.3222
Trypanosoma cruzi	cysteine peptidase, putative	0.0068	0.0699	0.2917
Brugia malayi	Protein kinase domain containing protein	0.0189	0.2395	0.3222
Echinococcus multilocularis	tyrosine protein kinase csk	0.0189	0.2395	0.2395
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0361	0.4789	0.6443
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0699	0.1263
Echinococcus granulosus	tyrosine protein kinase Fyn	0.055	0.7433	0.7433
Schistosoma mansoni	tyrosine kinase	0.0189	0.2395	0.2395
Schistosoma mansoni	shc transforming protein	0.0361	0.4789	0.4789
Entamoeba histolytica	serine/threonine kinase, putative	0.0189	0.2395	0.3222
Brugia malayi	Protein kinase domain containing protein	0.0189	0.2395	0.3222
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.055	0.7433	0.7433
Brugia malayi	Protein kinase domain containing protein	0.055	0.7433	1
Loa Loa (eye worm)	TK/DDR protein kinase	0.0189	0.2395	0.3222
Brugia malayi	Tensin	0.0361	0.4789	0.6443
Echinococcus granulosus	hypothetical protein	0.0361	0.4789	0.4789
Entamoeba histolytica	tyrosine kinase, putative	0.0189	0.2395	0.3222
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0189	0.2395	0.2395
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0083	0.0913	1
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0189	0.2395	0.3222
Entamoeba histolytica	tyrosin kinase, putative	0.0189	0.2395	0.3222
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.055	0.7433	0.7433
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0189	0.2395	0.2395
Brugia malayi	Variant SH3 domain containing protein	0.0361	0.4789	0.6443
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Trypanosoma brucei	protein kinase, putative	0.0189	0.2395	1
Loa Loa (eye worm)	hypothetical protein	0.0189	0.2395	0.3222
Brugia malayi	Receptor family ligand binding region containing protein	0.0189	0.2395	0.3222
Leishmania major	protein kinase, putative	0.0189	0.2395	1
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0189	0.2395	0.2395
Loa Loa (eye worm)	hypothetical protein	0.0361	0.4789	0.6443
Echinococcus granulosus	SHC transforming protein 3	0.0361	0.4789	0.4789
Plasmodium falciparum	protein kinase, putative	0.0189	0.2395	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0189	0.2395	0.3222
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0361	0.4789	0.6443
Entamoeba histolytica	protein kinase, putative	0.0189	0.2395	0.3222
Brugia malayi	Probable ClpP-like protease	0.0083	0.0913	0.1228
Echinococcus multilocularis	insulin receptor	0.0189	0.2395	0.2395
Entamoeba histolytica	protein kinase, putative	0.0189	0.2395	0.3222
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0128	0.1532	1
Echinococcus granulosus	receptor type guanylyl cyclase	0.0189	0.2395	0.2395
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Brugia malayi	Protein kinase domain containing protein	0.0189	0.2395	0.3222
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0699	0.1263
Entamoeba histolytica	protein kinase domain containing protein	0.0189	0.2395	0.3222
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0189	0.2395	0.3222
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0361	0.4789	0.6443
Brugia malayi	Protein kinase domain containing protein	0.0189	0.2395	0.3222
Loa Loa (eye worm)	hypothetical protein	0.0189	0.2395	0.3222
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Schistosoma mansoni	tyrosine kinase	0.0189	0.2395	0.2395
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Echinococcus multilocularis	activated cdc42 kinase 1	0.0189	0.2395	0.2395
Brugia malayi	Sex muscle abnormal protein 5	0.0361	0.4789	0.6443
Loa Loa (eye worm)	SH2 domain-containing protein	0.0361	0.4789	0.6443
Schistosoma mansoni	growth factor receptor-bound protein	0.0361	0.4789	0.4789
Loa Loa (eye worm)	TK/FER protein kinase	0.055	0.7433	1
Entamoeba histolytica	protein kinase domain containing protein	0.0189	0.2395	0.3222
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0189	0.2395	0.3222
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0189	0.2395	0.2395
Echinococcus multilocularis	tyrosine kinase	0.0189	0.2395	0.2395
Loa Loa (eye worm)	TK protein kinase	0.0189	0.2395	0.3222
Echinococcus granulosus	signal transduction protein lnk realted	0.0361	0.4789	0.4789
Entamoeba histolytica	protein kinase, putative	0.0189	0.2395	0.3222
Entamoeba histolytica	tyrosine kinase, putative	0.0189	0.2395	0.3222
