Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0632 | 0.1076 | 0.1044 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1523 | 0.3096 | 0.4647 |
Echinococcus granulosus | protein kinase c epsilon type | 0.1523 | 0.3096 | 0.4647 |
Schistosoma mansoni | integrin alpha | 0.0805 | 0.1468 | 0.2175 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.2954 | 0.6341 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.4568 | 1 | 1 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.1523 | 0.3096 | 0.4647 |
Trichomonas vaginalis | AGC family protein kinase | 0.1523 | 0.3096 | 0.3096 |
Echinococcus multilocularis | protein kinase c iota type | 0.1523 | 0.3096 | 0.4647 |
Trichomonas vaginalis | AGC family protein kinase | 0.1523 | 0.3096 | 0.3096 |
Brugia malayi | Kelch motif family protein | 0.025 | 0.0212 | 0.0026 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.2954 | 0.6341 | 0.9573 |
Trichomonas vaginalis | serine/threonine-protein kinase sgk, putative | 0.149 | 0.3022 | 0.3022 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.4568 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.1523 | 0.3096 | 0.3096 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.3078 | 0.6622 | 1 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.2954 | 0.6341 | 0.9575 |
Echinococcus multilocularis | fibrillin 1 | 0.0175 | 0.004 | 0.0006 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.1523 | 0.3096 | 0.4647 |
Echinococcus granulosus | integrin alpha ps | 0.0361 | 0.0462 | 0.0647 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0239 | 0.0186 | 0.0228 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.025 | 0.0212 | 0.0176 |
Entamoeba histolytica | protein kinase, putative | 0.4568 | 1 | 1 |
Echinococcus multilocularis | nervana 2 | 0.2921 | 0.6266 | 0.946 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.2954 | 0.6341 | 0.9573 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1523 | 0.3096 | 0.4647 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.1523 | 0.3096 | 0.3071 |
Trichomonas vaginalis | AGC family protein kinase | 0.1523 | 0.3096 | 0.3096 |
Loa Loa (eye worm) | hypothetical protein | 0.0444 | 0.065 | 0.0617 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.3078 | 0.6622 | 1 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.1523 | 0.3096 | 0.4647 |
Brugia malayi | hypothetical protein | 0.025 | 0.0212 | 0.0026 |
Echinococcus multilocularis | integrin beta 2 | 0.1221 | 0.2412 | 0.3607 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0239 | 0.0186 | 0.0151 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 0.0186 | 0.0151 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0743 | 0.1329 | 0.1963 |
Echinococcus granulosus | nervana 2 | 0.2921 | 0.6266 | 0.946 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.1523 | 0.3096 | 0.4647 |
Echinococcus granulosus | integrin beta 2 | 0.1221 | 0.2412 | 0.3607 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.124 | 0.2456 | 0.2429 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0239 | 0.0186 | 0.0294 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.1523 | 0.3096 | 0.4647 |
Echinococcus multilocularis | nervana 2 | 0.2921 | 0.6266 | 0.946 |
Trichomonas vaginalis | AGC family protein kinase | 0.4568 | 1 | 1 |
Echinococcus granulosus | nervana 2 | 0.2921 | 0.6266 | 0.946 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.2954 | 0.6341 | 0.9573 |
Brugia malayi | Hr1 repeat family protein | 0.1523 | 0.3096 | 0.2965 |
Toxoplasma gondii | AGC kinase | 0.4444 | 0.9719 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.4568 | 1 | 1 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.2921 | 0.6266 | 0.946 |
Leishmania major | hypothetical protein, conserved | 0.0239 | 0.0186 | 1 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.2921 | 0.6266 | 0.946 |
Echinococcus multilocularis | integrin alpha 3 | 0.0617 | 0.1042 | 0.1528 |
Brugia malayi | Protein kinase domain containing protein | 0.1523 | 0.3096 | 0.2965 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.1523 | 0.3096 | 0.3071 |
Schistosoma mansoni | atypical protein kinase C | 0.1523 | 0.3096 | 0.4647 |
Trichomonas vaginalis | AGC family protein kinase | 0.1647 | 0.3378 | 0.3378 |
Entamoeba histolytica | protein kinase, putative | 0.4444 | 0.9719 | 0.9719 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.2954 | 0.6341 | 1 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0239 | 0.0186 | 0.0228 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.1523 | 0.3096 | 0.4647 |
