TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 617.863 | Formula: C32H47N3O5S2
H donors: 0 H acceptors: 5 LogP: 4.02 Rotable bonds: 12
Rule of 5 violations (Lipinski): 2
SMILES: CCN(C(=O)Cc1ccc(cc1)S(=O)(=O)C)C1CCN(CC1)CC[C@@H](c1cccc(c1)C)C1CCN(CC1)S(=O)(=O)C
InChi: 1S/C32H47N3O5S2/c1-5-35(32(36)24-26-9-11-30(12-10-26)41(3,37)38)29-15-18-33(19-16-29)20-17-31(28-8-6-7-25(2)23-28)27-13-21-34(22-14-27)42(4,39)40/h6-12,23,27,29,31H,5,13-22,24H2,1-4H3/t31-/m1/s1
InChiKey: SUOVSKFZWHJHSK-WJOKGBTCSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	chemokine (C-C motif) receptor 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	tyrosine kinase	0.0153	0.8859	1
Schistosoma mansoni	biogenic amine receptor	0.0023	0.0365	0.0412
Echinococcus multilocularis	epidermal growth factor receptor	0.0153	0.8859	1
Brugia malayi	ORL1-like opioid receptor	0.0023	0.0365	0.0412
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0153	0.8859	0.8859
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Echinococcus multilocularis	neuropeptide s receptor	0.0023	0.0365	0.0412
Echinococcus multilocularis	G protein coupled receptor 139	0.0023	0.0365	0.0412
Brugia malayi	integrin-linked kinase	0.0153	0.8859	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0023	0.0365	0.0412
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0365	0.0412
Trypanosoma brucei	protein kinase, putative	0.0153	0.8859	1
Echinococcus granulosus	tyrosine protein kinase HCK	0.0153	0.8859	1
Entamoeba histolytica	protein kinase, putative	0.0153	0.8859	0.8859
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0365	0.0412
Entamoeba histolytica	tyrosine kinase, putative	0.0153	0.8859	0.8859
Trichomonas vaginalis	CAMK family protein kinase	0.0153	0.8859	1
Brugia malayi	SH2 domain containing protein	0.0153	0.8859	1
Brugia malayi	G-protein coupled receptor	0.0023	0.0365	0.0412
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Echinococcus granulosus	tyrosine kinase	0.0153	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0365	0.0412
Schistosoma mansoni	tyrosine kinase	0.0153	0.8859	1
Entamoeba histolytica	protein kinase domain containing protein	0.0153	0.8859	0.8859
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0153	0.8859	1
Echinococcus granulosus	epidermal growth factor receptor	0.0153	0.8859	1
Entamoeba histolytica	protein kinase domain containing protein	0.0153	0.8859	0.8859
Loa Loa (eye worm)	TK/FER protein kinase	0.0153	0.8859	1
Onchocerca volvulus		0.0023	0.0365	0.0412
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0153	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Brugia malayi	Protein kinase domain containing protein	0.0153	0.8859	1
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0153	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1386	0.1564
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0153	0.8859	1
Loa Loa (eye worm)	TK protein kinase	0.0153	0.8859	1
Echinococcus multilocularis	protein kinase	0.0153	0.8859	1
Echinococcus granulosus	tyrosine kinase	0.0153	0.8859	1
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0153	0.8859	1
Entamoeba histolytica	receptor protein kinase, putative	0.0153	0.8859	0.8859
Loa Loa (eye worm)	TK/FER protein kinase	0.0153	0.8859	1
Echinococcus granulosus	protein tyrosine kinase	0.0153	0.8859	1
Schistosoma mansoni	hypothetical protein	0.0023	0.0365	0.0412
Echinococcus multilocularis	integrin linked protein kinase	0.0153	0.8859	1
Schistosoma mansoni	tyrosine kinase	0.0153	0.8859	1
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0153	0.8859	1
Entamoeba histolytica	tyrosin kinase, putative	0.0153	0.8859	0.8859
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0153	0.8859	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0153	0.8859	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0023	0.0365	0.0412
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0153	0.8859	1
Entamoeba histolytica	protein kinase, putative	0.0153	0.8859	0.8859
Onchocerca volvulus		0.0153	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0365	0.0412
Brugia malayi	Protein kinase domain containing protein	0.0153	0.8859	1
Onchocerca volvulus		0.0153	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0023	0.0365	0.0412
Echinococcus granulosus	neuropeptide Y receptor	0.0023	0.0365	0.0412
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0365	0.0412
Entamoeba histolytica	tyrosine kinase, putative	0.0153	0.8859	0.8859
Onchocerca volvulus		0.0023	0.0365	0.0412
Onchocerca volvulus		0.0023	0.0365	0.0412
Trichomonas vaginalis	AGC family protein kinase	0.0153	0.8859	1
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0153	0.8859	1
Brugia malayi	hypothetical protein	0.0023	0.0365	0.0412
Entamoeba histolytica	tyrosine kinase, putative	0.0153	0.8859	0.8859
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0153	0.8859	1
Onchocerca volvulus		0.0023	0.0365	0.0412
Schistosoma mansoni	tyrosine kinase	0.0153	0.8859	1
Schistosoma mansoni	tyrosine kinase	0.0153	0.8859	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0153	0.8859	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0153	0.8859	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0023	0.0365	0.0412
Echinococcus granulosus	insulin receptor	0.0153	0.8859	1
Echinococcus granulosus	somatostatin receptor	0.0023	0.0365	0.0412
Trichomonas vaginalis	STE family protein kinase	0.0153	0.8859	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0023	0.0365	0.0412
Trichomonas vaginalis	conserved hypothetical protein	0.0153	0.8859	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0153	0.8859	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0153	0.8859	1
Toxoplasma gondii	protein kinase	0.0153	0.8859	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0153	0.8859	1
Entamoeba histolytica	protein kinase, putative	0.0153	0.8859	0.8859
Echinococcus granulosus	orexin receptor type 2	0.0023	0.0365	0.0412
Trypanosoma cruzi	protein kinase, putative	0.0153	0.8859	1
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0153	0.8859	1
