TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 322.318 | Formula: C17H14N4O3
H donors: 2 H acceptors: 4 LogP: 0.91 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ncoc1c1cccc(c1)C(=O)N)NCc1ccncc1
InChi: 1S/C17H14N4O3/c18-16(22)13-3-1-2-12(8-13)15-14(21-10-24-15)17(23)20-9-11-4-6-19-7-5-11/h1-8,10H,9H2,(H2,18,22)(H,20,23)
InChiKey: CMVWBPVSUGWWDZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glycogen synthase kinase 3 beta	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Neospora caninum	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus multilocularis	protein kinase shaggy	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium vivax	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium berghei	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus granulosus	protein kinase shaggy	Get druggable targets OG5_126888	All targets in OG5_126888
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma japonicum	ko:K08822 glycogen synthase kinase 3 alpha, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma brucei	protein kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium yoelii	Protein kinase domain, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Cryptosporidium parvum	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Theileria parva	glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Candida albicans	second truncated form of RIM11 Serine/threonine protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Giardia lamblia	Kinase, CMGC GSK	Get druggable targets OG5_126888	All targets in OG5_126888
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium falciparum	glycogen synthase kinase 3	Get druggable targets OG5_126888	All targets in OG5_126888
Loa Loa (eye worm)	CMGC/GSK protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus multilocularis	glycogen synthase kinase 3 beta	Get druggable targets OG5_126888	All targets in OG5_126888
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Candida albicans	Serine/threonine protein kinase required for induction of IME2 by Ime1p	Get druggable targets OG5_126888	All targets in OG5_126888
Candida albicans	second truncated form of RIM11 Serine/threonine protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Loa Loa (eye worm)	CMGC/GSK protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Onchocerca volvulus		Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania infantum	glycogen synthase kinase 3	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma congolense	protein kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma cruzi	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium knowlesi	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_126888	All targets in OG5_126888
Giardia lamblia	Kinase, CMGC GSK	Get druggable targets OG5_126888	All targets in OG5_126888
Babesia bovis	protein kinase domain containing protein	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania donovani	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Candida albicans	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus granulosus	glycogen synthase kinase 3 beta	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	Get druggable targets OG5_126888	All targets in OG5_126888
Brugia malayi	intracellular kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania mexicana	protein kinase, putative,glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania braziliensis	protein kinase, putative,glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma brucei gambiense	protein kinase, putative,glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	SH2 domain containing protein	0.073	0.3706	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.073	0.3706	0.3708
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0512	0.1035	0.1035
Echinococcus granulosus	kinase suppressor of Ras 1	0.0512	0.1035	0.1035
Loa Loa (eye worm)	TK/FER protein kinase	0.1242	0.9993	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0512	0.1035	0.1035
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0512	0.1035	0.1035
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Echinococcus multilocularis	insulin receptor	0.0512	0.1035	0.1036
Echinococcus granulosus	tyrosine protein kinase csk	0.0512	0.1035	0.1035
Echinococcus multilocularis	NCK adaptor protein	0.073	0.3706	0.3708
