Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | potassium voltage-gated channel, subfamily H (eag-related), member 2 | Starlite/ChEMBL | References |
Homo sapiens | sodium channel, voltage-gated, type V, alpha subunit | Starlite/ChEMBL | References |
Homo sapiens | sodium channel, voltage-gated, type IX, alpha subunit | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.3445 | 0.8141 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.2708 | 0.6401 |
Echinococcus multilocularis | family S10 non peptidase ue (S10 family) | 0.0035 | 0.2193 | 0.2193 |
Echinococcus granulosus | lysosomal protective protein | 0.0039 | 0.2708 | 0.2708 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.005 | 0.4231 | 0.4231 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0039 | 0.2708 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0039 | 0.2708 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.005 | 0.4231 | 0.4231 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0094 | 1 | 1 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0039 | 0.2708 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0054 | 0.4779 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.005 | 0.4231 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.3055 | 0.5 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0094 | 1 | 1 |
Echinococcus multilocularis | sodium channel protein | 0.0094 | 1 | 1 |
Schistosoma mansoni | family S10 non-peptidase homologue (S10 family) | 0.0039 | 0.2708 | 0.5668 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0039 | 0.2708 | 0.5 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0039 | 0.2708 | 0.5 |
Echinococcus granulosus | family S10 non peptidase ue S10 family | 0.0035 | 0.2193 | 0.2193 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0039 | 0.2708 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0054 | 0.4779 | 1 |
Schistosoma mansoni | family S10 unassigned peptidase (S10 family) | 0.0039 | 0.2708 | 0.5668 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.005 | 0.4231 | 1 |
Brugia malayi | Serine carboxypeptidase F41C3.5 precursor | 0.0039 | 0.2708 | 0.6401 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.3055 | 0.5 |
Echinococcus multilocularis | lysosomal protective protein | 0.0039 | 0.2708 | 0.2708 |
Onchocerca volvulus | Uncharacterized serine carboxypeptidase homolog | 0.0039 | 0.2708 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0039 | 0.2708 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.04 uM | Antagonist activity at human NaV1.5 channel by patchXpress assay | ChEMBL. | 22318156 |
IC50 (functional) | = 0.16 uM | Antagonist activity at human NaV1.7 channel by patchXpress assay | ChEMBL. | 22318156 |
Ki (binding) | = 2.3 uM | Displacement of dofetilide from human ERG | ChEMBL. | 22318156 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.