Schistosoma mansoni	protein kinase	0.0153	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0153	0.8859	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.0365	0.0412
Echinococcus multilocularis	FL cytokine receptor	0.0153	0.8859	1
Onchocerca volvulus		0.0023	0.0365	0.0412
Schistosoma mansoni	protein kinase	0.0153	0.8859	1
Giardia lamblia	Kinase	0.0153	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.0365	0.0412
Entamoeba histolytica	protein kinase domain containing protein	0.0153	0.8859	0.8859
Onchocerca volvulus		0.0023	0.0365	0.0412
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0153	0.8859	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0153	0.8859	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0023	0.0365	0.0412
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0153	0.8859	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0023	0.0365	0.0412
Loa Loa (eye worm)	TK protein kinase	0.0153	0.8859	1
Entamoeba histolytica	protein kinase, putative	0.0153	0.8859	0.8859
Entamoeba histolytica	hypothetical protein	0.0153	0.8859	0.8859
Trichomonas vaginalis	conserved hypothetical protein	0.0153	0.8859	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0023	0.0365	0.0412
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.1579	0.1782
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0153	0.8859	1
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.2038	0.23
Brugia malayi	Protein kinase domain containing protein	0.0153	0.8859	1
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0153	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0365	0.0412
Entamoeba histolytica	tyrosin kinase, putative	0.0153	0.8859	0.8859
Schistosoma mansoni	amine GPCR	0.0023	0.0365	0.0412
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0153	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Onchocerca volvulus		0.0153	0.8859	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0153	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0365	0.0412
Brugia malayi	Protein kinase domain containing protein	0.0153	0.8859	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0153	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Schistosoma mansoni	hypothetical protein	0.0023	0.0365	0.0412
Brugia malayi	Melatonin receptor type 1A	0.0023	0.0365	0.0412
Entamoeba histolytica	cysteine surface protein, putative	0.0153	0.8859	0.8859
Schistosoma mansoni	myosin xvIII	0.0023	0.0365	0.0412
Brugia malayi	hypothetical protein	0.0023	0.0365	0.0412
Brugia malayi	larval opioid receptor	0.0023	0.0365	0.0412
Schistosoma mansoni	hypothetical protein	0.0023	0.0365	0.0412
Echinococcus multilocularis	g protein coupled receptor	0.0023	0.0365	0.0412
Brugia malayi	G protein-coupled receptor F59B2.13	0.0023	0.0365	0.0412
Onchocerca volvulus		0.0153	0.8859	1
Entamoeba histolytica	tyrosine kinase, putative	0.0153	0.8859	0.8859
Brugia malayi	Raf kinase	0.0153	0.8859	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0153	0.8859	1
Echinococcus multilocularis	allatostatin A receptor	0.0023	0.0365	0.0412
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0153	0.8859	1
Entamoeba histolytica	tyrosine kinase, putative	0.0153	0.8859	0.8859
Echinococcus granulosus	tyrosine protein kinase pr2	0.0153	0.8859	1
Schistosoma mansoni	protein kinase	0.0153	0.8859	1
Echinococcus granulosus	tyrosine protein kinase Srms	0.0153	0.8859	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0023	0.0365	0.0412
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0023	0.0365	0.0412
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Entamoeba histolytica	protein kinase, putative	0.0153	0.8859	0.8859
Schistosoma mansoni	opsin-like receptor	0.0023	0.0365	0.0412
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0153	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Onchocerca volvulus		0.0153	0.8859	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0153	0.8859	1
Onchocerca volvulus		0.0023	0.0365	0.0412
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0153	0.8859	1
Schistosoma mansoni	neuropeptide receptor	0.0023	0.0365	0.0412
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0153	0.8859	1
Schistosoma mansoni	biogenic amine receptor	0.0023	0.0365	0.0412
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0153	0.8859	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0023	0.0365	0.0412
Brugia malayi	Protein kinase domain containing protein	0.0153	0.8859	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0023	0.0365	0.0412
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0153	0.8859	0.8859
Brugia malayi	hypothetical protein	0.0153	0.8859	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0023	0.0365	0.0412
Onchocerca volvulus		0.0023	0.0365	0.0412
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0365	0.0412
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0365	0.0412
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0153	0.8859	1
Entamoeba histolytica	protein kinase, putative	0.0153	0.8859	0.8859
Trypanosoma cruzi	protein kinase, putative	0.0153	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Brugia malayi	G protein-coupled receptor	0.0023	0.0365	0.0412
Schistosoma mansoni	serine/threonine protein kinase	0.0153	0.8859	1
Entamoeba histolytica	protein kinase domain containing protein	0.0153	0.8859	0.8859
Trichomonas vaginalis	conserved hypothetical protein	0.0153	0.8859	1
Onchocerca volvulus		0.0153	0.8859	1
Giardia lamblia	Kinase, NEK	0.0153	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Brugia malayi	Protein kinase domain containing protein	0.0153	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0153	0.8859	1
Brugia malayi	Protein kinase domain containing protein	0.0153	0.8859	1
Entamoeba histolytica	protein kinase domain containing protein	0.0153	0.8859	0.8859
Loa Loa (eye worm)	TK/CSK protein kinase	0.0153	0.8859	1
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0153	0.8859	1
Entamoeba histolytica	tyrosine kinase, putative	0.0153	0.8859	0.8859
Trichomonas vaginalis	conserved hypothetical protein	0.0153	0.8859	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0153	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Echinococcus granulosus	integrin linked protein kinase	0.0153	0.8859	1