Brugia malayi	Protein kinase domain containing protein	0.1242	0.9993	1
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0512	0.1035	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.1242	0.9993	1
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Echinococcus granulosus	SH2 domain containing protein 7	0.073	0.3706	0.3706
Plasmodium vivax	protein kinase, putative	0.0512	0.1035	0.5
Brugia malayi	Tyrosine-protein kinase abl-1	0.1242	0.9993	1
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0512	0.1035	0.1036
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0512	0.1035	0.1035
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.1242	0.9993	1
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0512	0.1035	0.1035
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0513	0.1042	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.1242	0.9993	1
Loa Loa (eye worm)	TK protein kinase	0.1242	0.9993	1
Loa Loa (eye worm)	hypothetical protein	0.073	0.3706	0.2981
Brugia malayi	Variant SH3 domain containing protein	0.073	0.3706	0.2981
Echinococcus granulosus	suppressor of cytokine signaling 7	0.073	0.3706	0.3706
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.1242	0.9993	1
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0512	0.1035	0.1036
Giardia lamblia	Kinase, NEK	0.0512	0.1035	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.1242	0.9993	0.9993
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.073	0.3706	0.2981
Brugia malayi	cytokine inducible SH2-containing protein 5	0.073	0.3706	0.2981
Brugia malayi	Variant SH3 domain containing protein	0.073	0.3706	0.2981
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.1242	0.9993	0.9993
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.1242	0.9993	1
Onchocerca volvulus		0.073	0.3706	0.2981
Echinococcus granulosus	activin receptor type	0.0513	0.1042	0.1042
Trichomonas vaginalis	AGC family protein kinase	0.0512	0.1035	0.5
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0512	0.1035	0.1036
Onchocerca volvulus		0.1242	0.9993	1
Schistosoma mansoni	SH2A	0.073	0.3706	0.2981
Echinococcus granulosus	tyrosine protein kinase Src64B	0.1242	0.9993	0.9993
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.1242	0.9993	1
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0512	0.1035	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Onchocerca volvulus		0.1242	0.9993	1
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Echinococcus multilocularis	transfer RNA-Thr	0.0512	0.1035	0.1036
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0512	0.1035	0.1036
Onchocerca volvulus		0.1242	0.9993	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.073	0.3706	0.2981
Echinococcus multilocularis	tyrosine kinase	0.0512	0.1035	0.1036
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Loa Loa (eye worm)	hypothetical protein	0.073	0.3706	0.2981
Schistosoma mansoni	signal transduction protein lnk-related	0.073	0.3706	0.2981
Giardia lamblia	Kinase, NEK	0.0512	0.1035	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.1242	0.9993	0.9993
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Loa Loa (eye worm)	TK/ABL protein kinase	0.1242	0.9993	1
Schistosoma mansoni	protein kinase	0.0513	0.1042	0.0008
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.073	0.3706	0.3708
Loa Loa (eye worm)	hypothetical protein	0.073	0.3706	0.2981
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.073	0.3706	0.2981
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.073	0.3706	0.2981
Schistosoma mansoni	adapter molecule crk	0.073	0.3706	0.2981
Loa Loa (eye worm)	SH2 domain-containing protein	0.073	0.3706	0.2981
Echinococcus multilocularis	tyrosine protein kinase csk	0.0512	0.1035	0.1036
Loa Loa (eye worm)	hypothetical protein	0.073	0.3706	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Echinococcus multilocularis	growth factor receptor bound protein 2	0.073	0.3706	0.3708
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0512	0.1035	0.1035
Echinococcus granulosus	activated cdc42 kinase 1	0.0512	0.1035	0.1035
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0731	0.3713	0.2989
Echinococcus granulosus	SH2 motif	0.073	0.3706	0.3706
Loa Loa (eye worm)	hypothetical protein	0.073	0.3706	0.2981
