TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 364.439 | Formula: C16H16N2O4S2
H donors: 2 H acceptors: 4 LogP: 2.11 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: ONC(=O)[C@@H]1CSCN1S(=O)(=O)c1ccc(cc1)c1ccccc1
InChi: 1S/C16H16N2O4S2/c19-16(17-20)15-10-23-11-18(15)24(21,22)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9,15,20H,10-11H2,(H,17,19)/t15-/m0/s1
InChiKey: UNRBDNFPHSIAEP-HNNXBMFYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	Starlite/ChEMBL	References
Homo sapiens	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1792	0.1792
Brugia malayi	Variant SH3 domain containing protein	0.013	0.5556	0.5556
Brugia malayi	Hemopexin family protein	0.006	0.1109	0.1109
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.013	0.5556	0.4585
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.013	0.5556	0.5556
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0074	0.1989	0.024
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0071	0.1792	0.5
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1792	0.1792
Loa Loa (eye worm)	hypothetical protein	0.013	0.5556	0.5556
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.013	0.5556	0.4585
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.1983	0.1983
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1792	0.1792
Echinococcus granulosus	SH2 motif	0.013	0.5556	0.4585
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0071	0.1792	0.1792
Schistosoma mansoni	tyrosine kinase	0.0071	0.1792	0.1792
Entamoeba histolytica	protein kinase, putative	0.013	0.5556	0.4585
Schistosoma mansoni	SH2A	0.013	0.5556	0.5556
Mycobacterium leprae	PROBABLE HYDROLASE	0.0051	0.0578	0.5
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.013	0.5556	0.4585
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1792	0.1792
Schistosoma mansoni	serine/threonine protein kinase	0.0071	0.1792	0.1792
Schistosoma mansoni	tyrosine kinase	0.0071	0.1792	0.1792
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0071	0.1792	0.5
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.013	0.5556	0.5556
Plasmodium falciparum	tyrosine kinase-like protein	0.0071	0.1792	0.5
Brugia malayi	C-terminal src kinase protein 1	0.0071	0.1792	0.1792
Brugia malayi	RNA binding protein	0.0074	0.1983	0.1983
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0071	0.1792	0.1792
Schistosoma mansoni	tyrosine kinase	0.0071	0.1792	0.1792
Brugia malayi	SH2 domain containing protein	0.013	0.5556	0.5556
Giardia lamblia	Protein 21.1	0.0071	0.1792	0.5
Schistosoma mansoni	tyrosine kinase	0.0071	0.1792	0.1792
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1792	0.1792
Echinococcus multilocularis		0.013	0.5556	0.4585
Loa Loa (eye worm)	hypothetical protein	0.013	0.5556	0.5556
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0071	0.1792	0.1792
Echinococcus granulosus	growth factor receptor bound protein 2	0.013	0.5556	0.4585
Loa Loa (eye worm)	SH2 domain-containing protein	0.013	0.5556	0.5556
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1792	0.1792
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0058	0.0995	0.0995
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Entamoeba histolytica	protein kinase, putative	0.0074	0.1989	0.024
Schistosoma mansoni	protein kinase	0.0071	0.1792	0.1792
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0071	0.1792	0.1792
Schistosoma mansoni	tyrosine kinase	0.0071	0.1792	0.1792
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1792	0.1792
Schistosoma mansoni	serine/threonine RGC	0.0071	0.1792	0.1792
Brugia malayi	Tyrosine-protein kinase PR2	0.0071	0.1792	0.1792
Loa Loa (eye worm)	TAR-binding protein	0.0074	0.1983	0.1983
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1792	0.1792
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0071	0.1792	0.1792
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.1792	0.5
Brugia malayi	SH2 domain containing protein	0.013	0.5556	0.5556
Loa Loa (eye worm)	matrixin family protein	0.0093	0.3231	0.3231
Loa Loa (eye worm)	TK protein kinase	0.0071	0.1792	0.1792
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0071	0.1792	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Schistosoma mansoni	protein kinase	0.0071	0.1792	0.1792
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1792	0.1792
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1792	0.1792
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.1792	0.5
