Detailed information for compound 1628412

Basic information

Technical information
  • TDR Targets ID: 1628412
  • Name: (E)-3-chloro-2-(3,4-dichlorophenyl)-3-(3,4-di methoxyphenyl)prop-2-enal
  • MW: 371.642 | Formula: C17H13Cl3O3
  • H donors: 0 H acceptors: 1 LogP: 5.06 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C/C(=C(\c1ccc(c(c1)OC)OC)/Cl)/c1ccc(c(c1)Cl)Cl
  • InChi: 1S/C17H13Cl3O3/c1-22-15-6-4-11(8-16(15)23-2)17(20)12(9-21)10-3-5-13(18)14(19)7-10/h3-9H,1-2H3/b17-12-
  • InChiKey: LHHYMABXISBAHT-ATVHPVEESA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-chloro-2-(3,4-dichlorophenyl)-3-(3,4-dimethoxyphenyl)prop-2-enal
  • (E)-3-chloro-2-(3,4-dichlorophenyl)-3-(3,4-dimethoxyphenyl)acrolein
  • 3-chloro-2-(3,4-dichlorophenyl)-3-(3,4-dimethoxyphenyl)acrolein
  • NSC623178
  • NCI60_006920

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0478 0.1808 0.3306
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0103 0.0103
Brugia malayi Cytochrome P450 family protein 0.0065 0.015 0.015
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0133 0.0423 0.2089
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0133 0.0423 0.0748
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0133 0.0423 0.227
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0133 0.0423 0.2089
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0133 0.0423 0.227
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0071 0.0173 0.0662
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0478 0.1808 0.3306
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0133 0.0423 0.0423
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0133 0.0423 0.2089
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0478 0.1808 0.3306
Echinococcus granulosus chromobox protein 1 0.0081 0.0215 0.0902
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0133 0.0423 0.0423
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0133 0.0423 0.2089
Plasmodium vivax hypothetical protein, conserved 0.0345 0.1274 1
Trypanosoma cruzi hypothetical protein, conserved 0.0133 0.0423 0.1076
Loa Loa (eye worm) hypothetical protein 0.0046 0.0072 0.0072
Mycobacterium ulcerans putative regulatory protein 0.0345 0.1274 0.2601
Trypanosoma cruzi hypothetical protein, conserved 0.0133 0.0423 0.1076
Toxoplasma gondii hypothetical protein 0.0345 0.1274 1
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0345 0.1274 0.1274
Trichomonas vaginalis conserved hypothetical protein 0.0345 0.1274 0.2319
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1379 0.5431 1
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0133 0.0423 0.1076
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0133 0.0423 0.227
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0133 0.0423 0.0368
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0069 0.0165 0.0611
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0133 0.0423 0.0368
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.2517 1 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0133 0.0423 0.0368
Toxoplasma gondii hypothetical protein 0.0345 0.1274 1
Loa Loa (eye worm) CYP4Cod1 0.004 0.0051 0.0051
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0478 0.1808 0.3306
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0478 0.1808 0.5076
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0478 0.1808 0.3306
Trypanosoma brucei hypothetical protein, conserved 0.0133 0.0423 0.1076
Mycobacterium ulcerans putative regulatory protein 0.0345 0.1274 0.2601
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0478 0.1808 1
Mycobacterium leprae conserved hypothetical protein 0.0345 0.1274 1
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0133 0.0423 0.1205
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0478 0.1808 0.3306
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0478 0.1808 0.1808
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0173 0.0354
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0478 0.1808 0.3306
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0478 0.1808 0.5076
Plasmodium falciparum GAF domain-related protein, putative 0.0345 0.1274 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0478 0.1808 0.3306
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1035 0.4047 0.7442
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0072 0.0099
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0133 0.0423 0.0368
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0478 0.1808 0.3306
Brugia malayi Heterochromatin protein 1 0.0081 0.0215 0.0215
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0478 0.1808 0.3306
Echinococcus multilocularis chromobox protein 1 0.0081 0.0215 0.0902
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0133 0.0423 0.0748
Trypanosoma cruzi hypothetical protein, conserved 0.0133 0.0423 0.1076
Giardia lamblia Hypothetical protein 0.0133 0.0423 0.5
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0478 0.1808 0.3306
Trichomonas vaginalis chromobox protein, putative 0.0049 0.0086 0.0124
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0051 0.0051
Brugia malayi jmjC domain containing protein 0.0069 0.0165 0.0165
Onchocerca volvulus 0.0036 0.0032 0.3773
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0133 0.0423 0.1076
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0173 0.0354
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0133 0.0423 0.227