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0153	0.8859	1
Entamoeba histolytica	hypothetical protein	0.0153	0.8859	0.8859
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0023	0.0365	0.0412
Trichomonas vaginalis	conserved hypothetical protein	0.0153	0.8859	1
Echinococcus multilocularis	tyrosine protein kinase	0.0153	0.8859	1
Entamoeba histolytica	protein kinase, putative	0.0153	0.8859	0.8859
Entamoeba histolytica	serine/threonine kinase, putative	0.0153	0.8859	0.8859
Loa Loa (eye worm)	TK protein kinase	0.0153	0.8859	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0023	0.0365	0.0412
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0153	0.8859	1
Schistosoma mansoni	protein kinase	0.0153	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0153	0.8859	1
Entamoeba histolytica	protein kinase domain containing protein	0.0153	0.8859	0.8859
Echinococcus granulosus	neuropeptide s receptor	0.0023	0.0365	0.0412
Echinococcus granulosus	neuropeptide receptor	0.0023	0.0365	0.0412
Loa Loa (eye worm)	TK/FER protein kinase	0.0153	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Echinococcus multilocularis	fmrfamide receptor	0.0023	0.0365	0.0412
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0023	0.0365	0.0412
Entamoeba histolytica	hypothetical protein	0.0153	0.8859	0.8859
Echinococcus granulosus	neuropeptides capa receptor	0.0023	0.0365	0.0412
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Echinococcus multilocularis	tyrosine kinase	0.0153	0.8859	1
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0153	0.8859	0.8859
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0153	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0153	0.8859	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0153	0.8859	1
Trypanosoma brucei	Pseudokinase, putative	0.0153	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0153	0.8859	0.8859
Schistosoma mansoni	neuropeptide receptor	0.0023	0.0365	0.0412
Loa Loa (eye worm)	TK/ACK protein kinase	0.0153	0.8859	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0153	0.8859	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0023	0.0365	0.0412
Echinococcus granulosus	receptor type guanylyl cyclase	0.0153	0.8859	1
Brugia malayi	putative neuropeptide receptor	0.0023	0.0365	0.0412
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0023	0.0365	0.0412
Brugia malayi	Tyrosine-protein kinase abl-1	0.0153	0.8859	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0153	0.8859	0.8859
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0365	0.0412
Loa Loa (eye worm)	TK/FER protein kinase	0.0153	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0365	0.0412
Brugia malayi	Protein kinase domain containing protein	0.0153	0.8859	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0153	0.8859	0.8859
Schistosoma mansoni	tyrosine kinase	0.0153	0.8859	1
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0153	0.8859	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0153	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0365	0.0412
Entamoeba histolytica	hypothetical protein	0.0153	0.8859	0.8859
Loa Loa (eye worm)	TK/ALK protein kinase	0.0153	0.8859	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0153	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0365	0.0412
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0153	0.8859	1
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0153	0.8859	1
Echinococcus granulosus	g protein coupled receptor	0.0023	0.0365	0.0412
Entamoeba histolytica	tyrosine kinase, putative	0.0153	0.8859	0.8859
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0153	0.8859	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0153	0.8859	0.8859
Brugia malayi	Protein kinase domain containing protein	0.0153	0.8859	1
Brugia malayi	Protein kinase domain containing protein	0.0153	0.8859	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0153	0.8859	1
Schistosoma mansoni	histamine h1 receptor	0.0023	0.0365	0.0412
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0153	0.8859	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0023	0.0365	0.0412
Entamoeba histolytica	receptor protein kinase, putative	0.0153	0.8859	0.8859
Entamoeba histolytica	protein kinase, putative	0.0153	0.8859	0.8859
Brugia malayi	Protein kinase domain containing protein	0.0153	0.8859	1
Echinococcus granulosus	neuropeptide Y receptor	0.0023	0.0365	0.0412
Onchocerca volvulus		0.0023	0.0365	0.0412
Echinococcus granulosus	g protein coupled receptor	0.0023	0.0365	0.0412
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0023	0.0365	0.0412
Onchocerca volvulus		0.0153	0.8859	1
Echinococcus multilocularis	g protein coupled receptor	0.0023	0.0365	0.0412
Entamoeba histolytica	protein kinase, putative	0.0153	0.8859	0.8859
Loa Loa (eye worm)	TK/FER protein kinase	0.0153	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0153	0.8859	1
Schistosoma mansoni	tyrosine kinase	0.0153	0.8859	1
Brugia malayi	protein-tyrosine kinase	0.0153	0.8859	1
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0153	0.8859	1
Brugia malayi	Protein kinase domain containing protein	0.0153	0.8859	1
Echinococcus granulosus	c src tyrosine kinase	0.0153	0.8859	1
Echinococcus multilocularis	somatostatin receptor	0.0023	0.0365	0.0412
Leishmania major	protein kinase, putative	0.0153	0.8859	1
Schistosoma mansoni	tyrosine kinase	0.0153	0.8859	1
Entamoeba histolytica	protein kinase domain containing protein	0.0153	0.8859	0.8859
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0023	0.0365	0.0412
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0153	0.8859	0.8859
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0365	0.0412
Brugia malayi	hypothetical protein	0.0023	0.0365	0.0412
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Loa Loa (eye worm)	TK protein kinase	0.0153	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0023	0.0365	0.0412
Echinococcus granulosus	natriuretic peptide receptor 1	0.0153	0.8859	1
