Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adrenoceptor alpha 1B | Starlite/ChEMBL | References |
Homo sapiens | adrenoceptor alpha 2A | Starlite/ChEMBL | References |
Homo sapiens | adrenoceptor alpha 2C | Starlite/ChEMBL | References |
Homo sapiens | adrenoceptor alpha 1A | Starlite/ChEMBL | References |
Homo sapiens | adrenoceptor alpha 2B | Starlite/ChEMBL | References |
Homo sapiens | adrenoceptor alpha 1D | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Get druggable targets OG5_128924 | All targets in OG5_128924 |
Schistosoma japonicum | Alpha-1D adrenergic receptor, putative | Get druggable targets OG5_128924 | All targets in OG5_128924 |
Schistosoma mansoni | amine GPCR | Get druggable targets OG5_128924 | All targets in OG5_128924 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 5.1 nM | Binding affinity against human Alpha-1a adrenergic receptor | ChEMBL. | 10522703 |
Ki (binding) | = 5.1 nM | Binding affinity against human Alpha-1a adrenergic receptor | ChEMBL. | 10522703 |
Ki (binding) | = 99 nM | Binding affinity against human Alpha-2a adrenergic receptor | ChEMBL. | 10522703 |
Ki (binding) | = 99 nM | Binding affinity against human Alpha-2a adrenergic receptor | ChEMBL. | 10522703 |
Ki (binding) | = 237 nM | Binding affinity against human Alpha-2b adrenergic receptor | ChEMBL. | 10522703 |
Ki (binding) | = 237 nM | Binding affinity against human Alpha-2b adrenergic receptor | ChEMBL. | 10522703 |
Ki (binding) | = 347 nM | Binding affinity against human Alpha-1b adrenergic receptor | ChEMBL. | 10522703 |
Ki (binding) | = 347 nM | Binding affinity against human Alpha-1b adrenergic receptor | ChEMBL. | 10522703 |
Ki (binding) | = 355 nM | Binding affinity against human Alpha-2c adrenergic receptor | ChEMBL. | 10522703 |
Ki (binding) | = 355 nM | Binding affinity against human Alpha-2c adrenergic receptor | ChEMBL. | 10522703 |
Ki (binding) | = 454 nM | Binding affinity against human Alpha-1d adrenergic receptor | ChEMBL. | 10522703 |
Ki (binding) | = 454 nM | Binding affinity against human Alpha-1d adrenergic receptor | ChEMBL. | 10522703 |
Ratio (binding) | > 20 | Ratio of binding affinity against human alpha 1d-adrenoceptor by human alpha 1a-adrenoceptor | ChEMBL. | 10522703 |
Ratio (binding) | > 20 | Ratio of binding affinity against human alpha 1b-adrenoceptor by human alpha 1a-adrenoceptor | ChEMBL. | 10522703 |
Ratio (binding) | > 20 | Ratio of binding affinity against human alpha 1d-adrenoceptor by human alpha 1a-adrenoceptor | ChEMBL. | 10522703 |
Ratio (binding) | > 20 | Ratio of binding affinity against human alpha 2a-adrenoceptor by human alpha 1a-adrenoceptor | ChEMBL. | 10522703 |
Ratio (binding) | > 20 | Ratio of binding affinity against human alpha 2b-adrenoceptor by human alpha 1a-adrenoceptor | ChEMBL. | 10522703 |
Ratio (binding) | > 20 | Ratio of binding affinity against human alpha 2c-adrenoceptor by human alpha 1a-adrenoceptor | ChEMBL. | 10522703 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.