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0478 0.1808 0.3306
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0103 0.0046
Loa Loa (eye worm) heterochromatin protein 1 0.0081 0.0215 0.0215
Echinococcus multilocularis chromobox protein 1 0.0081 0.0215 0.0902
Brugia malayi Cytochrome P450 family protein 0.004 0.0051 0.0051
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0478 0.1808 0.3306
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0049 0.0086 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0103 0.0261
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.0423 0.0748
Loa Loa (eye worm) hypothetical protein 0.0133 0.0423 0.0423
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1035 0.4047 0.7442
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0133 0.0423 0.227
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0133 0.0423 0.227
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0478 0.1808 0.3306
Trichomonas vaginalis chromobox protein, putative 0.0081 0.0215 0.0364
Trichomonas vaginalis conserved hypothetical protein 0.1379 0.5431 1
Trichomonas vaginalis conserved hypothetical protein 0.0345 0.1274 0.2319
Entamoeba histolytica hypothetical protein 0.0042 0.0057 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0071 0.0173 0.0354
Loa Loa (eye worm) hypothetical protein 0.2517 1 1
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.1246 0.4897 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0133 0.0423 0.227
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0133 0.0423 0.227
Brugia malayi hypothetical protein 0.0042 0.0057 0.0057
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0133 0.0423 0.2089
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0071 0.0173 0.0494
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0478 0.1808 0.3306
Toxoplasma gondii GAF domain-containing protein 0.0345 0.1274 1
Schistosoma mansoni chromobox protein 0.0081 0.0215 0.0159
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0478 0.1808 1
Loa Loa (eye worm) hypothetical protein 0.0133 0.0423 0.0423
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0478 0.1808 0.3306
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0478 0.1808 0.176
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.1379 0.5431 1
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0133 0.0423 0.0423
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0478 0.1808 0.5076
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.1379 0.5431 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0478 0.1808 0.3306
Trichomonas vaginalis conserved hypothetical protein 0.0345 0.1274 0.2319
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0133 0.0423 0.0748
Loa Loa (eye worm) cytochrome P450 family protein 0.0065 0.015 0.015
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0133 0.0423 0.0748
Trichomonas vaginalis conserved hypothetical protein 0.0345 0.1274 0.2319
Leishmania major hypothetical protein, conserved 0.0133 0.0423 0.1205
Brugia malayi jmjC domain containing protein 0.0069 0.0165 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0072 0.0099
Schistosoma mansoni jumonji/arid domain-containing protein 0.0069 0.0165 0.0108
Entamoeba histolytica hypothetical protein 0.0042 0.0057 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0103 0.0261
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0133 0.0423 0.1076
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0133 0.0423 0.227
Echinococcus multilocularis lysine specific demethylase 5A 0.0069 0.0165 0.0611
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0133 0.0423 0.0748
Mycobacterium tuberculosis Conserved hypothetical protein 0.0902 0.3512 0.7173
Loa Loa (eye worm) PDE1B protein 0.0133 0.0423 0.0423
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0103 0.0103
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0133 0.0423 0.2089
Echinococcus granulosus lysine specific demethylase 5A 0.0069 0.0165 0.0611
Toxoplasma gondii hypothetical protein 0.0345 0.1274 1
Entamoeba histolytica hypothetical protein 0.0042 0.0057 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0478 0.1808 0.3306
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0133 0.0423 0.227
Trypanosoma cruzi hypothetical protein, conserved 0.0133 0.0423 0.1076
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0133 0.0423 0.0748
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0478 0.1808 0.3306
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.0423 0.0748
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.0902 0.3512 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0069 0.0165 0.0108
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0133 0.0423 0.0423
Leishmania major hypothetical protein, conserved 0.0902 0.3512 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0103 0.0046
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0478 0.1808 0.3306
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0133 0.0423 0.0748
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0071 0.0173 0.0662
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0133 0.0423 0.2089
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0133 0.0423 0.227
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0133 0.0423 0.227
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0478 0.1808 0.3306
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0133 0.0423 0.1076
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0133 0.0423 0.1076