Loa Loa (eye worm)	TK/FER protein kinase	0.0189	0.2395	0.3222
Schistosoma mansoni	tyrosine kinase	0.055	0.7433	0.7433
Toxoplasma gondii	protein kinase domain-containing protein	0.0189	0.2395	1
Brugia malayi	SH2 domain containing protein	0.0361	0.4789	0.6443
Echinococcus granulosus	expressed conserved protein	0.0361	0.4789	0.4789
Loa Loa (eye worm)	TK protein kinase	0.0189	0.2395	0.3222
Entamoeba histolytica	tyrosine kinase, putative	0.0189	0.2395	0.3222
Schistosoma mansoni	protein kinase	0.0189	0.2395	0.2395
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0189	0.2395	0.3222
Echinococcus granulosus	tyrosine protein kinase Blk	0.055	0.7433	0.7433
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Schistosoma mansoni	serine/threonine protein kinase	0.0189	0.2395	0.2395
Schistosoma mansoni	tensin	0.0361	0.4789	0.4789
Echinococcus granulosus	activin receptor type	0.0189	0.2395	0.2395
Echinococcus multilocularis	thioredoxin glutathione reductase	0.005	0.0454	0.0454
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0361	0.4789	0.6443
Schistosoma mansoni	hypothetical protein	0.0361	0.4789	0.4789
Echinococcus multilocularis		0.0361	0.4789	0.4789
Schistosoma mansoni	tyrosine kinase	0.055	0.7433	0.7433
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0189	0.2395	1
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0083	0.0913	0.0913
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Brugia malayi	RhoGAP domain containing protein	0.0361	0.4789	0.6443
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0189	0.2395	0.3222
Schistosoma mansoni	tyrosine kinase	0.055	0.7433	0.7433
Loa Loa (eye worm)	TK/FER protein kinase	0.0189	0.2395	0.3222
Trichomonas vaginalis	STE family protein kinase	0.0189	0.2395	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0068	0.0699	0.2917
Brugia malayi	Guanylyl cyclase protein 23	0.0189	0.2395	0.3222
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Onchocerca volvulus		0.055	0.7433	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0699	0.1263
Schistosoma mansoni	suppressor of cytokine signaling	0.0361	0.4789	0.4789
Echinococcus multilocularis	transfer RNA-Thr	0.0189	0.2395	0.2395
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0198	0.2514	0.3383
Loa Loa (eye worm)	hypothetical protein	0.0361	0.4789	0.6443
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0115	0.1353	0.8705
Echinococcus granulosus	tyrosine protein kinase	0.0189	0.2395	0.2395
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0361	0.4789	0.4789
Entamoeba histolytica	tyrosine kinase, putative	0.0189	0.2395	0.3222
Brugia malayi	Tyrosine-protein kinase abl-1	0.055	0.7433	1
Echinococcus granulosus	tumor protein p63	0.036	0.477	0.477
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Entamoeba histolytica	protein kinase, putative	0.0189	0.2395	0.3222
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0189	0.2395	0.3222
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0189	0.2395	0.3222
Echinococcus multilocularis	FL cytokine receptor	0.0189	0.2395	0.2395
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.055	0.7433	0.7433
Loa Loa (eye worm)	hypothetical protein	0.0361	0.4789	0.6443
Loa Loa (eye worm)	hypothetical protein	0.0189	0.2395	0.3222
Loa Loa (eye worm)	hypothetical protein	0.0361	0.4789	0.6443
Loa Loa (eye worm)	TK/ABL protein kinase	0.055	0.7433	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0699	0.1263
Schistosoma mansoni	protein kinase	0.0189	0.2395	0.2395
Brugia malayi	Protein kinase domain containing protein	0.0189	0.2395	0.3222
Brugia malayi	hypothetical protein	0.0361	0.4789	0.6443
Echinococcus granulosus	protein kinase	0.0189	0.2395	0.2395
Onchocerca volvulus		0.0361	0.4789	0.6443
Schistosoma mansoni	serine/threonine protein kinase	0.0189	0.2395	0.2395
Loa Loa (eye worm)	TK/ALK protein kinase	0.0189	0.2395	0.3222
Echinococcus granulosus	tyrosine protein kinase Srms	0.055	0.7433	0.7433
Leishmania major	cathepsin L-like protease	0.0068	0.0699	0.2917
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Echinococcus granulosus	insulin receptor	0.0189	0.2395	0.2395
Schistosoma mansoni	tyrosine kinase	0.0189	0.2395	0.2395
Schistosoma mansoni	protein kinase	0.0189	0.2395	0.2395
Trichomonas vaginalis	conserved hypothetical protein	0.0189	0.2395	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0189	0.2395	0.2395
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0699	0.1263