Onchocerca volvulus		0.0023	0.0365	0.0412
Brugia malayi	Furin-like cysteine rich region family protein	0.0153	0.8859	1
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0153	0.8859	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0153	0.8859	1
Loa Loa (eye worm)	TK protein kinase	0.0153	0.8859	1
Brugia malayi	Protein kinase domain containing protein	0.0153	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0365	0.0412
Schistosoma mansoni	tyrosine kinase	0.0153	0.8859	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0023	0.0365	0.0412
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Loa Loa (eye worm)	TYRA-2 protein	0.0023	0.0365	0.0412
Schistosoma mansoni	tyrosine kinase	0.0153	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0365	0.0412
Schistosoma mansoni	hypothetical protein	0.0153	0.8859	1
Brugia malayi	Protein kinase domain containing protein	0.0153	0.8859	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.0365	0.0412
Brugia malayi	Protein kinase domain containing protein	0.0153	0.8859	1
Entamoeba histolytica	protein kinase, putative	0.0153	0.8859	0.8859
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Brugia malayi	Protein kinase domain containing protein	0.0153	0.8859	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0023	0.0365	0.0412
Schistosoma mansoni	tyrosine kinase	0.0153	0.8859	1
Echinococcus multilocularis	heat shock protein 70	0.0153	0.8859	1
Schistosoma mansoni	tyrosine kinase	0.0153	0.8859	1
Loa Loa (eye worm)	TK/ABL protein kinase	0.0153	0.8859	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0023	0.0365	0.0412
Entamoeba histolytica	protein kinase domain containing protein	0.0153	0.8859	0.8859
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0153	0.8859	1
Schistosoma mansoni	opsin-like receptor	0.0023	0.0365	0.0412
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0153	0.8859	1
Entamoeba histolytica	hypothetical protein, conserved	0.0153	0.8859	0.8859
Loa Loa (eye worm)	TK protein kinase	0.0153	0.8859	1
Onchocerca volvulus		0.0023	0.0365	0.0412
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0153	0.8859	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0153	0.8859	1
Brugia malayi	Protein kinase domain containing protein	0.0153	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0153	0.8859	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0023	0.0365	0.0412
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0153	0.8859	1
Trichomonas vaginalis	conserved hypothetical protein	0.0153	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0365	0.0412
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0365	0.0412
Entamoeba histolytica	hypothetical protein	0.0153	0.8859	0.8859
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0365	0.0412
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0023	0.0365	0.0412
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0153	0.8859	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0153	0.8859	1
Schistosoma mansoni	tyrosine kinase	0.0153	0.8859	1
Brugia malayi	Protein kinase domain containing protein	0.0153	0.8859	1
Echinococcus granulosus	activated cdc42 kinase 1	0.0153	0.8859	1
Brugia malayi	hypothetical protein	0.0023	0.0365	0.0412
Schistosoma mansoni	tyrosine kinase	0.0153	0.8859	1
Echinococcus multilocularis	protein kinase	0.0153	0.8859	1
Brugia malayi	hypothetical protein	0.0023	0.0365	0.0412
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Schistosoma mansoni	serine/threonine RGC	0.0153	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0365	0.0412
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0153	0.8859	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0153	0.8859	0.8859
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0365	0.0412
Brugia malayi	hypothetical protein	0.0153	0.8859	1
Schistosoma mansoni	serine/threonine protein kinase	0.0153	0.8859	1
Entamoeba histolytica	tyrosin kinase, putative	0.0153	0.8859	0.8859
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0023	0.0365	0.0412
Brugia malayi	Dopamine receptor protein 2	0.0023	0.0365	0.0412
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0153	0.8859	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0153	0.8859	1
Toxoplasma gondii	STE kinase	0.0153	0.8859	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0153	0.8859	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0023	0.0365	0.0412
Entamoeba histolytica	protein kinase domain containing protein	0.0153	0.8859	0.8859
Loa Loa (eye worm)	TK/FAK protein kinase	0.0153	0.8859	1
Schistosoma mansoni	protein kinase	0.0153	0.8859	1
Brugia malayi	SH2 domain containing protein	0.0153	0.8859	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.0365	0.0412
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.0365	0.0412
Schistosoma mansoni	tyrosine kinase	0.0153	0.8859	1
Schistosoma mansoni	biogenic amine receptor	0.0023	0.0365	0.0412
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0023	0.0365	0.0412
Entamoeba histolytica	protein kinase, putative	0.0153	0.8859	0.8859
Entamoeba histolytica	tyrosine kinase, putative	0.0153	0.8859	0.8859
Brugia malayi	Serotonin receptor	0.0023	0.0365	0.0412
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0023	0.0365	0.0412
Brugia malayi	SRC-1	0.0153	0.8859	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0153	0.8859	1
Schistosoma mansoni	amine GPCR	0.0023	0.0365	0.0412
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0153	0.8859	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0023	0.0365	0.0412
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0153	0.8859	1
Schistosoma mansoni	protein kinase	0.0153	0.8859	1
Schistosoma mansoni	hypothetical protein	0.0023	0.0365	0.0412
Echinococcus granulosus	neuropeptide FF receptor 2	0.0023	0.0365	0.0412
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0023	0.0365	0.0412
Onchocerca volvulus		0.0153	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Schistosoma mansoni	tyrosine kinase	0.0153	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Schistosoma mansoni	serine/threonine protein kinase	0.0153	0.8859	1