Schistosoma mansoni	vav2	0.073	0.3706	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Echinococcus granulosus	c src tyrosine kinase	0.1242	0.9993	0.9993
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.1242	0.9993	1
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.073	0.3706	0.3708
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Echinococcus multilocularis	tyrosine kinase	0.1242	0.9993	1
Echinococcus multilocularis	SH2 motif	0.073	0.3706	0.3708
Schistosoma mansoni	growth factor receptor-bound protein	0.073	0.3706	0.2981
Onchocerca volvulus		0.073	0.3706	0.2981
Echinococcus granulosus	natriuretic peptide receptor 1	0.0512	0.1035	0.1035
Echinococcus granulosus	signal transduction protein lnk realted	0.073	0.3706	0.3706
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Echinococcus granulosus	growth factor receptor bound protein 2	0.073	0.3706	0.3706
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Echinococcus multilocularis	activated cdc42 kinase 1	0.0512	0.1035	0.1036
Echinococcus granulosus	ephrin type A receptor 4 A	0.0512	0.1035	0.1035
Brugia malayi	Variant SH3 domain containing protein	0.073	0.3706	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Echinococcus granulosus	tyrosine protein kinase Src42A	0.1242	0.9993	0.9993
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.1242	0.9993	1
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Echinococcus multilocularis	tensin	0.073	0.3706	0.3708
Echinococcus multilocularis	N chimaerin	0.073	0.3706	0.3708
Brugia malayi	SH2 domain containing protein	0.073	0.3706	0.2981
Echinococcus multilocularis	tyrosine protein kinase Abl	0.1242	0.9993	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.073	0.3706	0.3708
Schistosoma mansoni	tensin	0.073	0.3706	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0512	0.1035	0.1035
Schistosoma mansoni	suppressor of cytokine signaling	0.073	0.3706	0.2981
Echinococcus granulosus	protein kinase	0.0512	0.1035	0.1035
Brugia malayi	Variant SH3 domain containing protein	0.073	0.3706	0.2981
Brugia malayi	STAT protein, DNA binding domain containing protein	0.073	0.3706	0.2981
Echinococcus multilocularis	epidermal growth factor receptor	0.0512	0.1035	0.1036
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0512	0.1035	0.1035
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.1242	0.9993	1
Onchocerca volvulus		0.073	0.3706	0.2981
Echinococcus granulosus	expressed conserved protein	0.073	0.3706	0.3706
Loa Loa (eye worm)	TK/FER protein kinase	0.1242	0.9993	1
Echinococcus granulosus	tyrosine protein kinase pr2	0.0512	0.1035	0.1035
Brugia malayi	SRC-1	0.1242	0.9993	1
Echinococcus granulosus	N chimaerin	0.073	0.3706	0.3706
Loa Loa (eye worm)	hypothetical protein	0.073	0.3706	0.2981
Brugia malayi	SH2 domain containing protein	0.073	0.3706	0.2981
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0512	0.1035	0.1036
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Echinococcus granulosus	hypothetical protein	0.073	0.3706	0.3706
Onchocerca volvulus		0.1242	0.9993	1
Echinococcus granulosus	SH2 domain containing adapter protein F	0.073	0.3706	0.3706
Schistosoma mansoni	protein kinase	0.0513	0.1042	0.0008
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.1242	0.9993	1
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.073	0.3706	0.3708
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.073	0.3706	0.2981
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.1242	0.9993	1
Trichomonas vaginalis	CAMK family protein kinase	0.0512	0.1035	0.5
Loa Loa (eye worm)	hypothetical protein	0.073	0.3706	0.2981
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0512	0.1035	0.1036
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0512	0.1035	0.5
Plasmodium falciparum	protein kinase, putative	0.0513	0.1042	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.1242	0.9993	1
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Loa Loa (eye worm)	hypothetical protein	0.073	0.3706	0.2981
Onchocerca volvulus		0.073	0.3706	0.2981
Onchocerca volvulus		0.073	0.3706	0.2981
Schistosoma mansoni	protein kinase	0.0513	0.1042	0.0008
Echinococcus multilocularis	protein kinase	0.0512	0.1035	0.1036
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0512	0.1035	0.1036
Echinococcus granulosus	tyrosine protein kinase Blk	0.1242	0.9993	0.9993
