Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Kynurenine 3-monooxygenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Candida albicans | potential monooxygenase similar to S. cerevisiae BNA4 (YBL098W) kynurenine 3-monooxygenase, biosynthesis of Nicotinic Acid | Get druggable targets OG5_129812 | All targets in OG5_129812 |
Candida albicans | potential monooxygenase similar to S. cerevisiae BNA4 (YBL098W) kynurenine 3-monooxygenase, biosynthesis of Nicotinic Acid | Get druggable targets OG5_129812 | All targets in OG5_129812 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.3356 | 0.3356 |
Mycobacterium leprae | possibleputative FAD-linked oxidoreductase | 0.0018 | 0.3365 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0011 | 0.1028 | 0.1145 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.3356 | 0.374 |
Toxoplasma gondii | FAD binding domain-containing protein | 0.0018 | 0.3365 | 1 |
Chlamydia trachomatis | monooxygenase | 0.0018 | 0.3365 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.3356 | 0.4075 |
Mycobacterium ulcerans | oxidoreductase | 0.0018 | 0.3365 | 1 |
Schistosoma mansoni | monoxygenase | 0.0018 | 0.3365 | 0.3365 |
Mycobacterium ulcerans | hypothetical protein | 0.0018 | 0.3365 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.3356 | 0.5 |
Echinococcus granulosus | ubiquinone biosynthesis monooxygenase COQ6 | 0.0018 | 0.3365 | 0.3751 |
Mycobacterium ulcerans | hypothetical protein | 0.0018 | 0.3365 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0034 | 0.8236 | 1 |
Mycobacterium ulcerans | FAD-linked oxidoreductase | 0.0018 | 0.3365 | 1 |
Echinococcus granulosus | voltage gated potassium channel | 0.0011 | 0.1028 | 0.1145 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0018 | 0.3365 | 1 |
Mycobacterium ulcerans | oxidoreductase | 0.0018 | 0.3365 | 1 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0018 | 0.3365 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0018 | 0.3365 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.3365 | 0.3365 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0018 | 0.3365 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0018 | 0.3365 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0018 | 0.3365 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0037 | 0.8972 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.3356 | 0.3356 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.3356 | 0.374 |
Echinococcus multilocularis | protein MICAL 3 | 0.0018 | 0.3365 | 0.3751 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.3356 | 0.374 |
Echinococcus multilocularis | ubiquinone biosynthesis monooxygenase COQ6 | 0.0018 | 0.3365 | 0.3751 |
Plasmodium falciparum | FAD-dependent monooxygenase, putative | 0.0018 | 0.3365 | 1 |
Trypanosoma brucei | Monooxygenase, putative | 0.0018 | 0.3365 | 1 |
Mycobacterium ulcerans | membrane-associated oxidoreductase | 0.0018 | 0.3365 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0011 | 0.1028 | 0.1028 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0011 | 0.1028 | 0.1145 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0.3356 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.004 | 1 | 1 |
Trypanosoma cruzi | Monooxygenase, putative | 0.0018 | 0.3365 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0018 | 0.3365 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.3365 | 0.3751 |
Plasmodium vivax | FAD-dependent monooxygenase, putative | 0.0018 | 0.3365 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0018 | 0.3365 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0018 | 0.3365 | 1 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0018 | 0.3365 | 1 |
Toxoplasma gondii | FAD binding domain-containing protein | 0.0018 | 0.3365 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0037 | 0.8972 | 1 |
Wolbachia endosymbiont of Brugia malayi | 2-polyprenyl-6-methoxyphenol 4-hydroxylase | 0.0018 | 0.3365 | 1 |
Mycobacterium ulcerans | oxidoreductase GMC-type | 0.0018 | 0.3365 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.1028 | 0.1145 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0011 | 0.1028 | 0.1028 |
Trypanosoma brucei | kynurenine 3-monooxygenase, putative | 0.0018 | 0.3365 | 1 |
Mycobacterium ulcerans | FAD-dependent oxidoreductase | 0.0018 | 0.3365 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.3356 | 0.4075 |
Echinococcus granulosus | protein MICAL 3 | 0.0018 | 0.3365 | 0.3751 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.3356 | 0.374 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.3356 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.7495 | 0.8354 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0011 | 0.1028 | 0.1145 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0037 | 0.8972 | 1 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0011 | 0.1028 | 0.1145 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0034 | 0.8236 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0037 | 0.8972 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.6 uM | Inhibition of rat brain KYN 3-OHase. | ChEMBL. | 9873646 |
IC50 (binding) | = 5.6 uM | Inhibition of rat brain KYN 3-OHase. | ChEMBL. | 9873646 |
IC50 (binding) | = 9.1 uM | Inhibition of rat liver KYN 3-OHase. | ChEMBL. | 9873646 |
IC50 (binding) | = 9.1 uM | Inhibition of rat liver KYN 3-OHase. | ChEMBL. | 9873646 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.