Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0283 | 0.1387 | 0.1387 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0283 | 0.1387 | 0.1387 |
Echinococcus multilocularis | acetylcholinesterase | 0.1677 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1677 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1677 | 1 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0283 | 0.1387 | 0.1387 |
Brugia malayi | Carboxylesterase family protein | 0.1677 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0283 | 0.1387 | 0.5 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0283 | 0.1387 | 0.1387 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1677 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0283 | 0.1387 | 0.4708 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0283 | 0.1387 | 0.1387 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0283 | 0.1387 | 0.4708 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1677 | 1 | 1 |
Echinococcus multilocularis | neuroligin | 0.0283 | 0.1387 | 0.1387 |
Schistosoma mansoni | acetylcholinesterase | 0.0283 | 0.1387 | 0.1387 |
Onchocerca volvulus | 0.0283 | 0.1387 | 0.5 | |
Onchocerca volvulus | 0.0283 | 0.1387 | 0.5 | |
Onchocerca volvulus | 0.0283 | 0.1387 | 0.5 | |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0283 | 0.1387 | 0.1387 |
Echinococcus granulosus | neuroligin | 0.0283 | 0.1387 | 0.1387 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0536 | 0.2946 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.1677 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0283 | 0.1387 | 0.5 |
Onchocerca volvulus | 0.0283 | 0.1387 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.1677 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0283 | 0.1387 | 0.1387 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0283 | 0.1387 | 0.1387 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0283 | 0.1387 | 0.1387 |
Echinococcus granulosus | acetylcholinesterase | 0.1677 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1677 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.1677 | 1 | 1 |
Schistosoma mansoni | gliotactin | 0.0283 | 0.1387 | 0.1387 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0576 | 0.3197 | 1 |
Onchocerca volvulus | 0.0283 | 0.1387 | 0.5 | |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0059 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0283 | 0.1387 | 0.4339 |
Loa Loa (eye worm) | hypothetical protein | 0.1677 | 1 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0059 | 0 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0576 | 0.3197 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0283 | 0.1387 | 0.4708 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0283 | 0.1387 | 0.1387 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0283 | 0.1387 | 0.1387 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Effect of the compound on electrically evoked contractions in mouse vas deferens at 10E-8 to 10E-6 M concentration; No effect | ChEMBL. | 15139773 | |
Activity (functional) | 0 | Effect of the compound on electrically evoked contractions in mouse vas deferens at 10E-8 to 10E-6 M concentration; No effect | ChEMBL. | 15139773 |
Activity (functional) | 0 | Effect of the compound on electrically evoked contractions in mesenteric plexus longitudinal muscles of guinea pig at 10E-8 to 2.4E-6 M; No effect | ChEMBL. | 15139773 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.