Leishmania major	protein kinase, putative	0.0512	0.1035	0.9934
Echinococcus granulosus	tyrosine protein kinase csk	0.0512	0.1035	0.1035
Schistosoma mansoni	GTPase activating protein	0.073	0.3706	0.2981
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.073	0.3706	0.3706
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Echinococcus granulosus	tyrosine protein kinase csk	0.0512	0.1035	0.1035
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0512	0.1035	0.1036
Brugia malayi	SH2 domain containing protein	0.1242	0.9993	1
Loa Loa (eye worm)	STAT protein	0.073	0.3706	0.2981
Echinococcus multilocularis	SHC transforming protein 3	0.073	0.3706	0.3708
Onchocerca volvulus		0.1242	0.9993	1
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.073	0.3706	0.3708
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.073	0.3706	0.2981
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0512	0.1035	0.1036
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0512	0.1035	0.1035
Brugia malayi	SH2 domain containing protein	0.073	0.3706	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Brugia malayi	hypothetical protein	0.073	0.3706	0.2981
Schistosoma mansoni	tyrosine kinase	0.1242	0.9993	1
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.1242	0.9993	0.9993
Onchocerca volvulus		0.073	0.3706	0.2981
Schistosoma mansoni	tyrosine kinase	0.1242	0.9993	1
Brugia malayi	SH2 domain containing protein	0.073	0.3706	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0512	0.1035	0.1036
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0512	0.1035	0.1036
Schistosoma mansoni	shc transforming protein	0.073	0.3706	0.2981
Echinococcus multilocularis	tyrosine protein kinase csk	0.0512	0.1035	0.1036
Trichomonas vaginalis	conserved hypothetical protein	0.0512	0.1035	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.1242	0.9993	1
Echinococcus granulosus	tyrosine protein kinase Srms	0.1242	0.9993	0.9993
Schistosoma mansoni	tyrosine kinase	0.1242	0.9993	1
Loa Loa (eye worm)	SRC-1	0.1242	0.9993	1
Loa Loa (eye worm)	TK/FER protein kinase	0.1242	0.9993	1
Echinococcus multilocularis	protein tyrosine kinase	0.0512	0.1035	0.1036
Loa Loa (eye worm)	hypothetical protein	0.1242	0.9993	1
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0512	0.1035	0.1036
Brugia malayi	Protein kinase domain containing protein	0.1242	0.9993	1
Leishmania major	protein kinase, putative	0.0513	0.1042	1
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.1242	0.9993	0.9993
Loa Loa (eye worm)	SH2 domain-containing protein	0.073	0.3706	0.2981
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0512	0.1035	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Echinococcus granulosus	tyrosine kinase	0.0512	0.1035	0.1035
Echinococcus multilocularis	signal transduction protein lnk realted	0.073	0.3706	0.3708
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Onchocerca volvulus		0.1242	0.9993	1
Schistosoma mansoni	tyrosine kinase	0.1242	0.9993	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0512	0.1035	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0512	0.1035	0.1035
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Echinococcus multilocularis	protein kinase	0.0512	0.1035	0.1036
Brugia malayi	Protein kinase domain containing protein	0.1242	0.9993	1
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0512	0.1035	0.1036
Leishmania major	hypothetical protein, conserved	0.0512	0.1035	0.9934
Trichomonas vaginalis	TK family protein kinase	0.0512	0.1035	0.5
Brugia malayi	Protein kinase domain containing protein	0.1242	0.9993	1
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0512	0.1035	0.1036
Echinococcus granulosus	tyrosine kinase	0.1242	0.9993	0.9993
Echinococcus granulosus	tyrosine protein kinase Src42A	0.073	0.3706	0.3706
Giardia lamblia	Protein 21.1	0.0512	0.1035	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.1242	0.9993	1
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.073	0.3706	0.3706
Trichomonas vaginalis	conserved hypothetical protein	0.0512	0.1035	0.5
Echinococcus granulosus	tyrosine kinase	0.1242	0.9993	0.9993
Echinococcus granulosus	epidermal growth factor receptor	0.0512	0.1035	0.1035
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0512	0.1035	0.1036
Entamoeba histolytica	SH2 domain containing protein	0.073	0.3706	0.2981
