Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cyclin-dependent kinase 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | cyclin-dependent kinase 3 | 305 aa | 303 aa | 32.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | 0.0052 | 0.1289 | 1 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0097 | 0.258 | 1 |
Giardia lamblia | Kinase, CMGC CDK | 0.0052 | 0.1289 | 0.4997 |
Brugia malayi | cell division control protein 2 homolog | 0.0052 | 0.1289 | 0.1788 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0097 | 0.258 | 1 |
Plasmodium vivax | protein kinase Crk2 | 0.0052 | 0.1289 | 0.4997 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0097 | 0.258 | 1 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0052 | 0.1289 | 1 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0052 | 0.1289 | 1 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0052 | 0.1289 | 0.4997 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0097 | 0.258 | 1 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0052 | 0.1289 | 0.4997 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0052 | 0.1289 | 0.4997 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0052 | 0.1289 | 0.4997 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0052 | 0.1289 | 1 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0052 | 0.1289 | 1 |
Giardia lamblia | Telomerase catalytic subunit | 0.0097 | 0.258 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0052 | 0.1289 | 1 |
Plasmodium falciparum | protein kinase 5 | 0.0052 | 0.1289 | 0.4997 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0097 | 0.258 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0052 | 0.1289 | 1 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0052 | 0.1289 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0052 | 0.1289 | 1 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0052 | 0.1289 | 0.4997 |
Brugia malayi | Protein kinase domain containing protein | 0.0052 | 0.1289 | 0.1788 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0097 | 0.258 | 1 |
Brugia malayi | Telomerase reverse transcriptase | 0.0258 | 0.7212 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0052 | 0.1289 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.1289 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1273 | 0.9876 |
Giardia lamblia | Kinase, CMGC CDK | 0.0052 | 0.1289 | 0.4997 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0052 | 0.1289 | 0.4997 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0052 | 0.1289 | 0.4997 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0052 | 0.1289 | 0.4997 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0052 | 0.1289 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.1289 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0052 | 0.1289 | 1 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0097 | 0.258 | 1 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0052 | 0.1289 | 1 |
Echinococcus granulosus | cyclin dependent kinase | 0.0052 | 0.1289 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.1289 | 1 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0052 | 0.1289 | 0.4997 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0052 | 0.1289 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = -5.2 | The logarithmic molar concentration inhibiting 50% net cell growth was measured on HCT-116(M) colon cancer cell lines. | ChEMBL. | 10425100 |
IC50 (binding) | Inhibition of human SIRT1 | ChEMBL. | 17149860 | |
IC50 (binding) | 0 | Inhibition of human SIRT1 | ChEMBL. | 17149860 |
IC50 (binding) | = 1 uM | In vitro inhibitory activity against cyclin-dependent kinase 1-cyclin B (Cyclin-Dependent Kinase) harvested from starfish oocytes. | ChEMBL. | 10425100 |
IC50 (binding) | = 1 uM | In vitro inhibitory activity against cyclin-dependent kinase 1-cyclin B (Cyclin-Dependent Kinase) harvested from starfish oocytes. | ChEMBL. | 10425100 |
Inhibition (binding) | = 43.1 % | Inhibition of human recombinant SIRT2 at 50 uM | ChEMBL. | 17149860 |
Inhibition (binding) | = 43.1 % | Inhibition of human recombinant SIRT2 at 50 uM | ChEMBL. | 17149860 |
Log GI50 (functional) | = -5.2 | The logarithmic molar concentration inhibiting 50% net cell growth was measured on HCT-116(M) colon cancer cell lines. | ChEMBL. | 10425100 |
Log GI50 (functional) | = -5 | Antitumor activity for each out of 60 human tumor cell lines. | ChEMBL. | 10425100 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.