Detailed information for compound 1628438

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 474.533 | Formula: C22H23N2O4PS2
  • H donors: 1 H acceptors: 3 LogP: 5.64 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cn1c2cccc[n+]2c(c1C)P(=S)(c1ccccc1)c1ccccc1.COS(=O)(=O)[O-]
  • InChi: 1S/C21H20N2PS.CH4O4S/c1-17-21(23-16-10-9-15-20(23)22(17)2)24(25,18-11-5-3-6-12-18)19-13-7-4-8-14-19;1-5-6(2,3)4/h3-16H,1-2H3;1H3,(H,2,3,4)/q+1;/p-1
  • InChiKey: BTTUVRKQKPMSRP-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RAD52 homolog (S. cerevisiae) Starlite/ChEMBL No references
Homo sapiens proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi 26S proteasome regulatory subunit rpn11 Get druggable targets OG5_127757 All targets in OG5_127757
Cryptosporidium parvum 26S proteasome-associated Mov34/MPN/PAD-1 family. JAB domain. Get druggable targets OG5_127757 All targets in OG5_127757
Candida albicans similar to S. cerevisiae RAD52 (YML032C) dsDNA break repair annealing factor Get druggable targets OG5_130806 All targets in OG5_130806
Candida albicans similar to S. cerevisiae RAD52 (YML032C) dsDNA break repair annealing factor Get druggable targets OG5_130806 All targets in OG5_130806
Giardia lamblia DNA repair protein RAD52 Get druggable targets OG5_130806 All targets in OG5_130806
Echinococcus granulosus 26S proteasome regulatory subunit N11 Get druggable targets OG5_127757 All targets in OG5_127757
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative Get druggable targets OG5_127757 All targets in OG5_127757
Giardia lamblia Non ATPase subunit MPR1 of 26S proteasome Get druggable targets OG5_127757 All targets in OG5_127757
Plasmodium yoelii Mov34/MPN/PAD-1 family, putative Get druggable targets OG5_127757 All targets in OG5_127757
Trypanosoma brucei proteasome regulatory non-ATPase subunit 11 Get druggable targets OG5_127757 All targets in OG5_127757
Candida albicans similar to S. cerevisiae RPN11 (YFR004W) deubiquitinylating metalloisopeptidase subunit of the 19S regulatory particle of the 26 Get druggable targets OG5_127757 All targets in OG5_127757
Loa Loa (eye worm) proteasome 26S subunit Get druggable targets OG5_127757 All targets in OG5_127757
Echinococcus multilocularis 26S proteasome regulatory subunit N11 Get druggable targets OG5_127757 All targets in OG5_127757
Trypanosoma brucei proteasome regulatory non-ATPase subunit 11 Get druggable targets OG5_127757 All targets in OG5_127757
Leishmania infantum proteasome regulatory non-ATP-ase subunit 11, putative,19S proteasome regulatory subunit, Metallo- peptidase, Clan MP, Family M6 Get druggable targets OG5_127757 All targets in OG5_127757
Babesia bovis 26S proteasome regulatory subunit, putative Get druggable targets OG5_127757 All targets in OG5_127757
Trypanosoma brucei gambiense proteasome regulatory non-ATPase subunit 11,19S proteasome regulatory subunit, Metallo-peptidase, Clan MP, Family M67, putative Get druggable targets OG5_127757 All targets in OG5_127757
Theileria parva proteasome regulatory subunit, putative Get druggable targets OG5_127757 All targets in OG5_127757
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase Get druggable targets OG5_127757 All targets in OG5_127757
Neospora caninum CBR-CSN-5 protein, related Get druggable targets OG5_127757 All targets in OG5_127757
Trypanosoma brucei gambiense proteasome regulatory non-ATPase subunit 11,19S proteasome regulatory subunit, Metallo-peptidase, Clan MP, Family M67 Get druggable targets OG5_127757 All targets in OG5_127757
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III Get druggable targets OG5_127757 All targets in OG5_127757
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 Get druggable targets OG5_127757 All targets in OG5_127757
Plasmodium knowlesi 26S proteasome regulatory subunit RPN11, putative Get druggable targets OG5_127757 All targets in OG5_127757
Leishmania mexicana proteasome regulatory non-ATP-ase subunit 11, putative,19S proteasome regulatory subunit, Metallo- peptidase, Clan MP, Family M6 Get druggable targets OG5_127757 All targets in OG5_127757
Leishmania major proteasome regulatory non-ATP-ase subunit 11, putative,19S proteasome regulatory subunit, Metallo- peptidase, Clan MP, Family M6 Get druggable targets OG5_127757 All targets in OG5_127757
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 11, putative Get druggable targets OG5_127757 All targets in OG5_127757
Schistosoma japonicum ko:K03030 26S proteasome regulatory subunit N11, putative Get druggable targets OG5_127757 All targets in OG5_127757
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative Get druggable targets OG5_127757 All targets in OG5_127757
Echinococcus granulosus 26S proteasome regulatory subunit N11 Get druggable targets OG5_127757 All targets in OG5_127757
Leishmania donovani proteasome regulatory non-ATPase subunit 11, putative Get druggable targets OG5_127757 All targets in OG5_127757
Leishmania braziliensis proteasome regulatory non-ATP-ase subunit 11, putative,19S proteasome regulatory subunit, Metallo- peptidase, Clan MP, Family M6 Get druggable targets OG5_127757 All targets in OG5_127757
Toxoplasma gondii proteasome regulatory subunit Get druggable targets OG5_127757 All targets in OG5_127757
Cryptosporidium hominis Mov34/MPN/PAD-1 family proteasome regulatory subunit Get druggable targets OG5_127757 All targets in OG5_127757
Plasmodium berghei 26S proteasome regulatory subunit RPN11, putative Get druggable targets OG5_127757 All targets in OG5_127757
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative Get druggable targets OG5_127757 All targets in OG5_127757
Entamoeba histolytica DNA repair and recombination protein RAD52, putative Get druggable targets OG5_130806 All targets in OG5_130806