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.073	0.3706	0.2981
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0513	0.1042	0.1042
Echinococcus multilocularis	tyrosine protein kinase Blk	0.1242	0.9993	1
Brugia malayi	SH2 domain containing protein	0.073	0.3706	0.2981
Schistosoma mansoni	tensin-related	0.073	0.3706	0.2981
Schistosoma mansoni	hypothetical protein	0.073	0.3706	0.2981
Brugia malayi	SH2 domain containing protein	0.073	0.3706	0.2981
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0512	0.1035	0.1036
Brugia malayi	Protein kinase domain containing protein	0.1242	0.9993	1
Loa Loa (eye worm)	hypothetical protein	0.073	0.3706	0.2981
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0513	0.1042	0.1043
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0512	0.1035	0.1036
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.073	0.3706	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Schistosoma mansoni	tyrosine kinase	0.1242	0.9993	1
Schistosoma mansoni	tensin	0.073	0.3706	0.2981
Echinococcus granulosus	epidermal growth factor receptor	0.0512	0.1035	0.1035
Schistosoma mansoni	nck2/grb4	0.073	0.3706	0.2981
Loa Loa (eye worm)	hypothetical protein	0.073	0.3706	0.2981
Loa Loa (eye worm)	hypothetical protein	0.073	0.3706	0.2981
Echinococcus granulosus	integrin linked protein kinase	0.0512	0.1035	0.1035
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.1242	0.9993	0.9993
Loa Loa (eye worm)	SH2 domain-containing protein	0.073	0.3706	0.2981
Brugia malayi	tRNA modification GTPase TrmE family protein	0.073	0.3706	0.2981
Trichomonas vaginalis	conserved hypothetical protein	0.0512	0.1035	0.5
Echinococcus multilocularis		0.073	0.3706	0.3708
Echinococcus multilocularis	FL cytokine receptor	0.0512	0.1035	0.1036
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0512	0.1035	0.1035
Trichomonas vaginalis	conserved hypothetical protein	0.0512	0.1035	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0513	0.1042	1
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Echinococcus multilocularis	epidermal growth factor receptor	0.0512	0.1035	0.1036
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.1242	0.9993	1
Giardia lamblia	Kinase	0.0512	0.1035	0.5
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0512	0.1035	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0513	0.1042	0.0008
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0513	0.1042	1
Echinococcus granulosus	suppressor of cytokine signaling 6	0.073	0.3706	0.3706
Loa Loa (eye worm)	hypothetical protein	0.073	0.3706	0.2981
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.073	0.3706	0.3706
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0513	0.1042	1
Trichomonas vaginalis	conserved hypothetical protein	0.0512	0.1035	0.5
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0512	0.1035	0.1035
Echinococcus granulosus	tyrosine protein kinase	0.0512	0.1035	0.1035
Echinococcus multilocularis	integrin linked protein kinase	0.0512	0.1035	0.1036
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Brugia malayi	Tensin	0.073	0.3706	0.2981
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0512	0.1035	0.1035
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.073	0.3706	0.2981
Echinococcus multilocularis	tyrosine protein kinase	0.0512	0.1035	0.1036
Echinococcus granulosus	insulin receptor	0.0512	0.1035	0.1035
Echinococcus granulosus	receptor type guanylyl cyclase	0.0512	0.1035	0.1035
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0512	0.1035	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.073	0.3706	0.2981
Entamoeba histolytica	protein kinase, putative	0.0731	0.3713	0.2989
Echinococcus multilocularis	tyrosine protein kinase csk	0.0512	0.1035	0.1036
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0512	0.1035	0.1035
Brugia malayi	hypothetical protein	0.1242	0.9993	1
Loa Loa (eye worm)	TK/FER protein kinase	0.1242	0.9993	1
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.1242	0.9993	0.9993
Brugia malayi	RhoGAP domain containing protein	0.073	0.3706	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.1242	0.9993	1
Schistosoma mansoni	tensin	0.073	0.3706	0.2981
Schistosoma mansoni	hypothetical protein	0.073	0.3706	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.073	0.3706	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Echinococcus multilocularis	tensin	0.073	0.3706	0.3708
