TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 414.319 | Formula: C19H16BrN3OS
H donors: 0 H acceptors: 1 LogP: 4.36 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O=C1CSC(=N1)N1N=C(CC1c1ccc(cc1)C)c1ccc(cc1)Br
InChi: 1S/C19H16BrN3OS/c1-12-2-4-14(5-3-12)17-10-16(13-6-8-15(20)9-7-13)22-23(17)19-21-18(24)11-25-19/h2-9,17H,10-11H2,1H3
InChiKey: UIDCZJGQYLGZEO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	epidermal growth factor receptor	Starlite/ChEMBL	References
Homo sapiens	erb-b2 receptor tyrosine kinase 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	IPR000494,EGF receptor, L domain,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	ko:K05085 receptor tyrosine-protein kinase erbB-4, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-2 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Tyrosine-protein kinase transforming protein erbB, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Loa Loa (eye worm)	TK/EGFR protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis		Get druggable targets OG5_128597	All targets in OG5_128597
Brugia malayi	Furin-like cysteine rich region family protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-4 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	NCK adaptor protein	0.037	0.4614	0.4368
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0208	0.0438	0.5
Loa Loa (eye worm)	hypothetical protein	0.037	0.4614	0.4368
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0208	0.0438	0.0438
Plasmodium falciparum	protein kinase, putative	0.0208	0.0438	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0208	0.0438	0.5
Brugia malayi	Furin-like cysteine rich region family protein	0.0567	0.9692	0.9678
Schistosoma mansoni	tyrosine kinase	0.0208	0.0438	0.0438
Schistosoma mansoni	tyrosine kinase	0.0208	0.0438	0.0438
Echinococcus granulosus	NCK adaptor protein	0.037	0.4614	0.4368
Schistosoma mansoni	SH2A	0.037	0.4614	0.4614
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0208	0.0438	0.0438
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Entamoeba histolytica	SH2 domain containing protein	0.037	0.4614	0.4368
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0208	0.0438	0.5
Plasmodium falciparum	tyrosine kinase-like protein	0.0208	0.0438	0.5
Loa Loa (eye worm)	hypothetical protein	0.037	0.4614	0.4368
Entamoeba histolytica	protein kinase, putative	0.037	0.4614	0.4368
Echinococcus granulosus	hypothetical protein	0.037	0.4614	0.4368
Loa Loa (eye worm)	SH2 domain-containing protein	0.037	0.4614	0.4368
Brugia malayi	Variant SH3 domain containing protein	0.037	0.4614	0.4368
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.037	0.4614	0.4368
Schistosoma mansoni	hypothetical protein	0.0208	0.0438	0.0438
Schistosoma mansoni	protein kinase	0.0208	0.0438	0.0438
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0321	0.3359	0.3055
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0208	0.0438	0.0438
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0208	0.0438	0.5
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.04	0.5386	0.5175
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.037	0.4614	0.4368
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Schistosoma mansoni	protein kinase	0.0208	0.0438	0.0438
Leishmania major	protein kinase, putative	0.0208	0.0438	0.5
Schistosoma mansoni	serine/threonine RGC	0.0208	0.0438	0.0438
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0208	0.0438	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Schistosoma mansoni	protein kinase	0.0208	0.0438	0.0438
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0208	0.0438	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Echinococcus granulosus	signal transduction protein lnk realted	0.037	0.4614	0.4368
Echinococcus granulosus	SH2 motif	0.037	0.4614	0.4368
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.037	0.4614	0.4368
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0208	0.0438	0.0438
Schistosoma mansoni	tyrosine kinase	0.0208	0.0438	0.0438
Echinococcus multilocularis	N chimaerin	0.037	0.4614	0.4368
Loa Loa (eye worm)	hypothetical protein	0.037	0.4614	0.4368
Brugia malayi	SH2 domain containing protein	0.037	0.4614	0.4368
Loa Loa (eye worm)	hypothetical protein	0.037	0.4614	0.4368
Schistosoma mansoni	shc transforming protein	0.037	0.4614	0.4614
Schistosoma mansoni	tyrosine kinase	0.0208	0.0438	0.0438
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.037	0.4614	0.4368
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Entamoeba histolytica	hypothetical protein	0.0217	0.0664	0.0237
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0208	0.0438	0.5
Schistosoma mansoni	GTPase activating protein	0.037	0.4614	0.4614
