Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1916 | 0.3111 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.1916 | 0.3111 | 0.2354 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.1916 | 0.3111 | 0.3111 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1916 | 0.3111 | 0.3111 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1916 | 0.3111 | 0.3111 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1916 | 0.3111 | 0.3111 |
Onchocerca volvulus | 0.1916 | 0.3111 | 1 | |
Echinococcus granulosus | cathepsin b | 0.386 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1916 | 0.3111 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1498 | 0.1628 | 0.1628 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1916 | 0.3111 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1916 | 0.3111 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.1498 | 0.1628 | 0.5233 |
Leishmania major | cathepsin L-like protease | 0.1916 | 0.3111 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1916 | 0.3111 | 0.3111 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1916 | 0.3111 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1916 | 0.3111 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1916 | 0.3111 | 0.3111 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.1916 | 0.3111 | 0.3111 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1916 | 0.3111 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.1318 | 0.099 | 0.099 |
Brugia malayi | Cathepsin L-like precursor | 0.1318 | 0.099 | 0.099 |
Brugia malayi | Cathepsin L-like precursor | 0.1916 | 0.3111 | 0.3111 |
Onchocerca volvulus | Cathepsin F homolog | 0.1916 | 0.3111 | 1 |
Leishmania major | cathepsin L-like protease | 0.1916 | 0.3111 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.1916 | 0.3111 | 1 |
Echinococcus multilocularis | cathepsin b | 0.386 | 1 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.1916 | 0.3111 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1916 | 0.3111 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1916 | 0.3111 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.1916 | 0.3111 | 0.3111 |
Leishmania major | cysteine peptidase A (CPA) | 0.1916 | 0.3111 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1916 | 0.3111 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1318 | 0.099 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.1916 | 0.3111 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1916 | 0.3111 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1916 | 0.3111 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1916 | 0.3111 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.386 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1318 | 0.099 | 0.3182 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.1916 | 0.3111 | 0.3111 |
Echinococcus multilocularis | cysteine protease | 0.1916 | 0.3111 | 0.3111 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1916 | 0.3111 | 1 |
Leishmania major | cathepsin L-like protease | 0.1916 | 0.3111 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1916 | 0.3111 | 1 |
Onchocerca volvulus | 0.1916 | 0.3111 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1916 | 0.3111 | 0.3111 |
Giardia lamblia | Cathepsin B precursor | 0.1498 | 0.1628 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1916 | 0.3111 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1916 | 0.3111 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.1318 | 0.099 | 0.099 |
Leishmania major | cathepsin L-like protease | 0.1916 | 0.3111 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1916 | 0.3111 | 0.2354 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1916 | 0.3111 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1916 | 0.3111 | 1 |
Leishmania major | cathepsin L-like protease | 0.1916 | 0.3111 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1916 | 0.3111 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.1916 | 0.3111 | 0.3111 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1916 | 0.3111 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1916 | 0.3111 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.1916 | 0.3111 | 1 |
Onchocerca volvulus | 0.1916 | 0.3111 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.1916 | 0.3111 | 0.3111 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1916 | 0.3111 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.1916 | 0.3111 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.1916 | 0.3111 | 0.2354 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.386 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.1916 | 0.3111 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.1916 | 0.3111 | 0.2354 |
Leishmania major | cathepsin L-like protease | 0.1916 | 0.3111 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1318 | 0.099 | 0.099 |
Echinococcus multilocularis | cathepsin b | 0.386 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.1318 | 0.099 | 0.099 |
Onchocerca volvulus | 0.1916 | 0.3111 | 1 | |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.386 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1318 | 0.099 | 0.099 |
Giardia lamblia | Cathepsin B precursor | 0.1498 | 0.1628 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1916 | 0.3111 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1916 | 0.3111 | 0.3111 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.1916 | 0.3111 | 0.3111 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1916 | 0.3111 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.1916 | 0.3111 | 0.2354 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1916 | 0.3111 | 1 |
Onchocerca volvulus | 0.1916 | 0.3111 | 1 | |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.1916 | 0.3111 | 0.3111 |
Echinococcus multilocularis | cysteine protease | 0.1916 | 0.3111 | 0.3111 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.1318 | 0.099 | 0.099 |
Loa Loa (eye worm) | cathepsin B | 0.1498 | 0.1628 | 0.0708 |
Brugia malayi | Cathepsin L-like precursor | 0.1916 | 0.3111 | 0.3111 |
Echinococcus granulosus | cathepsin l1 | 0.1916 | 0.3111 | 0.3111 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.1498 | 0.1628 | 0.1628 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1318 | 0.099 | 0.3182 |
Plasmodium vivax | vivapain-2 | 0.1916 | 0.3111 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1916 | 0.3111 | 0.3111 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1916 | 0.3111 | 1 |
Onchocerca volvulus | 0.1916 | 0.3111 | 1 | |
Onchocerca volvulus | 0.1916 | 0.3111 | 1 | |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.386 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.1916 | 0.3111 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.386 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1916 | 0.3111 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.1916 | 0.3111 | 1 |
Leishmania major | cathepsin L-like protease | 0.1916 | 0.3111 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1916 | 0.3111 | 0.3111 |
Leishmania major | cathepsin L-like protease | 0.1916 | 0.3111 | 1 |
Echinococcus granulosus | cathepsin b | 0.386 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1916 | 0.3111 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.1916 | 0.3111 | 0.3111 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.1916 | 0.3111 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.1916 | 0.3111 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1916 | 0.3111 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.386 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.1498 | 0.1628 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1916 | 0.3111 | 1 |
Loa Loa (eye worm) | fibroinase | 0.1916 | 0.3111 | 0.2354 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1916 | 0.3111 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1916 | 0.3111 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1916 | 0.3111 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1916 | 0.3111 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.1498 | 0.1628 | 0.5233 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1916 | 0.3111 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.