Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Cryptosporidium parvum | inosine-5-monophosphate dehydrogenase | Starlite/ChEMBL | References |
Bacillus anthracis | Inosine-5'-monophosphate dehydrogenase | Starlite/ChEMBL | References |
Homo sapiens | IMP (inosine 5'-monophosphate) dehydrogenase 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | tRNA pseudouridine synthase-like 1 homolog | Inosine-5'-monophosphate dehydrogenase | 487 aa | 484 aa | 40.1 % |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | Antiparasitic activity against Cryptosporidium parvum infection model | ChEMBL. | 22310229 | |
EC50 (functional) | = 0.3 uM | Antiparasitic activity against hypoxanthine-guanine-xanthine phosphoribosyltransferase gene knock out Toxoplasma gondii expressing Cryptosporidium parvum IMPDH infected in human foreskin fibroblasts assessed as parasite proliferation by fluorescence assay | ChEMBL. | 22310229 |
EC50 (functional) | = 2.7 uM | Antiparasitic activity against wild type Toxoplasma gondii expressing endogenous IMPDH infected in human foreskin fibroblasts assessed as inhibition of parasite proliferation by fluorescence assay | ChEMBL. | 22310229 |
IC50 (binding) | = 8 nM | Inhibition of recombinant Cryptosporidium parvum IMPDH expressed in Escherichia coli assessed as NADH production preincubated for 5 mins by fluorescence assay | ChEMBL. | 22310229 |
IC50 (binding) | = 14 nM | Inhibition of recombinant Cryptosporidium parvum IMPDH expressed in Escherichia coli assessed as NADH production preincubated for 5 mins by fluorescence assay in presence of bovine serum albumin | ChEMBL. | 22310229 |
IC50 (binding) | > 5 uM | Inhibition of human IMPDH2 | ChEMBL. | 22310229 |
Ki (binding) | = 13 nM | Un-competitive inhibition of Cryptosporidium IMPDH preincubated for 10 mins before IMP substrate addition by spectrophotometry | ChEMBL. | 25147601 |
Ki (binding) | = 14 nM | Non-competitive inhibition of Cryptosporidium IMPDH preincubated for 10 mins before NAD+ substrate addition by spectrophotometry | ChEMBL. | 25147601 |
Ki (binding) | = 44 nM | Non-competitive inhibition of Bacillus anthracis IMPDH preincubated for 10 mins before NAD+ substrate addition by spectrophotometry | ChEMBL. | 25147601 |
Ki (binding) | = 820 nM | Non-competitive inhibition of Bacillus anthracis IMPDH preincubated for 10 mins before IMP substrate addition by spectrophotometry | ChEMBL. | 25147601 |
Ratio EC50 (functional) | = 9 | Selectivity ratio of EC50 for wild type Toxoplasma gondii expressing endogenous IMPDH to EC50 for hypoxanthine-guanine-xanthine phosphoribosyltransferase gene knock out Toxoplasma gondii expressing Cryptosporidium parvum IMPDH | ChEMBL. | 22310229 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Toxoplasma gondii | ChEMBL23 | 22310229 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.