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0189	0.2395	0.3222
Loa Loa (eye worm)	hypothetical protein	0.0361	0.4789	0.6443
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.055	0.7433	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Brugia malayi	Variant SH3 domain containing protein	0.0361	0.4789	0.6443
Entamoeba histolytica	protein kinase, putative	0.0189	0.2395	0.3222
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0699	0.1263
Brugia malayi	SH2 domain containing protein	0.055	0.7433	1
Trichomonas vaginalis	conserved hypothetical protein	0.0189	0.2395	1
Onchocerca volvulus		0.0189	0.2395	0.3222
Entamoeba histolytica	tyrosine kinase, putative	0.0189	0.2395	0.3222
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0913	0.1228
Entamoeba histolytica	protein kinase, putative	0.0189	0.2395	0.3222
Onchocerca volvulus		0.0189	0.2395	0.3222
Brugia malayi	Protein kinase domain containing protein	0.0189	0.2395	0.3222
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0083	0.0913	0.3811
Loa Loa (eye worm)	TK protein kinase	0.0189	0.2395	0.3222
Schistosoma mansoni	tyrosine kinase	0.0189	0.2395	0.2395
Brugia malayi	Protein kinase domain containing protein	0.055	0.7433	1
Brugia malayi	integrin-linked kinase	0.0189	0.2395	0.3222
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0189	0.2395	0.3222
Brugia malayi	hypothetical protein	0.0189	0.2395	0.3222
Loa Loa (eye worm)	hypothetical protein	0.0189	0.2395	0.3222
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0189	0.2395	0.2395
Schistosoma mansoni	tyrosine kinase	0.0189	0.2395	0.2395
Echinococcus granulosus	activated cdc42 kinase 1	0.0189	0.2395	0.2395
Loa Loa (eye worm)	hypothetical protein	0.0361	0.4789	0.6443
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Echinococcus multilocularis	tyrosine protein kinase shark	0.055	0.7433	0.7433
Onchocerca volvulus		0.0189	0.2395	0.3222
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Echinococcus granulosus	ephrin type A receptor 4 A	0.0189	0.2395	0.2395
Entamoeba histolytica	tyrosine kinase, putative	0.0189	0.2395	0.3222
Echinococcus granulosus	SH2 domain containing protein 7	0.0361	0.4789	0.4789
Brugia malayi	Protein kinase domain containing protein	0.0189	0.2395	0.3222
Entamoeba histolytica	protein kinase domain containing protein	0.0189	0.2395	0.3222
Entamoeba histolytica	protein kinase domain containing protein	0.0189	0.2395	0.3222
Loa Loa (eye worm)	TK protein kinase	0.0189	0.2395	0.3222
Onchocerca volvulus	Tyrosine kinase homolog	0.0189	0.2395	0.3222
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Schistosoma mansoni	serine/threonine RGC	0.0189	0.2395	0.2395
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0189	0.2395	0.2395
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0361	0.4789	0.4789
Entamoeba histolytica	protein kinase domain containing protein	0.0189	0.2395	0.3222
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0189	0.2395	1
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.055	0.7433	0.7433
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0189	0.2395	0.3222
Trypanosoma cruzi	protein kinase, putative	0.0189	0.2395	1
Loa Loa (eye worm)	hypothetical protein	0.0189	0.2395	0.3222
Entamoeba histolytica	tyrosine kinase, putative	0.0189	0.2395	0.3222
Entamoeba histolytica	protein kinase domain containing protein	0.0189	0.2395	0.3222
Brugia malayi	glutathione reductase	0.005	0.0454	0.061
Entamoeba histolytica	protein kinase domain containing protein	0.0189	0.2395	0.3222
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0189	0.2395	0.3222
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0189	0.2395	0.3222
Loa Loa (eye worm)	TK/FAK protein kinase	0.0189	0.2395	0.3222
Brugia malayi	hypothetical protein	0.0189	0.2395	0.3222
Echinococcus granulosus	peptidase Clp S14 family	0.0055	0.0513	0.0513
Loa Loa (eye worm)	hypothetical protein	0.0361	0.4789	0.6443
Loa Loa (eye worm)	TK/FER protein kinase	0.0189	0.2395	0.3222
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0115	0.1353	0.8342
Echinococcus granulosus	tyrosine protein kinase HCK	0.0189	0.2395	0.2395
Plasmodium vivax	protein kinase, putative	0.0189	0.2395	1
Echinococcus granulosus	growth factor receptor bound protein 2	0.0361	0.4789	0.4789
Loa Loa (eye worm)	TK/Met protein kinase	0.0189	0.2395	0.3222
Trichomonas vaginalis	CAMK family protein kinase	0.0189	0.2395	1
