Detailed information for compound 1637541

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 2059.99 | Formula: C90H131N4NaO48
  • H donors: 28 H acceptors: 28 LogP: -6.38 Rotable bonds: 46
    Rule of 5 violations (Lipinski): 4
  • SMILES: COC(=O)N[C@@H]1C(O)C(OC2C(O)[C@H](O[C@@H]3C(CO)O[C@H](C(C3O[C@@H]3OC(C)[C@@H](C(C3O)O)O)Nc3ccc4c(c3)cccc4)OCCCO[C@H]3CCC[C@H](C3)OCCCO[C@@H]3OC(CO)[C@H](C(C3Nc3ccc4c(c3)cccc4)O[C@@H]3OC(C)[C@@H](C(C3O)O)O)O[C@@H]3OC(CO)[C@@H](C(C3O)OC3[C@@H](OC([C@@H](C3O)NC(=O)OC)[C@@H]([C@@H](CO)O)O)C(=O)O)O)OC([C@@H]2O)CO)[C@@H](OC1[C@@H]([C@@H](CO)O)O)C(=O)[O-].[Na+]
  • InChi: 1S/C90H132N4O48.Na/c1-35-55(103)63(111)65(113)85(129-35)141-73-53(91-41-20-18-37-12-5-7-14-39(37)26-41)83(133-49(33-99)69(73)139-87-67(115)75(59(107)47(31-97)131-87)137-77-61(109)51(93-89(121)123-3)71(57(105)45(101)29-95)135-79(77)81(117)118)127-24-10-22-125-43-16-9-17-44(28-43)126-23-11-25-128-84-54(92-42-21-19-38-13-6-8-15-40(38)27-42)74(142-86-66(114)64(112)56(104)36(2)130-86)70(50(34-100)134-84)140-88-68(116)76(60(108)48(32-98)132-88)138-78-62(110)52(94-90(122)124-4)72(58(106)46(102)30-96)136-80(78)82(119)120;/h5-8,12-15,18-21,26-27,35-36,43-80,83-88,91-92,95-116H,9-11,16-17,22-25,28-34H2,1-4H3,(H,93,121)(H,94,122)(H,117,118)(H,119,120);/q;+1/p-1/t35?,36?,43-,44+,45-,46-,47?,48?,49?,50?,51-,52-,53?,54?,55+,56+,57-,58-,59+,60+,61?,62?,63?,64?,65?,66?,67?,68?,69-,70-,71?,72?,73?,74?,75?,76?,77?,78?,79-,80-,83-,84-,85+,86+,87+,88+;/m1./s1
  • InChiKey: ZOFKNKLMOIKHDA-PMIINHQUSA-M  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0161 0.1641 0.1648
Echinococcus granulosus tyrosine kinase 0.0161 0.1641 0.1641
Schistosoma mansoni suppressor of cytokine signaling 0.0203 0.3364 0.3378
Brugia malayi Protein kinase domain containing protein 0.0161 0.1641 0.1648
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0203 0.3364 0.3378
Loa Loa (eye worm) TK/INSR protein kinase 0.0161 0.1641 0.1648
Schistosoma mansoni tyrosine kinase 0.0161 0.1641 0.1648
Echinococcus granulosus epidermal growth factor receptor 0.0161 0.1641 0.1641
Schistosoma mansoni protein kinase 0.0161 0.1641 0.1648
Loa Loa (eye worm) RGC/RGC protein kinase 0.0161 0.1641 0.1648
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0364 0.996 0.996
Echinococcus granulosus activated cdc42 kinase 1 0.0161 0.1641 0.1641
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0161 0.1641 0.1648
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0161 0.1641 0.1648
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0364 0.996 0.996
Schistosoma mansoni tyrosine kinase 0.0161 0.1641 0.1648
Loa Loa (eye worm) serine/threonine protein kinase 0.0161 0.1641 0.1648
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Echinococcus granulosus SHC transforming protein 3 0.0203 0.3364 0.3364
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0161 0.1641 0.1648
Brugia malayi Tyrosine-protein kinase PR2 0.0161 0.1641 0.1648
Onchocerca volvulus 0.0364 0.996 1
Entamoeba histolytica protein kinase domain containing protein 0.0162 0.1681 0.0048
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Echinococcus granulosus tyrosine kinase 0.0364 0.996 0.996
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Echinococcus granulosus N chimaerin 0.0203 0.3364 0.3364
Echinococcus multilocularis tyrosine protein kinase Blk 0.0364 0.996 1
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0364 0.996 1
Loa Loa (eye worm) TK/FER protein kinase 0.0364 0.996 1
Trichomonas vaginalis STE family protein kinase 0.0161 0.1641 0.5
Brugia malayi Protein kinase domain containing protein 0.0161 0.1641 0.1648
Loa Loa (eye worm) TK/FER protein kinase 0.0161 0.1641 0.1648
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0161 0.1641 0.1648
Loa Loa (eye worm) hypothetical protein 0.0203 0.3364 0.3378
Echinococcus multilocularis protein KINase family member (kin 25) 0.0161 0.1641 0.1648
Schistosoma mansoni tyrosine kinase 0.0161 0.1641 0.1648
Onchocerca volvulus 0.0364 0.996 1
Echinococcus granulosus kinase suppressor of Ras 1 0.0161 0.1641 0.1641
Loa Loa (eye worm) TK/FAK protein kinase 0.0161 0.1641 0.1648
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0162 0.1681 0.1688
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0203 0.3364 0.3378
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0203 0.3364 0.3378