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Schistosoma mansoni	hypothetical protein	0.037	0.4614	0.4614
Schistosoma mansoni	protein kinase	0.0208	0.0438	0.0438
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Schistosoma mansoni	protein tyrosine kinase	0.0208	0.0438	0.0438
Schistosoma mansoni	signal transduction protein lnk-related	0.037	0.4614	0.4614
Brugia malayi	Variant SH3 domain containing protein	0.037	0.4614	0.4368
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.037	0.4614	0.4614
Leishmania major	protein kinase, putative	0.0208	0.0438	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Schistosoma mansoni	tyrosine kinase	0.0208	0.0438	0.0438
Plasmodium falciparum	protein kinase, putative	0.0208	0.0438	0.5
Echinococcus granulosus	tensin	0.037	0.4614	0.4368
Giardia lamblia	Kinase, NEK	0.0208	0.0438	0.5
Schistosoma mansoni	protein kinase	0.0208	0.0438	0.0438
Loa Loa (eye worm)	hypothetical protein	0.037	0.4614	0.4368
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.037	0.4614	0.4614
Trichomonas vaginalis	STE family protein kinase	0.0208	0.0438	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Echinococcus granulosus	SHC transforming protein 3	0.037	0.4614	0.4368
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.037	0.4614	0.4368
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0208	0.0438	0.5
Plasmodium falciparum	protein kinase, putative	0.0208	0.0438	0.5
Echinococcus multilocularis	tensin	0.037	0.4614	0.4368
Schistosoma mansoni	tyrosine kinase	0.0208	0.0438	0.0438
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Schistosoma mansoni	tyrosine kinase	0.04	0.5386	0.5386
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0567	0.9692	0.9678
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0208	0.0438	0.5
Echinococcus multilocularis	SH2 motif	0.037	0.4614	0.4368
Echinococcus granulosus	insulin receptor	0.0321	0.3359	0.3055
Brugia malayi	SH2 domain containing protein	0.037	0.4614	0.4368
Trichomonas vaginalis	conserved hypothetical protein	0.0208	0.0438	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Schistosoma mansoni	protein kinase	0.0208	0.0438	0.0438
Echinococcus granulosus	expressed conserved protein	0.037	0.4614	0.4368
Brugia malayi	hypothetical protein	0.037	0.4614	0.4368
Echinococcus granulosus	suppressor of cytokine signaling 6	0.037	0.4614	0.4368
Leishmania major	hypothetical protein, conserved	0.0208	0.0438	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0208	0.0438	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Brugia malayi	Sex muscle abnormal protein 5	0.037	0.4614	0.4368
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Echinococcus multilocularis	SHC transforming protein 3	0.037	0.4614	0.4368
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0208	0.0438	0.5
Schistosoma mansoni	tensin	0.037	0.4614	0.4614
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Echinococcus granulosus	SH2 motif	0.037	0.4614	0.4368
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.037	0.4614	0.4368
Schistosoma mansoni	nck2/grb4	0.037	0.4614	0.4614
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Schistosoma mansoni	tyrosine kinase	0.0208	0.0438	0.0438
Toxoplasma gondii	protein kinase domain-containing protein	0.0208	0.0438	0.5
Brugia malayi	Variant SH3 domain containing protein	0.037	0.4614	0.4368
Echinococcus multilocularis	epidermal growth factor receptor	0.0567	0.9692	0.9678
Brugia malayi	SH2 domain containing protein	0.037	0.4614	0.4368
Echinococcus multilocularis	SH2 motif	0.037	0.4614	0.4368
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Trichomonas vaginalis	protein kinase atn1, putative	0.0208	0.0438	0.5
Schistosoma mansoni	hypothetical protein	0.037	0.4614	0.4614
Schistosoma mansoni	serine/threonine protein kinase	0.0208	0.0438	0.0438
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.037	0.4614	0.4368
Brugia malayi	RhoGAP domain containing protein	0.037	0.4614	0.4368
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Loa Loa (eye worm)	hypothetical protein	0.037	0.4614	0.4368
Trypanosoma cruzi	protein kinase, putative	0.0208	0.0438	0.5
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.037	0.4614	0.4368
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Schistosoma mansoni	protein kinase	0.0208	0.0438	0.0438
Brugia malayi	tRNA modification GTPase TrmE family protein	0.037	0.4614	0.4368
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Schistosoma mansoni	growth factor receptor-bound protein	0.037	0.4614	0.4614
Schistosoma mansoni	ephrin receptor	0.0208	0.0438	0.0438
Echinococcus multilocularis		0.037	0.4614	0.4368
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Echinococcus granulosus	N chimaerin	0.037	0.4614	0.4368
