TDR Targets

Basic information

Technical information

TDR Targets ID: 1634055
Name: 3-chloro-N'-(1,4,5,6-tetrahydropyrimidin-2-yl )propanehydrazide
MW: 204.657 | Formula: C7H13ClN4O
H donors: 3 H acceptors: 1 LogP: -0.19 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: ClCCC(=O)NN=C1NCCCN1
InChi: 1S/C7H13ClN4O/c8-3-2-6(13)11-12-7-9-4-1-5-10-7/h1-5H2,(H,11,13)(H2,9,10,12)
InChiKey: IIAWBIBLLSBPKZ-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

3-chloro-N'-(1,4,5,6-tetrahydropyrimidin-2-yl)propionohydrazide
3-Chloro-N'-(1,4,5,6-tetrahydro-2-pyrimidinyl)propanohydrazide hydroiodide
AIDS-158728
AIDS158728
NCI60_026888
NSC676161 (HYDROIODIDE SALT)

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0228	0.0232	0.0379
Onchocerca volvulus		0.0228	0.0232	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0228	0.0232	0.0379
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0228	0.0232	1
Toxoplasma gondii	cathepsin CPC2	0.153	0.3647	0.3647
Brugia malayi	Cathepsin L-like precursor	0.0228	0.0232	0.389
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0228	0.0232	0.0379
Onchocerca volvulus		0.0228	0.0232	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0228	0.0232	0.0379
Onchocerca volvulus		0.0228	0.0232	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0228	0.0232	0.0379
Schistosoma mansoni	cathepsin F (C01 family)	0.0228	0.0232	0.0232
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0156	0.0041	0.0068
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.153	0.3647	0.3647
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0342	0.0531	0.0531
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0228	0.0232	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0228	0.0232	0.0379
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0228	0.0232	0.389
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0228	0.0232	0.4368
Toxoplasma gondii	cathepsin CPL	0.0228	0.0232	0.0232
Trypanosoma cruzi	cysteine peptidase, putative	0.0228	0.0232	0.4368
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0228	0.0232	0.4368
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0342	0.0531	0.0531
Leishmania major	cathepsin L-like protease	0.0228	0.0232	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0228	0.0232	0.0379
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0228	0.0232	0.0379
Leishmania major	cathepsin L-like protease	0.0228	0.0232	1
Entamoeba histolytica	cysteine proteinase, putative	0.0228	0.0232	1
Entamoeba histolytica	cysteine protease, putative	0.0228	0.0232	1
Loa Loa (eye worm)	fibroinase	0.0228	0.0232	0.4368
Schistosoma mansoni	cathepsin F (C01 family)	0.0228	0.0232	0.0232
Schistosoma mansoni	cathepsin F (C01 family)	0.0156	0.0041	0.0041
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0228	0.0232	1
Toxoplasma gondii	cathepsin CPC1	0.395	1	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0342	0.0531	0.0531
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0228	0.0232	0.0379
Entamoeba histolytica	cysteine proteinase, putative	0.0228	0.0232	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0228	0.0232	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0228	0.0232	0.389
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.153	0.3647	0.3647
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0228	0.0232	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0228	0.0232	0.0379
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0228	0.0232	0.0379
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.395	1	1
Loa Loa (eye worm)	hypothetical protein	0.0342	0.0531	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0228	0.0232	0.0379
Leishmania major	cysteine peptidase A (CPA)	0.0228	0.0232	1
Loa Loa (eye worm)	ctsf protein	0.0228	0.0232	0.4368
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0228	0.0232	0.0379
Leishmania major	cathepsin L-like protease	0.0228	0.0232	1
Onchocerca volvulus		0.0228	0.0232	1
Leishmania major	cathepsin L-like protease	0.0228	0.0232	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0228	0.0232	0.0379
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0228	0.0232	0.0379
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0156	0.0041	0.0068
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0156	0.0041	0.0782
Brugia malayi	Cathepsin L-like precursor	0.0228	0.0232	0.389
Echinococcus multilocularis	cathepsin b	0.0342	0.0531	1
Onchocerca volvulus	Cathepsin L homolog	0.0228	0.0232	1
Leishmania major	cathepsin L-like protease	0.0228	0.0232	1
Echinococcus multilocularis	cathepsin b	0.0342	0.0531	1
Brugia malayi	Cathepsin L-like precursor	0.0228	0.0232	0.389
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0342	0.0531	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0228	0.0232	0.0379
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0228	0.0232	0.0379
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0228	0.0232	0.0379
Loa Loa (eye worm)	hypothetical protein	0.0156	0.0041	0.0782
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0342	0.0531	0.0531
Brugia malayi	cathepsin B-like cysteine proteinase	0.0342	0.0531	1
Brugia malayi	Papain family cysteine protease containing protein	0.0228	0.0232	0.389
Loa Loa (eye worm)	hypothetical protein	0.0228	0.0232	0.4368
Brugia malayi	Cathepsin L-like precursor	0.0228	0.0232	0.389
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0228	0.0232	0.0379
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0228	0.0232	0.0379
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0228	0.0232	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0228	0.0232	0.4368
Trypanosoma cruzi	cruzipain precursor, putative	0.0228	0.0232	0.4368
Loa Loa (eye worm)	hypothetical protein	0.0156	0.0041	0.0782
Onchocerca volvulus		0.0228	0.0232	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.247	0.6115	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0228	0.0232	1
Toxoplasma gondii	preprocathepsin c precursor, putative	0.395	1	1
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.395	1	1
Echinococcus granulosus	cathepsin b	0.0342	0.0531	1
Onchocerca volvulus		0.0228	0.0232	1
Onchocerca volvulus	Cathepsin F homolog	0.0228	0.0232	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0228	0.0232	0.0379
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.395	1	1
Leishmania major	cathepsin L-like protease	0.0228	0.0232	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0228	0.0232	0.4368
Brugia malayi	Cathepsin L-like precursor	0.0228	0.0232	0.389
Trypanosoma cruzi	cysteine peptidase, putative	0.0228	0.0232	0.4368
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.395	1	1
Leishmania major	cathepsin L-like protease	0.0228	0.0232	1
Onchocerca volvulus	Cathepsin L homolog	0.0228	0.0232	1
Leishmania major	cathepsin L-like protease	0.0228	0.0232	1
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.153	0.3647	0.3496
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0228	0.0232	0.0379
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0228	0.0232	0.0379
Giardia lamblia	Encystation-specific protease	0.153	0.3647	0.3647
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0228	0.0232	1
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.153	0.3647	0.3496
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0228	0.0232	0.0379
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0228	0.0232	1
Loa Loa (eye worm)	cysteine protease	0.0228	0.0232	0.4368
Loa Loa (eye worm)	hypothetical protein	0.0156	0.0041	0.0782
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0228	0.0232	0.0379
Echinococcus granulosus	cathepsin l1	0.0228	0.0232	0.389
Echinococcus granulosus	cathepsin b	0.0342	0.0531	1
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.395	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0228	0.0232	1
Brugia malayi	Cathepsin L-like precursor	0.0228	0.0232	0.389
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0228	0.0232	1
Onchocerca volvulus		0.0228	0.0232	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2009019

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1634055