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Loa Loa (eye worm) hypothetical protein 0.0203 0.3364 0.3378
Schistosoma mansoni tyrosine kinase 0.0161 0.1641 0.1648
Echinococcus granulosus tyrosine protein kinase Fyn 0.0364 0.996 0.996
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0364 0.996 0.996
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0161 0.1641 0.1648
Loa Loa (eye worm) hypothetical protein 0.0161 0.1641 0.1648
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0161 0.1641 0.1648
Leishmania major protein kinase, putative 0.0162 0.1681 1
Giardia lamblia Kinase 0.0161 0.1641 0.5
Loa Loa (eye worm) hypothetical protein 0.0203 0.3364 0.3378
Echinococcus granulosus ephrin type A receptor 4 A 0.0161 0.1641 0.1641
Echinococcus multilocularis activin receptor type 0.0162 0.1681 0.1688
Schistosoma mansoni tyrosine kinase 0.0161 0.1641 0.1648
Trichomonas vaginalis conserved hypothetical protein 0.0161 0.1641 0.5
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0161 0.1641 0.1641
Schistosoma mansoni suppressor of cytokine signaling 0.0203 0.3364 0.3378
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Echinococcus multilocularis insulin receptor 0.0161 0.1641 0.1648
Schistosoma mansoni tyrosine protein kinase 0.0161 0.1641 0.1648
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0203 0.3364 0.3378
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0161 0.1641 0.5
Loa Loa (eye worm) hypothetical protein 0.0161 0.1641 0.1648
Schistosoma mansoni tyrosine kinase 0.0161 0.1641 0.1648
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Echinococcus granulosus tyrosine protein kinase 0.0161 0.1641 0.1641
Loa Loa (eye worm) STAT protein 0.0203 0.3364 0.3378
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0161 0.1641 0.1648
Loa Loa (eye worm) hypothetical protein 0.0203 0.3364 0.3378
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0203 0.3364 0.3378
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0161 0.1641 0.1648
Plasmodium vivax tyrosine kinase-like protein, putative 0.0161 0.1641 0.5
Echinococcus granulosus tyrosine protein kinase ABL1 0.0364 0.996 0.996
Echinococcus granulosus tyrosine protein kinase HCK 0.0161 0.1641 0.1641
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0161 0.1641 0.1648
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0161 0.1641 0.1648
Schistosoma mansoni tensin-related 0.0203 0.3364 0.3378
Brugia malayi Protein kinase domain containing protein 0.0161 0.1641 0.1648
Echinococcus granulosus SH2 domain containing protein 7 0.0203 0.3364 0.3364
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Echinococcus granulosus fibroblast growth factor receptor 4 0.0161 0.1641 0.1641
Onchocerca volvulus 0.0161 0.1641 0.1648
Brugia malayi protein-tyrosine kinase 0.0364 0.996 1
Schistosoma mansoni tyrosine kinase 0.0364 0.996 1
Brugia malayi hypothetical protein 0.0203 0.3364 0.3378
Brugia malayi Protein kinase domain containing protein 0.0161 0.1641 0.1648
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0364 0.996 1
Loa Loa (eye worm) hypothetical protein 0.0203 0.3364 0.3378
Onchocerca volvulus Tyrosine kinase homolog 0.0161 0.1641 0.1648
Echinococcus multilocularis tensin 0.0203 0.3364 0.3378
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0161 0.1641 0.1648
Echinococcus granulosus receptor type guanylyl cyclase 0.0161 0.1641 0.1641
Echinococcus granulosus tyrosine protein kinase csk 0.0161 0.1641 0.1641
Giardia lamblia Kinase, NEK 0.0161 0.1641 0.5
Schistosoma mansoni ephrin receptor 0.0161 0.1641 0.1648
Loa Loa (eye worm) TK/ALK protein kinase 0.0161 0.1641 0.1648
Loa Loa (eye worm) hypothetical protein 0.0203 0.3364 0.3378
Echinococcus granulosus protein tyrosine kinase 0.0161 0.1641 0.1641
Loa Loa (eye worm) TK/EGFR protein kinase 0.0161 0.1641 0.1648
Brugia malayi STAT protein, DNA binding domain containing protein 0.0203 0.3364 0.3378
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0161 0.1641 0.1648
Brugia malayi Protein kinase domain containing protein 0.0364 0.996 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0161 0.1641 0.1648
Echinococcus granulosus insulin receptor 0.0161 0.1641 0.1641
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0161 0.1641 0.1648
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0364 0.996 1