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0133 0.0423 0.0368
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0133 0.0423 0.5
Schistosoma mansoni chromobox protein 0.0081 0.0215 0.0159
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0478 0.1808 0.3306
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0133 0.0423 0.1076
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0133 0.0423 0.2089
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0478 0.1808 0.5076
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.004 0.0051 0.0103
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0103 0.0261
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0069 0.0165 0.0611
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0133 0.0423 0.227
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0133 0.0423 0.2089
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0133 0.0423 0.1076
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0133 0.0423 0.227
Trypanosoma brucei GAF domain/TIP41-like family, putative 0.0902 0.3512 1
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0133 0.0423 0.1076
Leishmania major cAMP-specific phosphodiesterase, putative 0.0133 0.0423 0.1205
Trichomonas vaginalis chromobox protein, putative 0.0081 0.0215 0.0364
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0133 0.0423 0.0748
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0133 0.0423 0.2089
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0133 0.0423 0.0423
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0478 0.1808 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0103 0.0046
Echinococcus multilocularis geminin 0.0198 0.0683 0.3573
Leishmania major hypothetical protein, conserved 0.0133 0.0423 0.1205
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0133 0.0423 0.227
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0133 0.0423 0.0368
Leishmania major cytochrome p450-like protein 0.004 0.0051 0.0144
Giardia lamblia hypothetical protein 0.0133 0.0423 0.5
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0133 0.0423 0.0368
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0478 0.1808 0.3306
Entamoeba histolytica hypothetical protein 0.0042 0.0057 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0478 0.1808 0.3306
Trichomonas vaginalis chromobox protein, putative 0.0049 0.0086 0.0124
Echinococcus granulosus geminin 0.0198 0.0683 0.3573
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0478 0.1808 0.3306
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.1246 0.4897 1
Loa Loa (eye worm) hypothetical protein 0.0133 0.0423 0.0423
Brugia malayi Cytochrome P450 family protein 0.004 0.0051 0.0051
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0133 0.0423 0.0748
Brugia malayi chromobox protein homolog 3 0.0046 0.0072 0.0072
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0478 0.1808 0.3306
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0133 0.0423 0.2089
Schistosoma mansoni jumonji domain containing protein 0.0069 0.0165 0.0108
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0478 0.1808 1
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.0902 0.3512 1
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0133 0.0423 0.0368
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0133 0.0423 0.227
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0478 0.1808 0.5076
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0173 0.0354
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0046 0.0072 0.8381
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0478 0.1808 0.3306
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0133 0.0423 0.227
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0103 0.0261
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0133 0.0423 0.1076
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0345 0.1274 0.2601
Schistosoma mansoni hypothetical protein 0.0198 0.0683 0.0629
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0173 0.0117
Trypanosoma cruzi hypothetical protein, conserved 0.0133 0.0423 0.1076
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0133 0.0423 0.0368
Schistosoma mansoni hypothetical protein 0.0198 0.0683 0.0629
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0133 0.0423 0.227
Trypanosoma cruzi hypothetical protein, conserved 0.0133 0.0423 0.1076
Loa Loa (eye worm) jmjC domain-containing protein 0.0069 0.0165 0.0165
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0133 0.0423 0.2089
Loa Loa (eye worm) hypothetical protein 0.0036 0.0032 0.0032
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0133 0.0423 0.0748
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0478 0.1808 0.3306
Echinococcus granulosus chromobox protein 1 0.0081 0.0215 0.0902
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0173 0.0117

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5.571 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.569 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.537 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.369 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.341 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.23 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.135 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.893 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.737 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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