Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0129 | 0.0129 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.0262 | 0.0262 |
Echinococcus granulosus | MAM | 0.0316 | 0.0971 | 0.1753 |
Loa Loa (eye worm) | hypothetical protein | 0.1474 | 0.5388 | 0.5389 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0135 | 0.028 | 0.028 |
Loa Loa (eye worm) | hypothetical protein | 0.0316 | 0.0971 | 0.0971 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0131 | 0.0262 | 0.0262 |
Echinococcus granulosus | twitchin | 0.0096 | 0.0129 | 0.0233 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0074 | 0.0047 | 0.0086 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0129 | 0.0129 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.0262 | 0.0262 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0129 | 0.0129 |
Onchocerca volvulus | 0.0351 | 0.1104 | 1 | |
Echinococcus multilocularis | roundabout 2 | 0.0131 | 0.0262 | 0.0474 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0129 | 0.0129 |
Schistosoma mansoni | cell adhesion molecule | 0.0131 | 0.0262 | 0.0951 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0096 | 0.0129 | 0.0233 |
Echinococcus multilocularis | MAM | 0.0316 | 0.0971 | 0.1753 |
Echinococcus granulosus | neuroglian | 0.0096 | 0.0129 | 0.0233 |
Loa Loa (eye worm) | hypothetical protein | 0.0316 | 0.0971 | 0.0971 |
Schistosoma mansoni | vesicular amine transporter | 0.0096 | 0.0129 | 0.0468 |
Echinococcus granulosus | roundabout 2 | 0.0131 | 0.0262 | 0.0474 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0785 | 0.2759 | 0.4981 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0039 | 0.0039 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0106 | 0.0166 | 0.0166 |
Brugia malayi | hypothetical protein | 0.0316 | 0.0971 | 0.0971 |
Echinococcus multilocularis | Immunoglobulin | 0.0096 | 0.0129 | 0.0233 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0136 | 0.0282 | 0.0282 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0785 | 0.2759 | 0.4981 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0096 | 0.0129 | 0.0468 |
Loa Loa (eye worm) | TK protein kinase | 0.1513 | 0.5538 | 0.554 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0106 | 0.0166 | 0.0166 |
Echinococcus multilocularis | Immunoglobulin | 0.0096 | 0.0129 | 0.0233 |
Echinococcus multilocularis | neuroglian | 0.0096 | 0.0129 | 0.0233 |
Brugia malayi | MH2 domain containing protein | 0.0136 | 0.0282 | 0.0282 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.0262 | 0.0262 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0129 | 0.0129 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0136 | 0.0282 | 0.0282 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0135 | 0.028 | 0.028 |
Echinococcus granulosus | Immunoglobulin | 0.0096 | 0.0129 | 0.0233 |
Brugia malayi | hypothetical protein | 0.0131 | 0.0262 | 0.0262 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0106 | 0.0166 | 0.0166 |
Echinococcus granulosus | tyrosine protein kinase | 0.1513 | 0.5538 | 1 |
Loa Loa (eye worm) | TK/ALK protein kinase | 0.2681 | 0.9997 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.0166 | 0.0166 |
Schistosoma mansoni | nephrin | 0.0131 | 0.0262 | 0.0951 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0074 | 0.0047 | 0.0086 |
Schistosoma mansoni | ephrin receptor | 0.0074 | 0.0047 | 0.0172 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0072 | 0.0039 | 0.0039 |
Brugia malayi | Protein kinase domain containing protein | 0.1513 | 0.5538 | 0.5538 |
Echinococcus multilocularis | tyrosine protein kinase | 0.1513 | 0.5538 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2325 | 0.8638 | 0.8641 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0129 | 0.0129 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0794 | 0.2793 | 0.5044 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0096 | 0.0129 | 0.0468 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0131 | 0.0262 | 0.0262 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0096 | 0.0129 | 0.0233 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.0039 | 0.014 |
Schistosoma mansoni | hypothetical protein | 0.0316 | 0.0971 | 0.352 |
Schistosoma mansoni | hypothetical protein | 0.0316 | 0.0971 | 0.352 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0785 | 0.2759 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0316 | 0.0971 | 0.0971 |
Echinococcus granulosus | defective proboscis extension response | 0.0096 | 0.0129 | 0.0233 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.582 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.285 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.893 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.868 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.813 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.756 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.701 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.668 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.652 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.504 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.307 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.