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Loa Loa (eye worm) hypothetical protein 0.0203 0.3364 0.3378
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Echinococcus granulosus SH2 domain containing adapter protein F 0.0203 0.3364 0.3364
Loa Loa (eye worm) RGC/RGC protein kinase 0.0161 0.1641 0.1648
Loa Loa (eye worm) TK/ABL protein kinase 0.0364 0.996 1
Onchocerca volvulus 0.0161 0.1641 0.1648
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Onchocerca volvulus 0.0161 0.1641 0.1648
Echinococcus multilocularis tyrosine protein kinase Abl 0.0364 0.996 1
Brugia malayi Protein kinase domain containing protein 0.0161 0.1641 0.1648
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0364 0.996 1
Schistosoma mansoni tensin-related 0.0203 0.3364 0.3378
Echinococcus granulosus epidermal growth factor receptor 0.0161 0.1641 0.1641
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0203 0.3364 0.3378
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0203 0.3364 0.3378
Echinococcus multilocularis tyrosine protein kinase csk 0.0161 0.1641 0.1648
Echinococcus granulosus activated cdc42 kinase 1 0.0161 0.1641 0.1641
Schistosoma mansoni adapter molecule crk 0.0203 0.3364 0.3378
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0364 0.996 1
Brugia malayi Protein kinase domain containing protein 0.0364 0.996 1
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0161 0.1641 0.1648
Echinococcus granulosus tyrosine protein kinase Src42A 0.0364 0.996 0.996
Loa Loa (eye worm) hypothetical protein 0.0203 0.3364 0.3378
Brugia malayi Tensin 0.0203 0.3364 0.3378
Brugia malayi RhoGAP domain containing protein 0.0203 0.3364 0.3378
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0364 0.996 0.996
Brugia malayi Protein kinase domain containing protein 0.0161 0.1641 0.1648
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0364 0.996 1
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0162 0.1681 1
Schistosoma mansoni hypothetical protein 0.0203 0.3364 0.3378
Giardia lamblia Kinase, NEK 0.0161 0.1641 0.5
Loa Loa (eye worm) TK/ACK protein kinase 0.0161 0.1641 0.1648
Brugia malayi Protein kinase domain containing protein 0.0161 0.1641 0.1648
Onchocerca volvulus 0.0161 0.1641 0.1648
Echinococcus granulosus tyrosine protein kinase Fyn 0.0364 0.996 0.996
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0161 0.1641 0.1648
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0162 0.1681 1
Echinococcus granulosus expressed conserved protein 0.0203 0.3364 0.3364
Loa Loa (eye worm) hypothetical protein 0.0364 0.996 1
Giardia lamblia Protein 21.1 0.0161 0.1641 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0161 0.1641 0.5
Brugia malayi Protein kinase domain containing protein 0.0161 0.1641 0.1648
Echinococcus granulosus retinal guanylyl cyclase 2 0.0161 0.1641 0.1641
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Schistosoma mansoni serine/threonine RGC 0.0161 0.1641 0.1648
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Echinococcus granulosus tyrosine kinase 0.0364 0.996 0.996
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0161 0.1641 0.1648
Loa Loa (eye worm) TK protein kinase 0.0161 0.1641 0.1648
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Echinococcus multilocularis epidermal growth factor receptor 0.0161 0.1641 0.1648
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0161 0.1641 0.1648
Echinococcus multilocularis natriuretic peptide receptor 1 0.0161 0.1641 0.1648
Brugia malayi Protein kinase domain containing protein 0.0161 0.1641 0.1648
Brugia malayi Furin-like cysteine rich region family protein 0.0161 0.1641 0.1648
Onchocerca volvulus 0.0161 0.1641 0.1648
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0203 0.3364 0.3378
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0161 0.1641 0.1648
Schistosoma mansoni protein kinase 0.0161 0.1641 0.1648
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0161 0.1641 0.1641
Echinococcus multilocularis transfer RNA-Thr 0.0161 0.1641 0.1648
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0161 0.1641 0.1641
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0203 0.3364 0.3378
Schistosoma mansoni growth factor receptor-bound protein 0.0203 0.3364 0.3378
Schistosoma mansoni serine/threonine protein kinase 0.0161 0.1641 0.1648
Echinococcus granulosus tyrosine protein kinase Blk 0.0364 0.996 0.996