Echinococcus multilocularis	growth factor receptor bound protein 2	0.013	0.5556	0.4585
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1792	0.1792
Schistosoma mansoni	signal transduction protein lnk-related	0.013	0.5556	0.5556
Brugia malayi	ephrin receptor 1 precursor	0.0071	0.1792	0.1792
Echinococcus multilocularis	tensin	0.013	0.5556	0.4585
Schistosoma mansoni	protein kinase	0.0071	0.1792	0.1792
Schistosoma mansoni	serine/threonine protein kinase	0.0071	0.1792	0.1792
Onchocerca volvulus		0.0071	0.1792	0.1792
Echinococcus granulosus	SHC transforming protein 3	0.013	0.5556	0.4585
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Brugia malayi	STAT protein, DNA binding domain containing protein	0.013	0.5556	0.5556
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.1983	0.1983
Brugia malayi	TAR-binding protein	0.0074	0.1983	0.1983
Loa Loa (eye worm)	TK/Met protein kinase	0.0071	0.1792	0.1792
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0071	0.1792	0.1792
Trypanosoma cruzi	protein kinase, putative	0.0071	0.1792	0.5
Schistosoma mansoni	tyrosine kinase	0.0071	0.1792	0.1792
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Loa Loa (eye worm)	TK protein kinase	0.0071	0.1792	0.1792
Trichomonas vaginalis	CAMK family protein kinase	0.0071	0.1792	0.5
Schistosoma mansoni	protein kinase	0.0071	0.1792	0.1792
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.1983	0.1983
Schistosoma mansoni	tyrosine kinase	0.0071	0.1792	0.1792
Loa Loa (eye worm)	TK protein kinase	0.0071	0.1792	0.1792
Toxoplasma gondii	protein kinase domain-containing protein	0.0071	0.1792	0.5
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0071	0.1792	0.1792
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.013	0.5556	0.4585
Loa Loa (eye worm)	TK/FER protein kinase	0.0071	0.1792	0.1792
Loa Loa (eye worm)	TK protein kinase	0.0071	0.1792	0.1792
Echinococcus multilocularis	N chimaerin	0.013	0.5556	0.4585
Schistosoma mansoni	ephrin receptor	0.0071	0.1792	0.1792
Schistosoma mansoni	nck2/grb4	0.013	0.5556	0.5556
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0071	0.1792	0.1792
Onchocerca volvulus		0.013	0.5556	0.5556
Echinococcus granulosus	tensin	0.013	0.5556	0.4585
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Loa Loa (eye worm)	hypothetical protein	0.013	0.5556	0.5556
Loa Loa (eye worm)	hypothetical protein	0.013	0.5556	0.5556
Loa Loa (eye worm)	hypothetical protein	0.013	0.5556	0.5556
Brugia malayi	Sex muscle abnormal protein 5	0.013	0.5556	0.5556
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1792	0.1792
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0074	0.1983	0.1983
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1792	0.1792
Brugia malayi	Raf kinase	0.0071	0.1792	0.1792
Echinococcus granulosus	SH2 domain containing adapter protein F	0.013	0.5556	0.4585
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0071	0.1792	0.5
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1792	0.1792
Onchocerca volvulus		0.013	0.5556	0.5556
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.013	0.5556	0.4585
Schistosoma mansoni	tyrosine kinase	0.0071	0.1792	0.1792
Onchocerca volvulus		0.0071	0.1792	0.1792
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.1983	0.1983
Echinococcus granulosus	tar DNA binding protein	0.0074	0.1983	0.0232
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0071	0.1792	0.1792
Entamoeba histolytica	SH2 domain containing protein	0.013	0.5556	0.4585
Onchocerca volvulus		0.013	0.5556	0.5556
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.1792	0.5
Loa Loa (eye worm)	TK/RYK protein kinase	0.0071	0.1792	0.1792
Schistosoma mansoni	protein kinase	0.0071	0.1792	0.1792
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0071	0.1792	0.1792
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Schistosoma mansoni	tensin-related	0.013	0.5556	0.5556
Schistosoma mansoni	tyrosine kinase	0.0071	0.1792	0.1792
Schistosoma mansoni	tyrosine kinase	0.0071	0.1792	0.1792
Schistosoma mansoni	ephrin receptor	0.0071	0.1792	0.1792
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Loa Loa (eye worm)	TK/INSR protein kinase	0.0071	0.1792	0.1792
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.013	0.5556	0.4585
Brugia malayi	RhoGAP domain containing protein	0.013	0.5556	0.5556
Loa Loa (eye worm)	TK/FER protein kinase	0.0071	0.1792	0.1792
Echinococcus granulosus	N chimaerin	0.013	0.5556	0.4585