Brugia malayi	hypothetical protein	0.0023	0.0365	0.0412
Loa Loa (eye worm)	serine/threonine protein kinase	0.0153	0.8859	1
Schistosoma mansoni	tyrosine kinase	0.0153	0.8859	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0023	0.0365	0.0412
Entamoeba histolytica	protein kinase domain containing protein	0.0153	0.8859	0.8859
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0153	0.8859	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0023	0.0365	0.0412
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0153	0.8859	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0153	0.8859	1
Echinococcus multilocularis	insulin receptor	0.0153	0.8859	1
Entamoeba histolytica	hypothetical protein	0.0153	0.8859	0.8859
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0023	0.0365	0.0412
Echinococcus granulosus	tm gpcr rhodopsin	0.0023	0.0365	0.0412
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.0365	0.0412
Entamoeba histolytica	protein kinase, putative	0.0153	0.8859	0.8859
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0153	0.8859	1
Entamoeba histolytica	protein kinase domain containing protein	0.0153	0.8859	0.8859
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.0365	0.0412
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Schistosoma mansoni	adenoreceptor	0.0023	0.0365	0.0412
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.0365	0.0412
Onchocerca volvulus		0.0153	0.8859	1
Entamoeba histolytica	protein kinase domain containing protein	0.0153	0.8859	0.8859
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0153	0.8859	1
Schistosoma mansoni	ephrin receptor	0.0153	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0365	0.0412
Brugia malayi	follicle stimulating hormone receptor	0.0023	0.0365	0.0412
Loa Loa (eye worm)	TK protein kinase	0.0153	0.8859	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0023	0.0365	0.0412
Schistosoma mansoni	tyrosine kinase	0.0153	0.8859	1
Onchocerca volvulus	Tyrosine kinase homolog	0.0153	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Brugia malayi	C-terminal src kinase protein 1	0.0153	0.8859	1
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0153	0.8859	1
Brugia malayi	Protein kinase domain containing protein	0.0153	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0153	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0365	0.0412
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0153	0.8859	0.8859
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0153	0.8859	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0023	0.0365	0.0412
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Entamoeba histolytica	protein kinase, putative	0.0153	0.8859	0.8859
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0365	0.0412
Entamoeba histolytica	protein kinase domain containing protein	0.0153	0.8859	0.8859
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0153	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Schistosoma mansoni	amine GPCR	0.0023	0.0365	0.0412
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0023	0.0365	0.0412
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0153	0.8859	1
Entamoeba histolytica	tyrosine kinase, putative	0.0153	0.8859	0.8859
Loa Loa (eye worm)	TK protein kinase	0.0153	0.8859	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0023	0.0365	0.0412
Echinococcus granulosus	7TM GPCR rhodopsin	0.0023	0.0365	0.0412
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0023	0.0365	0.0412
Onchocerca volvulus		0.0153	0.8859	1
Onchocerca volvulus		0.0153	0.8859	1
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0153	0.8859	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0023	0.0365	0.0412
Entamoeba histolytica	tyrosine kinase, putative	0.0153	0.8859	0.8859
Entamoeba histolytica	protein kinase domain containing protein	0.0153	0.8859	0.8859
Echinococcus granulosus	activated cdc42 kinase 1	0.0153	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Giardia lamblia	Protein 21.1	0.0153	0.8859	1
Entamoeba histolytica	protein kinase domain containing protein	0.0153	0.8859	0.8859
Schistosoma mansoni	tyrosine kinase	0.0153	0.8859	1
Schistosoma mansoni	ephrin receptor	0.0153	0.8859	1
Brugia malayi	G-protein coupled receptor	0.0023	0.0365	0.0412
Loa Loa (eye worm)	hypothetical protein	0.0153	0.8859	1
Schistosoma mansoni	tyrosine kinase	0.0153	0.8859	1
Echinococcus granulosus	neuropeptide receptor A26	0.0023	0.0365	0.0412
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0023	0.0365	0.0412
Plasmodium vivax	protein kinase, putative	0.0153	0.8859	1
Onchocerca volvulus		0.0153	0.8859	1
Echinococcus granulosus	hypothetical protein	0.0023	0.0365	0.0412
Entamoeba histolytica	protein kinase domain containing protein	0.0153	0.8859	0.8859
Entamoeba histolytica	tyrosine kinase, putative	0.0153	0.8859	0.8859
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.0365	0.0412
Entamoeba histolytica	ankyrin repeat protein	0.0153	0.8859	0.8859
Loa Loa (eye worm)	hypothetical protein	0.0153	0.8859	1
Echinococcus multilocularis	neuropeptide receptor	0.0023	0.0365	0.0412
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0153	0.8859	1
Entamoeba histolytica	tyrosine kinase, putative	0.0153	0.8859	0.8859
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0153	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Echinococcus granulosus	g-protein coupled receptor	0.0023	0.0365	0.0412
Entamoeba histolytica	protein kinase domain containing protein	0.0153	0.8859	0.8859
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0365	0.0412
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0153	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0365	0.0412
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0023	0.0365	0.0412
Brugia malayi	hypothetical protein	0.0023	0.0365	0.0412
Trichomonas vaginalis	conserved hypothetical protein	0.0153	0.8859	1
Brugia malayi	Protein kinase domain containing protein	0.0153	0.8859	1
Brugia malayi	GnHR receptor homolog	0.0023	0.0365	0.0412
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0045	0.177	0.1998