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0204 0.3405 0.212
Entamoeba histolytica SH2 domain containing protein 0.0203 0.3364 0.2072
Schistosoma mansoni SH2A 0.0203 0.3364 0.3378
Echinococcus multilocularis tyrosine protein kinase 0.0161 0.1641 0.1648
Brugia malayi cytokine inducible SH2-containing protein 5 0.0203 0.3364 0.3378
Loa Loa (eye worm) TK/RYK protein kinase 0.0161 0.1641 0.1648
Schistosoma mansoni tyrosine kinase 0.0161 0.1641 0.1648
Brugia malayi Protein kinase domain containing protein 0.0161 0.1641 0.1648
Echinococcus multilocularis N chimaerin 0.0203 0.3364 0.3378
Onchocerca volvulus 0.0161 0.1641 0.1648
Brugia malayi Protein kinase domain containing protein 0.0161 0.1641 0.1648
Onchocerca volvulus 0.0364 0.996 1
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Loa Loa (eye worm) TK protein kinase 0.0161 0.1641 0.1648
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Brugia malayi hypothetical protein 0.0161 0.1641 0.1648
Loa Loa (eye worm) TK protein kinase 0.0161 0.1641 0.1648
Brugia malayi Raf kinase 0.0161 0.1641 0.1648
Schistosoma mansoni protein kinase 0.0161 0.1641 0.1648
Brugia malayi Protein kinase domain containing protein 0.0161 0.1641 0.1648
Loa Loa (eye worm) hypothetical protein 0.0203 0.3364 0.3378
Trypanosoma brucei protein kinase, putative 0.0162 0.1681 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0161 0.1641 0.1648
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0203 0.3364 0.3378
Loa Loa (eye worm) RGC/RGC protein kinase 0.0161 0.1641 0.1648
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0203 0.3364 0.3378
Loa Loa (eye worm) hypothetical protein 0.0161 0.1641 0.1648
Onchocerca volvulus 0.0203 0.3364 0.3378
Schistosoma mansoni tyrosine kinase 0.0364 0.996 1
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0203 0.3364 0.3378
Schistosoma mansoni nck2/grb4 0.0203 0.3364 0.3378
Trichomonas vaginalis conserved hypothetical protein 0.0161 0.1641 0.5
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Schistosoma mansoni protein tyrosine kinase 0.0161 0.1641 0.1648
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Echinococcus multilocularis protein kinase 0.0161 0.1641 0.1648
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0161 0.1641 0.1648
Trichomonas vaginalis conserved hypothetical protein 0.0161 0.1641 0.5
Loa Loa (eye worm) hypothetical protein 0.0203 0.3364 0.3378
Brugia malayi SH2 domain containing protein 0.0203 0.3364 0.3378
Loa Loa (eye worm) SH2 domain-containing protein 0.0203 0.3364 0.3378
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0161 0.1641 0.1641
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Schistosoma mansoni tyrosine kinase 0.0161 0.1641 0.1648
Brugia malayi Variant SH3 domain containing protein 0.0203 0.3364 0.3378
Schistosoma mansoni tyrosine kinase 0.0161 0.1641 0.1648
Loa Loa (eye worm) TK protein kinase 0.0161 0.1641 0.1648
Echinococcus granulosus c src tyrosine kinase 0.0364 0.996 0.996
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0161 0.1641 0.1648
Loa Loa (eye worm) hypothetical protein 0.0203 0.3364 0.3378
Echinococcus granulosus NCK adaptor protein 0.0203 0.3364 0.3364
Trichomonas vaginalis conserved hypothetical protein 0.0161 0.1641 0.5
Echinococcus multilocularis SH2 motif 0.0203 0.3364 0.3378
Loa Loa (eye worm) TK/FER protein kinase 0.0364 0.996 1
Schistosoma mansoni tensin 0.0203 0.3364 0.3378
Brugia malayi Variant SH3 domain containing protein 0.0203 0.3364 0.3378
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0364 0.996 1
Schistosoma mansoni tyrosine kinase 0.0161 0.1641 0.1648
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0203 0.3364 0.3378
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0364 0.996 1
Schistosoma mansoni signal transduction protein lnk-related 0.0203 0.3364 0.3378
Loa Loa (eye worm) TK protein kinase 0.0161 0.1641 0.1648
Onchocerca volvulus 0.0161 0.1641 0.1648
Brugia malayi Guanylyl cyclase protein 23 0.0161 0.1641 0.1648
Echinococcus multilocularis tensin 0.0203 0.3364 0.3378
Schistosoma mansoni tyrosine kinase 0.0364 0.996 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0161 0.1641 0.1648
Brugia malayi Protein kinase domain containing protein 0.0161 0.1641 0.1648
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Loa Loa (eye worm) hypothetical protein 0.0203 0.3364 0.3378