Schistosoma mansoni	tyrosine kinase	0.0071	0.1792	0.1792
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Schistosoma mansoni	hypothetical protein	0.006	0.1109	0.1109
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0071	0.1792	0.1792
Brugia malayi	Receptor family ligand binding region containing protein	0.0071	0.1792	0.1792
Brugia malayi	Variant SH3 domain containing protein	0.013	0.5556	0.5556
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0071	0.1792	0.1792
Onchocerca volvulus		0.013	0.5556	0.5556
Brugia malayi	SH2 domain containing protein	0.013	0.5556	0.5556
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0071	0.1792	0.1792
Entamoeba histolytica	hypothetical protein	0.0074	0.1989	0.024
Giardia lamblia	Kinase	0.0071	0.1792	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Trypanosoma cruzi	protein kinase, putative	0.0071	0.1792	0.5
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.013	0.5556	0.4585
Onchocerca volvulus		0.013	0.5556	0.5556
Onchocerca volvulus		0.013	0.5556	0.5556
Plasmodium falciparum	tyrosine kinase-like protein	0.0071	0.1792	0.5
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1792	0.1792
Brugia malayi	SH2 domain containing protein	0.013	0.5556	0.5556
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.013	0.5556	0.5556
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.1792	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Loa Loa (eye worm)	TK/FAK protein kinase	0.0071	0.1792	0.1792
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1792	0.1792
Toxoplasma gondii	STE kinase	0.0071	0.1792	0.5
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0071	0.1792	0.1792
Loa Loa (eye worm)	TK/CSK protein kinase	0.0071	0.1792	0.1792
Schistosoma mansoni	tensin	0.013	0.5556	0.5556
Schistosoma mansoni	protein kinase	0.0071	0.1792	0.1792
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Loa Loa (eye worm)	hypothetical protein	0.013	0.5556	0.5556
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.013	0.5556	0.4585
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1792	0.1792
Plasmodium vivax	protein kinase, putative	0.0071	0.1792	0.5
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0071	0.1792	0.1792
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1792	0.1792
Schistosoma mansoni	matrix metallopeptidase-9 (M10 family)	0.01	0.3647	0.3647
Brugia malayi	Furin-like cysteine rich region family protein	0.0071	0.1792	0.1792
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0071	0.1792	0.1792
Loa Loa (eye worm)	TK protein kinase	0.0071	0.1792	0.1792
Loa Loa (eye worm)	TK/ROR protein kinase	0.0071	0.1792	0.1792
Loa Loa (eye worm)	RNA binding protein	0.0074	0.1983	0.1983
Loa Loa (eye worm)	TK/FER protein kinase	0.0071	0.1792	0.1792
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0071	0.1792	0.5
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0071	0.1792	0.5
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.013	0.5556	0.5556
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.013	0.5556	0.4585
Loa Loa (eye worm)	hypothetical protein	0.013	0.5556	0.5556
Schistosoma mansoni	tensin-related	0.013	0.5556	0.5556
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.013	0.5556	0.5556
Schistosoma mansoni	tensin	0.013	0.5556	0.5556
Loa Loa (eye worm)	serine/threonine protein kinase	0.0071	0.1792	0.1792
Schistosoma mansoni	tyrosine kinase	0.0071	0.1792	0.1792
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0071	0.1792	0.1792
Loa Loa (eye worm)	hypothetical protein	0.013	0.5556	0.5556
Loa Loa (eye worm)	TK/FER protein kinase	0.0071	0.1792	0.1792
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Schistosoma mansoni	tyrosine kinase	0.0071	0.1792	0.1792
Loa Loa (eye worm)	TK protein kinase	0.0071	0.1792	0.1792
Plasmodium falciparum	protein kinase, putative	0.0071	0.1792	0.5
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0071	0.1792	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Schistosoma mansoni	vav2	0.013	0.5556	0.5556
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0071	0.1792	0.1792
Loa Loa (eye worm)	SH2 domain-containing protein	0.013	0.5556	0.5556
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Schistosoma mansoni	protein kinase	0.0071	0.1792	0.1792
Loa Loa (eye worm)	TK/EPH protein kinase	0.0071	0.1792	0.1792
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.013	0.5556	0.5556