Trichomonas vaginalis	TK family protein kinase	0.0189	0.2395	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Brugia malayi	Protein kinase domain containing protein	0.0189	0.2395	0.3222
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0361	0.4789	0.4789
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.055	0.7433	0.7433
Entamoeba histolytica	tyrosine kinase, putative	0.0189	0.2395	0.3222
Echinococcus granulosus	N chimaerin	0.0361	0.4789	0.4789
Loa Loa (eye worm)	TK/FER protein kinase	0.055	0.7433	1
Schistosoma mansoni	tyrosine kinase	0.0189	0.2395	0.2395
Mycobacterium tuberculosis	Probable oxidoreductase	0.0128	0.1532	1
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0189	0.2395	0.3222
Leishmania major	trypanothione reductase	0.005	0.0454	0.1894
Onchocerca volvulus		0.0189	0.2395	0.3222
Plasmodium vivax	thioredoxin reductase, putative	0.005	0.0454	0.1894
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0189	0.2395	0.2395
Echinococcus granulosus	protein tyrosine kinase	0.0189	0.2395	0.2395
Schistosoma mansoni	tyrosine kinase	0.055	0.7433	0.7433
Brugia malayi	Protein kinase domain containing protein	0.0189	0.2395	0.3222
Loa Loa (eye worm)	hypothetical protein	0.055	0.7433	1
Echinococcus granulosus	SH2 motif	0.0361	0.4789	0.4789
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0189	0.2395	0.3222
Entamoeba histolytica	hypothetical protein	0.0189	0.2395	0.3222
Echinococcus granulosus	NCK adaptor protein	0.0361	0.4789	0.4789
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0189	0.2395	1
Brugia malayi	SH2 domain containing protein	0.055	0.7433	1
Toxoplasma gondii	thioredoxin reductase	0.005	0.0454	0.1894
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0361	0.4789	0.4789
Echinococcus multilocularis	integrin linked protein kinase	0.0189	0.2395	0.2395
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0189	0.2395	0.2395
Echinococcus granulosus	tyrosine protein kinase csk	0.0189	0.2395	0.2395
Brugia malayi	SRC-1	0.055	0.7433	1
Schistosoma mansoni	tyrosine kinase	0.0189	0.2395	0.2395
Echinococcus multilocularis	SHC transforming protein 3	0.0361	0.4789	0.4789
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0189	0.2395	0.2395
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0361	0.4789	0.6443
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0189	0.2395	0.3222
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Loa Loa (eye worm)	TK protein kinase	0.0189	0.2395	0.3222
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0189	0.2395	0.2395
Brugia malayi	Protein kinase domain containing protein	0.0189	0.2395	0.3222
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.055	0.7433	0.7433
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0083	0.0913	0.5
Echinococcus multilocularis	tyrosine kinase	0.055	0.7433	0.7433
Echinococcus multilocularis	tyrosine protein kinase csk	0.0189	0.2395	0.2395
Echinococcus multilocularis	N chimaerin	0.0361	0.4789	0.4789
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0189	0.2395	1
Loa Loa (eye worm)	TK protein kinase	0.0189	0.2395	0.3222
Trypanosoma brucei	Pseudokinase, putative	0.0189	0.2395	1
Schistosoma mansoni	protein kinase	0.0189	0.2395	0.2395
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.055	0.7433	0.7433
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0083	0.0913	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0699	0.1263
Loa Loa (eye worm)	TK/FER protein kinase	0.0189	0.2395	0.3222
Schistosoma mansoni	SH2A	0.0361	0.4789	0.4789
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0361	0.4789	0.6443
Echinococcus granulosus	tyrosine protein kinase ABL1	0.055	0.7433	0.7433
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.055	0.7433	0.7433
Schistosoma mansoni	tyrosine kinase	0.0189	0.2395	0.2395
Echinococcus multilocularis	NCK adaptor protein	0.0361	0.4789	0.4789
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0189	0.2395	0.3222
Schistosoma mansoni	tyrosine kinase	0.055	0.7433	0.7433
Onchocerca volvulus		0.0189	0.2395	0.3222
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Leishmania major	hypothetical protein, conserved	0.0189	0.2395	1
Entamoeba histolytica	protein kinase, putative	0.0189	0.2395	0.3222
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0189	0.2395	0.3222
Schistosoma mansoni	ephrin receptor	0.0189	0.2395	0.2395
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Plasmodium falciparum	protein kinase, putative	0.0189	0.2395	1
