Detailed information for compound 1637883

Basic information

Technical information
  • TDR Targets ID: 1637883
  • Name: N-(3-chlorophenyl)-3-ethoxy-3-iminopropanamid e
  • MW: 240.686 | Formula: C11H13ClN2O2
  • H donors: 1 H acceptors: 1 LogP: 2.2 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=N)CC(=O)Nc1cccc(c1)Cl
  • InChi: 1S/C11H13ClN2O2/c1-2-16-10(13)7-11(15)14-9-5-3-4-8(12)6-9/h3-6,13H,2,7H2,1H3,(H,14,15)
  • InChiKey: PWCOQOHCAJRFKV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(3-chlorophenyl)-3-ethoxy-3-imino-propanamide
  • N-(3-chlorophenyl)-3-ethoxy-3-imino-propionamide
  • NCI60_006196

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus GPCR family 2 0.0018 0.0099 0.0099
Schistosoma mansoni cercarial elastase (S01 family) 0.0062 0.0438 0.0438
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0048 0.0048
Schistosoma mansoni cercarial elastase (S01 family) 0.0062 0.0438 0.0438
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0406 0.0406
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0048
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0048 0.0048
Trypanosoma cruzi serine peptidase, Clan SC, Family S10, putative 0.1292 1 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0048 0.0048
Leishmania major serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 0.1292 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0048 0.0048
Echinococcus multilocularis cpg binding protein 0.0035 0.0231 0.0231
Schistosoma mansoni hypothetical protein 0.0018 0.0099 0.0099
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0048 0.0048
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0099 0.0099
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0048 0.0048
Loa Loa (eye worm) histone methyltransferase 0.001 0.0037 0.0037
Echinococcus granulosus enteropeptidase 0.0062 0.0438 0.0438
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0.0005 0.0005
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0062 0.0438 0.0438
Mycobacterium ulcerans hypothetical protein 0.0062 0.0438 0.5
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0048 0.0048
Giardia lamblia Kinase, PLK 0.011 0.0808 0.5
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0048 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0048 0.0048
Schistosoma mansoni hypothetical protein 0.0018 0.0099 0.0099
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0048 0.0048
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0062 0.0438 0.0438
Brugia malayi CXXC zinc finger family protein 0.0033 0.0216 0.0216
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0048 0.0048
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0216 0.0216
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0048 0.0048
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0048 0.0048
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0006 0.0005 0.0005
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0021 0.0021
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0048 0.0048
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0048 0.0048
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0048 0.0048
Brugia malayi Trypsin family protein 0.0062 0.0438 0.0438
Schistosoma mansoni cercarial elastase (S01 family) 0.0062 0.0438 0.0438
Trypanosoma cruzi serine carboxypeptidase (CBP1), putative 0.1292 1 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0406 0.0406
Entamoeba histolytica serine/threonine protein kinase, putative 0.011 0.0808 0.5
Brugia malayi steroid hormone receptor 0.0012 0.0048 0.0048
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.0378 0.4577
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0808 1
Echinococcus multilocularis GPCR, family 2 0.0018 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0006 0.0005 0.0005
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0062 0.0438 0.0438
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0048 0.0048
Echinococcus multilocularis transmembrane protease serine 3 0.0062 0.0438 0.0438
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0048 0.0048
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0062 0.0438 0.0438
Onchocerca volvulus Uncharacterized serine carboxypeptidase homolog 0.1292 1 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0406 0.0406
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0048 0.0048
Schistosoma mansoni cercarial elastase (S01 family) 0.0062 0.0438 0.0438
Onchocerca volvulus 0.0062 0.0438 0.0438
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0048 0.0048
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0048 0.0048
Schistosoma mansoni cpg binding protein 0.0033 0.0216 0.0216
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0021 0.0021
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0808 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0048
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0099 0.0099
Schistosoma mansoni hypothetical protein 0.0062 0.0438 0.0438
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0048
Echinococcus granulosus family S10 non peptidase ue S10 family 0.1164 0.9007 0.9007
Schistosoma mansoni coup transcription factor 0.0012 0.0048 0.0048
Brugia malayi nuclear receptor NHR-88 0.0012 0.0048 0.0048
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0447 0.5
Schistosoma mansoni cercarial elastase (S01 family) 0.0062 0.0438 0.0438
Loa Loa (eye worm) hypothetical protein 0.0006 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0062 0.0438 0.0438
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0048
Schistosoma mansoni cpg binding protein 0.0035 0.0231 0.0231
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0048 0.0048
Echinococcus multilocularis enteropeptidase 0.0062 0.0438 0.0438
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0048 0.0048
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0048 0.0048
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0048 0.0048
Schistosoma mansoni hypothetical protein 0.0062 0.0438 0.0438
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0048 0.0048
Schistosoma mansoni cercarial elastase (S01 family) 0.0062 0.0438 0.0438
Brugia malayi Trypsin family protein 0.0062 0.0438 0.0438
Echinococcus granulosus cpg binding protein 0.0035 0.0231 0.0231
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0062 0.0438 0.0438
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0048 0.0048
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0048 0.0048
Echinococcus granulosus glycoprotein Antigen 5 0.0062 0.0438 0.0438
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0048 0.0048
Schistosoma mansoni hypothetical protein 0.0474 0.3643 0.3643
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0021 0.0021
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.0378 0.4577
Loa Loa (eye worm) hypothetical protein 0.0006 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.004 0.0264 0.0264
Trypanosoma cruzi serine peptidase, Clan SC, Family S10, putative 0.1292 1 1
Brugia malayi Trypsin family protein 0.0062 0.0438 0.0438
Schistosoma mansoni cercarial elastase (S01 family) 0.0062 0.0438 0.0438
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0062 0.0438 0.0438
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0037 0.0037
