Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | eukaryotic initiation factor-2B, gamma subunit, putative | 0.0125 | 0.1275 | 0.5429 |
Toxoplasma gondii | acetyl-coA carboxylase ACC2 | 0.0175 | 0.2048 | 1 |
Toxoplasma gondii | acetyl-CoA carboxylase ACC1 | 0.0175 | 0.2048 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0125 | 0.1275 | 0.0952 |
Treponema pallidum | licC protein (licC) | 0.0125 | 0.1275 | 0.5 |
Loa Loa (eye worm) | carboxyl transferase domain-containing protein | 0.0169 | 0.1952 | 0.5 |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | 0.0684 | 1 | 1 |
Echinococcus multilocularis | acetyl coenzyme A carboxylase 1 | 0.0175 | 0.2048 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0125 | 0.1275 | 0.0952 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.0684 | 1 | 1 |
Mycobacterium ulcerans | bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase | 0.0684 | 1 | 1 |
Echinococcus granulosus | acetyl coenzyme A carboxylase 1 | 0.0175 | 0.2048 | 1 |
Leishmania major | acetyl-CoA carboxylase, putative | 0.0175 | 0.2048 | 1 |
Mycobacterium ulcerans | molybdopterin-guanine dinucleotide biosynthesis protein A | 0.0125 | 0.1275 | 0.0952 |
Mycobacterium ulcerans | hypothetical protein | 0.0125 | 0.1275 | 0.0952 |
Plasmodium vivax | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0127 | 0.1293 | 0.5 |
Chlamydia trachomatis | biotin carboxylase | 0.0061 | 0.0261 | 0.5 |
Brugia malayi | Carboxyl transferase domain containing protein | 0.0169 | 0.1952 | 0.5 |
Trypanosoma brucei | acetyl-CoA carboxylase | 0.0175 | 0.2048 | 1 |
Trypanosoma cruzi | acetyl-CoA carboxylase | 0.0108 | 0.1007 | 1 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0067 | 0.0357 | 0.1741 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0067 | 0.0357 | 0.1741 |
Schistosoma mansoni | acetyl-CoA carboxylase | 0.0175 | 0.2048 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0125 | 0.1275 | 0.0952 |
Plasmodium falciparum | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0127 | 0.1293 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 200 uM | Inhibition of Streptococcus pneumoniae acetyltransferase activity of GlmU using acetyl-CoA and glucosamine-1-phosphate after 30 mins by Ellman's method | ChEMBL. | 22297115 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.