Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Protein kinase domain containing protein | 0.0742 | 0.0378 | 0.0968 |
Loa Loa (eye worm) | Na/Ca eXchangers family member | 0.0355 | 0.0099 | 0.0099 |
Loa Loa (eye worm) | hypothetical protein | 0.2103 | 0.1361 | 0.1361 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.0018 | 0.0018 |
Loa Loa (eye worm) | hypothetical protein | 0.0355 | 0.0099 | 0.0099 |
Echinococcus granulosus | sodium:potassium:calcium exchanger | 0.0355 | 0.0099 | 0.0081 |
Loa Loa (eye worm) | solute carrier family 8 | 1.4065 | 1 | 1 |
Echinococcus multilocularis | sodium:potassium:calcium exchanger | 0.0355 | 0.0099 | 0.0081 |
Brugia malayi | K+-dependent Na+/Ca+ exchanger related-protein | 0.0355 | 0.0099 | 0.0253 |
Onchocerca volvulus | 0.2103 | 0.1361 | 1 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.2103 | 0.1361 | 0.1346 |
Loa Loa (eye worm) | hypothetical protein | 0.0742 | 0.0378 | 0.0378 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.0018 | 0.0018 |
Schistosoma mansoni | potassium-dependent sodium-calcium exchanger 3 4 | 0.0355 | 0.0099 | 0.0081 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0355 | 0.0099 | 0.0477 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0742 | 0.0378 | 0.0361 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0742 | 0.0378 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.0018 | 0.0018 |
Mycobacterium ulcerans | hypothetical protein | 0.0243 | 0.0018 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0742 | 0.0378 | 0.0361 |
Onchocerca volvulus | 0.0742 | 0.0378 | 0.2681 | |
Schistosoma mansoni | na/ca exchanger | 0.0355 | 0.0099 | 0.0081 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0355 | 0.0099 | 0.0477 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.2103 | 0.1361 | 0.1346 |
Toxoplasma gondii | kringle domain-containing protein | 0.0742 | 0.0378 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2103 | 0.1361 | 0.1361 |
Echinococcus multilocularis | sodium calcium exchanger | 1.4065 | 1 | 1 |
Onchocerca volvulus | 0.0249 | 0.0022 | 0.003 | |
Echinococcus granulosus | sodium:potassium:calcium exchanger 6 | 0.0355 | 0.0099 | 0.0081 |
Brugia malayi | Sodium/calcium exchanger protein | 0.5626 | 0.3906 | 1 |
Echinococcus multilocularis | sodium:potassium:calcium exchanger 6 | 0.0355 | 0.0099 | 0.0081 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0355 | 0.0099 | 0.0477 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.2481 | 0.1634 | 1 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0742 | 0.0378 | 1 |
Brugia malayi | Trypsin family protein | 0.0243 | 0.0018 | 0.0045 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.2481 | 0.1634 | 1 |
Brugia malayi | Na/Ca eXchangers family member (ncx-4) | 0.0355 | 0.0099 | 0.0253 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0742 | 0.0378 | 0.0361 |
Brugia malayi | Trypsin family protein | 0.0243 | 0.0018 | 0.0045 |
Schistosoma mansoni | sodium/calcium exchanger | 1.4065 | 1 | 1 |
Entamoeba histolytica | sodium/calcium exchanger protein, putative | 0.0355 | 0.0099 | 0.5 |
Schistosoma mansoni | potassium-dependent sodium-calcium exchanger 3 4 | 0.0355 | 0.0099 | 0.0081 |
Onchocerca volvulus | 0.186 | 0.1186 | 0.8694 | |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.0018 | 0.0018 |
Loa Loa (eye worm) | trypsin family protein | 0.0243 | 0.0018 | 0.0018 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0742 | 0.0378 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0355 | 0.0099 | 0.0081 |
Loa Loa (eye worm) | hypothetical protein | 0.0355 | 0.0099 | 0.0099 |
Loa Loa (eye worm) | hypothetical protein | 0.0355 | 0.0099 | 0.0099 |
Brugia malayi | hypothetical protein | 0.0243 | 0.0018 | 0.0045 |
Brugia malayi | Trypsin family protein | 0.0243 | 0.0018 | 0.0045 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0243 | 0.0018 | 0.0045 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0243 | 0.0018 | 0.0045 |
Echinococcus multilocularis | expressed conserved protein | 0.0795 | 0.0417 | 0.04 |
Echinococcus granulosus | expressed conserved protein | 0.0795 | 0.0417 | 0.04 |
Loa Loa (eye worm) | hypothetical protein | 0.5626 | 0.3906 | 0.3906 |
Mycobacterium leprae | Probable ionic transporter integral membrane protein ChaA | 0.0355 | 0.0099 | 0.5 |
Brugia malayi | Kringle domain containing protein | 0.0742 | 0.0378 | 0.0968 |
Leishmania major | hypothetical protein, conserved | 0.0742 | 0.0378 | 0.5 |
Treponema pallidum | hypothetical protein | 0.0355 | 0.0099 | 0.5 |
Mycobacterium tuberculosis | Probable ionic transporter integral membrane protein ChaA | 0.0355 | 0.0099 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.0018 | 0.0018 |
Onchocerca volvulus | Sodium\/potassium\/calcium exchanger | 0.0355 | 0.0099 | 0.0602 |
Brugia malayi | Trypsin family protein | 0.2103 | 0.1361 | 0.3485 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0742 | 0.0378 | 0.0378 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.