Brugia malayi hypothetical protein 0.0006 0.0005 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0048 0.0048
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0808 1
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0005 0.0005
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0062 0.0438 0.0438
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0048
Onchocerca volvulus 0.0033 0.0216 0.0216
Onchocerca volvulus 0.0012 0.0048 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0048 0.0048
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0048 0.0048
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0048 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0048 0.0048
Echinococcus multilocularis lysosomal protective protein 0.1292 1 1
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0062 0.0438 0.0438
Echinococcus granulosus transmembrane protease serine 3 0.0062 0.0438 0.0438
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0005 0.0005
Echinococcus granulosus Mastin 0.0062 0.0438 0.0438
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0062 0.0438 0.0438
Loa Loa (eye worm) hypothetical protein 0.0062 0.0438 0.0438
Brugia malayi Trypsin-like protease protein 5 0.0062 0.0438 0.0438
Schistosoma mansoni serine/threonine protein kinase 0.011 0.0808 0.0808
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0048 0.0048
Echinococcus multilocularis glycoprotein Antigen 5 0.0062 0.0438 0.0438
Echinococcus granulosus dnaJ subfamily B 0.0474 0.3643 0.3643
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0006 0.0005 0.0005
Brugia malayi nuclear hormone receptor 0.0012 0.0048 0.0048
Schistosoma mansoni cercarial elastase (S01 family) 0.0062 0.0438 0.0438
Onchocerca volvulus 0.0062 0.0438 0.0438
Schistosoma mansoni cercarial elastase (S01 family) 0.0062 0.0438 0.0438
Brugia malayi nuclear receptor RXR 0.0006 0.0005 0.0005
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0048 0.0048
Onchocerca volvulus 0.0062 0.0438 0.0438
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.011 0.0808 0.0808
Echinococcus granulosus serine:threonine protein kinase PLK1 0.011 0.0808 0.0808
Onchocerca volvulus 0.0062 0.0438 0.0438
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0048 0.0048
Trypanosoma brucei serine peptidase, Clan SC, Family S10 0.1292 1 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0018 0.0099 0.0099
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0808 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0438 0.0438
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0099 0.0099
Schistosoma mansoni kinase 0.0056 0.039 0.039
Loa Loa (eye worm) trypsin family protein 0.0062 0.0438 0.0438
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0048 0.0048
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0048 0.0048
Onchocerca volvulus 0.0062 0.0438 0.0438
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0021 0.0021
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0048 0.0048
Echinococcus multilocularis Mastin 0.0062 0.0438 0.0438
Onchocerca volvulus 0.0062 0.0438 0.0438
Schistosoma mansoni hypothetical protein 0.0018 0.0099 0.0099
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0048 0.0048
Brugia malayi serine/threonine-protein kinase plk-2 0.011 0.0808 0.0808
Schistosoma mansoni cpg binding protein 0.0035 0.0231 0.0231
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0006 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0018 0.0099 0.0099
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0048 0.0048
Trypanosoma cruzi serine carboxypeptidase (CBP1), putative 0.1292 1 1
Schistosoma mansoni family S10 unassigned peptidase (S10 family) 0.1292 1 1
Loa Loa (eye worm) hypothetical protein 0.1292 1 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0062 0.0438 0.0438
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.0005 0.0005
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0048 0.0048
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0048 0.0048
Echinococcus multilocularis family S10 non peptidase ue (S10 family) 0.1164 0.9007 0.9007
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0048 0.0048
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.004 0.0264 0.0264
Trypanosoma brucei serine peptidase, Clan SC, Family S10 0.1292 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0048 0.0048
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0264 0.0264
Brugia malayi Trypsin family protein 0.0062 0.0438 0.0438
Echinococcus granulosus lysosomal protective protein 0.1292 1 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.0506 0.0506
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0062 0.0438 0.0438
Loa Loa (eye worm) hypothetical protein 0.0062 0.0438 0.0438
Schistosoma mansoni family S10 non-peptidase homologue (S10 family) 0.1292 1 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.011 0.0808 0.0808
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0062 0.0438 0.0438
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.011 0.0808 0.0808
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0062 0.0438 0.0438
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0062 0.0438 0.0438
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0048 0.0048
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0808 1
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0048 0.0048
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0062 0.0438 0.0438
Brugia malayi hypothetical protein 0.0062 0.0438 0.0438
Schistosoma mansoni cercarial elastase (S01 family) 0.0062 0.0438 0.0438
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0048
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0062 0.0438 0.0438
Schistosoma mansoni lysosomal protective protein precursor (cathepsin A) (carboxypeptidase 0.0128 0.095 0.095
Echinococcus multilocularis dnaJ subfamily B 0.0474 0.3643 0.3643
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0048 0.0048
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0048 0.0048
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0021 0.0021
Trypanosoma brucei serine peptidase, Clan SC, Family S10 0.1292 1 1
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0808 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0406 0.0406
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0048
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.0005 0.0005
Schistosoma mansoni cercarial elastase (S01 family) 0.0062 0.0438 0.0438
Brugia malayi ecdysteroid receptor 0.0012 0.0048 0.0048
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0048 0.0048
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0808 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0048 0.0048
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0099 0.0099
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0048 0.0048
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0006 0.0005 0.0005
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0048 0.0048
Brugia malayi hypothetical protein 0.0006 0.0005 0.0005
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0036 0.0036

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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