Onchocerca volvulus		0.0361	0.4789	0.6443
Schistosoma mansoni	protein kinase	0.0189	0.2395	0.2395
Brugia malayi	Protein kinase domain containing protein	0.0189	0.2395	0.3222
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0189	0.2395	0.3222
Brugia malayi	Protein kinase domain containing protein	0.0189	0.2395	0.3222
Entamoeba histolytica	protein kinase domain containing protein	0.0189	0.2395	0.3222
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Schistosoma mansoni	protein tyrosine kinase	0.0189	0.2395	0.2395
Brugia malayi	SH2 domain containing protein	0.0361	0.4789	0.6443
Schistosoma mansoni	protein kinase	0.0189	0.2395	0.2395
Echinococcus multilocularis	tyrosine protein kinase	0.0189	0.2395	0.2395
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0189	0.2395	0.2395
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0189	0.2395	0.3222
Brugia malayi	Protein kinase domain containing protein	0.055	0.7433	1
Loa Loa (eye worm)	TK/ACK protein kinase	0.0189	0.2395	0.3222
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Entamoeba histolytica	protein kinase domain containing protein	0.0189	0.2395	0.3222
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0189	0.2395	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0189	0.2395	0.2395
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0128	0.1532	1
Schistosoma mansoni	cellular tumor antigen P53	0.0053	0.0486	0.0486
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0361	0.4789	0.4789
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Entamoeba histolytica	tyrosine kinase, putative	0.0189	0.2395	0.3222
Brugia malayi	Protein kinase domain containing protein	0.0189	0.2395	0.3222
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0189	0.2395	0.3222
Leishmania major	cathepsin L-like protease	0.0068	0.0699	0.2917
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0361	0.4789	0.4789
Echinococcus multilocularis	tumor protein p63	0.036	0.477	0.477
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0361	0.4789	0.4789
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0083	0.0913	0.5
Loa Loa (eye worm)	TK/ROR protein kinase	0.0189	0.2395	0.3222
Brugia malayi	ephrin receptor 1 precursor	0.0189	0.2395	0.3222
Loa Loa (eye worm)	hypothetical protein	0.0361	0.4789	0.6443
Entamoeba histolytica	protein kinase domain containing protein	0.0189	0.2395	0.3222
Echinococcus multilocularis	tensin	0.0361	0.4789	0.4789
Entamoeba histolytica	hypothetical protein	0.0189	0.2395	0.3222
Loa Loa (eye worm)	STAT protein	0.0361	0.4789	0.6443
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0189	0.2395	0.3222
Loa Loa (eye worm)	TK protein kinase	0.055	0.7433	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0189	0.2395	1
Entamoeba histolytica	tyrosine kinase, putative	0.0189	0.2395	0.3222
Schistosoma mansoni	protein kinase	0.0189	0.2395	0.2395
Trichomonas vaginalis	conserved hypothetical protein	0.0189	0.2395	1
Schistosoma mansoni	tyrosine kinase	0.0189	0.2395	0.2395
Trichomonas vaginalis	TKL family protein kinase	0.0189	0.2395	1
Onchocerca volvulus		0.055	0.7433	1
Schistosoma mansoni	tyrosine kinase	0.0189	0.2395	0.2395
Echinococcus granulosus	tyrosine kinase	0.055	0.7433	0.7433
Loa Loa (eye worm)	TK/CSK protein kinase	0.0189	0.2395	0.3222
Brugia malayi	Variant SH3 domain containing protein	0.0361	0.4789	0.6443
Entamoeba histolytica	tyrosin kinase, putative	0.0189	0.2395	0.3222
Schistosoma mansoni	tyrosine kinase	0.0189	0.2395	0.2395
Brugia malayi	Protein kinase domain containing protein	0.0189	0.2395	0.3222
Echinococcus granulosus	epidermal growth factor receptor	0.0189	0.2395	0.2395
Trichomonas vaginalis	conserved hypothetical protein	0.0189	0.2395	1
Entamoeba histolytica	tyrosine kinase, putative	0.0189	0.2395	0.3222
Schistosoma mansoni	tyrosine kinase	0.0189	0.2395	0.2395
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.055	0.7433	0.7433
Brugia malayi	Protein kinase domain containing protein	0.0189	0.2395	0.3222
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0699	0.1263

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 3.46 ug ml-1	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7	ChEMBL.	22424611

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23	22424611

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1958281

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1616677