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.073	0.3706	0.3706
Echinococcus multilocularis	SH2 motif	0.073	0.3706	0.3708
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0512	0.1035	0.1036
Loa Loa (eye worm)	TK/FER protein kinase	0.1242	0.9993	1
Echinococcus multilocularis	activin receptor type	0.0513	0.1042	0.1043
Echinococcus multilocularis	tyrosine protein kinase shark	0.1242	0.9993	1
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Loa Loa (eye worm)	hypothetical protein	0.073	0.3706	0.2981
Echinococcus multilocularis	SH2 domain containing protein 7	0.073	0.3706	0.3708
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.073	0.3706	0.3706
Loa Loa (eye worm)	TK/FER protein kinase	0.1242	0.9993	1
Echinococcus multilocularis	SH2 motif	0.073	0.3706	0.3708
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.1242	0.9993	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.073	0.3706	0.3708
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Schistosoma mansoni	growth factor receptor-bound protein	0.073	0.3706	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Trypanosoma brucei	protein kinase, putative	0.0513	0.1042	1
Echinococcus granulosus	protein tyrosine kinase	0.0512	0.1035	0.1035
Brugia malayi	SH2 domain containing protein	0.1242	0.9993	1
Echinococcus granulosus	NCK adaptor protein	0.073	0.3706	0.3706
Schistosoma mansoni	tyrosine kinase	0.1242	0.9993	1
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Trichomonas vaginalis	protein kinase atn1, putative	0.0512	0.1035	0.5
Echinococcus granulosus	tensin	0.073	0.3706	0.3706
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0512	0.1035	0.1035
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.073	0.3706	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0512	0.1035	0.5
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.073	0.3706	0.2981
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.073	0.3706	0.2981
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0512	0.1035	0.1036
Echinococcus granulosus	activated cdc42 kinase 1	0.0512	0.1035	0.1035
Loa Loa (eye worm)	TK/FER protein kinase	0.1242	0.9993	1
Brugia malayi	protein-tyrosine kinase	0.1242	0.9993	1
Loa Loa (eye worm)	hypothetical protein	0.073	0.3706	0.2981
Schistosoma mansoni	tensin-related	0.073	0.3706	0.2981
Echinococcus granulosus	raf serine:threonine protein kinase	0.0512	0.1035	0.1035
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0512	0.1035	0.1035
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.1242	0.9993	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.073	0.3706	0.3708
Echinococcus granulosus	SHC transforming protein 3	0.073	0.3706	0.3706
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0512	0.1035	0.1036
Echinococcus granulosus	tyrosine protein kinase ABL1	0.1242	0.9993	0.9993
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Trichomonas vaginalis	STE family protein kinase	0.0512	0.1035	0.5
Echinococcus granulosus	tyrosine protein kinase HCK	0.0512	0.1035	0.1035
Trichomonas vaginalis	conserved hypothetical protein	0.0512	0.1035	0.5
Schistosoma mansoni	suppressor of cytokine signaling	0.073	0.3706	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0512	0.1035	0.1036
Echinococcus multilocularis	c src tyrosine kinase	0.1242	0.9993	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.073	0.3706	0.3708
Echinococcus multilocularis	heat shock protein 70	0.0512	0.1035	0.1036
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.1242	0.9993	0.9993
Echinococcus granulosus	tyrosine protein kinase shark	0.1242	0.9993	0.9993
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0512	0.1035	0.1036
Loa Loa (eye worm)	hypothetical protein	0.073	0.3706	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.1242	0.9993	1
Brugia malayi	Sex muscle abnormal protein 5	0.073	0.3706	0.2981
Echinococcus granulosus	SH2 motif	0.073	0.3706	0.3706
Trichomonas vaginalis	TKL family protein kinase	0.0512	0.1035	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 5.1	Inhibition of GSK3-beta by fluorescence polarization assay	ChEMBL.	22310227

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1957090

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1620316