Brugia malayi	Tensin	0.013	0.5556	0.5556
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1792	0.1792
Schistosoma mansoni	tyrosine kinase	0.0071	0.1792	0.1792
Echinococcus granulosus	suppressor of cytokine signaling 7	0.013	0.5556	0.4585
Brugia malayi	cytokine inducible SH2-containing protein 5	0.013	0.5556	0.5556
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Schistosoma mansoni	tyrosine kinase	0.0071	0.1792	0.1792
Plasmodium falciparum	protein kinase, putative	0.0071	0.1792	0.5
Brugia malayi	Guanylyl cyclase protein 23	0.0071	0.1792	0.1792
Schistosoma mansoni	tyrosine kinase	0.0071	0.1792	0.1792
Loa Loa (eye worm)	TK protein kinase	0.0071	0.1792	0.1792
Loa Loa (eye worm)	hypothetical protein	0.013	0.5556	0.5556
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0071	0.1792	0.1792
Schistosoma mansoni	tyrosine kinase	0.0071	0.1792	0.1792
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0071	0.1792	0.1792
Schistosoma mansoni	tyrosine kinase	0.0071	0.1792	0.1792
Onchocerca volvulus		0.006	0.1109	0.1109
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.1983	0.1983
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.1792	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Brugia malayi	Variant SH3 domain containing protein	0.013	0.5556	0.5556
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1792	0.1792
Onchocerca volvulus	Matrilysin homolog	0.0093	0.3231	0.3231
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1792	0.1792
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0071	0.1792	0.1792
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Loa Loa (eye worm)	SH2 domain-containing protein	0.013	0.5556	0.5556
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.1792	0.5
Schistosoma mansoni	tyrosine kinase	0.0071	0.1792	0.1792
Echinococcus granulosus	tyrosine protein kinase Src42A	0.013	0.5556	0.4585
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.013	0.5556	0.5556
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1792	0.1792
Loa Loa (eye worm)	TK/ALK protein kinase	0.0071	0.1792	0.1792
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0071	0.1792	0.1792
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1792	0.1792
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Giardia lamblia	Kinase, NEK	0.0071	0.1792	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.013	0.5556	0.5556
Schistosoma mansoni	tyrosine kinase	0.0071	0.1792	0.1792
Loa Loa (eye worm)	hypothetical protein	0.013	0.5556	0.5556
Onchocerca volvulus		0.0071	0.1792	0.1792
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Loa Loa (eye worm)	hypothetical protein	0.013	0.5556	0.5556
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Loa Loa (eye worm)	TK/ACK protein kinase	0.0071	0.1792	0.1792
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0578	0.0578
Schistosoma mansoni	suppressor of cytokine signaling	0.013	0.5556	0.5556
Echinococcus multilocularis	SHC transforming protein 3	0.013	0.5556	0.4585
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.013	0.5556	0.4585
Schistosoma mansoni	growth factor receptor-bound protein	0.013	0.5556	0.5556
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.013	0.5556	0.4585
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Brugia malayi	hypothetical protein	0.013	0.5556	0.5556
Trypanosoma brucei	Pseudokinase, putative	0.0071	0.1792	0.5
Schistosoma mansoni	GTPase activating protein	0.013	0.5556	0.5556
Brugia malayi	Variant SH3 domain containing protein	0.013	0.5556	0.5556
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Echinococcus multilocularis	NCK adaptor protein	0.013	0.5556	0.4585
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Schistosoma mansoni	suppressor of cytokine signaling	0.013	0.5556	0.5556
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Entamoeba histolytica	hypothetical protein	0.0074	0.1989	0.024
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1792	0.1792
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0071	0.1792	0.1792
Schistosoma mansoni	protein kinase	0.0071	0.1792	0.1792
Schistosoma mansoni	hypothetical protein	0.0071	0.1792	0.1792
Echinococcus granulosus	expressed conserved protein	0.013	0.5556	0.4585
Echinococcus granulosus	NCK adaptor protein	0.013	0.5556	0.4585
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Trichomonas vaginalis	protein kinase atn1, putative	0.0071	0.1792	0.5
Brugia malayi	hypothetical protein	0.0071	0.1792	0.1792
