Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | cysteine peptidase, putative | 0.1861 | 0.2969 | 0.2969 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1861 | 0.2969 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.1495 | 0.1694 | 0.5 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1281 | 0.0945 | 0.0945 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.3874 | 1 | 1 |
Onchocerca volvulus | 0.1861 | 0.2969 | 1 | |
Onchocerca volvulus | 0.1861 | 0.2969 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1861 | 0.2969 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1861 | 0.2969 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.1861 | 0.2969 | 0.2236 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.1861 | 0.2969 | 0.2969 |
Brugia malayi | Cathepsin L-like precursor | 0.1861 | 0.2969 | 0.2969 |
Plasmodium vivax | vivapain-2 | 0.1861 | 0.2969 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1281 | 0.0945 | 0.3182 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.1495 | 0.1694 | 0.1694 |
Echinococcus granulosus | cathepsin l1 | 0.1861 | 0.2969 | 0.2969 |
Brugia malayi | Cathepsin L-like precursor | 0.1861 | 0.2969 | 0.2969 |
Loa Loa (eye worm) | cathepsin B | 0.1495 | 0.1694 | 0.0828 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.1281 | 0.0945 | 0.0945 |
Echinococcus multilocularis | cysteine protease | 0.1861 | 0.2969 | 0.2969 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.1861 | 0.2969 | 0.2969 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.1861 | 0.2969 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1861 | 0.2969 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.1861 | 0.2969 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.3874 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.3874 | 1 | 1 |
Onchocerca volvulus | 0.1861 | 0.2969 | 1 | |
Onchocerca volvulus | 0.1861 | 0.2969 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1861 | 0.2969 | 1 |
Leishmania major | cathepsin L-like protease | 0.1861 | 0.2969 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1861 | 0.2969 | 0.2969 |
Leishmania major | cathepsin L-like protease | 0.1861 | 0.2969 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1861 | 0.2969 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.1861 | 0.2969 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.1861 | 0.2969 | 1 |
Echinococcus granulosus | cathepsin b | 0.3874 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1861 | 0.2969 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.1861 | 0.2969 | 0.2969 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1861 | 0.2969 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1861 | 0.2969 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1861 | 0.2969 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.1495 | 0.1694 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1861 | 0.2969 | 1 |
Loa Loa (eye worm) | fibroinase | 0.1861 | 0.2969 | 0.2236 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.3874 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1861 | 0.2969 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.1495 | 0.1694 | 0.5706 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1861 | 0.2969 | 1 |
Echinococcus granulosus | cathepsin b | 0.3874 | 1 | 1 |
Onchocerca volvulus | 0.1861 | 0.2969 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1861 | 0.2969 | 0.2969 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1861 | 0.2969 | 0.2969 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1861 | 0.2969 | 0.2969 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.1861 | 0.2969 | 0.2969 |
Loa Loa (eye worm) | ctsf protein | 0.1861 | 0.2969 | 0.2236 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1861 | 0.2969 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1861 | 0.2969 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1861 | 0.2969 | 0.2969 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.1861 | 0.2969 | 0.2969 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1861 | 0.2969 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1861 | 0.2969 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1861 | 0.2969 | 0.2969 |
Leishmania major | cathepsin L-like protease | 0.1861 | 0.2969 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.1495 | 0.1694 | 0.5706 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1861 | 0.2969 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1861 | 0.2969 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1495 | 0.1694 | 0.1694 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1861 | 0.2969 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.1861 | 0.2969 | 0.2969 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1861 | 0.2969 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1861 | 0.2969 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.1861 | 0.2969 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.1861 | 0.2969 | 1 |
Echinococcus multilocularis | cathepsin b | 0.3874 | 1 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.1861 | 0.2969 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1861 | 0.2969 | 0.2969 |
Leishmania major | cathepsin L-like protease | 0.1861 | 0.2969 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1281 | 0.0945 | 0.0945 |
Brugia malayi | cathepsin L-like precursor | 0.1281 | 0.0945 | 0.0945 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1861 | 0.2969 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3874 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1861 | 0.2969 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1861 | 0.2969 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.1861 | 0.2969 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1281 | 0.0945 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1861 | 0.2969 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.1861 | 0.2969 | 1 |
Leishmania major | cathepsin L-like protease | 0.1861 | 0.2969 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1861 | 0.2969 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1861 | 0.2969 | 1 |
Echinococcus multilocularis | cysteine protease | 0.1861 | 0.2969 | 0.2969 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1281 | 0.0945 | 0.3182 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.1861 | 0.2969 | 0.2969 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1861 | 0.2969 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1861 | 0.2969 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.1495 | 0.1694 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1861 | 0.2969 | 0.2969 |
Onchocerca volvulus | 0.1861 | 0.2969 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1861 | 0.2969 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1861 | 0.2969 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.1861 | 0.2969 | 0.2969 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1861 | 0.2969 | 1 |
Leishmania major | cathepsin L-like protease | 0.1861 | 0.2969 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1861 | 0.2969 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1861 | 0.2969 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.1281 | 0.0945 | 0.0945 |
Loa Loa (eye worm) | hypothetical protein | 0.1861 | 0.2969 | 0.2236 |
Leishmania major | cathepsin L-like protease | 0.1861 | 0.2969 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.1281 | 0.0945 | 0.0945 |
Echinococcus multilocularis | cathepsin b | 0.3874 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.1861 | 0.2969 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1281 | 0.0945 | 0.0945 |
Loa Loa (eye worm) | cysteine protease | 0.1861 | 0.2969 | 0.2236 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.3874 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.1861 | 0.2969 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.1861 | 0.2969 | 0.2236 |
Brugia malayi | Cathepsin L-like precursor | 0.1861 | 0.2969 | 0.2969 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1861 | 0.2969 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.1861 | 0.2969 | 1 |
Onchocerca volvulus | 0.1861 | 0.2969 | 1 | |
Entamoeba histolytica | cysteine protease, putative | 0.1861 | 0.2969 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MED (functional) | = 300 mg kg-1 | Anticonvulsant activity in ip dosed Swiss albino mouse assessed as protection against subcutaneous pentylenetetrazole-induced seizures after 4 hrs | ChEMBL. | 22487180 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.