Schistosoma mansoni	tensin-related	0.037	0.4614	0.4614
Echinococcus granulosus	growth factor receptor bound protein 2	0.037	0.4614	0.4368
Schistosoma mansoni	protein kinase	0.0208	0.0438	0.0438
Schistosoma mansoni	tyrosine kinase	0.0208	0.0438	0.0438
Brugia malayi	STAT protein, DNA binding domain containing protein	0.037	0.4614	0.4368
Schistosoma mansoni	tyrosine kinase	0.0208	0.0438	0.0438
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0208	0.0438	0.5
Echinococcus multilocularis	tensin	0.037	0.4614	0.4368
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.037	0.4614	0.4368
Brugia malayi	cytokine inducible SH2-containing protein 5	0.037	0.4614	0.4368
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.037	0.4614	0.4368
Trypanosoma brucei	Pseudokinase, putative	0.0208	0.0438	0.5
Echinococcus multilocularis	SH2 domain containing protein 7	0.037	0.4614	0.4368
Brugia malayi	SH2 domain containing protein	0.037	0.4614	0.4368
Echinococcus granulosus	tyrosine protein kinase Src42A	0.037	0.4614	0.4368
Brugia malayi	SH2 domain containing protein	0.037	0.4614	0.4368
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0217	0.0664	0.0237
Schistosoma mansoni	tyrosine kinase	0.0208	0.0438	0.0438
Schistosoma mansoni	tensin	0.037	0.4614	0.4614
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.037	0.4614	0.4368
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.037	0.4614	0.4368
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0208	0.0438	0.0438
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.037	0.4614	0.4368
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0208	0.0438	0.0438
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.037	0.4614	0.4368
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.037	0.4614	0.4368
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Schistosoma mansoni	tyrosine kinase	0.04	0.5386	0.5386
Echinococcus multilocularis	epidermal growth factor receptor	0.04	0.5386	0.5175
Schistosoma mansoni	tyrosine kinase	0.0321	0.3359	0.3359
Entamoeba histolytica	hypothetical protein	0.0217	0.0664	0.0237
Toxoplasma gondii	protein kinase	0.0208	0.0438	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0208	0.0438	0.5
Schistosoma mansoni	tyrosine protein kinase	0.0208	0.0438	0.0438
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Schistosoma mansoni	tyrosine kinase	0.0321	0.3359	0.3359
Schistosoma mansoni	tyrosine kinase	0.0208	0.0438	0.0438
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.037	0.4614	0.4368
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.037	0.4614	0.4368
Schistosoma mansoni	ephrin receptor	0.0208	0.0438	0.0438
Schistosoma mansoni	growth factor receptor-bound protein	0.037	0.4614	0.4614
Loa Loa (eye worm)	SH2 domain-containing protein	0.037	0.4614	0.4368
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Brugia malayi	Variant SH3 domain containing protein	0.037	0.4614	0.4368
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Brugia malayi	Protein kinase domain containing protein	0.0321	0.3359	0.3055
Giardia lamblia	Kinase	0.0208	0.0438	0.5
Onchocerca volvulus		0.037	0.4614	0.4368
Schistosoma mansoni	tensin-related	0.037	0.4614	0.4614
Schistosoma mansoni	tyrosine kinase	0.0208	0.0438	0.0438
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0208	0.0438	0.5
Onchocerca volvulus		0.037	0.4614	0.4368
Loa Loa (eye worm)	STAT protein	0.037	0.4614	0.4368
Loa Loa (eye worm)	hypothetical protein	0.037	0.4614	0.4368
Schistosoma mansoni	suppressor of cytokine signaling	0.037	0.4614	0.4614
Echinococcus granulosus	SH2 domain containing protein 7	0.037	0.4614	0.4368
Schistosoma mansoni	suppressor of cytokine signaling	0.037	0.4614	0.4614
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.037	0.4614	0.4614
Schistosoma mansoni	tyrosine kinase	0.0208	0.0438	0.0438
Entamoeba histolytica	protein kinase, putative	0.0217	0.0664	0.0237
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Echinococcus multilocularis	growth factor receptor bound protein 2	0.037	0.4614	0.4368
Loa Loa (eye worm)	hypothetical protein	0.037	0.4614	0.4368
Onchocerca volvulus		0.037	0.4614	0.4368
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Trypanosoma cruzi	protein kinase, putative	0.0208	0.0438	0.5
Loa Loa (eye worm)	hypothetical protein	0.037	0.4614	0.4368
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0321	0.3359	0.3055
Brugia malayi	SH2 domain containing protein	0.037	0.4614	0.4368
Schistosoma mansoni	tyrosine kinase	0.0208	0.0438	0.0438
Echinococcus multilocularis	signal transduction protein lnk realted	0.037	0.4614	0.4368
Schistosoma mansoni	serine/threonine protein kinase	0.0208	0.0438	0.0438
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Schistosoma mansoni	vav2	0.037	0.4614	0.4614