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0023	0.0365	0.0412
Entamoeba histolytica	protein kinase, putative	0.0153	0.8859	0.8859
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0153	0.8859	1
Loa Loa (eye worm)	SRC-1	0.0153	0.8859	1
Schistosoma mansoni	protein kinase	0.0153	0.8859	1
Echinococcus multilocularis	neuropeptide receptor	0.0023	0.0365	0.0412
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0153	0.8859	1
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0153	0.8859	1
Echinococcus granulosus	serotonin receptor	0.0023	0.0365	0.0412
Onchocerca volvulus		0.0153	0.8859	1
Echinococcus multilocularis	activated cdc42 kinase 1	0.0153	0.8859	1
Loa Loa (eye worm)	TK/RYK protein kinase	0.0153	0.8859	1
Echinococcus multilocularis	protein tyrosine kinase	0.0153	0.8859	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0153	0.8859	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0153	0.8859	1
Schistosoma mansoni	tyrosine kinase	0.0153	0.8859	1
Plasmodium falciparum	protein kinase, putative	0.0153	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Brugia malayi	hypothetical protein	0.0023	0.0365	0.0412
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0153	0.8859	1
Echinococcus granulosus	fmrfamide receptor	0.0023	0.0365	0.0412
Echinococcus multilocularis	activin receptor type	0.0153	0.8859	1
Echinococcus granulosus	neuropeptides capa receptor	0.0023	0.0365	0.0412
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0023	0.0365	0.0412
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0153	0.8859	1
Schistosoma mansoni	protein kinase	0.0153	0.8859	1
Trichomonas vaginalis	TK family protein kinase	0.0153	0.8859	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0153	0.8859	0.8859
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.0365	0.0412
Entamoeba histolytica	protein kinase, putative	0.0153	0.8859	0.8859
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.0365	0.0412
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0153	0.8859	1
Brugia malayi	hypothetical protein	0.0023	0.0365	0.0412
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0023	0.0365	0.0412
Loa Loa (eye worm)	TK protein kinase	0.0153	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0365	0.0412
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0153	0.8859	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0023	0.0365	0.0412
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0153	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Brugia malayi	Protein kinase domain containing protein	0.0153	0.8859	1
Onchocerca volvulus		0.0023	0.0365	0.0412
Loa Loa (eye worm)	hypothetical protein	0.0153	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0365	0.0412
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0153	0.8859	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0153	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0365	0.0412
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0153	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Brugia malayi	RE15519p	0.0023	0.0365	0.0412
Leishmania major	hypothetical protein, conserved	0.0153	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0153	0.8859	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0153	0.8859	1
Entamoeba histolytica	tyrosine kinase, putative	0.0153	0.8859	0.8859
Schistosoma mansoni	tyrosine kinase	0.0153	0.8859	1
Entamoeba histolytica	protein kinase domain containing protein	0.0153	0.8859	0.8859
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Brugia malayi	Protein kinase domain containing protein	0.0153	0.8859	1
Brugia malayi	Protein kinase domain containing protein	0.0153	0.8859	1
Onchocerca volvulus		0.0153	0.8859	1
Echinococcus granulosus	ephrin type A receptor 4 A	0.0153	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0153	0.8859	1
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0153	0.8859	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0023	0.0365	0.0412
Echinococcus granulosus	dro:myosuppressin receptor	0.0023	0.0365	0.0412
Entamoeba histolytica	tyrosine kinase, putative	0.0153	0.8859	0.8859
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0153	0.8859	1
Onchocerca volvulus		0.0023	0.0365	0.0412
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0153	0.8859	0.8859
Plasmodium falciparum	protein kinase, putative	0.0153	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0365	0.0412
Entamoeba histolytica	protein kinase domain containing protein	0.0153	0.8859	0.8859
Echinococcus granulosus	tyrosine protein kinase shark	0.0153	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0153	0.8859	1
Brugia malayi	Protein kinase domain containing protein	0.0153	0.8859	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0023	0.0365	0.0412
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0365	0.0412
Echinococcus granulosus	tyrosine kinase	0.0153	0.8859	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0153	0.8859	1
Echinococcus granulosus	protein kinase	0.0153	0.8859	1
Onchocerca volvulus		0.0023	0.0365	0.0412
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0023	0.0365	0.0412
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.0365	0.0412
Echinococcus multilocularis	neuropeptide Y receptor	0.0023	0.0365	0.0412
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0153	0.8859	1
Trichomonas vaginalis	protein kinase atn1, putative	0.0153	0.8859	1
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0153	0.8859	1
Entamoeba histolytica	protein kinase domain containing protein	0.0153	0.8859	0.8859
Echinococcus multilocularis	orexin receptor type 2	0.0023	0.0365	0.0412
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0023	0.0365	0.0412
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0153	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0365	0.0412
Brugia malayi	Receptor family ligand binding region containing protein	0.0153	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0365	0.0412
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Entamoeba histolytica	hypothetical protein	0.0153	0.8859	0.8859
