Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | potassium voltage-gated channel, subfamily H (eag-related), member 2 | Starlite/ChEMBL | References |
Homo sapiens | G protein-coupled receptor 119 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | G protein-coupled receptor 119 | 335 aa | 274 aa | 22.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0013 | 0.1414 | 0.1113 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.1414 | 0.1113 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.7603 | 0.8121 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.8312 | 0.8924 |
Onchocerca volvulus | 0.0046 | 0.9262 | 0.5 | |
Brugia malayi | cystatin | 0.0046 | 0.9262 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.9262 | 0.9262 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.9262 | 0.9262 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0045 | 0.9017 | 0.9722 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0045 | 0.9017 | 0.9722 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0045 | 0.9017 | 0.9722 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0009 | 0.043 | 0.043 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0009 | 0.043 | 0.043 |
Onchocerca volvulus | 0.0046 | 0.9262 | 0.5 | |
Loa Loa (eye worm) | cystatin-type cysteine proteinase inhibitor CPI-1 | 0.0046 | 0.9262 | 1 |
Echinococcus granulosus | proteinase inhibitor I25 cystatin | 0.0046 | 0.9262 | 1 |
Brugia malayi | cathepsin F-like cysteine proteinase | 0.0046 | 0.9262 | 1 |
Echinococcus multilocularis | proteinase inhibitor I25, cystatin | 0.0046 | 0.9262 | 1 |
Echinococcus granulosus | voltage gated potassium channel | 0.0013 | 0.1414 | 0.1113 |
Loa Loa (eye worm) | cysteine protease inhibitor | 0.0046 | 0.9262 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.9262 | 1 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0009 | 0.043 | 0.043 |
Onchocerca volvulus | 0.0046 | 0.9262 | 0.5 | |
Onchocerca volvulus | 0.0046 | 0.9262 | 0.5 | |
Schistosoma mansoni | cystatin B | 0.0046 | 0.9262 | 0.9262 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0013 | 0.1414 | 0.1113 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.8312 | 0.8924 |
Trichomonas vaginalis | Clan IH, family I25, phytocystatin-like peptidase inhibitor | 0.0046 | 0.9262 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0009 | 0.043 | 0.043 |
Echinococcus granulosus | Cystatin B Stefin B | 0.0046 | 0.9262 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0045 | 0.9017 | 0.9722 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0009 | 0.043 | 0.043 |
Onchocerca volvulus | 0.0046 | 0.9262 | 0.5 | |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.1414 | 0.1414 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.9262 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.1414 | 0.1414 |
Brugia malayi | cystatin-type cysteine proteinase inhibitor CPI-2, putative | 0.0046 | 0.9262 | 1 |
Echinococcus multilocularis | Cystatin B (Stefin B) | 0.0046 | 0.9262 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0013 | 0.1414 | 0.1113 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0009 | 0.043 | 0.043 |
Onchocerca volvulus | 0.0046 | 0.9262 | 0.5 | |
Echinococcus multilocularis | voltage gated potassium channel | 0.0013 | 0.1414 | 0.1113 |
Loa Loa (eye worm) | cystatin | 0.0046 | 0.9262 | 1 |
Brugia malayi | cystatin | 0.0046 | 0.9262 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 85 % | Agonist activity at human GPR119 receptor expressed in HEK293 cells assessed as cAMP accumulation after 45 mins by fluorescence assay relative to oleoylethanolamide | ChEMBL. | 22061639 |
EC50 (functional) | = 0.004 uM | Agonist activity at human GPR119 receptor expressed in HEK293 cells assessed as cAMP accumulation after 45 mins by fluorescence assay | ChEMBL. | 22061639 |
IC50 (binding) | = 4.2 uM | Binding affinity to human ERG | ChEMBL. | 22061639 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.