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Giardia lamblia	Kinase, NEK	0.0071	0.1792	0.5
Loa Loa (eye worm)	TK protein kinase	0.0071	0.1792	0.1792
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Onchocerca volvulus		0.0071	0.1792	0.1792
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0071	0.1792	0.5
Leishmania major	protein kinase, putative	0.0071	0.1792	0.5
Loa Loa (eye worm)	hypothetical protein	0.013	0.5556	0.5556
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.013	0.5556	0.4585
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Onchocerca volvulus		0.0071	0.1792	0.1792
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1792	0.1792
Toxoplasma gondii	protein kinase	0.0071	0.1792	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.1792	0.5
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.013	0.5556	0.4585
Schistosoma mansoni	tyrosine kinase	0.0071	0.1792	0.1792
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Loa Loa (eye worm)	hypothetical protein	0.013	0.5556	0.5556
Echinococcus multilocularis	SH2 motif	0.013	0.5556	0.4585
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0071	0.1792	0.1792
Onchocerca volvulus		0.0071	0.1792	0.1792
Schistosoma mansoni	tyrosine protein kinase	0.0071	0.1792	0.1792
Schistosoma mansoni	protein kinase	0.0071	0.1792	0.1792
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0071	0.1792	0.1792
Schistosoma mansoni	tyrosine kinase	0.0071	0.1792	0.1792
Schistosoma mansoni	protein kinase	0.0071	0.1792	0.1792
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Brugia malayi	SH2 domain containing protein	0.013	0.5556	0.5556
Trichomonas vaginalis	TK family protein kinase	0.0071	0.1792	0.5
Trichomonas vaginalis	STE family protein kinase	0.0071	0.1792	0.5
Echinococcus granulosus	SH2 domain containing protein 7	0.013	0.5556	0.4585
Schistosoma mansoni	tyrosine kinase	0.0071	0.1792	0.1792
Echinococcus multilocularis	SH2 domain containing protein 7	0.013	0.5556	0.4585
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0071	0.1792	0.1792
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1792	0.1792
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Brugia malayi	tRNA modification GTPase TrmE family protein	0.013	0.5556	0.5556
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Schistosoma mansoni	tyrosine kinase	0.0071	0.1792	0.1792
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1792	0.1792
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.013	0.5556	0.5556
Echinococcus multilocularis	tensin	0.013	0.5556	0.4585
Onchocerca volvulus	Tyrosine kinase homolog	0.0071	0.1792	0.1792
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.013	0.5556	0.5556
Loa Loa (eye worm)	hypothetical protein	0.013	0.5556	0.5556
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0071	0.1792	0.1792
Trypanosoma brucei	protein kinase, putative	0.0071	0.1792	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0071	0.1792	0.1792
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1792	0.1792
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.013	0.5556	0.5556
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1792	0.1792
Loa Loa (eye worm)	TK protein kinase	0.0071	0.1792	0.1792
Brugia malayi	Matrix metalloprotease, N-terminal domain containing protein	0.0051	0.0578	0.0578
Echinococcus granulosus	hypothetical protein	0.013	0.5556	0.4585
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0071	0.1792	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Schistosoma mansoni	hypothetical protein	0.013	0.5556	0.5556
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Loa Loa (eye worm)	hypothetical protein	0.013	0.5556	0.5556
Onchocerca volvulus	Matrix metalloproteinase homolog	0.0093	0.3231	0.3231
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1792	0.1792
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1792	0.1792
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Echinococcus multilocularis	matrix metallopeptidase 7 (M10 family)	0.0153	0.6992	0.6335
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1792	0.1792
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.013	0.5556	0.4585
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.013	0.5556	0.5556
Echinococcus multilocularis	SH2 motif	0.013	0.5556	0.4585
Brugia malayi	RNA recognition motif domain containing protein	0.0074	0.1983	0.1983
Echinococcus multilocularis	tar DNA binding protein	0.0074	0.1983	0.0232