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0153	0.8859	0.8859
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0153	0.8859	1
Brugia malayi	sulfakinin receptor protein	0.0023	0.0365	0.0412
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0153	0.8859	0.8859
Brugia malayi	Protein kinase domain containing protein	0.0153	0.8859	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0023	0.0365	0.0412
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0153	0.8859	0.8859
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0153	0.8859	1
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0045	0.177	0.1998
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0153	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0153	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0365	0.0412
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0153	0.8859	1
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0153	0.8859	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0023	0.0365	0.0412
Entamoeba histolytica	tyrosin kinase, putative	0.0153	0.8859	0.8859
Entamoeba histolytica	tyrosine kinase, putative	0.0153	0.8859	0.8859
Schistosoma mansoni	neuropeptide receptor	0.0023	0.0365	0.0412
Echinococcus granulosus	rhodopsin orphan GPCR	0.0023	0.0365	0.0412
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0153	0.8859	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0153	0.8859	0.8859
Schistosoma mansoni	neuropeptide receptor	0.0023	0.0365	0.0412
Loa Loa (eye worm)	TK/EPH protein kinase	0.0153	0.8859	1
Echinococcus granulosus	tyrosine protein kinase Blk	0.0153	0.8859	1
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0153	0.8859	1
Echinococcus granulosus	G protein coupled receptor 139	0.0023	0.0365	0.0412
Brugia malayi	hypothetical protein	0.0023	0.0365	0.0412
Echinococcus multilocularis	g-protein coupled receptor	0.0023	0.0365	0.0412
Brugia malayi	Dopamine receptor	0.0023	0.0365	0.0412
Schistosoma mansoni	tyrosine kinase	0.0153	0.8859	1
Entamoeba histolytica	protein kinase domain containing protein	0.0153	0.8859	0.8859
Echinococcus multilocularis	neuropeptide receptor A26	0.0023	0.0365	0.0412
Schistosoma mansoni	tyrosine kinase	0.0153	0.8859	1
Loa Loa (eye worm)	TK/ROR protein kinase	0.0153	0.8859	1
Onchocerca volvulus		0.0023	0.0365	0.0412
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0153	0.8859	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0153	0.8859	1
Echinococcus granulosus	allatostatin A receptor	0.0023	0.0365	0.0412
Schistosoma mansoni	tyrosine kinase	0.0153	0.8859	1
Schistosoma mansoni	amine GPCR	0.0023	0.0365	0.0412
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0023	0.0365	0.0412
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0153	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0365	0.0412
Brugia malayi	hypothetical protein	0.0153	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Toxoplasma gondii	protein kinase domain-containing protein	0.0153	0.8859	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.0365	0.0412
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0023	0.0365	0.0412
Brugia malayi	Dopamine receptor protein 1	0.0023	0.0365	0.0412
Echinococcus granulosus	raf serine:threonine protein kinase	0.0153	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0365	0.0412
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0153	0.8859	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0153	0.8859	0.8859
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0023	0.0365	0.0412
Plasmodium falciparum	tyrosine kinase-like protein	0.0153	0.8859	1
Schistosoma mansoni	serine/threonine protein kinase	0.0153	0.8859	1
Echinococcus granulosus	epidermal growth factor receptor	0.0153	0.8859	1
Schistosoma mansoni	tyrosine kinase	0.0153	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0153	0.8859	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0153	0.8859	1
Echinococcus multilocularis	g protein coupled receptor	0.0023	0.0365	0.0412
Echinococcus granulosus	sex peptide receptor	0.0023	0.0365	0.0412
Onchocerca volvulus		0.0153	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Echinococcus multilocularis	fmrfamide receptor	0.0023	0.0365	0.0412
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0365	0.0412
Entamoeba histolytica	protein kinase, putative	0.0153	0.8859	0.8859
Echinococcus multilocularis	serotonin receptor	0.0023	0.0365	0.0412
Echinococcus multilocularis	tyrosine protein kinase csk	0.0153	0.8859	1
Brugia malayi	neuropeptide F receptor	0.0023	0.0365	0.0412
Loa Loa (eye worm)	hypothetical protein	0.0153	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0365	0.0412
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0023	0.0365	0.0412
Loa Loa (eye worm)	TK/FER protein kinase	0.0153	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0365	0.0412
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.0365	0.0412
Loa Loa (eye worm)	TK/FER protein kinase	0.0153	0.8859	1
Echinococcus granulosus	tyrosine protein kinase	0.0153	0.8859	1
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0045	0.177	0.1998
Echinococcus granulosus	rhodopsin orphan GPCR	0.0023	0.0365	0.0412
Echinococcus multilocularis	transfer RNA-Thr	0.0153	0.8859	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0153	0.8859	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0023	0.0365	0.0412
Brugia malayi	AKH receptor	0.0023	0.0365	0.0412
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0023	0.0365	0.0412
Schistosoma mansoni	protein kinase	0.0153	0.8859	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.0365	0.0412
Echinococcus granulosus	rhodopsin orphan GPCR	0.0023	0.0365	0.0412
Brugia malayi	Protein kinase domain containing protein	0.0153	0.8859	1
Echinococcus granulosus	activin receptor type	0.0153	0.8859	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0023	0.0365	0.0412
Echinococcus multilocularis	dro:myosuppressin receptor	0.0023	0.0365	0.0412
Giardia lamblia	Kinase, NEK	0.0153	0.8859	1
Brugia malayi	Protein kinase domain containing protein	0.0153	0.8859	1
Schistosoma mansoni	opsin-like receptor	0.0023	0.0365	0.0412