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Schistosoma mansoni tyrosine kinase 0.0161 0.1641 0.1648
Echinococcus multilocularis ephrin type A receptor 4 A 0.0161 0.1641 0.1648
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0162 0.1681 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0364 0.996 0.996
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0364 0.996 1
Loa Loa (eye worm) TK protein kinase 0.0161 0.1641 0.1648
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0364 0.996 0.996
Schistosoma mansoni protein kinase 0.0161 0.1641 0.1648
Brugia malayi hypothetical protein 0.0364 0.996 1
Brugia malayi Protein kinase domain containing protein 0.0161 0.1641 0.1648
Loa Loa (eye worm) TK/FER protein kinase 0.0161 0.1641 0.1648
Echinococcus granulosus integrin linked protein kinase 0.0161 0.1641 0.1641
Brugia malayi Receptor family ligand binding region containing protein 0.0161 0.1641 0.1648
Echinococcus multilocularis activated cdc42 kinase 1 0.0161 0.1641 0.1648
Echinococcus multilocularis tyrosine protein kinase csk 0.0161 0.1641 0.1648
Brugia malayi integrin-linked kinase 0.0161 0.1641 0.1648
Echinococcus granulosus retinal guanylyl cyclase 2 0.0161 0.1641 0.1641
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0364 0.996 1
Trichomonas vaginalis protein tyrosine kinase, putative 0.0161 0.1641 0.5
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0161 0.1641 0.1641
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0161 0.1641 0.1648
Loa Loa (eye worm) RGC/RGC protein kinase 0.0161 0.1641 0.1648
Onchocerca volvulus 0.0161 0.1641 0.1648
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0161 0.1641 0.1641
Brugia malayi Protein kinase domain containing protein 0.0161 0.1641 0.1648
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0364 0.996 1
Schistosoma mansoni tyrosine kinase 0.0364 0.996 1
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0161 0.1641 0.1648
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Echinococcus multilocularis kinase suppressor of Ras 1 0.0161 0.1641 0.1648
Echinococcus granulosus tyrosine protein kinase csk 0.0161 0.1641 0.1641
Schistosoma mansoni protein kinase 0.0162 0.1681 0.1688
Trichomonas vaginalis TK family protein kinase 0.0161 0.1641 0.5
Brugia malayi Protein kinase domain containing protein 0.0161 0.1641 0.1648
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0161 0.1641 0.1648
Schistosoma mansoni tyrosine kinase 0.0161 0.1641 0.1648
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Loa Loa (eye worm) hypothetical protein 0.0161 0.1641 0.1648
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Echinococcus granulosus suppressor of cytokine signaling 7 0.0203 0.3364 0.3364
Brugia malayi tRNA modification GTPase TrmE family protein 0.0203 0.3364 0.3378
Onchocerca volvulus 0.0203 0.3364 0.3378
Loa Loa (eye worm) protein kinase domain-containing protein 0.0161 0.1641 0.1648
Echinococcus multilocularis receptor type guanylyl cyclase 0.0161 0.1641 0.1648
Loa Loa (eye worm) TK/FER protein kinase 0.0161 0.1641 0.1648
Loa Loa (eye worm) SH2 domain-containing protein 0.0203 0.3364 0.3378
Onchocerca volvulus 0.0161 0.1641 0.1648
Loa Loa (eye worm) TK/FER protein kinase 0.0364 0.996 1
Onchocerca volvulus 0.0203 0.3364 0.3378
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Loa Loa (eye worm) hypothetical protein 0.0203 0.3364 0.3378
Loa Loa (eye worm) TK protein kinase 0.0161 0.1641 0.1648
Echinococcus granulosus natriuretic peptide receptor 1 0.0161 0.1641 0.1641
Echinococcus multilocularis SHC transforming protein 3 0.0203 0.3364 0.3378
Brugia malayi Protein kinase domain containing protein 0.0364 0.996 1
Brugia malayi Protein kinase domain containing protein 0.0161 0.1641 0.1648
Schistosoma mansoni tensin 0.0203 0.3364 0.3378
Onchocerca volvulus 0.0203 0.3364 0.3378
Brugia malayi SH2 domain containing protein 0.0203 0.3364 0.3378
Brugia malayi SH2 domain containing protein 0.0203 0.3364 0.3378
Loa Loa (eye worm) TK/FER protein kinase 0.0161 0.1641 0.1648
Schistosoma mansoni hypothetical protein 0.0203 0.3364 0.3378
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0162 0.1681 0.1681
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0364 0.996 1
Echinococcus granulosus tyrosine protein kinase shark 0.0364 0.996 0.996