Loa Loa (eye worm)	matrixin family protein	0.0102	0.3761	0.3761
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0071	0.1792	0.1792
Brugia malayi	Matrixin family protein	0.0102	0.3761	0.3761
Mycobacterium tuberculosis	Probable peptidoglycan hydrolase	0.0051	0.0578	0.5
Schistosoma mansoni	tyrosine kinase	0.0071	0.1792	0.1792
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.013	0.5556	0.4585
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0071	0.1792	0.5
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1792	0.1792
Brugia malayi	SH2 domain containing protein	0.013	0.5556	0.5556
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Plasmodium falciparum	protein kinase, putative	0.0071	0.1792	0.5
Brugia malayi	hypothetical protein	0.0071	0.1792	0.1792
Loa Loa (eye worm)	TK/FER protein kinase	0.0071	0.1792	0.1792
Leishmania major	hypothetical protein, conserved	0.0071	0.1792	0.5
Echinococcus multilocularis	signal transduction protein lnk realted	0.013	0.5556	0.4585
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Schistosoma mansoni	hypothetical protein	0.013	0.5556	0.5556
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0071	0.1792	0.5
Brugia malayi	SH2 domain containing protein	0.013	0.5556	0.5556
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.1792	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0071	0.1792	0.5
Onchocerca volvulus		0.0071	0.1792	0.1792
Brugia malayi	integrin-linked kinase	0.0071	0.1792	0.1792
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0071	0.1792	0.5
Echinococcus granulosus	signal transduction protein lnk realted	0.013	0.5556	0.4585
Leishmania major	protein kinase, putative	0.0071	0.1792	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0071	0.1792	0.1792
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0058	0.0995	0.0995
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.013	0.5556	0.5556
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0995	0.0995
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0071	0.1792	0.1792
Schistosoma mansoni	shc transforming protein	0.013	0.5556	0.5556
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1792	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0071	0.1792	0.1792
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0058	0.0995	0.0995
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0071	0.1792	0.1792
Schistosoma mansoni	tensin	0.013	0.5556	0.5556
Echinococcus granulosus	suppressor of cytokine signaling 6	0.013	0.5556	0.4585
Onchocerca volvulus		0.0071	0.1792	0.1792
Onchocerca volvulus		0.0071	0.1792	0.1792
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.013	0.5556	0.5556
Schistosoma mansoni	protein kinase	0.0071	0.1792	0.1792
Mycobacterium ulcerans	hydrolase	0.0051	0.0578	0.5
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1792	0.1792
Schistosoma mansoni	adapter molecule crk	0.013	0.5556	0.5556
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1792	0.1792
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1792	0.1792
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0071	0.1792	0.5
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0071	0.1792	0.1792
Schistosoma mansoni	growth factor receptor-bound protein	0.013	0.5556	0.5556
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1792	0.1792
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0071	0.1792	0.1792
Schistosoma mansoni	protein tyrosine kinase	0.0071	0.1792	0.1792
Echinococcus granulosus	SH2 motif	0.013	0.5556	0.4585
Loa Loa (eye worm)	TK/DDR protein kinase	0.0071	0.1792	0.1792
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0071	0.1792	0.5
Echinococcus granulosus	matrix metallopeptidase 7 M10 family	0.0153	0.6992	0.6335
Loa Loa (eye worm)	STAT protein	0.013	0.5556	0.5556
Entamoeba histolytica	hypothetical protein	0.0074	0.1989	0.024
Echinococcus multilocularis	SH2 motif	0.013	0.5556	0.4585

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.2 uM	Inhibition of full length MMP2 using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured after 30 mins by spectrofluorimetry	ChEMBL.	22386984
IC50 (binding)	= 0.23 uM	Inhibition of MMP9 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured after 30 mins by spectrofluorimetry	ChEMBL.	22386984

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1957598

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1616719