Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | cruzipain precursor, putative | 0.176 | 0.3076 | 0.3076 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.176 | 0.3076 | 1 |
Leishmania major | cathepsin L-like protease | 0.176 | 0.3076 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.1385 | 0.1644 | 0.5 |
Echinococcus multilocularis | cathepsin b | 0.3574 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.176 | 0.3076 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.176 | 0.3076 | 0.3076 |
Entamoeba histolytica | cysteine proteinase, putative | 0.176 | 0.3076 | 1 |
Plasmodium vivax | vivapain-2 | 0.176 | 0.3076 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.176 | 0.3076 | 0.2325 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.176 | 0.3076 | 0.3076 |
Leishmania major | cathepsin L-like protease | 0.176 | 0.3076 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.176 | 0.3076 | 0.3076 |
Loa Loa (eye worm) | fibroinase | 0.176 | 0.3076 | 0.2325 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.176 | 0.3076 | 1 |
Onchocerca volvulus | 0.176 | 0.3076 | 1 | |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.176 | 0.3076 | 0.3076 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1211 | 0.0979 | 0.3182 |
Onchocerca volvulus | Cathepsin L homolog | 0.176 | 0.3076 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.176 | 0.3076 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.176 | 0.3076 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.176 | 0.3076 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.176 | 0.3076 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.1211 | 0.0979 | 0.0979 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.176 | 0.3076 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.1211 | 0.0979 | 0.0979 |
Onchocerca volvulus | 0.176 | 0.3076 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.176 | 0.3076 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1211 | 0.0979 | 0.0979 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.176 | 0.3076 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.176 | 0.3076 | 0.3076 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.176 | 0.3076 | 0.3076 |
Leishmania major | cathepsin L-like protease | 0.176 | 0.3076 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.176 | 0.3076 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.176 | 0.3076 | 1 |
Onchocerca volvulus | 0.176 | 0.3076 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.176 | 0.3076 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.176 | 0.3076 | 0.3076 |
Brugia malayi | Cathepsin L-like precursor | 0.176 | 0.3076 | 0.3076 |
Loa Loa (eye worm) | cathepsin B | 0.1385 | 0.1644 | 0.0737 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.176 | 0.3076 | 1 |
Leishmania major | cathepsin L-like protease | 0.176 | 0.3076 | 1 |
Leishmania major | cathepsin L-like protease | 0.176 | 0.3076 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.176 | 0.3076 | 0.3076 |
Leishmania major | cathepsin L-like protease | 0.176 | 0.3076 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.176 | 0.3076 | 0.3076 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.176 | 0.3076 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1211 | 0.0979 | 0.3182 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.176 | 0.3076 | 0.2325 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.176 | 0.3076 | 1 |
Onchocerca volvulus | 0.176 | 0.3076 | 1 | |
Onchocerca volvulus | 0.176 | 0.3076 | 1 | |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.1385 | 0.1644 | 0.5344 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.176 | 0.3076 | 0.3076 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.176 | 0.3076 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.1211 | 0.0979 | 0.0979 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.176 | 0.3076 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.176 | 0.3076 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1211 | 0.0979 | 0.0979 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.176 | 0.3076 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.176 | 0.3076 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.176 | 0.3076 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.176 | 0.3076 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.176 | 0.3076 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.176 | 0.3076 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.176 | 0.3076 | 0.3076 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.176 | 0.3076 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.176 | 0.3076 | 0.3076 |
Loa Loa (eye worm) | hypothetical protein | 0.176 | 0.3076 | 0.2325 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.1385 | 0.1644 | 0.1644 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.176 | 0.3076 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.176 | 0.3076 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.176 | 0.3076 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1385 | 0.1644 | 0.1644 |
Onchocerca volvulus | 0.176 | 0.3076 | 1 | |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.3574 | 1 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.176 | 0.3076 | 0.2325 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.176 | 0.3076 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.176 | 0.3076 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.176 | 0.3076 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.176 | 0.3076 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.1385 | 0.1644 | 0.5 |
Echinococcus multilocularis | cysteine protease | 0.176 | 0.3076 | 0.3076 |
Leishmania major | cathepsin L-like protease | 0.176 | 0.3076 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.176 | 0.3076 | 0.3076 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.176 | 0.3076 | 0.3076 |
Giardia lamblia | Cathepsin B precursor | 0.1385 | 0.1644 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.176 | 0.3076 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1211 | 0.0979 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.176 | 0.3076 | 1 |
Leishmania major | cathepsin L-like protease | 0.176 | 0.3076 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.176 | 0.3076 | 0.3076 |
Brugia malayi | Cathepsin L-like precursor | 0.176 | 0.3076 | 0.3076 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.176 | 0.3076 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.3574 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.176 | 0.3076 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3574 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.3574 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.3574 | 1 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.176 | 0.3076 | 0.3076 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.176 | 0.3076 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.1385 | 0.1644 | 0.5344 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.3574 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1211 | 0.0979 | 0.0979 |
Loa Loa (eye worm) | ctsf protein | 0.176 | 0.3076 | 0.2325 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.176 | 0.3076 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.176 | 0.3076 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.176 | 0.3076 | 0.3076 |
Onchocerca volvulus | 0.176 | 0.3076 | 1 | |
Entamoeba histolytica | cysteine protease, putative | 0.176 | 0.3076 | 1 |
Echinococcus multilocularis | cysteine protease | 0.176 | 0.3076 | 0.3076 |
Leishmania major | cysteine peptidase A (CPA) | 0.176 | 0.3076 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.1211 | 0.0979 | 0.0979 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.176 | 0.3076 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.3574 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.176 | 0.3076 | 1 |
Echinococcus granulosus | cathepsin b | 0.3574 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.176 | 0.3076 | 1 |
Echinococcus multilocularis | cathepsin b | 0.3574 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.176 | 0.3076 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.176 | 0.3076 | 0.3076 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.289 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.889 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.48 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.212 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.