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0161 0.1641 0.1641
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Brugia malayi Protein kinase domain containing protein 0.0161 0.1641 0.1648
Brugia malayi SH2 domain containing protein 0.0203 0.3364 0.3378
Onchocerca volvulus 0.0364 0.996 1
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0203 0.3364 0.3378
Echinococcus granulosus tyrosine protein kinase Srms 0.0364 0.996 0.996
Trichomonas vaginalis conserved hypothetical protein 0.0161 0.1641 0.5
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Schistosoma mansoni tyrosine kinase 0.0161 0.1641 0.1648
Plasmodium falciparum protein kinase, putative 0.0162 0.1681 1
Echinococcus multilocularis tyrosine protein kinase shark 0.0364 0.996 1
Schistosoma mansoni protein kinase 0.0162 0.1681 0.1688
Schistosoma mansoni tyrosine kinase 0.0161 0.1641 0.1648
Loa Loa (eye worm) SH2 domain-containing protein 0.0203 0.3364 0.3378
Echinococcus multilocularis SH2 motif 0.0203 0.3364 0.3378
Schistosoma mansoni tyrosine kinase 0.0161 0.1641 0.1648
Schistosoma mansoni vav2 0.0203 0.3364 0.3378
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0161 0.1641 0.1648
Echinococcus granulosus tyrosine protein kinase pr2 0.0161 0.1641 0.1641
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0161 0.1641 0.1641
Brugia malayi Tyrosine-protein kinase abl-1 0.0364 0.996 1
Schistosoma mansoni tyrosine kinase 0.0161 0.1641 0.1648
Schistosoma mansoni serine/threonine protein kinase 0.0161 0.1641 0.1648
Loa Loa (eye worm) hypothetical protein 0.0203 0.3364 0.3378
Echinococcus multilocularis raf serine:threonine protein kinase 0.0161 0.1641 0.1648
Schistosoma mansoni protein kinase 0.0161 0.1641 0.1648
Plasmodium vivax protein kinase, putative 0.0161 0.1641 0.5
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0161 0.1641 0.1641
Entamoeba histolytica protein kinase, putative 0.0204 0.3405 0.212
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0161 0.1641 0.1648
Brugia malayi Protein kinase domain containing protein 0.0161 0.1641 0.1648
Trichomonas vaginalis CAMK family protein kinase 0.0161 0.1641 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0161 0.1641 0.1648
Loa Loa (eye worm) hypothetical protein 0.0161 0.1641 0.1648
Schistosoma mansoni protein kinase 0.0162 0.1681 0.1688
Trichomonas vaginalis conserved hypothetical protein 0.0161 0.1641 0.5
Echinococcus multilocularis protein tyrosine kinase 0.0161 0.1641 0.1648
Loa Loa (eye worm) TK/FER protein kinase 0.0161 0.1641 0.1648
Brugia malayi Protein kinase domain containing protein 0.0161 0.1641 0.1648
Brugia malayi SH2 domain containing protein 0.0203 0.3364 0.3378
Echinococcus granulosus growth factor receptor bound protein 2 0.0203 0.3364 0.3364
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0161 0.1641 0.5
Brugia malayi Protein kinase domain containing protein 0.0161 0.1641 0.1648
Schistosoma mansoni serine/threonine protein kinase 0.0161 0.1641 0.1648
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Schistosoma mansoni tyrosine kinase 0.0161 0.1641 0.1648
Loa Loa (eye worm) TK/FER protein kinase 0.0364 0.996 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0161 0.1641 0.1648
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0203 0.3364 0.3378
Schistosoma mansoni protein kinase 0.0161 0.1641 0.1648
Echinococcus multilocularis tyrosine protein kinase HCK 0.0161 0.1641 0.1648
Brugia malayi SH2 domain containing protein 0.0364 0.996 1
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0161 0.1641 0.1648
Brugia malayi ephrin receptor 1 precursor 0.0161 0.1641 0.1648
Loa Loa (eye worm) TK/EPH protein kinase 0.0161 0.1641 0.1648
Schistosoma mansoni tyrosine kinase 0.0161 0.1641 0.1648
Schistosoma mansoni tyrosine kinase 0.0161 0.1641 0.1648
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0203 0.3364 0.3378
Echinococcus multilocularis c src tyrosine kinase 0.0364 0.996 1
Brugia malayi Sex muscle abnormal protein 5 0.0203 0.3364 0.3378
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0161 0.1641 0.1648
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Echinococcus granulosus signal transduction protein lnk realted 0.0203 0.3364 0.3364
Loa Loa (eye worm) TK protein kinase 0.0161 0.1641 0.1648
Echinococcus granulosus tensin 0.0203 0.3364 0.3364