Echinococcus granulosus	neuropeptide receptor	0.0023	0.0365	0.0412
Brugia malayi	putative neuropeptide receptor NPR1	0.0023	0.0365	0.0412
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.2038	0.23
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0023	0.0365	0.0412
Schistosoma mansoni	protein kinase	0.0153	0.8859	1
Brugia malayi	Tyrosine-protein kinase PR2	0.0153	0.8859	1
Brugia malayi	Protein kinase domain containing protein	0.0153	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0365	0.0412
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0153	0.8859	0.8859
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.0365	0.0412
Loa Loa (eye worm)	hypothetical protein	0.0153	0.8859	1
Schistosoma mansoni	tyrosine kinase	0.0153	0.8859	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0023	0.0365	0.0412
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0153	0.8859	0.8859
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0023	0.0365	0.0412
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0023	0.0365	0.0412
Schistosoma mansoni	neuropeptide F-like receptor	0.0023	0.0365	0.0412
Brugia malayi	neuropeptide F receptor	0.0023	0.0365	0.0412
Echinococcus granulosus	rhodopsin orphan GPCR	0.0023	0.0365	0.0412
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0365	0.0412
Loa Loa (eye worm)	TK/DDR protein kinase	0.0153	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.0365	0.0412
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0023	0.0365	0.0412
Loa Loa (eye worm)	TK/FER protein kinase	0.0153	0.8859	1
Brugia malayi	Protein kinase domain containing protein	0.0153	0.8859	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0153	0.8859	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0023	0.0365	0.0412
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0365	0.0412
Loa Loa (eye worm)	TK protein kinase	0.0153	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0153	0.8859	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0153	0.8859	1
Brugia malayi	Guanylyl cyclase protein 23	0.0153	0.8859	1
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0153	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0365	0.0412
Loa Loa (eye worm)	G-protein coupled receptor	0.0023	0.0365	0.0412
Schistosoma mansoni	neuropeptide F-like receptor	0.0023	0.0365	0.0412
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0153	0.8859	1
Schistosoma mansoni	tyrosine protein kinase	0.0153	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0153	0.8859	1
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0153	0.8859	1
Entamoeba histolytica	hypothetical protein	0.0153	0.8859	0.8859
Loa Loa (eye worm)	TK/INSR protein kinase	0.0153	0.8859	1
Entamoeba histolytica	protein kinase, putative	0.0153	0.8859	0.8859
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.1579	0.1782
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0365	0.0412
Plasmodium falciparum	protein kinase, putative	0.0153	0.8859	1
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0153	0.8859	1
Schistosoma mansoni	tyrosine kinase	0.0153	0.8859	1
Echinococcus granulosus	kinase suppressor of Ras 1	0.0153	0.8859	1
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0153	0.8859	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0153	0.8859	1
Echinococcus multilocularis	c src tyrosine kinase	0.0153	0.8859	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0153	0.8859	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0023	0.0365	0.0412
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0153	0.8859	1
Loa Loa (eye worm)	TK/Met protein kinase	0.0153	0.8859	1
Leishmania major	protein kinase, putative	0.0153	0.8859	1
Schistosoma mansoni	amine GPCR	0.0023	0.0365	0.0412
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0153	0.8859	0.8859
Echinococcus granulosus	rhodopsin orphan GPCR	0.0023	0.0365	0.0412
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0153	0.8859	1
Entamoeba histolytica	tyrosine kinase, putative	0.0153	0.8859	0.8859
Echinococcus granulosus	tyrosine protein kinase csk	0.0153	0.8859	1
Schistosoma mansoni	protein tyrosine kinase	0.0153	0.8859	1
Entamoeba histolytica	ankyrin repeat protein	0.0153	0.8859	0.8859
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Echinococcus multilocularis	tyrosine kinase	0.0153	0.8859	1
Entamoeba histolytica	protein kinase, putative	0.0153	0.8859	0.8859
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0023	0.0365	0.0412
Echinococcus multilocularis	sex peptide receptor	0.0023	0.0365	0.0412
Brugia malayi	Serotonin receptor	0.0023	0.0365	0.0412
Entamoeba histolytica	serine/threonine kinase, putative	0.0153	0.8859	0.8859
Schistosoma mansoni	tyrosine kinase	0.0153	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0365	0.0412
Loa Loa (eye worm)	TK/FER protein kinase	0.0153	0.8859	1
Entamoeba histolytica	protein kinase domain containing protein	0.0153	0.8859	0.8859
Echinococcus multilocularis	tyrosine protein kinase shark	0.0153	0.8859	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0153	0.8859	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0023	0.0365	0.0412
Entamoeba histolytica	tyrosine kinase, putative	0.0153	0.8859	0.8859
Schistosoma mansoni	tyrosine kinase	0.0153	0.8859	1
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0045	0.177	0.1998
Brugia malayi	ephrin receptor 1 precursor	0.0153	0.8859	1
Onchocerca volvulus		0.0023	0.0365	0.0412
Brugia malayi	Protein kinase domain containing protein	0.0153	0.8859	1
Onchocerca volvulus		0.0023	0.0365	0.0412
Schistosoma mansoni	tyrosine kinase	0.0153	0.8859	1
Schistosoma mansoni	protein kinase	0.0153	0.8859	1
Echinococcus granulosus	g protein coupled receptor	0.0023	0.0365	0.0412
Echinococcus multilocularis	serotonin receptor	0.0023	0.0365	0.0412
Trichomonas vaginalis	TKL family protein kinase	0.0153	0.8859	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.44 nM	Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cells	ChEMBL.	22266038

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1951913

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1617345