Echinococcus multilocularis	SH2 motif	0.037	0.4614	0.4368
Giardia lamblia	Protein 21.1	0.0208	0.0438	0.5
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0208	0.0438	0.5
Schistosoma mansoni	protein kinase	0.0208	0.0438	0.0438
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.037	0.4614	0.4368
Loa Loa (eye worm)	hypothetical protein	0.037	0.4614	0.4368
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.037	0.4614	0.4368
Echinococcus granulosus	epidermal growth factor receptor	0.04	0.5386	0.5175
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Onchocerca volvulus		0.037	0.4614	0.4368
Schistosoma mansoni	tyrosine kinase	0.0208	0.0438	0.0438
Echinococcus granulosus	SH2 domain containing adapter protein F	0.037	0.4614	0.4368
Schistosoma mansoni	tensin	0.037	0.4614	0.4614
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Schistosoma mansoni	protein kinase	0.0208	0.0438	0.0438
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.037	0.4614	0.4614
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Schistosoma mansoni	protein kinase	0.0208	0.0438	0.0438
Entamoeba histolytica	hypothetical protein	0.0217	0.0664	0.0237
Schistosoma mansoni	tyrosine kinase	0.0208	0.0438	0.0438
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.037	0.4614	0.4368
Echinococcus granulosus	epidermal growth factor receptor	0.0567	0.9692	0.9678
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.037	0.4614	0.4368
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.037	0.4614	0.4368
Onchocerca volvulus		0.037	0.4614	0.4368
Schistosoma mansoni	tyrosine kinase	0.0208	0.0438	0.0438
Echinococcus granulosus	suppressor of cytokine signaling 7	0.037	0.4614	0.4368
Giardia lamblia	Kinase, NEK	0.0208	0.0438	0.5
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0208	0.0438	0.5
Schistosoma mansoni	tyrosine kinase	0.0567	0.9692	0.9692
Schistosoma mansoni	tyrosine kinase	0.0208	0.0438	0.0438
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0208	0.0438	0.0438
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0208	0.0438	0.5
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.037	0.4614	0.4368
Brugia malayi	Tensin	0.037	0.4614	0.4368
Plasmodium falciparum	tyrosine kinase-like protein	0.0208	0.0438	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.037	0.4614	0.4368
Echinococcus multilocularis	insulin receptor	0.0321	0.3359	0.3055
Trichomonas vaginalis	CAMK family protein kinase	0.0208	0.0438	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0208	0.0438	0.5
Loa Loa (eye worm)	hypothetical protein	0.037	0.4614	0.4368
Loa Loa (eye worm)	hypothetical protein	0.037	0.4614	0.4368
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Schistosoma mansoni	adapter molecule crk	0.037	0.4614	0.4614
Brugia malayi	SH2 domain containing protein	0.037	0.4614	0.4368
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0208	0.0438	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0208	0.0438	0.0438
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Trichomonas vaginalis	TK family protein kinase	0.0208	0.0438	0.5
Plasmodium vivax	protein kinase, putative	0.0208	0.0438	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0208	0.0438	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0208	0.0438	0.5
Loa Loa (eye worm)	TK/INSR protein kinase	0.0321	0.3359	0.3055
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Schistosoma mansoni	tyrosine kinase	0.0208	0.0438	0.0438
Onchocerca volvulus		0.037	0.4614	0.4368
Loa Loa (eye worm)	hypothetical protein	0.037	0.4614	0.4368
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0208	0.0438	0.5
Schistosoma mansoni	tyrosine kinase	0.0208	0.0438	0.0438
Trypanosoma brucei	protein kinase, putative	0.0208	0.0438	0.5
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.037	0.4614	0.4614
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0208	0.0438	0.5
Loa Loa (eye worm)	hypothetical protein	0.037	0.4614	0.4368
Loa Loa (eye worm)	SH2 domain-containing protein	0.037	0.4614	0.4368
Toxoplasma gondii	STE kinase	0.0208	0.0438	0.5
Loa Loa (eye worm)	hypothetical protein	0.037	0.4614	0.4368

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 5.58 uM	Inhibition of histidine-tagged human recombinant cytoplasmic domain of EGFR expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/time-resolved fluorometric analysis	ChEMBL.	22361272
IC50 (binding)	= 7.04 uM	Inhibition of histidine-tagged human recombinant cytoplasmic domain of HER2 expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/time-resolved fluorometric analysis	ChEMBL.	22361272

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1958210

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1616679