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase Get druggable targets OG5_127757 All targets in OG5_127757
Echinococcus multilocularis 26S proteasome regulatory subunit N11 Get druggable targets OG5_127757 All targets in OG5_127757
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase Get druggable targets OG5_127757 All targets in OG5_127757
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei COP9 signalosome complex subunit 5, putative proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 310 aa 258 aa 27.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0736 0.1845 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0736 0.1845 0.2765
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0205 0.0467 0.3549
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0736 0.1845 0.1845
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.2127 0.5452 1
Trypanosoma brucei hypothetical protein, conserved 0.0205 0.0467 0.1317
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0736 0.1845 1
Toxoplasma gondii hypothetical protein 0.0531 0.1313 1
Plasmodium vivax hypothetical protein, conserved 0.0531 0.1313 1
Loa Loa (eye worm) hypothetical protein 0.0205 0.0467 0.0467
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0205 0.0467 0.1317
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0736 0.1845 0.5209
Trichomonas vaginalis conserved hypothetical protein 0.2127 0.5452 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0736 0.1845 0.2765
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0736 0.1845 0.2765
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0205 0.0467 0.1317
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1596 0.4074 0.7235
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0205 0.0467 0.3549
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0205 0.0467 0.3549
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0205 0.0467 0.3549
Trichomonas vaginalis conserved hypothetical protein 0.0531 0.1313 0.1698
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.2127 0.5452 1
Loa Loa (eye worm) hypothetical protein 0.3881 1 1
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.1922 0.492 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0205 0.0467 0.3549
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0205 0.0467 0.3549
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0205 0.0467 0.2525
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0736 0.1845 0.2765
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0736 0.1845 0.2765
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0736 0.1845 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0736 0.1845 0.2765
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1596 0.4074 0.7235
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0205 0.0467 0.3549
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0205 0.0467 0.3549
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0205 0.0467 0.1317
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0736 0.1845 0.2765
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0736 0.1845 0.2765
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0205 0.0467 0.2525
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0736 0.1845 0.5209
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0736 0.1845 0.1446
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0736 0.1845 0.2765
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0026 0.0001 0.0001
Mycobacterium leprae conserved hypothetical protein 0.0531 0.1313 0.5
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0736 0.1845 0.2765
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.3881 1 1
Mycobacterium ulcerans putative regulatory protein 0.0531 0.1313 0.2669
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0736 0.1845 0.2765
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0736 0.1845 0.2765
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0736 0.1845 0.5209
Toxoplasma gondii hypothetical protein 0.0531 0.1313 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0736 0.1845 0.2765
Loa Loa (eye worm) hypothetical protein 0.0531 0.1313 0.1313
Trichomonas vaginalis conserved hypothetical protein 0.0531 0.1313 0.1698
Plasmodium falciparum GAF domain-related protein, putative 0.0531 0.1313 1
Trichomonas vaginalis conserved hypothetical protein 0.0531 0.1313 0.1698
Toxoplasma gondii GAF domain-containing protein 0.0531 0.1313 1
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0205 0.0467 0.3549
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0205 0.0467 0.3549
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.2127 0.5452 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0205 0.0467 0.0467
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0205 0.0467 0.3549
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0736 0.1845 0.2765
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0205 0.0467 0.3549
Leishmania major cAMP-specific phosphodiesterase, putative 0.0205 0.0467 0.1317
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0205 0.0467 0.3549
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0205 0.0467 0.3549
Trypanosoma cruzi hypothetical protein, conserved 0.0205 0.0467 0.1317
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.042 0.1024 1
Trypanosoma cruzi hypothetical protein, conserved 0.0205 0.0467 0.1317
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0205 0.0467 0.3549
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0736 0.1845 0.5209
Trypanosoma cruzi hypothetical protein, conserved 0.0205 0.0467 0.1317
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0205 0.0467 0.3549