Loa Loa (eye worm) TK protein kinase 0.0161 0.1641 0.1648
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0161 0.1641 0.1648
Schistosoma mansoni protein kinase 0.0161 0.1641 0.1648
Plasmodium vivax tyrosine kinase-like protein, putative 0.0161 0.1641 0.5
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Brugia malayi Variant SH3 domain containing protein 0.0203 0.3364 0.3378
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0161 0.1641 0.1648
Schistosoma mansoni tyrosine kinase 0.0161 0.1641 0.1648
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Schistosoma mansoni tyrosine kinase 0.0161 0.1641 0.1648
Echinococcus multilocularis integrin linked protein kinase 0.0161 0.1641 0.1648
Loa Loa (eye worm) TK/FER protein kinase 0.0161 0.1641 0.1648
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Echinococcus multilocularis tyrosine kinase 0.0364 0.996 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0203 0.3364 0.3378
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0161 0.1641 0.5
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0364 0.996 1
Loa Loa (eye worm) TK protein kinase 0.0364 0.996 1
Schistosoma mansoni GTPase activating protein 0.0203 0.3364 0.3378
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Loa Loa (eye worm) hypothetical protein 0.0161 0.1641 0.1648
Echinococcus multilocularis tyrosine protein kinase Srms 0.0364 0.996 1
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0203 0.3364 0.3378
Echinococcus multilocularis epidermal growth factor receptor 0.0161 0.1641 0.1648
Onchocerca volvulus 0.0203 0.3364 0.3378
Echinococcus multilocularis tyrosine protein kinase csk 0.0161 0.1641 0.1648
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Echinococcus multilocularis heat shock protein 70 0.0161 0.1641 0.1648
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Brugia malayi bone morphogenetic protein type 1 receptor 0.0161 0.1641 0.1648
Brugia malayi Protein kinase domain containing protein 0.0364 0.996 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0161 0.1641 0.1641
Brugia malayi Protein kinase domain containing protein 0.0161 0.1641 0.1648
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0203 0.3364 0.3364
Echinococcus multilocularis protein kinase 0.0161 0.1641 0.1648
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0161 0.1641 0.1641
Brugia malayi SRC-1 0.0364 0.996 1
Brugia malayi SH2 domain containing protein 0.0203 0.3364 0.3378
Echinococcus multilocularis tyrosine kinase 0.0161 0.1641 0.1648
Schistosoma mansoni tyrosine kinase 0.0161 0.1641 0.1648
Schistosoma mansoni tyrosine kinase 0.0161 0.1641 0.1648
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0203 0.3364 0.3378
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0161 0.1641 0.1648
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Schistosoma mansoni tensin 0.0203 0.3364 0.3378
Loa Loa (eye worm) hypothetical protein 0.0161 0.1641 0.1648
Loa Loa (eye worm) TK/FER protein kinase 0.0364 0.996 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0203 0.3364 0.3364
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0162 0.1681 1
Schistosoma mansoni growth factor receptor-bound protein 0.0203 0.3364 0.3378
Echinococcus granulosus SH2 motif 0.0203 0.3364 0.3364
Echinococcus granulosus tyrosine protein kinase csk 0.0161 0.1641 0.1641
Echinococcus granulosus hypothetical protein 0.0203 0.3364 0.3364
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0161 0.1641 0.5
Schistosoma mansoni shc transforming protein 0.0203 0.3364 0.3378
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0203 0.3364 0.3364
Echinococcus granulosus tyrosine protein kinase Src64B 0.0364 0.996 0.996
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Echinococcus granulosus raf serine:threonine protein kinase 0.0161 0.1641 0.1641
Brugia malayi C-terminal src kinase protein 1 0.0161 0.1641 0.1648
Loa Loa (eye worm) TK/FER protein kinase 0.0364 0.996 1
Schistosoma mansoni hypothetical protein 0.0161 0.1641 0.1648
Loa Loa (eye worm) hypothetical protein 0.0161 0.1641 0.1648
Onchocerca volvulus 0.0364 0.996 1
Echinococcus multilocularis SH2 domain containing protein 7 0.0203 0.3364 0.3378
Loa Loa (eye worm) SRC-1 0.0364 0.996 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0364 0.996 1
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0161 0.1641 0.1641
