Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protease, serine, 1 (trypsin 1) | Starlite/ChEMBL | References |
Homo sapiens | coagulation factor X | Starlite/ChEMBL | References |
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Trypsin family protein | protease, serine, 1 (trypsin 1) | 247 aa | 287 aa | 21.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0028 | 0.047 | 0.047 |
Echinococcus granulosus | beta tubulin | 0.0028 | 0.047 | 0.047 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0124 | 1 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0028 | 0.047 | 0.047 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.012 | 0.9598 | 0.9578 |
Leishmania major | beta tubulin | 0.0028 | 0.047 | 0.047 |
Leishmania major | beta tubulin | 0.0028 | 0.047 | 0.047 |
Echinococcus granulosus | ubiquitin conjugating enzyme E2 N | 0.0124 | 1 | 1 |
Giardia lamblia | Beta tubulin | 0.0028 | 0.047 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.9598 | 0.9578 |
Giardia lamblia | Beta tubulin | 0.0028 | 0.047 | 0.5 |
Leishmania major | beta tubulin | 0.0028 | 0.047 | 0.047 |
Leishmania major | beta tubulin | 0.0028 | 0.047 | 0.047 |
Leishmania major | beta tubulin | 0.0028 | 0.047 | 0.047 |
Leishmania major | beta tubulin | 0.0028 | 0.047 | 0.047 |
Echinococcus multilocularis | tubulin beta 1 chain | 0.0028 | 0.047 | 0.047 |
Leishmania major | beta tubulin | 0.0028 | 0.047 | 0.047 |
Leishmania major | beta tubulin | 0.0028 | 0.047 | 0.047 |
Brugia malayi | Trypsin family protein | 0.012 | 0.9598 | 0.9578 |
Leishmania major | beta tubulin | 0.0028 | 0.047 | 0.047 |
Echinococcus granulosus | tubulin beta 1 chain | 0.0028 | 0.047 | 0.047 |
Echinococcus multilocularis | ubiquitin conjugating enzyme E2 N | 0.0124 | 1 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0028 | 0.047 | 0.047 |
Entamoeba histolytica | ubiquitin-conjugating enzyme family protein | 0.0124 | 1 | 1 |
Echinococcus granulosus | tubulin subunit beta | 0.0028 | 0.047 | 0.047 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0028 | 0.047 | 0.047 |
Plasmodium falciparum | ubiquitin-conjugating enzyme E2 N, putative | 0.0124 | 1 | 1 |
Leishmania major | beta tubulin | 0.0028 | 0.047 | 0.047 |
Echinococcus multilocularis | tubulin, beta 4A class IVa | 0.0028 | 0.047 | 0.047 |
Echinococcus granulosus | tubulin beta 4A class IVa | 0.0028 | 0.047 | 0.047 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0124 | 1 | 1 |
Plasmodium vivax | ubiquitin-conjugating enzyme E2 N, putative | 0.0124 | 1 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0028 | 0.047 | 0.047 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.9598 | 0.9578 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0028 | 0.047 | 0.047 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0028 | 0.047 | 0.047 |
Leishmania major | beta tubulin | 0.0028 | 0.047 | 0.047 |
Giardia lamblia | Beta tubulin | 0.0028 | 0.047 | 0.5 |
Leishmania major | beta tubulin | 0.0028 | 0.047 | 0.047 |
Echinococcus multilocularis | tubulin subunit beta | 0.0028 | 0.047 | 0.047 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0028 | 0.047 | 0.047 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0124 | 1 | 1 |
Onchocerca volvulus | 0.012 | 0.9598 | 1 | |
Brugia malayi | ubiquitin conjugating enzyme protein 13 | 0.0124 | 1 | 1 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0124 | 1 | 1 |
Leishmania major | ubiquitin-conjugating enzyme e2, putative | 0.0124 | 1 | 1 |
Echinococcus granulosus | beta tubulin | 0.0028 | 0.047 | 0.047 |
Leishmania major | beta tubulin | 0.0028 | 0.047 | 0.047 |
Echinococcus multilocularis | beta tubulin | 0.0028 | 0.047 | 0.047 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0028 | 0.047 | 0.047 |
Leishmania major | beta tubulin | 0.0028 | 0.047 | 0.047 |
Schistosoma mansoni | ubiquitin conjugating enzyme 13 | 0.0124 | 1 | 1 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0124 | 1 | 1 |
Leishmania major | beta tubulin | 0.0028 | 0.047 | 0.047 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0124 | 1 | 1 |
Echinococcus multilocularis | beta tubulin | 0.0028 | 0.047 | 0.047 |
Leishmania major | beta tubulin | 0.0028 | 0.047 | 0.047 |
Toxoplasma gondii | ubiquitin-conjugating enzyme subfamily protein | 0.0124 | 1 | 1 |
Leishmania major | beta tubulin | 0.0028 | 0.047 | 0.047 |
Trypanosoma brucei | ubiquitin-protein ligase, putative | 0.0124 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.012 | 0.9598 | 0.9578 |
Leishmania major | beta tubulin | 0.0028 | 0.047 | 0.047 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0028 | 0.047 | 0.047 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.0187 uM | In vitro inhibition of human coagulation factor Xa. | ChEMBL. | 11677132 |
IC50 (binding) | = 0.0187 uM | In vitro inhibition of human coagulation factor Xa. | ChEMBL. | 11677132 |
IC50 (binding) | = 4.39 uM | In vitro inhibition of human trypsin. | ChEMBL. | 11677132 |
IC50 (binding) | = 4.39 uM | In vitro inhibition of human trypsin. | ChEMBL. | 11677132 |
IC50 (binding) | > 10 uM | In vitro inhibition of human thrombin. | ChEMBL. | 11677132 |
IC50 (binding) | > 10 uM | In vitro inhibition of human thrombin. | ChEMBL. | 11677132 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.