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0736 0.1845 0.2765
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0205 0.0467 0.3549
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0205 0.0467 0.0467
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0119 0.0245 0.2382
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0205 0.0467 0.1317
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0205 0.0467 0.3549
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0205 0.0467 0.3549
Giardia lamblia DNA repair protein RAD52 0.042 0.1024 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0736 0.1845 0.2765
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0205 0.0467 0.2525
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0736 0.1845 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0205 0.0467 0.3549
Mycobacterium tuberculosis Conserved hypothetical protein 0.1391 0.3542 0.6179
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0205 0.0467 0.3549
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0205 0.0467 0.2525
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0736 0.1845 0.2765
Leishmania major hypothetical protein, conserved 0.0205 0.0467 0.1317
Mycobacterium ulcerans putative regulatory protein 0.0531 0.1313 0.2669
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0736 0.1845 0.2765
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0205 0.0467 0.1317
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0736 0.1845 0.5209
Plasmodium vivax phosphodiesterase gamma, putative 0.0205 0.0467 0.3549
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0205 0.0467 0.3549
Trypanosoma cruzi hypothetical protein, conserved 0.0205 0.0467 0.1317
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0736 0.1845 0.2765
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0736 0.1845 0.2765
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.1922 0.492 1
Loa Loa (eye worm) hypothetical protein 0.0205 0.0467 0.0467
Loa Loa (eye worm) PDE1B protein 0.0205 0.0467 0.0467
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0736 0.1845 0.2765
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0205 0.0467 0.2525
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0205 0.0467 0.1317
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0205 0.0467 0.1317
Entamoeba histolytica hypothetical protein 0.0119 0.0245 0.2382
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0736 0.1845 0.2765
Loa Loa (eye worm) hypothetical protein 0.0205 0.0467 0.0467
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0205 0.0467 0.1317
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0736 0.1845 0.2765
Trypanosoma cruzi hypothetical protein, conserved 0.0205 0.0467 0.1317
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0736 0.1845 0.2765
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0205 0.0467 0.2525
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0026 0.0001 0.0001
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0736 0.1845 0.2765
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0205 0.0467 0.3549
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0205 0.0467 0.3549
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0205 0.0467 0.2525
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.1391 0.3542 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0205 0.0467 0.3549
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0205 0.0467 0.2525
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0736 0.1845 0.2765
Plasmodium falciparum phosphodiesterase gamma, putative 0.0205 0.0467 0.3549
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0205 0.0467 0.0467
Trypanosoma brucei GAF domain/TIP41-like family, putative 0.1391 0.3542 1
Trypanosoma cruzi hypothetical protein, conserved 0.0205 0.0467 0.1317
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0205 0.0467 0.2525
Trichomonas vaginalis conserved hypothetical protein 0.0531 0.1313 0.1698
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.1391 0.3542 1
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0205 0.0467 0.2525
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0205 0.0467 0.1317
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0205 0.0467 0.1317
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0205 0.0467 0.0467
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0205 0.0467 0.0467
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0736 0.1845 0.2765
Leishmania major hypothetical protein, conserved 0.1391 0.3542 1
Plasmodium falciparum phosphodiesterase delta, putative 0.0205 0.0467 0.3549
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0205 0.0467 0.2525
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0736 0.1845 0.2765
Toxoplasma gondii hypothetical protein 0.0531 0.1313 1
Leishmania major hypothetical protein, conserved 0.0205 0.0467 0.1317
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0026 0.0001 0.0001
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0205 0.0467 0.2525

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 10.43 uM PubChem BioAssay. FRET-based HTS for detection of RAD52 Inhibitors Measured in Biochemical System Using Plate Reader - 7018-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) = 5.42 uM PUBCHEM_BIOASSAY: Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) = 62.8 uM PUBCHEM_BIOASSAY: Dose Response validation of uHTS RPN11 inhibitor hits using a Thrombin Fluorescence Polarization assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) > 100 uM PUBCHEM_BIOASSAY: Dose Response validation of uHTS RPN11 inhibitor hits using a MMP-2 Fluorescence assay. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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