Echinococcus granulosus | protein kinase c iota type | 0.1523 | 0.3096 | 0.4647 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1523 | 0.3096 | 0.4647 |
Loa Loa (eye worm) | hypothetical protein | 0.1523 | 0.3096 | 0.3071 |
Echinococcus multilocularis | integrin alpha ps | 0.0361 | 0.0462 | 0.0647 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0239 | 0.0186 | 0.0282 |
Echinococcus granulosus | NDR protein kinase | 0.1523 | 0.3096 | 0.4647 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.1523 | 0.3096 | 0.3071 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.4444 | 0.9719 | 0.9713 |
Schistosoma mansoni | serine/threonine kinase | 0.1523 | 0.3096 | 0.4647 |
Brugia malayi | Protein kinase domain containing protein | 0.1523 | 0.3096 | 0.2965 |
Echinococcus granulosus | integrin alpha 3 | 0.0617 | 0.1042 | 0.1528 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.2921 | 0.6266 | 0.946 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.1523 | 0.3096 | 0.4647 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.1523 | 0.3096 | 0.3071 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.3078 | 0.6622 | 0.6622 |
Trichomonas vaginalis | AGC family protein kinase | 0.4568 | 1 | 1 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0239 | 0.0186 | 0.0294 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.0609 | 0.1024 | 0.0853 |
Trichomonas vaginalis | AGC family protein kinase | 0.4568 | 1 | 1 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.1523 | 0.3096 | 0.3071 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.1523 | 0.3096 | 0.3071 |
Onchocerca volvulus | 0.0239 | 0.0186 | 0.5 | |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0743 | 0.1329 | 0.1963 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.1523 | 0.3096 | 0.4647 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.4444 | 0.9719 | 0.9718 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.007 | 0.0034 |
Brugia malayi | Integrin beta pat-3 precursor | 0.1648 | 0.338 | 0.3255 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1523 | 0.3096 | 0.4647 |
Trichomonas vaginalis | AGC family protein kinase | 0.4568 | 1 | 1 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0805 | 0.1468 | 0.1306 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1523 | 0.3096 | 0.4647 |
Loa Loa (eye worm) | hypothetical protein | 0.025 | 0.0212 | 0.0176 |
Echinococcus granulosus | serine/threonine protein kinase | 0.3078 | 0.6622 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1523 | 0.3096 | 0.4647 |
Schistosoma mansoni | integrin alpha-ps | 0.0361 | 0.0462 | 0.0647 |
Echinococcus granulosus | protein kinase C gamma type | 0.1523 | 0.3096 | 0.4647 |
Echinococcus multilocularis | integrin alpha ps | 0.0361 | 0.0462 | 0.0647 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.2921 | 0.6266 | 0.946 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.1523 | 0.3096 | 0.4647 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0743 | 0.1329 | 0.1963 |
Giardia lamblia | Kinase, AGC PKA | 0.2954 | 0.6341 | 0.5 |
Brugia malayi | protein kinase C II. | 0.1523 | 0.3096 | 0.2965 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.3078 | 0.6622 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1523 | 0.3096 | 0.4647 |
Loa Loa (eye worm) | hypothetical protein | 0.0609 | 0.1024 | 0.0991 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.1523 | 0.3096 | 0.4647 |
Schistosoma mansoni | hypothetical protein | 0.0239 | 0.0186 | 0.0228 |
Toxoplasma gondii | kringle domain-containing protein | 0.0239 | 0.0186 | 0.0192 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.3078 | 0.6622 | 1 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.1523 | 0.3096 | 0.4647 |
Schistosoma mansoni | integrin beta subunit | 0.0971 | 0.1844 | 0.2745 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.4568 | 1 | 1 |
Loa Loa (eye worm) | integrin beta-2 | 0.1648 | 0.338 | 0.3356 |
Echinococcus multilocularis | serine threonine protein kinase | 0.1523 | 0.3096 | 0.4647 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.1523 | 0.3096 | 0.4647 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.1523 | 0.3096 | 0.4647 |
Entamoeba histolytica | protein kinase 2, putative | 0.2954 | 0.6341 | 0.6341 |
Entamoeba histolytica | protein kinase, putative | 0.4568 | 1 | 1 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.3078 | 0.6622 | 0.6622 |
Schistosoma mansoni | integrin alpha-ps | 0.0188 | 0.007 | 0.0051 |
Trypanosoma cruzi | Protein kinase B | 0.3078 | 0.6622 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.4568 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.