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0364 0.996 1
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Onchocerca volvulus 0.0364 0.996 1
Echinococcus multilocularis SH2 motif 0.0203 0.3364 0.3378
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0203 0.3364 0.3378
Loa Loa (eye worm) TK/CSK protein kinase 0.0161 0.1641 0.1648
Brugia malayi Protein kinase domain containing protein 0.0364 0.996 1
Loa Loa (eye worm) TK/FER protein kinase 0.0364 0.996 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0203 0.3364 0.3378
Brugia malayi Protein kinase domain containing protein 0.0161 0.1641 0.1648
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Brugia malayi Protein kinase domain containing protein 0.0161 0.1641 0.1648
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0203 0.3364 0.3364
Brugia malayi SH2 domain containing protein 0.0203 0.3364 0.3378
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Schistosoma mansoni tyrosine kinase 0.0364 0.996 1
Brugia malayi Variant SH3 domain containing protein 0.0203 0.3364 0.3378
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0161 0.1641 0.1648
Loa Loa (eye worm) hypothetical protein 0.0161 0.1641 0.1648
Loa Loa (eye worm) hypothetical protein 0.0161 0.1641 0.1648
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0203 0.3364 0.3378
Loa Loa (eye worm) TK/FER protein kinase 0.0364 0.996 1
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0364 0.996 1
Loa Loa (eye worm) TK/ROR protein kinase 0.0161 0.1641 0.1648
Brugia malayi Immunoglobulin I-set domain containing protein 0.0161 0.1641 0.1648
Echinococcus multilocularis FL cytokine receptor 0.0161 0.1641 0.1648
Echinococcus granulosus suppressor of cytokine signaling 6 0.0203 0.3364 0.3364
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0203 0.3364 0.3364
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0161 0.1641 0.1648
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0161 0.1641 0.1641
Trichomonas vaginalis protein kinase atn1, putative 0.0161 0.1641 0.5
Echinococcus multilocularis 0.0203 0.3364 0.3378
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Brugia malayi Protein kinase domain containing protein 0.0161 0.1641 0.1648
Schistosoma mansoni tyrosine kinase 0.0364 0.996 1
Schistosoma mansoni tyrosine kinase 0.0161 0.1641 0.1648
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0203 0.3364 0.3378
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0161 0.1641 0.1648
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Loa Loa (eye worm) TK/DDR protein kinase 0.0161 0.1641 0.1648
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0203 0.3364 0.3364
Schistosoma mansoni tyrosine kinase 0.0161 0.1641 0.1648
Brugia malayi SH2 domain containing protein 0.0364 0.996 1
Loa Loa (eye worm) hypothetical protein 0.0203 0.3364 0.3378
Echinococcus granulosus protein kinase 0.0161 0.1641 0.1641
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Echinococcus multilocularis growth factor receptor bound protein 2 0.0203 0.3364 0.3378
Schistosoma mansoni protein kinase 0.0161 0.1641 0.1648
Loa Loa (eye worm) hypothetical protein 0.0161 0.1641 0.1648
Echinococcus multilocularis tyrosine protein kinase pr2 0.0161 0.1641 0.1648
Brugia malayi hypothetical protein 0.0161 0.1641 0.1648
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0161 0.1641 0.1648
Schistosoma mansoni ephrin receptor 0.0161 0.1641 0.1648
Echinococcus granulosus SH2 motif 0.0203 0.3364 0.3364
Echinococcus multilocularis NCK adaptor protein 0.0203 0.3364 0.3378
Echinococcus granulosus activin receptor type 0.0162 0.1681 0.1681
Trichomonas vaginalis TKL family protein kinase 0.0161 0.1641 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0364 0.996 1
Echinococcus multilocularis signal transduction protein lnk realted 0.0203 0.3364 0.3378
Onchocerca volvulus 0.0203 0.3364 0.3378
Loa Loa (eye worm) TK/Met protein kinase 0.0161 0.1641 0.1648
Trichomonas vaginalis AGC family protein kinase 0.0161 0.1641 0.5

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.041 mM Compound was evaluated for its inhibitory activity against adhesion of HL-60(human promyclocytic leukemia cells) to recombinant human soluble E-selectin(rhsE). ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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